P59383

PR
Gene name
Lrrn4
Protein name
Leucine-rich repeat neuronal protein 4
Names
Neuronal leucine-rich repeat protein 4, NLRR-4
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:320974
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

400-487 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P59383

Entry ID Method Resolution Chain Position Source
AF-P59383-F1 Predicted AlphaFoldDB

68 variants for P59383

Variant ID(s) Position Change Description Diseaes Association Provenance
rs265756073 6 M>T No EVA
rs3388587947 11 Q>H No EVA
rs247698080 15 Q>R No EVA
rs249086375 47 D>H No EVA
rs233438414 61 A>T No EVA
rs263635404 88 D>E No EVA
rs3388596256 89 G>D No EVA
rs240042918 104 R>H No EVA
rs242527940 124 G>S No EVA
rs244920041 138 H>Y No EVA
rs3392267675 142 T>P No EVA
rs3388594324 142 T>S No EVA
rs3392151900 147 C>R No EVA
rs3388586843 151 S>* No EVA
rs3392248228 152 G>V No EVA
rs3392229087 154 S>R No EVA
rs226887049 166 R>G No EVA
rs263597950 180 R>Q No EVA
rs3388594312 190 G>A No EVA
rs3388591228 211 L>S No EVA
rs3388581152 217 S>T No EVA
rs3388581079 220 R>K No EVA
rs219746138 223 S>P No EVA
rs3388595165 250 I>N No EVA
rs3388594373 259 Q>* No EVA
rs3388594405 273 T>I No EVA
rs3391956752 288 Q>V No EVA
rs27245855 325 D>N No EVA
rs27245864 334 A>E No EVA
rs3388581078 337 T>I No EVA
rs265437437 377 R>S No EVA
rs252882823 379 D>N No EVA
rs3388595999 380 H>Y No EVA
rs228426832 382 V>I No EVA
rs260820978 386 R>W No EVA
rs27245865 390 P>S No EVA
rs27245866 393 E>G No EVA
rs1132173059 413 P>L No EVA
rs1135020392 418 T>A No EVA
rs223548987 425 W>* No EVA
rs246024639 425 W>R No EVA
rs3388594799 429 D>E No EVA
rs262954725 430 A>T No EVA
rs240173845 431 S>P No EVA
rs1132468644 436 Q>H No EVA
rs3388591598 447 S>T No EVA
rs3388581102 449 A>S No EVA
rs3388594730 453 A>D No EVA
rs3388595151 462 A>D No EVA
rs3388597951 464 H>R No EVA
rs3388594746 507 A>V No EVA
rs3388596215 518 P>L No EVA
rs3388597953 539 P>H No EVA
rs3388587939 540 Q>K No EVA
rs3388586810 540 Q>R No EVA
rs3392255095 547 H>Q No EVA
rs3388591198 548 P>A No EVA
rs3412697085 551 H>R No EVA
rs3392255112 555 P>S No EVA
rs3392229044 562 R>G No EVA
rs3392207557 563 F>C No EVA
rs3392222135 566 R>C No EVA
rs3388588213 580 P>S No EVA
rs3388588198 612 V>M No EVA
rs3388594280 623 V>M No EVA
rs3388596232 658 S>* No EVA
rs3388596899 664 R>M No EVA
rs217247870 733 E>* No EVA

No associated diseases with P59383

8 regional properties for P59383

Type Name Position InterPro Accession
repeat Leucine-rich repeat 130 - 185 IPR001611
repeat Leucine-rich repeat, typical subtype 105 - 126 IPR003591-1
repeat Leucine-rich repeat, typical subtype 128 - 151 IPR003591-2
repeat Leucine-rich repeat, typical subtype 153 - 175 IPR003591-3
repeat Leucine-rich repeat, typical subtype 176 - 199 IPR003591-4
repeat Leucine-rich repeat, typical subtype 205 - 228 IPR003591-5
repeat Leucine-rich repeat, typical subtype 229 - 253 IPR003591-6
domain Fibronectin type III 576 - 675 IPR003961

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
long-term memory The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
visual learning Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.

