P59169

PR
Gene name
HTR4 (At4g40030, T5J17.200;, HTR5, At4g40040, T5J17.210;, HTR8, At5g10980, T30N20_250, T5K6.6)
Protein name
Histone H3.3
Names
Histone H3.2
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G10980
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P59169

Entry ID Method Resolution Chain Position Source
4PL6 X-ray 168 A C/D 2-12 PDB
4PLI X-ray 165 A C/D 33-42 PDB
4PLL X-ray 260 A C/D 33-42 PDB
7UX9 EM 320 A E/F 1-136 PDB
AF-P59169-F1 Predicted AlphaFoldDB

No variants for P59169

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P59169

No associated diseases with P59169

1 regional properties for P59169

Type Name Position InterPro Accession
domain Histone H2A/H2B/H3 1 - 132 IPR007125

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome
  • Nucleus, nucleolus
  • Localized at rDNA loci in the nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
rDNA protrusion Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
protein heterodimerization activity Binding to a nonidentical protein to form a heterodimer.
structural constituent of chromatin The action of a molecule that contributes to the structural integrity of chromatin.

No GO annotations of biological process

Name Definition
No GO annotations for biological process

37 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P68428 Histone H3.2 Triticum aestivum (Wheat) PR
Q5E9F8 H3-3B Histone H3.3 Bos taurus (Bovine) PR
P68432 Histone H3.1 Bos taurus (Bovine) PR
P84227 Histone H3.2 Bos taurus (Bovine) PR
P84247 H3-X Histone H3.3 Gallus gallus (Chicken) PR
P84229 H3-VIII Histone H3.2 Gallus gallus (Chicken) PR
P02299 His3 Histone H3 Drosophila melanogaster (Fruit fly) PR
Q71H73 Histone H3.3 Vitis vinifera (Grape) PR
P68431 H3C12 Histone H3.1 Homo sapiens (Human) PR
P84243 H3-3B Histone H3.3 Homo sapiens (Human) PR
Q71DI3 H3C13 Histone H3.2 Homo sapiens (Human) PR
Q16695 H3-4 Histone H3.1t Homo sapiens (Human) PR
P69246 H3C4 Histone H3.2 Zea mays (Maize) PR
P68433 H3c11 Histone H3.1 Mus musculus (Mouse) PR
P84228 H3c15 Histone H3.2 Mus musculus (Mouse) PR
P84244 H3-3b Histone H3.3 Mus musculus (Mouse) PR
P02301 H3-5 Histone H3.3C Mus musculus (Mouse) PR
Q71LE2 H3-3A Histone H3.3 Sus scrofa (Pig) PR
O35799 Hfe Hereditary hemochromatosis protein homolog Rattus norvegicus (Rat) PR
P84245 H3-3b Histone H3.3 Rattus norvegicus (Rat) PR
Q6LED0 Histone H3.1 Rattus norvegicus (Rat) PR
Q2RAD9 H3R-21 Histone H3.2 Oryza sativa subsp japonica (Rice) PR
Q0JCT1 H3 Histone H3.3 Oryza sativa subsp japonica (Rice) PR
P08898 his-2 Histone H3 Caenorhabditis elegans PR
Q10453 his-71 Histone H3.3 type 1 Caenorhabditis elegans PR
Q27490 his-70 Histone H3.3-like type 1 Caenorhabditis elegans PR
Q27532 his-74 Histone H3.3-like type 2 Caenorhabditis elegans PR
Q9U281 his-72 Histone H3.3 type 2 Caenorhabditis elegans PR
P59226 HTR2 Histone H3.1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FKQ3 At5g65350 Histone H3-like 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FX60 At1g13370 Histone H3-like 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FXI7 MGH3 Histone H3-like 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LR02 At1g75600 Histone H3-like 3 Arabidopsis thaliana (Mouse-ear cress) PR
Q6P823 TGas113e22.1 Histone H3.3 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q28D37 TGas081o10.1 Histone H3.2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q4QRF4 zgc:113984; Histone H3.2 Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q6PI20 h3f3a Histone H3.3 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MARTKQTARK STGGKAPRKQ LATKAARKSA PTTGGVKKPH RYRPGTVALR EIRKYQKSTE
70 80 90 100 110 120
LLIRKLPFQR LVREIAQDFK TDLRFQSHAV LALQEAAEAY LVGLFEDTNL CAIHAKRVTI
130
MPKDIQLARR IRGERA