AiPD: Autoinhibited Protein Database

P57682

Gene name	KLF3 (BKLF)
Protein name	Krueppel-like factor 3
Names	Basic krueppel-like factor, CACCC-box-binding protein BKLF, TEF-2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:51274
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-284 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-284 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P57682

Entry ID	Method	Resolution	Chain	Position	Source
AF-P57682-F1	Predicted				AlphaFoldDB

228 variants for P57682

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1465433180 CA356598407	2	L>H		No	ClinGen gnomAD
CA356598416 rs1388578864	3	M>I		No	ClinGen gnomAD
rs1188143224 CA356598414	3	M>T		No	ClinGen TOPMed gnomAD
CA356598434 rs1446786564	5	D>E		No	ClinGen gnomAD
CA95626754 rs542048069	6	P>L		No	ClinGen 1000Genomes
rs775480358 CA2888469	7	V>I		No	ClinGen ExAC TOPMed gnomAD
rs775480358 CA2888468	7	V>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	8	P>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1214343824 CA356598452	9	V>L		No	ClinGen TOPMed
CA356598472 rs768274115	12	E>K		No	ClinGen ExAC gnomAD
rs768274115 CA2888470	12	E>Q		No	ClinGen ExAC gnomAD
CA356598493 rs1385017891	14	M>I		No	ClinGen gnomAD
rs773927544 CA2888471	15	D>Y		No	ClinGen ExAC TOPMed gnomAD
CA356598501 rs1318074337	16	P>T		No	ClinGen gnomAD
rs1384550081 CA356598510	17	V>D		No	ClinGen gnomAD
rs1267220807 CA356598508	17	V>L		No	ClinGen TOPMed
rs767146040 CA2888473	18	S>L		No	ClinGen ExAC gnomAD
rs1296656520 CA356598521	19	V>G		No	ClinGen gnomAD
rs373009633 CA95631214	22	P>S		No	ClinGen ESP
rs760301740 CA2888494	32	N>D		No	ClinGen ExAC gnomAD
CA2888495 rs770622269	33	K>R		No	ClinGen ExAC gnomAD
rs1334690588 CA356599065	34	Y>C		No	ClinGen TOPMed
TCGA novel	36	V>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs369534232 CA2888497	41	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA356599124 rs1253090258	43	P>R		No	ClinGen TOPMed gnomAD
rs1189588775 CA356599133	44	E>D		No	ClinGen gnomAD
rs753246595 CA2888499	45	K>E		No	ClinGen ExAC TOPMed gnomAD
CA356599146 rs1180730740	46	F>S		No	ClinGen gnomAD
rs1482413031 CA356599172	50	P>S		No	ClinGen TOPMed
TCGA novel	52	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs144262675 CA2888502	54	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757351497 CA2888503	55	H>R		No	ClinGen ExAC gnomAD
rs200524146 CA95631332	56	G>R		No	ClinGen TOPMed gnomAD
CA95631338 rs1040395293	57	I>K		No	ClinGen Ensembl
rs1407920553 CA356599225	58	Q>H		No	ClinGen gnomAD
CA2888504 rs781573258	59	M>I		No	ClinGen ExAC gnomAD
CA356599227 rs1579128714	59	M>L		No	ClinGen Ensembl
TCGA novel	63	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1300765519 CA356599275	66	V>M		No	ClinGen gnomAD
CA2888508 rs748083085	69	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2888507 rs778961008	69	R>W		No	ClinGen ExAC TOPMed gnomAD
CA2888510 rs201836837	70	S>C		No	ClinGen ExAC TOPMed
CA356599309 rs1579128784	71	S>P		No	ClinGen Ensembl
CA2888516 rs375331147	73	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs375331147 CA2888517	73	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs375331147 CA2888515	73	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA2888520 rs150818202	74	S>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA2888519 rs150818202	74	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA2888518 rs775966171	74	S>T		No	ClinGen ExAC gnomAD
CA356599324 rs150818202	74	S>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1362678424 CA356599325	75	A>T		No	ClinGen gnomAD
rs1168915953 CA356599336	76	G>V		No	ClinGen gnomAD
rs1560418607 CA356599331	76	G>W		No	ClinGen Ensembl
rs372969202 CA2888522	77	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs369311053 CA2888524	78	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs767805661 CA2888523	78	S>P		No	ClinGen ExAC gnomAD
