P57097
SS
Gene name |
Mertk (Mer) |
Protein name |
Tyrosine-protein kinase Mer |
Names |
EC 2.7.10.1 , Proto-oncogene c-Mer , Receptor tyrosine kinase MerTK |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:65037 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Tyrosine-protein kinase Mer (Mertk) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of Mertk.
Autoinhibitory domains (AIDs)
Accessory elements
735-760 (Activation loop from InterPro)
Target domain |
582-852 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for P57097
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P57097-F1 | Predicted | AlphaFoldDB |
No variants for P57097
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P57097 | |||||
1 associated diseases with P57097
Without disease ID
4 regional properties for P57097
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ras-like guanine nucleotide exchange factor, N-terminal | 49 - 175 | IPR000651 |
| domain | Ras guanine-nucleotide exchange factors catalytic domain | 197 - 433 | IPR001895 |
| domain | EF-hand domain | 466 - 501 | IPR002048 |
| domain | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | 540 - 597 | IPR002219 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| photoreceptor outer segment | The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
21 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic cell clearance | The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| lymphocyte activation | A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. |
| natural killer cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. |
| negative regulation of cytokine production | Any process that stops, prevents, or reduces the rate of production of a cytokine. |
| negative regulation of leukocyte apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process. |
| negative regulation of lymphocyte activation | Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| neutrophil clearance | The selective elimination of senescent neutrophils from the body by autoregulatory mechanisms. |
| phagocytosis | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| platelet activation | A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. |
| positive regulation of phagocytosis | Any process that activates or increases the frequency, rate or extent of phagocytosis. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| retina development in camera-type eye | The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. |
| secretion by cell | The controlled release of a substance by a cell. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
| substrate adhesion-dependent cell spreading | The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vagina development | The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure. |
53 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P08581 | MET | Hepatocyte growth factor receptor | Homo sapiens (Human) | EV |
| P30530 | AXL | Tyrosine-protein kinase receptor UFO | Homo sapiens (Human) | PR |
| Q04912 | MST1R | Macrophage-stimulating protein receptor | Homo sapiens (Human) | EV |
| Q12866 | MERTK | Tyrosine-protein kinase Mer | Homo sapiens (Human) | EV |
| Q06418 | TYRO3 | Tyrosine-protein kinase receptor TYRO3 | Homo sapiens (Human) | SS |
| P34925 | RYK | Tyrosine-protein kinase RYK | Homo sapiens (Human) | PR |
| P55144 | Tyro3 | Tyrosine-protein kinase receptor TYRO3 | Mus musculus (Mouse) | SS |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q01887 | Ryk | Tyrosine-protein kinase RYK | Mus musculus (Mouse) | PR |
| Q2QLE0 | MET | Hepatocyte growth factor receptor | Sus scrofa (Pig) | PR |
| Q64716 | Insrr | Insulin receptor-related protein | Rattus norvegicus (Rat) | SS |
| G3V9H8 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Rattus norvegicus (Rat) | SS |
| Q62838 | Musk | Muscle, skeletal receptor tyrosine protein kinase | Rattus norvegicus (Rat) | SS |
| Q63604 | Ntrk2 | BDNF/NT-3 growth factors receptor | Rattus norvegicus (Rat) | SS |
| P35739 | Ntrk1 | High affinity nerve growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q03351 | Ntrk3 | NT-3 growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q91ZT1 | Flt4 | Vascular endothelial growth factor receptor 3 | Rattus norvegicus (Rat) | SS |
| O08775 | Kdr | Vascular endothelial growth factor receptor 2 | Rattus norvegicus (Rat) | SS |
| P24062 | Igf1r | Insulin-like growth factor 1 receptor | Rattus norvegicus (Rat) | SS |
| Q498D6 | Fgfr4 | Fibroblast growth factor receptor 4 | Rattus norvegicus (Rat) | PR |
| P97523 | Met | Hepatocyte growth factor receptor | Rattus norvegicus (Rat) | PR |
| Q62956 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Rattus norvegicus (Rat) | SS |
| Q62799 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Rattus norvegicus (Rat) | SS |
| Q05030 | Pdgfrb | Platelet-derived growth factor receptor beta | Rattus norvegicus (Rat) | SS |
| P20786 | Pdgfra | Platelet-derived growth factor receptor alpha | Rattus norvegicus (Rat) | SS |