36 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3MHH9 ECM2 Extracellular matrix protein 2 Bos taurus (Bovine) PR
P58874 OPTC Opticin Bos taurus (Bovine) PR
Q24K06 LRRC10 Leucine-rich repeat-containing protein 10 Bos taurus (Bovine) PR
Q9V780 Lap1 Protein lap1 Drosophila melanogaster (Fruit fly) PR
Q96NW7 LRRC7 Leucine-rich repeat-containing protein 7 Homo sapiens (Human) PR
Q8IWT6 LRRC8A Volume-regulated anion channel subunit LRRC8A Homo sapiens (Human) PR
Q9HCJ2 LRRC4C Leucine-rich repeat-containing protein 4C Homo sapiens (Human) PR
Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 Homo sapiens (Human) PR
Q96L50 LRR1 Leucine-rich repeat protein 1 Homo sapiens (Human) PR
Q86UN2 RTN4RL1 Reticulon-4 receptor-like 1 Homo sapiens (Human) PR
Q8IWK6 ADGRA3 Adhesion G protein-coupled receptor A3 Homo sapiens (Human) PR
Q7L1W4 LRRC8D Volume-regulated anion channel subunit LRRC8D Homo sapiens (Human) PR
Q96FE5 LINGO1 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Homo sapiens (Human) PR
Q8TDW0 LRRC8C Volume-regulated anion channel subunit LRRC8C Homo sapiens (Human) PR
Q38SD2 LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens (Human) EV
A6H694 Lrrc63 Leucine-rich repeat-containing protein 63 Mus musculus (Mouse) PR
Q9D9Q0 Lrrc69 Leucine-rich repeat-containing protein 69 Mus musculus (Mouse) PR
Q8BGI7 Lrrc39 Leucine-rich repeat-containing protein 39 Mus musculus (Mouse) PR
Q7TT36 Adgra3 Adhesion G protein-coupled receptor A3 Mus musculus (Mouse) PR
Q9D1T0 Lingo1 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 Mus musculus (Mouse) PR
Q8R502 Lrrc8c Volume-regulated anion channel subunit LRRC8C Mus musculus (Mouse) PR
Q80WG5 Lrrc8a Volume-regulated anion channel subunit LRRC8A Mus musculus (Mouse) PR
Q8K0S5 Rtn4rl1 Reticulon-4 receptor-like 1 Mus musculus (Mouse) PR
Q80TE7 Lrrc7 Leucine-rich repeat-containing protein 7 Mus musculus (Mouse) PR
Q5DU41 Lrrc8b Volume-regulated anion channel subunit LRRC8B Mus musculus (Mouse) PR
Q8C031 Lrrc4c Leucine-rich repeat-containing protein 4C Mus musculus (Mouse) PR
Q5RKR3 Islr2 Immunoglobulin superfamily containing leucine-rich repeat protein 2 Mus musculus (Mouse) PR
P70587 Lrrc7 Leucine-rich repeat-containing protein 7 Rattus norvegicus (Rat) PR
Q4V8G0 Lrrc63 Leucine-rich repeat-containing protein 63 Rattus norvegicus (Rat) PR
Q80WD0 Rtn4rl1 Reticulon-4 receptor-like 1 Rattus norvegicus (Rat) PR
Q9TZM3 lrk-1 Leucine-rich repeat serine/threonine-protein kinase 1 Caenorhabditis elegans SS
Q9SHI4 RLP3 Receptor-like protein 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q5G5E0 PIRL5 Plant intracellular Ras-group-related LRR protein 5 Arabidopsis thaliana (Mouse-ear cress) PR
B0JZ65 lrwd1 Leucine-rich repeat and WD repeat-containing protein 1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q68F79 lrrc8e Volume-regulated anion channel subunit LRRC8E Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
B0R160 lrwd1 Leucine-rich repeat and WD repeat-containing protein 1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MRWTLMLQLL QLLLQLLMAQ SQSLERISQD RIPLFRLTQQ GDWDSLDRHP TDSLCVGLPA
70 80 90 100 110 120
AGVTTLNLAN RSLESLPSCL PRTLRSLDGS HNLLRALSEP VLGRLPELRV LTLHHNRISV
130 140 150 160 170 180
LHWGRDTLAE LRELDLSHNL LTELPPCAGP SGSSLRSLAL AGNPLRALLP RTFACFPALR
190 200 210 220 230 240
LLNLSCSELG HIAQEAFAGV DGGPLAALEL LDLSGTSLER VESGWIRNLP KLKSLFLRKM
250 260 270 280 290 300
PRLKTLEGDI FKMTPNLRQL DCGDSPALTS VHTEIFQDTP NLQVLQFQNC NLSSFGPWNS
310 320 330 340 350 360
SQVLSVSLFG NPLICSCELA WLLVDVNKTV LHRAADTMCE PALGSTGPFS GPLSLSHLSN
370 380 390 400 410 420
VCRSDQSTTL LPSNPGRFDH SVFAPRIQGP SIEQSTALSA QPGGSQQNIT KVPSLTMTSP
430 440 450 460 470 480
TQGSWMYKDA SEETAQSTNS ELVYSPSRAL PGAASSGAEQ TATHILEPNI SSASTPLVSK
490 500 510 520 530 540
YLEPLPTSPN PRSLPQTKQR TQATPRALHT DPPQDEIPVL LLDDDSEEEE TRDQVAAPPQ
550 560 570 580 590 600
DVSCEYHPCK HLQTPCAELQ RRFRCRCPGL SGEDTTPDPP TLQGVSEVTD TSVLVHWCAP
610 620 630 640 650 660
NSVVLWYQIH YVAEGRSGNQ SVVDIYATAR QHPLYKLTPG TTYHVCVLAA NRAGLSQSQT
670 680 690 700 710 720
SGWRRSCATF TTKPSSVVIF WGLCTASGLL LVSTLVLSVC LWRQRWKPHR QFYDTHLVAF
730
KNPARAEEVT QWE