CA356599349 rs1437210747	79	P>A		No	ClinGen gnomAD
CA95631435 rs117461542	80	S>F		No	ClinGen 1000Genomes TOPMed
CA356599364 rs1230844627	81	S>F		No	ClinGen gnomAD
rs17857398 CA2888528	85	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA95631443 rs17857398	85	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA356599400 rs1226691328	87	S>L		No	ClinGen gnomAD
CA356599408 rs1311600709	88	H>Q		No	ClinGen TOPMed gnomAD
CA2888531 rs374324359	88	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA2888532 rs761153626	89	R>Q	Variant assessed as Somatic; 4.62e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA356599417 rs1221557465	90	R>T		No	ClinGen gnomAD
rs780803803 CA2888533	91	A>V		No	ClinGen ExAC TOPMed gnomAD
CA2888535 rs368422949	92	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2888534 rs745581332	92	S>T		No	ClinGen ExAC gnomAD
TCGA novel	94	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768992554 CA2888538	94	G>E		No	ClinGen ExAC TOPMed gnomAD
rs1350078258 CA356599461	97	M>I		No	ClinGen TOPMed
CA356599466 rs1166360331	98	P>S		No	ClinGen TOPMed
CA356599483 rs1413745939	101	S>G		No	ClinGen TOPMed
rs200788104 CA2888539	101	S>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1560418692 CA356599488	101	S>R		No	ClinGen Ensembl
CA356599507 rs767752575	104	I>M		No	ClinGen ExAC gnomAD
CA356599505 rs1321548436	104	I>T		No	ClinGen TOPMed gnomAD
rs553313192 CA2888542	108	S>P		No	ClinGen 1000Genomes ExAC
rs766713070 CA356599540	109	P>L		No	ClinGen ExAC gnomAD
rs766713070 CA2888544	109	P>R		No	ClinGen ExAC gnomAD
CA2888543 rs371074043	109	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA356599537 rs371074043	109	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1560418707 CA356599541	110	P>T		No	ClinGen Ensembl
rs752385388 CA2888545	111	S>P		No	ClinGen ExAC gnomAD
CA95631514 rs374745533	113	G>R		No	ClinGen ESP TOPMed
rs200138091 CA2888547	114	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
COSM1186549 CA95631536 rs17854688	116	P>H	lung [Cosmic]	No	ClinGen cosmic curated Ensembl
CA356599578 rs1357582353	116	P>S		No	ClinGen TOPMed gnomAD
CA356599590 rs780750739	118	G>C		No	ClinGen ExAC TOPMed gnomAD
CA2888550 rs780750739	118	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	119	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs745389848 CA356599595	119	V>L		No	ClinGen ExAC TOPMed gnomAD
rs745389848 CA2888551	119	V>M		No	ClinGen ExAC TOPMed gnomAD
rs1472371597 CA356599612	122	S>P		No	ClinGen gnomAD
CA356599622 rs1294884647	123	M>I		No	ClinGen TOPMed
CA356599619 rs1410111741	123	M>T		No	ClinGen gnomAD
rs199559194 CA2888554	123	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA356599626 rs1433685012	124	P>A		No	ClinGen TOPMed
CA356599632 rs1458828739	125	P>S		No	ClinGen gnomAD
CA2888555 rs769102407	126	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	127	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs372172237 CA2888556	128	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA356599654 rs1336448449	128	A>V		No	ClinGen gnomAD
rs1432238621 CA356599655	129	A>S		No	ClinGen TOPMed
rs1447795767 CA356599675	132	S>A		No	ClinGen gnomAD
rs773358983 CA2888559	132	S>L		No	ClinGen ExAC gnomAD
CA2888560 rs773358983	132	S>W		No	ClinGen ExAC gnomAD
rs35098477 CA2888562	133	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs919273371 CA95631601	135	G>R		No	ClinGen Ensembl
CA356599693 rs1266930334	135	G>V		No	ClinGen gnomAD
rs762635083 CA2888563	136	I>M		No	ClinGen ExAC gnomAD
rs751450178 CA2888565	137	R>Q		No	ClinGen ExAC gnomAD
CA2888564 rs764010396	137	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA2888566 rs376784680	138	S>T		No	ClinGen ESP ExAC gnomAD
rs755648642 CA2888570	144	V>I		No	ClinGen ExAC TOPMed gnomAD
CA356599758 rs1174491078	146	Q>H		No	ClinGen gnomAD
