P60842

PR
Gene name
EIF4A1 (DDX2A, EIF4A)
Protein name
Eukaryotic initiation factor 4A-I
Names
eIF-4A-I, eIF4A-I, ATP-dependent RNA helicase eIF4A-1
Species
Homo sapiens (Human)
KEGG Pathway
hsa:1973
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

11 structures for P60842

Entry ID Method Resolution Chain Position Source
2G9N X-ray 225 A A/B 20-238 PDB
2ZU6 X-ray 280 A A/C/D/F 20-406 PDB
3EIQ X-ray 350 A A/D 1-406 PDB
5ZBZ X-ray 131 A A 20-238 PDB
5ZC9 X-ray 200 A A 19-406 PDB
6ZMW EM 370 A j 1-406 PDB
7PPZ X-ray 252 A B 20-406 PDB
7PQ0 X-ray 300 A B 20-406 PDB
8HUJ EM 376 A A 2-406 PDB
8OZ0 EM 350 A 1/3 1-406 PDB
AF-P60842-F1 Predicted AlphaFoldDB

126 variants for P60842

Variant ID(s) Position Change Description Diseaes Association Provenance
CA397803592
rs139517056
 2 S>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs139517056
CA8351687
 2 S>F No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA8351688
rs779627306
 3 A>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
TOPMed
gnomAD
CA287456596
rs891239542
 3 A>V No ClinGen
TOPMed
gnomAD
CA8351690
rs768379368
 4 S>N No ClinGen
ExAC
TOPMed
gnomAD
rs200951325
CA8351692
 4 S>R No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs759758160
CA8351695
 5 Q>H No ClinGen
ExAC
TOPMed
gnomAD
CA397803628
rs149681191
 5 Q>L No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA8351694
rs149681191
 5 Q>P No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs149681191
CA8351693
 5 Q>R No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs950953435
CA287456646
 6 D>G No ClinGen
TOPMed
CA8351696
rs199974690
COSM707102
 7 S>F lung Variant assessed as Somatic; 0.0 impact. large_intestine urinary_tract [Cosmic, NCI-TCGA] No ClinGen
cosmic curated
1000Genomes
ExAC
NCI-TCGA
gnomAD
CA397803652
rs1272295986
 7 S>P No ClinGen
gnomAD
rs199974690
CA287456653
 7 S>Y Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
1000Genomes
ExAC
NCI-TCGA
gnomAD
rs928267905
COSM244232
CA287456665
 8 R>* endometrium prostate [Cosmic] No ClinGen
cosmic curated
Ensembl
rs560471589
CA8351698
 8 R>Q No ClinGen
ExAC
TOPMed
gnomAD
rs372189155
CA8351754
 18 E>D No ClinGen
ESP
ExAC
TOPMed
gnomAD
TCGA novel 20 E>K Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1258002273
CA397804797
 24 E>K No ClinGen
TOPMed
CA397804914
rs1233262122
 25 S>C No ClinGen
gnomAD
CA8351797
rs749545098
 25 S>T No ClinGen
ExAC
gnomAD
CA397804921
rs1277319699
 26 N>D No ClinGen
TOPMed
CA397804959
rs1364069393
 28 N>D No ClinGen
TOPMed
TCGA novel 28 N>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA397804993
rs1233986181
 29 E>D No ClinGen
gnomAD
rs11552651
CA287458835
 30 I>F No ClinGen
Ensembl
rs779337219
CA8351799
 33 S>N No ClinGen
ExAC
gnomAD
CA397805051
rs1415163964
 33 S>R No ClinGen
gnomAD
rs1485050805
CA397805064
 34 F>S No ClinGen
gnomAD
TCGA novel 35 D>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1270678661
CA397805095
 36 D>A No ClinGen
TOPMed
