AiPD: Autoinhibited Protein Database

P59190

Gene name	RAB15
Protein name	Ras-related protein Rab-15
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:376267
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

145-212 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

145-212 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P59190

Entry ID	Method	Resolution	Chain	Position	Source
AF-P59190-F1	Predicted				AlphaFoldDB

156 variants for P59190

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA390037554 rs1171391787	4	Q>H		No	ClinGen gnomAD
rs765768922 CA7232219	5	Y>*		No	ClinGen ExAC gnomAD
TCGA novel	8	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA262711469 rs867382047	10	R>L		No	ClinGen Ensembl
rs1261741198 CA390037512	11	L>P		No	ClinGen gnomAD
CA7232212 rs770505396 CA390037492	15	G>R		No	ClinGen ExAC TOPMed gnomAD
CA390037487 rs762799909	16	D>H		No	ClinGen ExAC TOPMed gnomAD
CA7232211 rs762799909	16	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1412566498 CA390037479	17	S>P		No	ClinGen Ensembl
CA262711436 rs866985440	20	G>D		No	ClinGen Ensembl
rs769741233 CA7232209	23	C>G		No	ClinGen ExAC gnomAD
rs374073902 CA262711429	23	C>S		No	ClinGen ESP TOPMed
rs903658120 CA390037423	26	C>F		No	ClinGen gnomAD
rs903658120 CA262711423	26	C>Y		No	ClinGen gnomAD
rs377176510 CA7232207	27	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7232206 rs377176510	27	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA390037419 rs1354794506	27	R>P		No	ClinGen gnomAD
CA390037403 rs1194030662	29	T>I		No	ClinGen TOPMed
CA390037397 rs1467567256	30	D>V		No	ClinGen gnomAD
CA7232205 rs747103222	31	N>D		No	ClinGen ExAC gnomAD
CA390037389 rs1249687945	31	N>K		No	ClinGen TOPMed
TCGA novel	34	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1427326442 CA390037365	34	H>Q		No	ClinGen gnomAD
CA390037369 rs1481063104	34	H>Y		No	ClinGen gnomAD
rs1488274678 CA390037352	36	S>*		No	ClinGen gnomAD
CA390037354 rs1488274678	36	S>L		No	ClinGen gnomAD
rs1456225797 CA390037340	38	I>N		No	ClinGen gnomAD
CA7232201 rs779191211	41	I>V		No	ClinGen ExAC gnomAD
rs1189770621 CA390037316	42	G>C		No	ClinGen TOPMed
rs1274510537 CA390035778	46	K>E		No	ClinGen gnomAD
rs377675042 CA7232167	46	K>N		No	ClinGen ESP ExAC TOPMed
rs1217343545 CA390035772	46	K>T		No	ClinGen gnomAD
rs752076835 CA7232166	48	K>R		No	ClinGen ExAC TOPMed gnomAD
rs1566843055 CA390035701	50	I>T		No	ClinGen Ensembl
rs745962156 CA7232165	51	E>*		No	ClinGen ExAC gnomAD
rs1388708860 CA390035674	52	V>A		No	ClinGen gnomAD
rs1036200534 CA262698413	52	V>I		No	ClinGen TOPMed
CA262698407 rs866858844	54	G>D		No	ClinGen Ensembl
CA390035651 rs1292716065	54	G>S		No	ClinGen TOPMed gnomAD
CA390035598 rs1168396668	58	R>Q		No	ClinGen TOPMed gnomAD
CA390035600 rs1425506513	58	R>W		No	ClinGen TOPMed gnomAD
rs771340281 CA7232163	59	I>L		No	ClinGen ExAC gnomAD
rs1377678590 CA390035586	59	I>M		No	ClinGen gnomAD
rs1162298318 CA390035433	66	G>R		No	ClinGen TOPMed
CA7232137 rs778442280	68	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA390035323 rs1255509421	69	R>S		No	ClinGen gnomAD
TCGA novel	69	R>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA262697892 rs1007476459	72	T>I		No	ClinGen Ensembl