rs1252716275 CA356599757	146	Q>R		No	ClinGen TOPMed
rs1579129168 CA356599777	149	V>G		No	ClinGen Ensembl
rs753574203 CA2888572	150	V>G		No	ClinGen ExAC gnomAD
CA2888574 rs149694821	153	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1410941224 CA356599821	156	M>T		No	ClinGen gnomAD
TCGA novel	157	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA95631666 rs754576910	159	S>G		No	ClinGen gnomAD
CA356599848 rs1560418833	160	H>P		No	ClinGen Ensembl
CA2888576 rs772649026	160	H>Y		No	ClinGen ExAC gnomAD
rs1013156821 CA95631683	161	L>F		No	ClinGen gnomAD
rs747055477 CA2888578	162	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1198432819 CA356599875	164	P>A		No	ClinGen gnomAD
rs1473024062 CA356599877	164	P>L		No	ClinGen Ensembl
rs771094199 CA95631684	165	L>P		No	ClinGen ExAC TOPMed gnomAD
rs771094199 CA2888579	165	L>R		No	ClinGen ExAC TOPMed gnomAD
rs1483285175 CA356599886	166	M>T		No	ClinGen gnomAD
rs1033155676 CA95631701	166	M>V		No	ClinGen TOPMed
CA356599894 rs1249562475	167	V>A		No	ClinGen gnomAD
rs145534981 CA2888580	167	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA356599897 rs1293934980	168	S>P		No	ClinGen gnomAD
rs547830183 CA95631711	170	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes NCI-TCGA TOPMed gnomAD
rs780386000 CA2888582	172	E>K		No	ClinGen ExAC TOPMed gnomAD
CA2888583 rs148849961	177	S>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA2888584 rs761622672	177	S>R		No	ClinGen ExAC gnomAD
rs767398463 CA2888585	179	S>N		No	ClinGen ExAC TOPMed gnomAD
rs767398463 CA356599978	179	S>T		No	ClinGen ExAC TOPMed gnomAD
CA2888588 rs765969641 COSM1642471	180	M>I	stomach [Cosmic]	No	ClinGen cosmic curated ExAC
rs760078799 CA2888587	180	M>T		No	ClinGen ExAC gnomAD
rs750396918 CA2888586	180	M>V		No	ClinGen ExAC gnomAD
rs1156376462	182	V>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356600022 rs1322097109	184	V>E		No	ClinGen gnomAD
rs1399575727 CA356600019	184	V>I		No	ClinGen TOPMed
CA2888612 rs758824666	186	E>G		No	ClinGen ExAC gnomAD
CA356600046 rs1165447195	188	Y>H		No	ClinGen TOPMed
CA95632297 rs997635288	189	E>K		No	ClinGen Ensembl
CA356600076 rs1295121505	192	I>V		No	ClinGen gnomAD
TCGA novel	197	I>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA356600116 rs1245397890	197	I>M		No	ClinGen gnomAD
CA2888614 rs751979944	197	I>V		No	ClinGen ExAC gnomAD
rs757728554 CA2888615	199	I>L		No	ClinGen ExAC TOPMed gnomAD
rs781576441 CA2888616	199	I>M		No	ClinGen ExAC gnomAD
CA356600128 rs1560419163	199	I>T		No	ClinGen Ensembl
rs1242996264 CA356600150	203	I>F		No	ClinGen TOPMed
rs377705302 CA2888617	204	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA2888618 rs143460542	205	P>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	206	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780223899 CA2888619	207	R>G		No	ClinGen ExAC gnomAD
rs17616226 CA95632344 VAR_052715	207	R>S		No	ClinGen UniProt Ensembl dbSNP
rs1016654265 CA95632348	211	Y>C		No	ClinGen Ensembl
TCGA novel	214	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs761224497 CA95632350	216	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs749567089 CA2888620	217	P>S		No	ClinGen ExAC gnomAD
CA2888621 rs771847684	218	P>L		No	ClinGen ExAC gnomAD
rs1260051731	219	L>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
CA356600262 rs1368432957	219	L>F		No	ClinGen gnomAD
rs1459359026 CA356600267	220	M>R		No	ClinGen gnomAD
rs1240522172 CA356600265	220	M>V		No	ClinGen TOPMed
rs1388814184 CA356600297	224	S>C		No	ClinGen gnomAD
rs746791511 CA2888623	226	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA356600309 rs746791511	226	P>R		No	ClinGen ExAC TOPMed gnomAD
CA2888626 rs759063951	227	Q>P		No	ClinGen ExAC gnomAD
CA356600317 COSM1429549 rs1338650901	228	A>T	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs764897827 CA2888627	228	A>V		No	ClinGen ExAC gnomAD
rs763849495 CA2888630	231	Q>K		No	ClinGen ExAC gnomAD
