P59226
PR
Gene name |
HTR2 (At1g09200, T12M4.9;, HTR3, At3g27360, K1G2.8;, HTR13, At5g10390, F12B17_260;, HTR9, At5g10400, F12B17_250;, HTR1, At5g65360, MNA5.9) |
Protein name |
Histone H3.1 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G65360 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
26 structures for P59226
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4FT2 | X-ray | 320 A | P | 2-16 | PDB |
| 4FT4 | X-ray | 270 A | P/Q | 2-33 | PDB |
| 4IUR | X-ray | 250 A | C | 2-16 | PDB |
| 4IUT | X-ray | 270 A | C | 2-16 | PDB |
| 4IUU | X-ray | 270 A | C | 2-16 | PDB |
| 4IUV | X-ray | 280 A | C | 2-16 | PDB |
| 5HH7 | X-ray | 190 A | P | 2-16 | PDB |
| 5VAH | X-ray | 240 A | C/D | 22-36 | PDB |
| 5VBC | X-ray | 210 A | C/D | 24-37 | PDB |
| 5YC3 | X-ray | 260 A | P | 2-10 | PDB |
| 5YC4 | X-ray | 270 A | P | 2-10 | PDB |
| 5YKO | X-ray | 290 A | P | 2-11 | PDB |
| 5YVX | X-ray | 159 A | C | 2-10 | PDB |
| 5Z8L | X-ray | 200 A | P | 21-36 | PDB |
| 5Z8N | X-ray | 310 A | P/Q/R | 2-16 | PDB |
| 5ZNP | X-ray | 280 A | P/Q | 2-16 | PDB |
| 5ZNR | X-ray | 320 A | P/Q | 21-37 | PDB |
| 5ZWX | X-ray | 190 A | P/Q | 2-16 | PDB |
| 6IP4 | X-ray | 260 A | B | 25-36 | PDB |
| 6LQE | X-ray | 190 A | P | 2-16 | PDB |
| 6LQF | X-ray | 150 A | P | 2-16 | PDB |
| 7CCE | X-ray | 240 A | P | 21-38 | PDB |
| 7DE9 | X-ray | 171 A | P | 2-16 | PDB |
| 7T7T | X-ray | 317 A | W/X | 2-46 | PDB |
| 7YTA | X-ray | 231 A | P/Q/R | 2-16 | PDB |
| AF-P59226-F1 | Predicted | AlphaFoldDB |
14 variants for P59226
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_3_10129813_C_G | 19 | K>N | No | 1000Genomes | |
| tmp_3_10129810_T_A | 20 | Q>H | No | 1000Genomes | |
| ENSVATH10829990 | 31 | P>L | No | 1000Genomes | |
| tmp_3_10129773_T_C | 33 | T>A | No | 1000Genomes | |
| ENSVATH06948058 | 48 | A>T | No | 1000Genomes | |
| ENSVATH01027091 | 49 | L>F | No | 1000Genomes | |
| ENSVATH06948057 | 56 | Q>* | No | 1000Genomes | |
| ENSVATH02218788 | 75 | I>V | No | 1000Genomes | |
| tmp_5_3270651_T_G | 80 | K>Q | No | 1000Genomes | |
| ENSVATH05935887 | 101 | L>F | No | 1000Genomes | |
| tmp_3_10129548_T_A | 108 | T>S | No | 1000Genomes | |
| tmp_5_3270558_A_C | 111 | C>G | No | 1000Genomes | |
| tmp_3_10129479_T_C,G | 131 | I>L | No | 1000Genomes | |
| tmp_3_10129479_T_C,G | 131 | I>V | No | 1000Genomes |
No associated diseases with P59226
1 regional properties for P59226
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Histone H2A/H2B/H3 | 1 - 132 | IPR007125 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromocenter | A region in which centric, heterochromatic portions from more than one chromosomes form a compact structure. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| nucleosome | A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plastid | Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| protein heterodimerization activity | Binding to a nonidentical protein to form a heterodimer. |
| structural constituent of chromatin | The action of a molecule that contributes to the structural integrity of chromatin. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
