P60838

PR
Gene name
SUMM2
Protein name
Disease resistance protein SUMM2
Names
Disease resistance protein At1g12280, Protein SUPPRESSOR OF MKK1 MKK2 2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT1G12280
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

11-97 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P60838

Entry ID Method Resolution Chain Position Source
AF-P60838-F1 Predicted AlphaFoldDB

110 variants for P60838

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH00019559 13 E>Q No 1000Genomes
tmp_1_4177516_A_G 15 V>A No 1000Genomes
tmp_1_4177517_C_T 15 V>M No 1000Genomes
ENSVATH00019558 22 L>V No 1000Genomes
tmp_1_4177451_C_A 37 V>L No 1000Genomes
tmp_1_4177441_T_G 40 K>T No 1000Genomes
ENSVATH04563909 45 V>M No 1000Genomes
ENSVATH04563908 46 L>V No 1000Genomes
ENSVATH04563907 53 V>M No 1000Genomes
ENSVATH00019555 57 V>L No 1000Genomes
ENSVATH11048332 59 I>M No 1000Genomes
ENSVATH11048331 63 T>R No 1000Genomes
ENSVATH04563905 67 E>K No 1000Genomes
tmp_1_4177336_C_T 75 W>* No 1000Genomes
ENSVATH00019554 83 E>D No 1000Genomes
tmp_1_4177288_G_C 91 T>S No 1000Genomes
tmp_1_4177279_T_G 94 D>A No 1000Genomes
ENSVATH00019553 98 Q>H No 1000Genomes
tmp_1_4177258_C_A 101 C>F No 1000Genomes
ENSVATH11048330 123 M>L No 1000Genomes
tmp_1_4177183_T_C 126 E>G No 1000Genomes
tmp_1_4177149_A_C 137 D>E No 1000Genomes
ENSVATH00019552 148 I>T No 1000Genomes
ENSVATH04563904 150 E>K No 1000Genomes
ENSVATH01040823 163 M>I No 1000Genomes
ENSVATH04563903 164 L>F No 1000Genomes
ENSVATH11048329 170 R>C No 1000Genomes
tmp_1_4177051_C_T 170 R>H No 1000Genomes
ENSVATH04563901 192 L>F No 1000Genomes
tmp_1_4176932_C_G 210 V>L No 1000Genomes
tmp_1_4176923_C_T 213 V>M No 1000Genomes
tmp_1_4176875_C_T 229 G>R No 1000Genomes
ENSVATH04563897 232 L>I No 1000Genomes
ENSVATH00019550 240 D>N No 1000Genomes
ENSVATH04563896 266 D>H No 1000Genomes
tmp_1_4176676_G_A 295 S>F No 1000Genomes
tmp_1_4176673_C_T,A 296 R>I No 1000Genomes
tmp_1_4176673_C_T,A 296 R>K No 1000Genomes
tmp_1_4176672_T_A 296 R>S No 1000Genomes
tmp_1_4176671_C_A 297 D>Y No 1000Genomes
tmp_1_4176659_G_A 301 R>C No 1000Genomes
ENSVATH01040822 301 R>L No 1000Genomes
ENSVATH01040821 304 V>A No 1000Genomes
tmp_1_4176637_A_G 308 M>T No 1000Genomes
ENSVATH04563894 315 P>S No 1000Genomes
tmp_1_4176600_T_A 320 E>D No 1000Genomes
tmp_1_4176597_C_A 321 L>F No 1000Genomes
ENSVATH00019549 328 E>G No 1000Genomes
ENSVATH00019548 338 P>L No 1000Genomes