rs200642404 CA95587089	233	N>D		No	ClinGen Ensembl
rs145874381 CA2888652	233	N>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs761105610 CA2888653	236	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1433376572 CA356598056	238	I>L		No	ClinGen TOPMed gnomAD
rs201522223 CA2888658	239	V>M		No	ClinGen ExAC TOPMed gnomAD
CA2888659 rs150243974	240	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA2888662 rs769802252	244	R>K		No	ClinGen ExAC gnomAD
CA356598101 rs1296496275	245	P>T		No	ClinGen TOPMed gnomAD
CA95587195 rs920094929	251	P>L		No	ClinGen TOPMed gnomAD
TCGA novel	255	R>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768335434 CA2888666	256	K>R		No	ClinGen ExAC gnomAD
CA2888668 rs183262895	257	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	257	R>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2888670 rs773394208	265	D>G		No	ClinGen ExAC TOPMed gnomAD
rs1560420781 CA356598259	268	N>D		No	ClinGen Ensembl
rs1190212199 CA356598262	268	N>T		No	ClinGen gnomAD
rs985226995 CA95587254	270	V>G		No	ClinGen TOPMed gnomAD
CA2888671 rs372657986	270	V>M		No	ClinGen ExAC gnomAD
TCGA novel	271	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	282	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs763121021 CA2888699	293	T>A		No	ClinGen ExAC gnomAD
rs1283128420 CA551139719	293	T>CKKCVR*		No	ClinGen gnomAD
rs1180798237 CA356598593	294	W>*		No	ClinGen gnomAD
CA2888700 rs764187784	296	G>R		No	ClinGen ExAC gnomAD
CA95589460 rs376533805	298	T>A		No	ClinGen ESP
CA356598638 rs1323916572	300	K>R		No	ClinGen TOPMed
TCGA novel	302	A>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1185801175 CA356598659	303	R>P		No	ClinGen gnomAD
CA356598658 rs1185801175	303	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1472409063 CA356598657	303	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA356598718 rs1473620454	312	R>*		No	ClinGen gnomAD
rs1384560903 CA356598728	313	K>N		No	ClinGen gnomAD
rs778933698 CA2888706	314	H>D		No	ClinGen ExAC gnomAD
CA2888708 rs757967760	315	T>S		No	ClinGen ExAC gnomAD
rs777382745 CA2888709	317	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA2888713 rs766351747	323	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA356598795 rs766351747	323	P>R		No	ClinGen ExAC TOPMed gnomAD
rs773018621 CA2888712	323	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1017488009 CA95589566	327	R>H		No	ClinGen TOPMed gnomAD
TCGA novel	337	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1279063455 CA356598912	340	K>R		No	ClinGen TOPMed gnomAD
CA95589597 rs900327687	341	R>C		No	ClinGen TOPMed gnomAD
CA356598933 rs1183012335	343	M>I		No	ClinGen gnomAD
rs774714439 CA2888718	343	M>T		No	ClinGen ExAC gnomAD
rs764287640 CA2888717	343	M>V		No	ClinGen ExAC gnomAD
rs762063698 CA2888720	345	V>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	346	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA

No associated diseases with P57682

3 regional properties for P57682

Type	Name	Position	InterPro Accession
domain	Zinc finger C2H2-type	260 - 289	IPR013087-1
domain	Zinc finger C2H2-type	290 - 319	IPR013087-2
domain	Zinc finger C2H2-type	320 - 342	IPR013087-3

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.

5 GO annotations of molecular function

Name	Definition
DNA-binding transcription factor activity	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
DNA-binding transcription factor activity, RNA polymerase II-specific	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion binding	Binding to a metal ion.
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
sequence-specific double-stranded DNA binding	Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.

4 GO annotations of biological process

Name	Definition
cellular response to peptide	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.