rs1419941523
CA397805163
 40 S>A No ClinGen
gnomAD
rs1036532248
CA287458865
 40 S>L Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
TOPMed
gnomAD
TCGA novel 41 E>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA397805197
rs1455059798
 42 S>F No ClinGen
gnomAD
CA397805228
rs1400990316
 45 R>C No ClinGen
gnomAD
CA397805230
rs1414585747
 45 R>H No ClinGen
gnomAD
TCGA novel 45 R>V Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs762799240
CA8351809
 55 P>L No ClinGen
ExAC
gnomAD
TCGA novel 55 P>S Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs766144308
CA8351810
 57 A>V No ClinGen
ExAC
gnomAD
rs11552638
CA287458928
 61 R>L No ClinGen
Ensembl
CA397805448
rs1597847982
 62 A>T No ClinGen
Ensembl
TCGA novel 63 I>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA8351813
rs764244678
 66 C>S No ClinGen
ExAC
gnomAD
rs565470380
CA8351815
 68 K>R No ClinGen
1000Genomes
ExAC
gnomAD
CA397805803
rs1250791633
 70 Y>* No ClinGen
gnomAD
rs11552634
CA287459562
 75 Q>* No ClinGen
Ensembl
CA397806088
rs1280149606
 77 Q>H No ClinGen
TOPMed
gnomAD
CA287459586
rs11552641
 84 A>S No ClinGen
Ensembl
CA287459595
rs11552636
 89 S>A No ClinGen
Ensembl
CA8351891
rs768559825
 90 I>F No ClinGen
ExAC
gnomAD
CA8351890
rs768559825
 90 I>V No ClinGen
ExAC
gnomAD
TCGA novel 94 I>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs374811712
CA397806580
 95 E>A No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs374811712
CA8351893
 95 E>G No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1234645199
CA397806635
 97 D>G No ClinGen
gnomAD
rs145214315
CA8351894
 100 A>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA8351896
rs774233496
 107 A>T No ClinGen
ExAC
gnomAD
TCGA novel 110 R>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 111 E>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1466821541
CA397809261
 121 M>I No ClinGen
gnomAD
TCGA novel 122 A>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA397809327
rs1429277539
 124 G>R No ClinGen
TOPMed
CA287462108
rs1002645516
 126 Y>S No ClinGen
Ensembl
rs1567734571
CA397809425
COSM984774
 127 M>T endometrium [Cosmic] No ClinGen
cosmic curated
Ensembl
CA8351972
rs767102356
 127 M>V No ClinGen
ExAC
TOPMed
gnomAD
CA397809448
rs1170380404
 128 G>S No ClinGen
gnomAD
rs760193070
CA8351974
 129 A>S No ClinGen
ExAC
gnomAD
rs760193070
CA397809467
 129 A>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
TCGA novel 132 H>Y Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs148339522
CA8351977
 133 A>T No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA287462153
rs985461314
 138 T>I Variant assessed as Somatic; impact. [NCI-TCGA] No ClinGen
Ensembl
NCI-TCGA
rs1229174572
CA397809826
 139 N>S No ClinGen
TOPMed
CA397809846
rs1319861944
 140 V>M No ClinGen
gnomAD
CA8351983
rs756236929
 141 R>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
ExAC
NCI-TCGA
gnomAD
rs1489015522
CA397810119
 148 Q>H No ClinGen
gnomAD
CA287462156
