P57709
PR
Gene name |
ATP2C1 (SPCA) |
Protein name |
Calcium-transporting ATPase type 2C member 1 |
Names |
ATPase 2C1, ATP-dependent Ca(2+) pump PMR1, Ca(2+)/Mn(2+)-ATPase 2C1, Secretory pathway Ca(2+)-transporting ATPase type 1, SPCA1 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:327663 |
EC number |
7.2.2.10: Linked to the hydrolysis of a nucleoside triphosphate |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P57709
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P57709-F1 | Predicted | AlphaFoldDB |
94 variants for P57709
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs468540219 | 5 | L>F | No | EVA | |
| rs448167581 | 8 | S>* | No | EVA | |
| rs479459245 | 12 | Y>* | No | EVA | |
| rs459635518 | 13 | F>I | No | EVA | |
| rs456669262 | 22 | R>G | No | EVA | |
| rs439443027 | 31 | Q>P | No | EVA | |
| rs477363892 | 32 | K>I | No | EVA | |
| rs463283381 | 33 | E>D | No | EVA | |
| rs458290662 | 78 | N>S | No | EVA | |
| rs444713002 | 87 | H>D | No | EVA | |
| rs461977944 | 88 | R>M | No | EVA | |
| rs442010904 | 89 | R>G | No | EVA | |
| rs473216742 | 90 | A>S | No | EVA | |
| rs453240868 | 95 | N>K | No | EVA | |
| rs433298250 | 106 | W>R | No | EVA | |
| rs470769854 | 109 | Y>F | No | EVA | |
| rs457107374 | 111 | S>Y | No | EVA | |
| rs445304175 | 115 | N>D | No | EVA | |
| rs469031543 | 137 | A>V | No | EVA | |
| rs449064915 | 138 | V>I | No | EVA | |
| rs480357172 | 142 | V>M | No | EVA | |
| rs470812934 | 143 | A>P | No | EVA | |
| rs457202655 | 146 | I>S | No | EVA | |
| rs468155351 | 147 | V>D | No | EVA | |
| rs454553136 | 148 | V>I | No | EVA | |
| rs438680826 | 156 | Y>N | No | EVA | |
| rs480282781 | 177 | R>L | No | EVA | |
| rs523035951 | 227 | T>A | No | EVA | |
| rs472934126 | 239 | A>S | No | EVA | |
| rs483231639 | 271 | E>D | No | EVA | |
| rs378056568 | 297 | D>Y | No | EVA | |
| rs1116580037 | 310 | I>M | No | EVA | |
| rs1114905357 | 310 | I>V | No | EVA | |
| rs477342189 | 313 | I>N | No | EVA | |
| rs436777991 | 406 | R>S | No | EVA | |
| rs798604967 | 431 | Y>C | No | EVA | |
| rs515927136 | 449 | V>I | No | EVA | |
| rs447818091 | 577 | G>A | No | EVA | |
| rs467967051 | 577 | G>R | No | EVA | |
| rs207626025 | 617 | R>H | No | EVA | |
| rs519624954 | 646 | P>Q | No | EVA | |
| rs876270524 | 671 | S>P | No | EVA | |
| rs876196952 | 680 | V>G | No | EVA | |
| rs456295299 | 693 | V>I | No | EVA | |
| rs435936964 | 711 | L>M | No | EVA | |
| rs467432233 | 711 | L>R | No | EVA | |
| rs465034850 | 712 | V>A | No | EVA | |
| rs433625083 | 712 | V>L | No | EVA | |
| rs482887963 | 721 | S>P | No | EVA | |
| rs462903950 | 722 | A>G | No | EVA | |
| rs442583858 | 723 | I>F | No | EVA | |
| rs480503405 | 723 | I>M | No | EVA | |
| rs460439643 | 724 | E>A | No | EVA | |
| rs440333823 | 724 | E>D | No | EVA | |
| rs451269888 | 725 | E>D | No | EVA | |
| rs471388473 | 725 | E>G | No | EVA | |
| rs444053365 | 726 | G>R | No | EVA | |
| rs475461493 | 726 | G>V | No | EVA | |
| rs455367344 | 727 | K>I | No | EVA | |
| rs436567424 | 730 | Y>H | No | EVA | |
| rs467976016 | 731 | N>H | No | EVA | |
| rs454409677 | 735 | N>H | No | EVA | |
| rs468439871 | 843 | T>P | No | EVA | |
| rs434635584 | 844 | M>I | No | EVA | |
| rs465908466 | 845 | T>S | No | EVA | |
| rs475096450 | 865 | K>T | No | EVA | |
| rs461427608 | 868 | F>I | No | EVA | |
| rs440966926 | 869 | E>A | No | EVA | |
| rs452281627 | 872 | L>H | No | EVA | |
| rs432298192 | 873 | C>R | No | EVA | |
| rs476316885 | 879 | C>G | No | EVA | |
| rs456071828 | 881 | A>G | No | EVA | |
| rs453778367 | 902 | F>S | No | EVA | |
| rs434966092 | 905 | E>* | No | EVA | |
| rs466418485 | 909 | I>T | No | EVA | |
| rs478057546 | 912 | L>* | No | EVA | |
| rs450370672 | 915 | L>R | No | EVA | |
| rs481895553 | 919 | T>S | No | EVA | |
| rs441754666 | 920 | S>A | No | EVA | |
| rs479316560 | 922 | V>E | No | EVA | |
| rs460538753 | 923 | C>G | No | EVA | |
| rs440582243 | 924 | I>M | No | EVA | |
| rs471880470 | 929 | I>T | No | EVA | |
| rs452011907 | 931 | K>M | No | EVA | |
| rs444378643 | 932 | V>A | No | EVA | |
| rs444378643 | 932 | V>G | No | EVA | |
| rs475890417 | 933 | E>K | No | EVA | |
| rs455751860 | 933 | E>V | No | EVA | |
| rs435630830 | 940 | Q>K | No | EVA | |
| rs467075117 | 944 | S>C | No | EVA | |
| rs453092549 | 946 | T>I | No | EVA | |
| rs464401209 | 952 | E>D | No | EVA | |
| rs450801257 | 953 | V>L | No | EVA | |
| rs481872584 | 954 | V>R | No | EVA |
No associated diseases with P57709
4 regional properties for P57709
