P57784
Gene name |
Snrpa1 |
Protein name |
U2 small nuclear ribonucleoprotein A' |
Names |
U2 snRNP A' |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:68981 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P57784
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P57784-F1 | Predicted | AlphaFoldDB |
10 variants for P57784
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388919695 | 9 | I>F | No | EVA | |
| rs3388916998 | 36 | N>K | No | EVA | |
| rs3388895543 | 37 | L>M | No | EVA | |
| rs3388917000 | 48 | D>E | No | EVA | |
| rs3388907844 | 51 | D>G | No | EVA | |
| rs3388915946 | 63 | L>S | No | EVA | |
| rs3388917459 | 75 | R>G | No | EVA | |
| rs3388874314 | 189 | T>A | No | EVA | |
| rs3388914619 | 210 | N>H | No | EVA | |
| rs3388899680 | 216 | E>K | No | EVA |
No associated diseases with P57784
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| catalytic step 2 spliceosome | A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. |
| nuclear body | Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. |
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spliceosomal complex | Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA. |
| U2 snRNP | A ribonucleoprotein complex that contains small nuclear RNA U2, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U2 snRNP, most of which remain associated with the U2 snRNA both while the U2 snRNP is free or assembled into a series of spliceosomal complexes. |
| U2-type catalytic step 2 spliceosome | A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs. |
| U2-type precatalytic spliceosome | A spliceosomal complex that is formed by the recruitment of the preassembled U4/U6.U5 tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the U1, U2 and U4/U6.U5 snRNPs. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| U2 snRNA binding | Binding to a U2 small nuclear RNA (U2 snRNA). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P09661 | SNRPA1 | U2 small nuclear ribonucleoprotein A' | Homo sapiens (Human) | PR |
| Q9BTT0 | ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E | Homo sapiens (Human) | SS |
| P43333 | At1g09760 | U2 small nuclear ribonucleoprotein A' | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVKLTAELIE | QAAQYTNAVR | DRELDLRGYK | IPVIENLGAT | LDQFDAIDFS | DNEIRKLDGF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PLLRRLKTLL | VNNNRICRIG | EGLDQALPCL | TELILTNNSL | VELGDLDPLA | SLKSLTYLSI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LRNPVTNKKH | YRLYVIYKVP | QVRVLDFQKV | KLKERQEAEK | MFKGKRGAQL | AKDIARRSKT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FNPGAGLPTD | KKKGGPSAGD | VEAIKNAIAN | ASTLAEVERL | KGLLQSGQIP | GRERRSGPSD |
| 250 | |||||
| EGEEEIEDDT | VTNGS |