hemopoiesis	The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
regulation of transcription by RNA polymerase II	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

177 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q08DS3	OSR1	Protein odd-skipped-related 1	Bos taurus (Bovine)	PR
Q2VWH6	FEZF2	Fez family zinc finger protein 2	Bos taurus (Bovine)	PR
A6QNZ0	ZSCAN26	Zinc finger and SCAN domain-containing protein 26	Bos taurus (Bovine)	PR
A7MBI1	ZFP69	Zinc finger protein 69 homolog	Bos taurus (Bovine)	PR
Q08705	CTCF	Transcriptional repressor CTCF	Gallus gallus (Chicken)	PR
O42409	GFI1B	Zinc finger protein Gfi-1b	Gallus gallus (Chicken)	PR
A2T6W2	ZNF449	Zinc finger protein 449	Pan troglodytes (Chimpanzee)	PR
Q9U405	grau	Transcription factor grauzone	Drosophila melanogaster (Fruit fly)	PR
Q7K0S9	sug	Zinc finger protein GLIS2 homolog	Drosophila melanogaster (Fruit fly)	PR
P20385	Cf2	Chorion transcription factor Cf2	Drosophila melanogaster (Fruit fly)	PR
Q86P48	ATbp	AT-rich binding protein	Drosophila melanogaster (Fruit fly)	PR
P28698	MZF1	Myeloid zinc finger 1	Homo sapiens (Human)	PR
Q9NTW7	ZFP64	Zinc finger protein 64	Homo sapiens (Human)	PR
O14978	ZNF263	Zinc finger protein 263	Homo sapiens (Human)	PR
O60304	ZNF500	Zinc finger protein 500	Homo sapiens (Human)	PR
P08151	GLI1	Zinc finger protein GLI1	Homo sapiens (Human)	PR
Q9UFB7	ZBTB47	Zinc finger and BTB domain-containing protein 47	Homo sapiens (Human)	PR
Q9UNY5	ZNF232	Zinc finger protein 232	Homo sapiens (Human)	PR
Q96SZ4	ZSCAN10	Zinc finger and SCAN domain-containing protein 10	Homo sapiens (Human)	PR
P17028	ZNF24	Zinc finger protein 24	Homo sapiens (Human)	PR
P25490	YY1	Transcriptional repressor protein YY1	Homo sapiens (Human)	SS
O43296	ZNF264	Zinc finger protein 264	Homo sapiens (Human)	PR
P49711	CTCF	Transcriptional repressor CTCF	Homo sapiens (Human)	PR
Q9NQX1	PRDM5	PR domain zinc finger protein 5	Homo sapiens (Human)	PR
Q9HBE1	PATZ1	POZ-, AT hook-, and zinc finger-containing protein 1	Homo sapiens (Human)	PR
Q8TAX0	OSR1	Protein odd-skipped-related 1	Homo sapiens (Human)	PR
Q9UL58	ZNF215	Zinc finger protein 215	Homo sapiens (Human)	PR
Q8TBJ5	FEZF2	Fez family zinc finger protein 2	Homo sapiens (Human)	PR
Q96SR6	ZNF382	Zinc finger protein 382	Homo sapiens (Human)	PR
Q96IT1	ZNF496	Zinc finger protein 496	Homo sapiens (Human)	PR
Q96N95	ZNF396	Zinc finger protein 396	Homo sapiens (Human)	PR
Q9ULJ3	ZBTB21	Zinc finger and BTB domain-containing protein 21	Homo sapiens (Human)	PR
Q9H9D4	ZNF408	Zinc finger protein 408	Homo sapiens (Human)	PR
Q13127	REST	RE1-silencing transcription factor	Homo sapiens (Human)	PR
Q8IZM8	ZNF654	Zinc finger protein 654	Homo sapiens (Human)	PR
Q14526	HIC1	Hypermethylated in cancer 1 protein	Homo sapiens (Human)	PR
P17022	ZNF18	Zinc finger protein 18	Homo sapiens (Human)	PR
Q86XF7	ZNF575	Zinc finger protein 575	Homo sapiens (Human)	PR
Q8NAM6	ZSCAN4	Zinc finger and SCAN domain-containing protein 4	Homo sapiens (Human)	PR
Q08ER8	ZNF543	Zinc finger protein 543	Homo sapiens (Human)	PR
P17029	ZKSCAN1	Zinc finger protein with KRAB and SCAN domains 1	Homo sapiens (Human)	PR
Q8N680	ZBTB2	Zinc finger and BTB domain-containing protein 2	Homo sapiens (Human)	PR
O95625	ZBTB11	Zinc finger and BTB domain-containing protein 11	Homo sapiens (Human)	PR
Q9NPC7	MYNN	Myoneurin	Homo sapiens (Human)	PR
Q96BV0	ZNF775	Zinc finger protein 775	Homo sapiens (Human)	PR