tmp_1_4176500_C_T 354 A>T No 1000Genomes
tmp_1_4176421_G_A 380 S>L No 1000Genomes
ENSVATH11048328 381 Y>F No 1000Genomes
ENSVATH04563892 405 E>G No 1000Genomes
ENSVATH04563891 410 C>R No 1000Genomes
tmp_1_4176298_T_G 421 Y>S No 1000Genomes
tmp_1_4176250_A_T 437 F>Y No 1000Genomes
tmp_1_4176232_C_T 443 S>N No 1000Genomes
ENSVATH04563889 466 E>V No 1000Genomes
ENSVATH04563888 477 H>Y No 1000Genomes
tmp_1_4176122_C_T 480 V>I No 1000Genomes
tmp_1_4176080_G_A 494 H>Y No 1000Genomes
ENSVATH04563887 508 E>V No 1000Genomes
tmp_1_4175995_G_A 522 S>L No 1000Genomes
ENSVATH04563886 533 G>A No 1000Genomes
ENSVATH13884931 534 S>R No 1000Genomes
tmp_1_4175953_T_C 536 E>G No 1000Genomes
tmp_1_4175954_C_T 536 E>K No 1000Genomes
ENSVATH11048327 546 Q>H No 1000Genomes
ENSVATH04563885 560 R>W No 1000Genomes
ENSVATH04563884 571 S>L No 1000Genomes
tmp_1_4175812_A_G 583 I>T No 1000Genomes
tmp_1_4175770_G_C 597 T>R No 1000Genomes
ENSVATH00019544 599 I>M No 1000Genomes
ENSVATH11048326 601 R>L No 1000Genomes
ENSVATH04563883 601 R>W No 1000Genomes
tmp_1_4175752_G_T 603 P>H No 1000Genomes
ENSVATH00019543 607 Q>L No 1000Genomes
ENSVATH11048325 616 R>G No 1000Genomes
ENSVATH04563881 617 L>V No 1000Genomes
tmp_1_4175698_T_C 621 K>R No 1000Genomes
tmp_1_4175673_T_C 629 I>M No 1000Genomes
tmp_1_4175662_G_T 633 S>* No 1000Genomes
tmp_1_4175648_A_C 638 L>V No 1000Genomes
tmp_1_4175636_G_A 642 Q>* No 1000Genomes
tmp_1_4175632_G_T 643 S>Y No 1000Genomes
ENSVATH04563879 654 E>A No 1000Genomes
tmp_1_4175519_G_A 681 P>S No 1000Genomes
ENSVATH00019542 682 R>K No 1000Genomes
tmp_1_4175506_T_G 685 K>T No 1000Genomes
ENSVATH04563878 706 P>L No 1000Genomes
ENSVATH11048243 712 N>K No 1000Genomes
ENSVATH00019541 729 K>T No 1000Genomes
ENSVATH04563877 748 S>T No 1000Genomes
tmp_1_4175260_G_T 767 A>D No 1000Genomes
ENSVATH04563875 782 E>G No 1000Genomes
ENSVATH07510252 785 I>T No 1000Genomes
tmp_1_4175191_G_A 790 A>V No 1000Genomes
tmp_1_4175144_G_A 806 R>C No 1000Genomes
ENSVATH11048242 809 N>I No 1000Genomes
ENSVATH01040816 811 A>P No 1000Genomes
ENSVATH04563874 811 A>V No 1000Genomes
ENSVATH13884930 822 S>Y No 1000Genomes
tmp_1_4175071_T_C 830 H>R No 1000Genomes
tmp_1_4175063_T_A 833 K>* No 1000Genomes
tmp_1_4175027_C_A 845 E>* No 1000Genomes
ENSVATH00019538 848 I>L No 1000Genomes
tmp_1_4174956_C_T 868 W>* No 1000Genomes
ENSVATH11048241 875 L>F No 1000Genomes
ENSVATH11048240 880 F>I No 1000Genomes
ENSVATH04563871 890 V>I No 1000Genomes