rs756782637 CA7232136	74	T>A		No	ClinGen ExAC gnomAD
CA390035217 rs1379450684	75	K>N		No	ClinGen gnomAD
rs753445318 CA7232135	79	R>Q		No	ClinGen ExAC gnomAD
CA390035155 rs1445852274	79	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
COSM957086 CA390035138 rs1394250685	80	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1468652890 CA390035141	80	R>W		No	ClinGen TOPMed gnomAD
rs918193754 CA262697881	81	A>G		No	ClinGen gnomAD
CA390035125 rs918193754	81	A>V		No	ClinGen gnomAD
rs1444230901 CA390035104	82	Q>H		No	ClinGen TOPMed
CA390035113 rs1158778544	82	Q>P		No	ClinGen gnomAD
CA390034879 rs1226453436	89	D>N		No	ClinGen gnomAD
rs748808005 CA7232111	90	I>T		No	ClinGen ExAC gnomAD
CA7232108 rs747867822	93	E>K		No	ClinGen ExAC gnomAD
rs747867822 CA390034802	93	E>Q		No	ClinGen ExAC gnomAD
rs367753617 CA7232107	94	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7232105 rs751503545	94	R>H		No	ClinGen ExAC TOPMed gnomAD
CA390034779 rs751503545	94	R>L		No	ClinGen ExAC TOPMed gnomAD
CA7232106 rs367753617	94	R>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA262697468 rs745992968	99	I>V		No	ClinGen Ensembl
rs1325929794 CA390034675	100	M>R		No	ClinGen gnomAD
rs1403900017 CA390034612	104	S>N		No	ClinGen gnomAD
rs758496557 CA7232103	106	V>M		No	ClinGen ExAC gnomAD
rs766813100 COSM1317848 CA7232054	109	Y>=	Variant assessed as Somatic; 0.0 impact. haematopoietic_and_lymphoid_tissue [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs761375914 CA7232053	110	A>T		No	ClinGen ExAC gnomAD
rs1187139973 CA390032717	110	A>V		No	ClinGen gnomAD
rs776073860 CA7232052	114	V>I		No	ClinGen ExAC gnomAD
rs768398931 CA7232051	115	Q>H		No	ClinGen ExAC gnomAD
rs923905243 CA262696821	123	A>T		No	ClinGen Ensembl
rs1291905785 CA390032418	124	D>G		No	ClinGen gnomAD
CA262696804 rs770838628 CA7232044	125	E>D		No	ClinGen ExAC TOPMed gnomAD
CA7232045 rs778896668	125	E>G		No	ClinGen ExAC TOPMed gnomAD
CA7232046 rs745670853	125	E>K		No	ClinGen ExAC TOPMed gnomAD
rs777766940 CA7232042	126	E>D		No	ClinGen ExAC gnomAD
rs146206891 CA7232043	126	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA390032338 rs1459201131	128	K>E		No	ClinGen gnomAD
COSM2248790 CA262696764 rs965050593 COSM194114	129	R>Q	kidney Variant assessed as Somatic; 0.0 impact. pancreas large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs199756068 CA7232038	131	V>G		No	ClinGen ExAC gnomAD
rs766908633 CA7232036	133	R>I		No	ClinGen ExAC
CA7232035 rs766908633	133	R>K		No	ClinGen ExAC
CA390032201 rs1293768964	136	G>V		No	ClinGen TOPMed
rs750960387 CA7232033	138	Q>H		No	ClinGen ExAC gnomAD
rs758819238 CA7232016	141	K>E		No	ClinGen ExAC gnomAD
CA262695616 rs897899483	141	K>R		No	ClinGen TOPMed
rs765849811 CA7232014	144	G>D		No	ClinGen ExAC gnomAD
rs750825974 CA7232015	144	G>S		No	ClinGen ExAC TOPMed gnomAD
CA262695601 rs375454884	145	M>I		No	ClinGen ESP gnomAD
CA390031659 rs1447171966	145	M>T		No	ClinGen gnomAD
CA262695613 rs915642437	145	M>V		No	ClinGen Ensembl
CA390031616 rs1326722897	148	Y>*		No	ClinGen gnomAD
rs755672399 CA7232013	148	Y>C		No	ClinGen ExAC gnomAD
CA7232012 rs752321397	150	T>I		No	ClinGen ExAC gnomAD
rs561822006 CA7232011	152	A>P		No	ClinGen 1000Genomes ExAC gnomAD