| P15127 | Insr | Insulin receptor | Rattus norvegicus (Rat) | SS |
| Q63474 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Rattus norvegicus (Rat) | SS |
| P53767 | Flt1 | Vascular endothelial growth factor receptor 1 | Rattus norvegicus (Rat) | PR |
| Q04589 | Fgfr1 | Fibroblast growth factor receptor 1 | Rattus norvegicus (Rat) | SS |
| P06494 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Rattus norvegicus (Rat) | SS |
| Q00495 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Rattus norvegicus (Rat) | PR |
| H2KZU7 | svh-2 | Tyrosine-protein kinase receptor svh-2 | Caenorhabditis elegans | SS |
| Q9SXB5 | At1g11303 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11303 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LPZ9 | SD113 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64783 | At1g61370 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61370 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64770 | At1g61490 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61490 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SYA0 | At1g61500 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61500 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O81833 | SD11 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8RWZ5 | SD25 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SXB4 | At1g11300 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11300 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64778 | At1g61420 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61420 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64776 | At1g61440 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61440 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64780 | At1g61400 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61400 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SY95 | At1g61550 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61550 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64782 | SD129 | G-type lectin S-receptor-like serine/threonine-protein kinase SD1-29 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O64774 | At1g61460 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61460 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64477 | At2g19130 | G-type lectin S-receptor-like serine/threonine-protein kinase At2g19130 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SXB8 | At1g11330 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g11330 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64793 | At1g67520 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g67520 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64784 | At1g61360 | G-type lectin S-receptor-like serine/threonine-protein kinase At1g61360 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39203 | SD22 | G-type lectin S-receptor-like serine/threonine-protein kinase SD2-2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVLAPLLLGL | LLLSALWNGG | TAEKEEEIKP | DQPFSGPLPG | SLPADHRPFF | APHSSGDQLS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PSQTGRSHPA | HTATPQMTSA | ASNLLPPVAF | KNTIGRIVLS | EHKSVKFNCS | INIPNVYQET |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AGISWWKDGK | ELLGAHHSIT | QFYPDEEGVS | IIALFSITSV | QRSDNGSYIC | KMKVNDREVV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SDPIYVEVQG | LPYFTKQPES | VNVTRNTAFN | LTCQAVGPPE | PVNIFWVQNS | SRVNENPERS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PSVLTVAGLT | ETAVFSCEAH | NDKGLTVSKG | VQINIKVIPS | PPTEVHILNS | TAHSILVSWV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| PGFDGYSPLQ | NCSIQVKEAD | QLSNGSVMVF | NTSASPHLYE | VQQLQALANY | SVTVSCRNEI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GWSAVSPWIL | ASTTEGAPAV | APLNITVFLN | ESSNNLEIRW | TKPPIKRQDG | ELVGYRISHV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| WESAGTSKEL | SEEVSQNGSW | AQVPVQMHNA | TCTVRIAVIT | KGGIGPFSEP | VDVAIPEHSR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VDYAPSSTPA | PGNTESMLII | LGCFCGFVLM | GLILYLSLAI | KRRVQETKFG | GAFSEEDSQL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VVNYRAKKSF | CRRAIELTLQ | SLGVSEELQN | KLEDVVVDRN | LLILGKVLGE | GEFGSVMEGN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LKQEDGTSQK | VAVKTMKLDN | FSLREIEEFL | SEAACMKDFN | HPNVIRLLGV | CIELSSQGIP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| KPMVILPFMK | YGDLHTFLLY | SRIESVPKSI | PLQTLLKFMV | DIAQGMEYLS | SRNFLHRDLA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ARNCMLRDDM | TVCVADFGLS | KKIYSGDYYR | QGRIAKMPVK | WIAIESLADR | VYTSKSDVWA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FGVTMWEIAT | RGMTPYPGVQ | NHEMYDYLLH | GHRLKQPEDC | LDDLYEIMYS | CWSADPLDRP |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TFSVLRLQLE | KLSESLPDAQ | DKESIIYINT | QLLESCEGLA | NRSSLAGLDM | NIDPDSIIAS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| CTAGAAVSVV | MAEVHENNLH | EERYILNGGN | EEWEDVASTP | FATVTAGKDG | VLPEDRLTKN |
| 970 | 980 | 990 | |||
| GISWSHHSTL | PLGSPSPDEL | LFADDSSGDS | EVLM |