No associated diseases with P60838

12 regional properties for P60838

Type Name Position InterPro Accession
domain Protein kinase domain 1079 - 1346 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 1079 - 1337 IPR001245
domain Sema domain 27 - 516 IPR001627
repeat Plexin repeat 521 - 562 IPR002165
domain IPT domain 563 - 656 IPR002909-1
domain IPT domain 657 - 740 IPR002909-2
domain IPT domain 742 - 837 IPR002909-3
domain IPT domain 839 - 935 IPR002909-4
active_site Tyrosine-protein kinase, active site 1201 - 1213 IPR008266
domain PSI domain 520 - 563 IPR016201
binding_site Protein kinase, ATP binding site 1085 - 1111 IPR017441
domain Tyrosine-protein kinase, catalytic domain 1079 - 1338 IPR020635

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ADP binding Binding to ADP, adenosine 5'-diphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

1 GO annotations of biological process

Name Definition
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

21 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
F1MHT9 NLRC4 NLR family CARD domain-containing protein 4 Bos taurus (Bovine) SS
O14727 APAF1 Apoptotic protease-activating factor 1 Homo sapiens (Human) EV
Q9NPP4 NLRC4 NLR family CARD domain-containing protein 4 Homo sapiens (Human) SS
Q3UP24 Nlrc4 NLR family CARD domain-containing protein 4 Mus musculus (Mouse) EV
F1M649 Nlrc4 NLR family CARD domain-containing protein 4 Rattus norvegicus (Rat) SS
O22727 At1g61190 Probable disease resistance protein At1g61190 Arabidopsis thaliana (Mouse-ear cress) PR
O64790 At1g61300 Probable disease resistance protein At1g61300 Arabidopsis thaliana (Mouse-ear cress) PR
O64973 RPS5 Disease resistance protein RPS5 Arabidopsis thaliana (Mouse-ear cress) PR
P0C8S1 RPP8L2 Probable disease resistance RPP8-like protein 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q38834 RPP13L4 Disease resistance RPP13-like protein 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q39214 RPM1 Disease resistance protein RPM1 Arabidopsis thaliana (Mouse-ear cress) PR
Q8W3K3 At1g58400 Putative disease resistance protein At1g58400 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C646 RXW24L Probable disease resistance protein RXW24L Arabidopsis thaliana (Mouse-ear cress) PR
Q9FJB5 RPP8L3 Disease resistance RPP8-like protein 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LRR4 RPPL1 Putative disease resistance RPP13-like protein 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9T048 At4g27190 Disease resistance protein At4g27190 Arabidopsis thaliana (Mouse-ear cress) PR
Q9XIF0 At1g59780 Putative disease resistance protein At1g59780 Arabidopsis thaliana (Mouse-ear cress) PR
Q5G5E0 PIRL5 Plant intracellular Ras-group-related LRR protein 5 Arabidopsis thaliana (Mouse-ear cress) PR
O64789 At1g61310 Probable disease resistance protein At1g61310 Arabidopsis thaliana (Mouse-ear cress) PR
Q940K0 UNI Disease resistance protein UNI Arabidopsis thaliana (Mouse-ear cress) PR
Q9I9H8 apaf1 Apoptotic protease-activating factor 1 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MGACLTLSFS CDEVVNQISQ GLCINVGYIC ELSKNVVAMK KDMEVLKKKR DDVKRRVDIE
70 80 90 100 110 120
EFTRRRERLS QVQGWLTNVS TVENKFNELL TTNDAELQRL CLFGFCSKNV KMSYLYGKRV
130 140 150 160 170 180
VLMLKEIESL SSQGDFDTVT LATPIARIEE MPIQPTIVGQ ETMLERVWTR LTEDGDEIVG
190 200 210 220 230 240
LYGMGGVGKT TLLTRINNKF SEKCSGFGVV IWVVVSKSPD IHRIQGDIGK RLDLGGEEWD
250 260 270 280 290 300
NVNENQRALD IYNVLGKQKF VLLLDDIWEK VNLEVLGVPY PSRQNGCKVV FTTRSRDVCG
310 320 330 340 350 360
RMRVDDPMEV SCLEPNEAWE LFQMKVGENT LKGHPDIPEL ARKVAGKCCG LPLALNVIGE
370 380 390 400 410 420
TMACKRMVQE WRNAIDVLSS YAAEFPGMEQ ILPILKYSYD NLNKEQVKPC FLYCSLFPED
430 440 450 460 470 480
YRMEKERLID YWICEGFIDE NESRERALSQ GYEIIGILVR ACLLLEEAIN KEQVKMHDVV
490 500 510 520 530 540
REMALWIASD LGEHKERCIV QVGVGLREVP KVKNWSSVRR MSLMENEIEI LSGSPECLEL
550 560 570 580 590 600
TTLFLQKNDS LLHISDEFFR CIPMLVVLDL SGNSSLRKLP NQISKLVSLR YLDLSWTYIK
610 620 630 640 650 660
RLPVGLQELK KLRYLRLDYM KRLKSISGIS NISSLRKLQL LQSKMSLDMS LVEELQLLEH
670 680 690 700 710 720
LEVLNISIKS SLVVEKLLNA PRLVKCLQIL VLRGVQEESS GVLTLPDMDN LNKVIIRKCG
730 740 750 760 770 780
MCEIKIERKT LSLSSNRSPK TQFLHNLSTV HISSCDGLKD LTWLLFAPNL TSLEVLDSEL
790 800 810 820 830 840
VEGIINQEKA MTMSGIIPFQ KLESLRLHNL AMLRSIYWQP LSFPCLKTIH ITKCPELRKL
850 860 870 880 890
PLDSEIAIRD EELVIKYQEE EWLERVEWDN EATRLRFLPF FKFFGPEWQV SYVR