rs561822006 CA7232010	152	A>S		No	ClinGen 1000Genomes ExAC gnomAD
CA390031546 rs1173862617	153	C>Y		No	ClinGen TOPMed gnomAD
CA7232009 rs774076750	156	L>I		No	ClinGen ExAC gnomAD
CA7232007 rs762812518	157	N>S		No	ClinGen ExAC gnomAD
CA390031466 rs773076080	160	E>*		No	ClinGen ExAC TOPMed gnomAD
rs773076080 CA7232006	160	E>K		No	ClinGen ExAC TOPMed gnomAD
CA7231983 rs760818772	161	S>P		No	ClinGen ExAC gnomAD
rs760818772 CA262695460	161	S>T		No	ClinGen ExAC gnomAD
CA7231982 rs775556694	162	F>L		No	ClinGen ExAC gnomAD
CA7231981 rs772404611	163	T>M		No	ClinGen ExAC gnomAD
rs368631376 CA7231978	164	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA7231977 rs374209406	164	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs755765495 CA262695430	166	T>I		No	ClinGen Ensembl
CA390031340 rs1374705899	167	E>K		No	ClinGen TOPMed
CA7231976 rs778349231	167	E>V		No	ClinGen ExAC gnomAD
rs1400423252 CA390031322	168	L>P		No	ClinGen gnomAD
CA390031326 rs1317213184	168	L>V		No	ClinGen gnomAD
CA7231975 rs754389307	169	V>M		No	ClinGen ExAC gnomAD
rs1460442865 CA390031289	171	Q>R		No	ClinGen TOPMed
CA390031255 rs1417216378	174	R>K		No	ClinGen gnomAD
rs779573746 CA7231973	177	L>P		No	ClinGen ExAC gnomAD
CA390031219 rs1166808617	177	L>V		No	ClinGen TOPMed
rs1375582808 CA390031201	179	G>S		No	ClinGen TOPMed
CA390031185 rs1476506466	180	L>R		No	ClinGen gnomAD
CA7231972 rs530144601	181	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1240520813 CA390031182	181	R>W		No	ClinGen TOPMed gnomAD
CA7231971 rs750200493	183	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA7231969 rs761598155	183	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7231970 rs761598155	183	R>L		No	ClinGen ExAC TOPMed gnomAD
rs764146525 CA7231967	184	A>V		No	ClinGen ExAC TOPMed gnomAD
rs947797436 CA262695385	185	S>T		No	ClinGen TOPMed
rs760663241 CA7231966	186	N>D		No	ClinGen ExAC TOPMed gnomAD
CA262695371 rs1045444691	187	E>K		No	ClinGen Ensembl
CA262695359 rs983828410 CA390031102	188	L>F		No	ClinGen TOPMed gnomAD
rs916242151 CA262695361	188	L>S		No	ClinGen TOPMed
CA390031086 rs1359258315	190	L>V		No	ClinGen TOPMed gnomAD
rs1269185738 CA390031053	192	E>D		No	ClinGen TOPMed gnomAD
rs1436776374 CA390031039	193	L>P		No	ClinGen gnomAD
rs1186861020 CA390031035	194	E>K		No	ClinGen TOPMed
CA7231964 rs772162699	196	E>K		No	ClinGen ExAC gnomAD
CA390030974 rs759780594	197	E>D		No	ClinGen ExAC TOPMed gnomAD
CA390030964 rs1566840698	198	G>D		No	ClinGen Ensembl
CA7231959 rs771356575	199	K>R		No	ClinGen ExAC gnomAD
CA390030939 rs1172029311	200	P>T		No	ClinGen gnomAD
CA390030923 rs1167509539	201	E>G		No	ClinGen gnomAD
rs187980551 CA7231957	201	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1478509131 CA390030908	202	G>V		No	ClinGen gnomAD
CA390030900 rs1254641074	203	P>L		No	ClinGen gnomAD
rs1254641074 CA390030904	203	P>R		No	ClinGen gnomAD
rs746474278 CA7231955	204	A>V		No	ClinGen ExAC gnomAD
rs1019869970 CA262695321	205	N>K		No	ClinGen TOPMed
CA390030859 rs1206576447	206	S>F		No	ClinGen gnomAD
CA7231953 rs757929489	207	S>L		No	ClinGen ExAC TOPMed gnomAD
CA390030839 rs757929489	207	S>W		No	ClinGen ExAC TOPMed gnomAD
rs1304811316 CA390030802	209	T>I		No	ClinGen TOPMed
CA7231951 rs778548277	211	W>R		No	ClinGen ExAC gnomAD