rs11552632
 148 Q>L No ClinGen
Ensembl
rs1186255431
CA397810135
 149 M>V No ClinGen
gnomAD
rs1171527049
CA397810341
 155 I>V No ClinGen
gnomAD
CA397810758
rs1350615995
 168 R>Q No ClinGen
gnomAD
rs1465951505
CA397811349
 174 K>R No ClinGen
gnomAD
rs1301237658
CA397811368
 175 Y>N No ClinGen
gnomAD
CA397811435
rs1330933425
 177 K>R No ClinGen
gnomAD
TCGA novel 177 K>T Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1374895713
CA397811502
 178 M>I No ClinGen
gnomAD
TCGA novel 178 M>L Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 185 D>H Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA397812034
rs1177832426
 192 F>C No ClinGen
gnomAD
CA397812087
rs1246790916
 194 D>N No ClinGen
TOPMed
TCGA novel 204 N>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 219 D>G Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs865904208 233 R>W Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1418798284 247 R>C Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
rs1283063684 251 I>V Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 253 V>G Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 268 E>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 284 K>N Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA397815719
rs1480750944
 291 K>M No ClinGen
TOPMed
TCGA novel 292 M>I Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs1317590696
CA397815733
 292 M>L No ClinGen
gnomAD
rs1567735382
CA397815761
 293 H>R No ClinGen
Ensembl
CA8352178
rs758502373
 295 R>Q No ClinGen
ExAC
gnomAD
CA397815850
rs1438216218
 299 V>I No ClinGen
gnomAD
CA397815891
rs1244960491
 301 A>T Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] No ClinGen
NCI-TCGA
gnomAD
CA287462939
rs112659619
 302 M>I No ClinGen
Ensembl
CA8352201
rs752935351
 306 M>T No ClinGen
ExAC
gnomAD
TCGA novel 311 R>* Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs186439250
CA287463038
 313 V>M No ClinGen
1000Genomes
gnomAD
TCGA novel 323 S>R Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 330 D>E Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA8352209
rs775034603
 331 L>M No ClinGen
ExAC
gnomAD
rs61730294
CA287463284
 344 V>L No ClinGen
Ensembl
CA397817783
rs1156365059
 347 Y>C No ClinGen
gnomAD
CA397817763
rs1296084728
 347 Y>H No ClinGen
gnomAD
TCGA novel 365 R>C Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
CA8352339
rs761383765
 373 I>V No ClinGen
ExAC
gnomAD
rs1363920037
CA397818981
 375 M>V No ClinGen
gnomAD
rs1274842003
CA397819122
 379 E>D No ClinGen
TOPMed
gnomAD
rs368951361
CA8352342
 380 D>E No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1567735983
CA397819151
 381 K>T No ClinGen
Ensembl
rs754812366
CA8352345
 384 L>V No ClinGen
ExAC
gnomAD
rs781174047
CA8352346
 385 R>Q No ClinGen
ExAC
gnomAD
TCGA novel 390 F>missing Variant assessed as Somatic; impact. [NCI-TCGA] No NCI-TCGA
rs746054327
CA8352350
 395 I>V No ClinGen
ExAC
TOPMed
gnomAD
rs1406896419
CA397819668
 401 N>S No ClinGen
gnomAD