38 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P68428 | Histone H3.2 | Triticum aestivum (Wheat) | PR | |
| Q5E9F8 | H3-3B | Histone H3.3 | Bos taurus (Bovine) | PR |
| P68432 | Histone H3.1 | Bos taurus (Bovine) | PR | |
| P84227 | Histone H3.2 | Bos taurus (Bovine) | PR | |
| P84247 | H3-X | Histone H3.3 | Gallus gallus (Chicken) | PR |
| P84229 | H3-VIII | Histone H3.2 | Gallus gallus (Chicken) | PR |
| P02299 | His3 | Histone H3 | Drosophila melanogaster (Fruit fly) | PR |
| Q71H73 | Histone H3.3 | Vitis vinifera (Grape) | PR | |
| P68431 | H3C12 | Histone H3.1 | Homo sapiens (Human) | PR |
| P84243 | H3-3B | Histone H3.3 | Homo sapiens (Human) | PR |
| Q71DI3 | H3C13 | Histone H3.2 | Homo sapiens (Human) | PR |
| Q16695 | H3-4 | Histone H3.1t | Homo sapiens (Human) | PR |
| P69246 | H3C4 | Histone H3.2 | Zea mays (Maize) | PR |
| P68433 | H3c11 | Histone H3.1 | Mus musculus (Mouse) | PR |
| P84228 | H3c15 | Histone H3.2 | Mus musculus (Mouse) | PR |
| P84244 | H3-3b | Histone H3.3 | Mus musculus (Mouse) | PR |
| P02301 | H3-5 | Histone H3.3C | Mus musculus (Mouse) | PR |
| Q71LE2 | H3-3A | Histone H3.3 | Sus scrofa (Pig) | PR |
| O35799 | Hfe | Hereditary hemochromatosis protein homolog | Rattus norvegicus (Rat) | PR |
| P84245 | H3-3b | Histone H3.3 | Rattus norvegicus (Rat) | PR |
| Q6LED0 | Histone H3.1 | Rattus norvegicus (Rat) | PR | |
| Q0JCT1 | H3 | Histone H3.3 | Oryza sativa subsp japonica (Rice) | PR |
| Q2RAD9 | H3R-21 | Histone H3.2 | Oryza sativa subsp japonica (Rice) | PR |
| Q27490 | his-70 | Histone H3.3-like type 1 | Caenorhabditis elegans | PR |
| P08898 | his-2 | Histone H3 | Caenorhabditis elegans | PR |
| Q10453 | his-71 | Histone H3.3 type 1 | Caenorhabditis elegans | PR |
| Q27532 | his-74 | Histone H3.3-like type 2 | Caenorhabditis elegans | PR |
| Q9U281 | his-72 | Histone H3.3 type 2 | Caenorhabditis elegans | PR |
| P59226 | HTR2 | Histone H3.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FKQ3 | At5g65350 | Histone H3-like 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FX60 | At1g13370 | Histone H3-like 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FXI7 | MGH3 | Histone H3-like 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LR02 | At1g75600 | Histone H3-like 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P59169 | HTR4 | Histone H3.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6P823 | TGas113e22.1 | Histone H3.3 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q28D37 | TGas081o10.1 | Histone H3.2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q4QRF4 | zgc:113984; | Histone H3.2 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| Q6PI20 | h3f3a | Histone H3.3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MARTKQTARK | STGGKAPRKQ | LATKAARKSA | PATGGVKKPH | RFRPGTVALR | EIRKYQKSTE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LLIRKLPFQR | LVREIAQDFK | TDLRFQSSAV | AALQEAAEAY | LVGLFEDTNL | CAIHAKRVTI |
| 130 | |||||
| MPKDIQLARR | IRGERA |