No associated diseases with P59190

1 regional properties for P59190

Type	Name	Position	InterPro Accession
domain	Small GTP-binding protein domain	10 - 162	IPR005225

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Lipid-anchor ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

12 GO annotations of cellular component

Name	Definition
cilium	A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endosome	A vacuole to which materials ingested by endocytosis are delivered.
endosome membrane	The lipid bilayer surrounding an endosome.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
insulin-responsive compartment	A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
recycling endosome	An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
synaptic vesicle	A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.

2 GO annotations of molecular function

Name	Definition
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

7 GO annotations of biological process

Name	Definition
cellular response to insulin stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
positive regulation of regulated secretory pathway	Any process that activates or increases the frequency, rate or extent of regulated secretory pathway.
protein localization to plasma membrane	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
protein secretion	The controlled release of proteins from a cell.
Rab protein signal transduction	The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state.
regulation of exocytosis	Any process that modulates the frequency, rate or extent of exocytosis.
vesicle docking involved in exocytosis	The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis.

10 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q1RMR4	RAB15	Ras-related protein Rab-15	Bos taurus (Bovine)	PR
P0C0E4	RAB40AL	Ras-related protein Rab-40A-like	Homo sapiens (Human)	PR
Q8WXH6	RAB40A	Ras-related protein Rab-40A	Homo sapiens (Human)	PR
Q12829	RAB40B	Ras-related protein Rab-40B	Homo sapiens (Human)	PR
Q96S21	RAB40C	Ras-related protein Rab-40C	Homo sapiens (Human)	PR
Q6IQ22	RAB12	Ras-related protein Rab-12	Homo sapiens (Human)	PR
Q92930	RAB8B	Ras-related protein Rab-8B	Homo sapiens (Human)	PR
P61006	RAB8A	Ras-related protein Rab-8A	Homo sapiens (Human)	PR
Q8K386	Rab15	Ras-related protein Rab-15	Mus musculus (Mouse)	PR
P35289	Rab15	Ras-related protein Rab-15	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MAKQYDVLFR	LLLIGDSGVG	KTCLLCRFTD	NEFHSSHIST	IGVDFKMKTI	EVDGIKVRIQ
70	80	90	100	110	120
IWDTAGQERY	QTITKQYYRR	AQGIFLVYDI	SSERSYQHIM	KWVSDVDEYA	PEGVQKILIG
130	140	150	160	170	180
NKADEEQKRQ	VGREQGQQLA	KEYGMDFYET	SACTNLNIKE	SFTRLTELVL	QAHRKELEGL
190	200	210
RMRASNELAL	AELEEEEGKP	EGPANSSKTC	WC