No associated diseases with P60842

8 regional properties for P60842

Type Name Position InterPro Accession
repeat Tetratricopeptide repeat 1 83 - 115 IPR001440
domain Calcineurin-like phosphoesterase domain, ApaH type 294 - 488 IPR004843
domain Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase 262 - 538 IPR006186
domain PPP domain 227 - 286 IPR013235
repeat Tetratricopeptide repeat 14 - 47 IPR019734-1
repeat Tetratricopeptide repeat 48 - 81 IPR019734-2
repeat Tetratricopeptide repeat 82 - 115 IPR019734-3
domain PP5, C-terminal metallophosphatase domain 234 - 549 IPR041753

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
eukaryotic translation initiation factor 4F complex The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome.
extracellular exosome A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

10 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
double-stranded RNA binding Binding to double-stranded RNA.
helicase activity Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA cap binding Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
translation factor activity, RNA binding Functions during translation by binding to RNA during polypeptide synthesis at the ribosome.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

2 GO annotations of biological process

Name Definition
cytoplasmic translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

27 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P41378 Eukaryotic initiation factor 4A Triticum aestivum (Wheat) PR
P10081 TIF2 ATP-dependent RNA helicase eIF4A Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q3SZ65 EIF4A2 Eukaryotic initiation factor 4A-II Bos taurus (Bovine) PR
Q3SZ54 EIF4A1 Eukaryotic initiation factor 4A-I Bos taurus (Bovine) PR
Q8JFP1 EIF4A2 Eukaryotic initiation factor 4A-II Gallus gallus (Chicken) PR
A5A6N4 EIF4A1 Eukaryotic initiation factor 4A-I Pan troglodytes (Chimpanzee) PR
Q8NHQ9 DDX55 ATP-dependent RNA helicase DDX55 Homo sapiens (Human) PR
Q14240 EIF4A2 Eukaryotic initiation factor 4A-II Homo sapiens (Human) PR
Q9Y6V7 DDX49 Probable ATP-dependent RNA helicase DDX49 Homo sapiens (Human) PR
Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 Homo sapiens (Human) PR
Q8TDD1 DDX54 ATP-dependent RNA helicase DDX54 Homo sapiens (Human) PR
Q9GZR7 DDX24 ATP-dependent RNA helicase DDX24 Homo sapiens (Human) PR
Q92499 DDX1 ATP-dependent RNA helicase DDX1 Homo sapiens (Human) PR
Q9NY93 DDX56 Probable ATP-dependent RNA helicase DDX56 Homo sapiens (Human) PR
Q9NUL7 DDX28 Probable ATP-dependent RNA helicase DDX28 Homo sapiens (Human) PR
Q7L014 DDX46 Probable ATP-dependent RNA helicase DDX46 Homo sapiens (Human) PR
Q41741 Eukaryotic initiation factor 4A Zea mays (Maize) PR
P10630 Eif4a2 Eukaryotic initiation factor 4A-II Mus musculus (Mouse) PR
P60843 Eif4a1 Eukaryotic initiation factor 4A-I Mus musculus (Mouse) PR
Q5RKI1 Eif4a2 Eukaryotic initiation factor 4A-II Rattus norvegicus (Rat) PR
Q6Z2Z4 Os02g0146600 Eukaryotic initiation factor 4A-3 Oryza sativa subsp japonica (Rice) PR
P35683 Os06g0701100 Eukaryotic initiation factor 4A-1 Oryza sativa subsp japonica (Rice) PR
P27639 inf-1 Eukaryotic initiation factor 4A Caenorhabditis elegans PR
Q3E9C3 RH58 DEAD-box ATP-dependent RNA helicase 58, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
Q9CAI7 TIF4A-3 Eukaryotic initiation factor 4A-3 Arabidopsis thaliana (Mouse-ear cress) PR
P41376 EIF4A1 Eukaryotic initiation factor 4A-1 Arabidopsis thaliana (Mouse-ear cress) PR
P41377 TIF4A-2 Eukaryotic initiation factor 4A-2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSASQDSRSR DNGPDGMEPE GVIESNWNEI VDSFDDMNLS ESLLRGIYAY GFEKPSAIQQ
70 80 90 100 110 120
RAILPCIKGY DVIAQAQSGT GKTATFAISI LQQIELDLKA TQALVLAPTR ELAQQIQKVV
130 140 150 160 170 180
MALGDYMGAS CHACIGGTNV RAEVQKLQME APHIIVGTPG RVFDMLNRRY LSPKYIKMFV
190 200 210 220 230 240
LDEADEMLSR GFKDQIYDIF QKLNSNTQVV LLSATMPSDV LEVTKKFMRD PIRILVKKEE
250 260 270 280 290 300
LTLEGIRQFY INVEREEWKL DTLCDLYETL TITQAVIFIN TRRKVDWLTE KMHARDFTVS
310 320 330 340 350 360
AMHGDMDQKE RDVIMREFRS GSSRVLITTD LLARGIDVQQ VSLVINYDLP TNRENYIHRI
370 380 390 400
GRGGRFGRKG VAINMVTEED KRTLRDIETF YNTSIEEMPL NVADLI