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cation-transporting P-type ATPase, N-terminal | 59 - 133 | IPR004014 |
| domain | Cation-transporting P-type ATPase, C-terminal | 760 - 931 | IPR006068 |
| ptm | P-type ATPase, phosphorylation site | 384 - 390 | IPR018303 |
| domain | P-type ATPase, haloacid dehalogenase domain | 364 - 727 | IPR044492 |
Functions
| Description | ||
|---|---|---|
| EC Number | 7.2.2.10 | Linked to the hydrolysis of a nucleoside triphosphate |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cis-Golgi network membrane | The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi cisterna membrane | The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of Golgi membrane | The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| manganese ion binding | Binding to a manganese ion (Mn). |
| P-type calcium transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out). |
| P-type ion transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate. |
| P-type manganese transporter activity | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(in) = ADP + H+ + Mn2+(out) + phosphate. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cytoskeleton reorganization | A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. |
| calcium ion transmembrane transport | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| calcium ion transport | The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules | The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction. |
| cellular calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell. |
| cellular manganese ion homeostasis | Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell. |
| epidermis development | The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. |
| Golgi calcium ion homeostasis | Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings. |
| Golgi calcium ion transport | The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus. |
| ion transmembrane transport | A process in which an ion is transported across a membrane. |
| manganese ion transport | The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| positive regulation of Golgi to plasma membrane protein transport | Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane. |
| positive regulation of I-kappaB kinase/NF-kappaB signaling | Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling. |
| trans-Golgi network membrane organization | A process which results in the assembly, arrangement of constituent parts, or disassembly of a trans-Golgi network membrane. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDNLLPQSRF | SYFKKYPIHA | IRKYLSMLRN | QKEEEQVARF | QKIPNAENET | MIPVLTSKKA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SELPVSEVAS | ILQADLQNGL | NKCEVSHRRA | FHGWNEFDIS | EDEPLWKKYI | SQFKNPLIML |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LLASAVISVL | MHQFDDAVSI | TVAILIVVTV | AFVQEYRSEK | SLEELSKLMP | PECHCVREGK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEHTLARDLV | PGDTVCLSVG | DRVPADLRLF | EAVDLSVDES | SLTGETTPCS | KVTAPQPAAT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NGDLASRSNI | AFMGTLVRCG | KAKGIVIGTG | ENSEFGEVFK | MMQAEEAPKT | PLQKSMDLLG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KQLSFYSFGI | IGIIMLVGWL | LGKDILEMFT | ISVSLAVAAI | PEGLPIVVTV | TLALGVMRMV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KKRAIVKKLP | IVETLGCCNV | ICSDKTGTLT | KNEMTVTHIF | TSDGLRAEVT | GVGYNPFGEV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IVDGDVVHGF | YNPSVSRIVE | AGCVCNDAVI | RNNTLMGKPT | EGALIALAMK | MGLDGLQQDY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IRKAEYPFSS | EQKWMAVKCV | HRTQQDRPEI | CFMKGAYEQV | IKYCTTYHSK | GQTLTLTQQQ |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RDLYQQEKAQ | MGSAGLRVLA | LASGPELGQL | TFLGLVGIID | PPRTGVKEAV | TTLIASGVSI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KMITGDSQET | AVAIASRLGL | YSKTSQSVSG | EEIDAMDVQQ | LSQIVPKVAV | FYRASPRHKM |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KIIKSLQKNG | SVVAMTGDGV | NDAVALKAAD | IGVAMGQTGT | DVCKEAADMI | LVDDDFQTIM |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SAIEEGKGIY | NNIKNFVRFQ | LSTSIAALTL | ISLATLMNFP | NPLNAMQILW | INIIMDGPPA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| QSLGVEPVDK | DVIRKPPRNW | KDSILTKNLI | LKILVSSIII | VCGTLFVFWR | ELRDNVITPR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DTTMTFTCFV | FFDMFNALSS | RSQTKSVFEI | GLCSNKMFCY | AVLGSIMGQL | LVIYFPPLQK |
| 910 | 920 | 930 | 940 | 950 | |
| VFQTESLSIL | DLLFLLGLTS | SVCIVAEIIK | KVERSREKIQ | KPVSSTSSSF | LEV |