Q8NF99	ZNF397	Zinc finger protein 397	Homo sapiens (Human)	PR
Q63HK3	ZKSCAN2	Zinc finger protein with KRAB and SCAN domains 2	Homo sapiens (Human)	PR
Q5FWF6	ZNF789	Zinc finger protein 789	Homo sapiens (Human)	PR
Q15776	ZKSCAN8	Zinc finger protein with KRAB and SCAN domains 8	Homo sapiens (Human)	PR
Q53GI3	ZNF394	Zinc finger protein 394	Homo sapiens (Human)	PR
O95125	ZNF202	Zinc finger protein 202	Homo sapiens (Human)	PR
Q05516	ZBTB16	Zinc finger and BTB domain-containing protein 16	Homo sapiens (Human)	PR
Q9H116	GZF1	GDNF-inducible zinc finger protein 1	Homo sapiens (Human)	PR
Q8N0Y2	ZNF444	Zinc finger protein 444	Homo sapiens (Human)	PR
Q6P9G9	ZNF449	Zinc finger protein 449	Homo sapiens (Human)	PR
Q8IW36	ZNF695	Zinc finger protein 695	Homo sapiens (Human)	PR
Q5VTD9	GFI1B	Zinc finger protein Gfi-1b	Homo sapiens (Human)	PR
Q6PG37	ZNF790	Zinc finger protein 790	Homo sapiens (Human)	PR
Q9NQV6	PRDM10	PR domain zinc finger protein 10	Homo sapiens (Human)	PR
Q9Y2D9	ZNF652	Zinc finger protein 652	Homo sapiens (Human)	PR
Q5TC79	ZBTB37	Zinc finger and BTB domain-containing protein 37	Homo sapiens (Human)	PR
Q9Y4E5	ZNF451	E3 SUMO-protein ligase ZNF451	Homo sapiens (Human)	PR
Q8ND82	ZNF280C	Zinc finger protein 280C	Homo sapiens (Human)	PR
Q49AA0	ZFP69	Zinc finger protein 69 homolog	Homo sapiens (Human)	PR
O43298	ZBTB43	Zinc finger and BTB domain-containing protein 43	Homo sapiens (Human)	PR
Q9Y330	ZBTB12	Zinc finger and BTB domain-containing protein 12	Homo sapiens (Human)	PR
Q13105	ZBTB17	Zinc finger and BTB domain-containing protein 17	Homo sapiens (Human)	PR
P51508	ZNF81	Zinc finger protein 81	Homo sapiens (Human)	PR
Q5JNZ3	ZNF311	Zinc finger protein 311	Homo sapiens (Human)	PR
Q9BRR0	ZKSCAN3	Zinc finger protein with KRAB and SCAN domains 3	Homo sapiens (Human)	PR
Q969J2	ZKSCAN4	Zinc finger protein with KRAB and SCAN domains 4	Homo sapiens (Human)	PR
P49910	ZNF165	Zinc finger protein 165	Homo sapiens (Human)	PR
P10074	ZBTB48	Telomere zinc finger-associated protein	Homo sapiens (Human)	PR
P17010	ZFX	Zinc finger X-chromosomal protein	Homo sapiens (Human)	PR
Q9H5H4	ZNF768	Zinc finger protein 768	Homo sapiens (Human)	PR
Q6NSZ9	ZSCAN25	Zinc finger and SCAN domain-containing protein 25	Homo sapiens (Human)	PR
Q9Y2L8	ZKSCAN5	Zinc finger protein with KRAB and SCAN domains 5	Homo sapiens (Human)	PR
Q86UZ6	ZBTB46	Zinc finger and BTB domain-containing protein 46	Homo sapiens (Human)	PR
Q9NX65	ZSCAN32	Zinc finger and SCAN domain-containing protein 32	Homo sapiens (Human)	PR
O14771	ZNF213	Zinc finger protein 213	Homo sapiens (Human)	PR
Q8IWY8	ZSCAN29	Zinc finger and SCAN domain-containing protein 29	Homo sapiens (Human)	PR
Q8NCP5	ZBTB44	Zinc finger and BTB domain-containing protein 44	Homo sapiens (Human)	PR
P41182	BCL6	B-cell lymphoma 6 protein	Homo sapiens (Human)	PR
Q9NQX0	PRDM6	Putative histone-lysine N-methyltransferase PRDM6	Homo sapiens (Human)	PR
Q9BU19	ZNF692	Zinc finger protein 692	Homo sapiens (Human)	PR
Q08AG5	ZNF844	Zinc finger protein 844	Homo sapiens (Human)	PR
Q6R2W3	ZBED9	SCAN domain-containing protein 3	Homo sapiens (Human)	PR
P98182	ZNF200	Zinc finger protein 200	Homo sapiens (Human)	PR
Q9UK11	ZNF223	Zinc finger protein 223	Homo sapiens (Human)	PR
O15156	ZBTB7B	Zinc finger and BTB domain-containing protein 7B	Homo sapiens (Human)	PR
Q6ZMS7	ZNF783	Zinc finger protein 783	Homo sapiens (Human)	PR
