P60843
PR
Gene name |
Eif4a1 (Ddx2a, Eif4a) |
Protein name |
Eukaryotic initiation factor 4A-I |
Names |
eIF-4A-I, eIF4A-I, ATP-dependent RNA helicase eIF4A-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13681 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P60843
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6XKI | X-ray | 287 A | A | 19-406 | PDB |
| 7DDX | X-ray | 250 A | B | 1-238 | PDB |
| AF-P60843-F1 | Predicted | AlphaFoldDB |
15 variants for P60843
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389108591 | 11 | D>E | No | EVA | |
| rs3389184285 | 58 | I>V | No | EVA | |
| rs3389184288 | 62 | A>V | No | EVA | |
| rs3389172429 | 82 | K>R | No | EVA | |
| rs3389135244 | 92 | Q>E | No | EVA | |
| rs3389182231 | 122 | A>T | No | EVA | |
| rs3389135144 | 182 | D>E | No | EVA | |
| rs3389184226 | 198 | D>E | No | EVA | |
| rs3389182161 | 211 | L>S | No | EVA | |
| rs3389145882 | 226 | K>N | No | EVA | |
| rs3389158745 | 231 | P>T | No | EVA | |
| rs3389184230 | 344 | V>I | No | EVA | |
| rs26908332 | 352 | N>S | No | EVA | |
| rs3389135245 | 392 | N>S | No | EVA | |
| rs3389172460 | 392 | N>Y | No | EVA |
No associated diseases with P60843
6 regional properties for P60843
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | ATP-dependent RNA helicase DEAD-box, conserved site | 180 - 188 | IPR000629 |
| domain | Helicase, C-terminal | 245 - 406 | IPR001650 |
| domain | DEAD/DEAH box helicase domain | 57 - 221 | IPR011545 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 51 - 249 | IPR014001 |
| domain | RNA helicase, DEAD-box type, Q motif | 32 - 60 | IPR014014 |
| domain | ATP-dependent RNA helicase eIF4A, DEAD-box helicase domain | 34 - 235 | IPR044728 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| eukaryotic translation initiation factor 4F complex | The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| double-stranded RNA binding | Binding to double-stranded RNA. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cytoplasmic translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
| translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
27 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P41378 | Eukaryotic initiation factor 4A | Triticum aestivum (Wheat) | PR | |
| P10081 | TIF2 | ATP-dependent RNA helicase eIF4A | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q3SZ54 | EIF4A1 | Eukaryotic initiation factor 4A-I | Bos taurus (Bovine) | PR |
| Q3SZ65 | EIF4A2 | Eukaryotic initiation factor 4A-II | Bos taurus (Bovine) | PR |
| Q8JFP1 | EIF4A2 | Eukaryotic initiation factor 4A-II | Gallus gallus (Chicken) | PR |
| A5A6N4 | EIF4A1 | Eukaryotic initiation factor 4A-I | Pan troglodytes (Chimpanzee) | PR |
| Q14240 | EIF4A2 | Eukaryotic initiation factor 4A-II | Homo sapiens (Human) | PR |
| P60842 | EIF4A1 | Eukaryotic initiation factor 4A-I | Homo sapiens (Human) | PR |
| Q41741 | Eukaryotic initiation factor 4A | Zea mays (Maize) | PR | |
| Q8K363 | Ddx18 | ATP-dependent RNA helicase DDX18 | Mus musculus (Mouse) | PR |
| Q4FZF3 | Ddx49 | Probable ATP-dependent RNA helicase DDX49 | Mus musculus (Mouse) | PR |
| Q8K4L0 | Ddx54 | ATP-dependent RNA helicase DDX54 | Mus musculus (Mouse) | PR |
| Q9CWX9 | Ddx47 | Probable ATP-dependent RNA helicase DDX47 | Mus musculus (Mouse) | PR |
| Q9CWT6 | Ddx28 | Probable ATP-dependent RNA helicase DDX28 | Mus musculus (Mouse) | PR |
| Q91VR5 | Ddx1 | ATP-dependent RNA helicase DDX1 | Mus musculus (Mouse) | PR |
| Q6ZPL9 | Ddx55 | ATP-dependent RNA helicase DDX55 | Mus musculus (Mouse) | PR |
| Q9ESV0 | Ddx24 | ATP-dependent RNA helicase DDX24 | Mus musculus (Mouse) | PR |
| P10630 | Eif4a2 | Eukaryotic initiation factor 4A-II | Mus musculus (Mouse) | PR |
| Q569Z5 | Ddx46 | Probable ATP-dependent RNA helicase DDX46 | Mus musculus (Mouse) | PR |
| Q5RKI1 | Eif4a2 | Eukaryotic initiation factor 4A-II | Rattus norvegicus (Rat) | PR |
| P35683 | Os06g0701100 | Eukaryotic initiation factor 4A-1 | Oryza sativa subsp japonica (Rice) | PR |
| Q6Z2Z4 | Os02g0146600 | Eukaryotic initiation factor 4A-3 | Oryza sativa subsp japonica (Rice) | PR |
| P27639 | inf-1 | Eukaryotic initiation factor 4A | Caenorhabditis elegans | PR |
| Q3E9C3 | RH58 | DEAD-box ATP-dependent RNA helicase 58, chloroplastic | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9CAI7 | TIF4A-3 | Eukaryotic initiation factor 4A-3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41377 | TIF4A-2 | Eukaryotic initiation factor 4A-2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P41376 | EIF4A1 | Eukaryotic initiation factor 4A-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSASQDSRSR | DNGPDGMEPE | GVIESNWNEI | VDSFDDMNLS | ESLLRGIYAY | GFEKPSAIQQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RAILPCIKGY | DVIAQAQSGT | GKTATFAISI | LQQIELDLKA | TQALVLAPTR | ELAQQIQKVV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MALGDYMGAS | CHACIGGTNV | RAEVQKLQME | APHIIVGTPG | RVFDMLNRRY | LSPKYIKMFV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LDEADEMLSR | GFKDQIYDIF | QKLNSNTQVV | LLSATMPSDV | LEVTKKFMRD | PIRILVKKEE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LTLEGIRQFY | INVEREEWKL | DTLCDLYETL | TITQAVIFIN | TRRKVDWLTE | KMHARDFTVS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AMHGDMDQKE | RDVIMREFRS | GSSRVLITTD | LLARGIDVQQ | VSLVINYDLP | TNRENYIHRI |
| 370 | 380 | 390 | 400 | ||
| GRGGRFGRKG | VAINMVTEED | KRTLRDIETF | YNTSIEEMPL | NVADLI |