P59923	ZNF445	Zinc finger protein 445	Homo sapiens (Human)	PR
Q8N859	ZNF713	Zinc finger protein 713	Homo sapiens (Human)	PR
Q8TD17	ZNF398	Zinc finger protein 398	Homo sapiens (Human)	PR
P52739	ZNF131	Zinc finger protein 131	Homo sapiens (Human)	PR
A6NGD5	ZSCAN5C	Zinc finger and SCAN domain-containing protein 5C	Homo sapiens (Human)	PR
Q7Z398	ZNF550	Zinc finger protein 550	Homo sapiens (Human)	PR
Q9Y2K1	ZBTB1	Zinc finger and BTB domain-containing protein 1	Homo sapiens (Human)	PR
Q96N20	ZNF75A	Zinc finger protein 75A	Homo sapiens (Human)	PR
A6NJL1	ZSCAN5B	Zinc finger and SCAN domain-containing protein 5B	Homo sapiens (Human)	PR
A1YPR0	ZBTB7C	Zinc finger and BTB domain-containing protein 7C	Homo sapiens (Human)	PR
Q9NWS9	ZNF446	Zinc finger protein 446	Homo sapiens (Human)	PR
P24278	ZBTB25	Zinc finger and BTB domain-containing protein 25	Homo sapiens (Human)	PR
Q96N38	ZNF714	Zinc finger protein 714	Homo sapiens (Human)	PR
Q86YH2	ZNF280B	Zinc finger protein 280B	Homo sapiens (Human)	PR
Q9Y5W3	KLF2	Krueppel-like factor 2	Homo sapiens (Human)	PR
Q06889	EGR3	Early growth response protein 3	Homo sapiens (Human)	PR
P18146	EGR1	Early growth response protein 1	Homo sapiens (Human)	PR
Q05215	EGR4	Early growth response protein 4	Homo sapiens (Human)	PR
Q9Y4X4	KLF12	Krueppel-like factor 12	Homo sapiens (Human)	PR
Q99612	KLF6	Krueppel-like factor 6	Homo sapiens (Human)	PR
O75840	KLF7	Krueppel-like factor 7	Homo sapiens (Human)	PR
O08584	Klf6	Krueppel-like factor 6	Mus musculus (Mouse)	PR
Q61164	Ctcf	Transcriptional repressor CTCF	Mus musculus (Mouse)	PR
Q810A1	Znf18	Zinc finger protein 18	Mus musculus (Mouse)	PR
Q8BGS3	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Mus musculus (Mouse)	PR
Q00899	Yy1	Transcriptional repressor protein YY1	Mus musculus (Mouse)	PR
P41183	Bcl6	B-cell lymphoma 6 protein homolog	Mus musculus (Mouse)	PR
Q9DAI4	Zbtb43	Zinc finger and BTB domain-containing protein 43	Mus musculus (Mouse)	PR
O70237	Gfi1b	Zinc finger protein Gfi-1b	Mus musculus (Mouse)	PR
Q99KZ6	Znf639	Zinc finger protein 639	Mus musculus (Mouse)	PR
Q9Z1D9	Znf394	Zinc finger protein 394	Mus musculus (Mouse)	PR
Q9CXE0	Prdm5	PR domain zinc finger protein 5	Mus musculus (Mouse)	PR
P43300	Egr3	Early growth response protein 3	Mus musculus (Mouse)	PR
Q9DAU9	Znf654	Zinc finger protein 654	Mus musculus (Mouse)	PR
Q9R1Y5	Hic1	Hypermethylated in cancer 1 protein	Mus musculus (Mouse)	PR
Q8R0T2	Znf768	Zinc finger protein 768	Mus musculus (Mouse)	PR
Q9WVG7	Osr1	Protein odd-skipped-related 1	Mus musculus (Mouse)	PR
Q8BI73	Znf775	Zinc finger protein 775	Mus musculus (Mouse)	PR
Q8VCZ7	Zbtb7c	Zinc finger and BTB domain-containing protein 7C	Mus musculus (Mouse)	PR
Q91VN1	Znf24	Zinc finger protein 24	Mus musculus (Mouse)	PR
Q9DB38	Znf580	Zinc finger protein 580	Mus musculus (Mouse)	PR
A7KBS4	Zscan4d	Zinc finger and SCAN domain containing protein 4D	Mus musculus (Mouse)	PR
Q91VW9	Zkscan3	Zinc finger protein with KRAB and SCAN domains 3	Mus musculus (Mouse)	PR
P10925	Zfy1	Zinc finger Y-chromosomal protein 1	Mus musculus (Mouse)	PR
P08046	Egr1	Early growth response protein 1	Mus musculus (Mouse)	PR
Q3TTC2	Yy2	Transcription factor YY2	Mus musculus (Mouse)	PR
Q3UTQ7	Prdm10	PR domain zinc finger protein 10	Mus musculus (Mouse)	PR
Q6P3Y5	Znf280c	Zinc finger protein 280C	Mus musculus (Mouse)	PR
Q9ERU3	Znf22	Zinc finger protein 22	Mus musculus (Mouse)	PR
Q8VIG1	Rest	RE1-silencing transcription factor	Mus musculus (Mouse)	PR
Q9Z1D8	Zkscan5	Zinc finger protein with KRAB and SCAN domains 5	Mus musculus (Mouse)	PR
Q8BID6	Zbtb46	Zinc finger and BTB domain-containing protein 46	Mus musculus (Mouse)	PR
P17012	Zfx	Zinc finger X-chromosomal protein	Mus musculus (Mouse)	PR
Q9WUK6	Zbtb18	Zinc finger and BTB domain-containing protein 18	Mus musculus (Mouse)	PR
O35738	Klf12	Krueppel-like factor 12	Mus musculus (Mouse)	PR
B2RXC5	Znf382	Zinc finger protein 382	Mus musculus (Mouse)	PR
O08900	Ikzf3	Zinc finger protein Aiolos	Mus musculus (Mouse)	PR
Q5DU09	Znf652	Zinc finger protein 652	Mus musculus (Mouse)	PR
Q5RJ54	Zscan26	Zinc finger and SCAN domain-containing protein 26	Mus musculus (Mouse)	PR
Q8BLM0	Klf8	Krueppel-like factor 8	Mus musculus (Mouse)	PR
Q99JB0	Klf7	Krueppel-like factor 7	Mus musculus (Mouse)	PR
Q8R0A2	Zbtb44	Zinc finger and BTB domain-containing protein 44	Mus musculus (Mouse)	PR
P20662	Zfy2	Zinc finger Y-chromosomal protein 2	Mus musculus (Mouse)	PR
Q80VJ6	Zscan4c	Zinc finger and SCAN domain containing protein 4C	Mus musculus (Mouse)	PR
Q3URS2	Zscan4f	Zinc finger and SCAN domain containing protein 4F	Mus musculus (Mouse)	PR
Q8K3J5	Znf131	Zinc finger protein 131	Mus musculus (Mouse)	PR
Q60980	Klf3	Krueppel-like factor 3	Mus musculus (Mouse)	PR
Q9Z2K3	Znf394	Zinc finger protein 394	Rattus norvegicus (Rat)	PR
Q642B9	Znf18	Zinc finger protein 18	Rattus norvegicus (Rat)	PR
B0K011	Osr1	Protein odd-skipped-related 1	Rattus norvegicus (Rat)	PR
D3ZUU2	Gzf1	GDNF-inducible zinc finger protein 1	Rattus norvegicus (Rat)	PR
B1WBU4	Zbtb8a	Zinc finger and BTB domain-containing protein 8A	Rattus norvegicus (Rat)	PR
Q7TNK3	Znf24	Zinc finger protein 24	Rattus norvegicus (Rat)	PR
O35819	Klf6	Krueppel-like factor 6	Rattus norvegicus (Rat)	PR
Q9R1D1	Ctcf	Transcriptional repressor CTCF	Rattus norvegicus (Rat)	PR
P43301	Egr3	Early growth response protein 3	Rattus norvegicus (Rat)	PR
P08154	Egr1	Early growth response protein 1	Rattus norvegicus (Rat)	PR
A0JPL0	Znf382	Zinc finger protein 382	Rattus norvegicus (Rat)	PR
Q4KLI1	Zkscan1	Zinc finger protein with KRAB and SCAN domains 1	Rattus norvegicus (Rat)	PR
A1L1J6	Znf652	Zinc finger protein 652	Rattus norvegicus (Rat)	PR
Q9SHD0	ZAT4	Zinc finger protein ZAT4	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0P4X6	zbtb44	Zinc finger and BTB domain-containing protein 44	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
A4II20	egr1	Early growth response protein 1	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q6P882	zbtb8a.2	Zinc finger and BTB domain-containing protein 8A.2	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q567C6	znf367	Zinc finger protein 367	Danio rerio (Zebrafish) (Brachydanio rerio)	PR
A7Y7X5	znf711	Zinc finger protein 711	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MLMFDPVPVK	QEAMDPVSVS	YPSNYMESMK	PNKYGVIYST	PLPEKFFQTP	EGLSHGIQME
70	80	90	100	110	120
PVDLTVNKRS	SPPSAGNSPS	SLKFPSSHRR	ASPGLSMPSS	SPPIKKYSPP	SPGVQPFGVP
130	140	150	160	170	180
LSMPPVMAAA	LSRHGIRSPG	ILPVIQPVVV	QPVPFMYTSH	LQQPLMVSLS	EEMENSSSSM
190	200	210	220	230	240
QVPVIESYEK	PISQKKIKIE	PGIEPQRTDY	YPEEMSPPLM	NSVSPPQALL	QENHPSVIVQ
250	260	270	280	290	300
PGKRPLPVES	PDTQRKRRIH	RCDYDGCNKV	YTKSSHLKAH	RRTHTGEKPY	KCTWEGCTWK
310	320	330	340
FARSDELTRH	FRKHTGIKPF	QCPDCDRSFS	RSDHLALHRK	RHMLV