AiPD: Autoinhibited Protein Database

Gene name	Usp5 (Isot)
Protein name	Ubiquitin carboxyl-terminal hydrolase 5
Names	Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:22225
EC number	3.4.19.12: Omega peptidases
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

579-667 (Predicted disordered autoinhibitory region) PR

579-667 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P56399-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs222313610	3	E>D	No	EVA
rs3388861961	16	I>F	No	EVA
rs3388861924	20	K>N	No	EVA
rs3388866802	46	C>Y	No	EVA
rs3388853728	58	V>M	No	EVA
rs249589399	79	P>L	No	EVA
rs3397309583	87	G>C	No	EVA
rs3388853800	97	T>I	No	EVA
rs3388861914	136	L>S	No	EVA
rs3396910520	146	R>W	No	EVA
rs3388844773	153	A>D	No	EVA
rs3388860927	169	W>*	No	EVA
rs3388857054	245	A>D	No	EVA
rs3388856998	245	A>T	No	EVA
rs3388863548	264	D>Y	No	EVA
rs3388858279	287	Q>R	No	EVA
rs3388863608	301	N>K	No	EVA
rs3388850461	303	R>W	No	EVA
rs3388841895	326	T>K	No	EVA
rs3388844735	364	N>S	No	EVA
rs3388841906	388	E>G	No	EVA
rs3388823608	403	P>L	No	EVA
rs228432918	404	E>D	No	EVA
rs3388863170	452	R>L	No	EVA
rs3388854371	463	F>L	No	EVA
rs3388862239	465	V>L	No	EVA
rs3388854297	484	D>V	No	EVA
rs3388863231	497	L>H	No	EVA
rs3388858332	517	V>M	No	EVA
rs3388858284	519	L>R	No	EVA
rs3388866739	523	V>A	No	EVA
rs3388866773	577	T>I	No	EVA
rs3396914332	601	Q>R	No	EVA
rs3388860851	624	P>S	No	EVA
rs3388861947	695	H>Q	No	EVA
rs3388841911	703	N>T	No	EVA
rs266234187	706	I>M	No	EVA
rs3388863218	711	S>I	No	EVA
rs241646899	724	P>S	No	EVA
rs3388862247	750	N>I	No	EVA
rs3397370929	756	V>E	No	EVA
rs3388866741	783	S>T	No	EVA
rs3388858318	787	S>Y	No	EVA
rs3388860413	791	G>E	No	EVA
rs3388853706	810	M>K	No	EVA
rs3397376323	813	S>Y	No	EVA
rs3388858312	819	Y>*	No	EVA
rs3388863168	822	H>Q	No	EVA
rs3388863184	831	I>T	No	EVA
rs3388857190	842	K>R	No	EVA

Type	Name	Position	InterPro Accession
domain	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	326 - 853	IPR001394
domain	Zinc finger, UBP-type	175 - 283	IPR001607
domain	Ubiquitin-associated domain	654 - 695	IPR015940-1
domain	Ubiquitin-associated domain	722 - 762	IPR015940-2
conserved_site	Ubiquitin specific protease, conserved site	327 - 342	IPR018200-1
conserved_site	Ubiquitin specific protease, conserved site	801 - 819	IPR018200-2
domain	Ubiquitin specific protease domain	326 - 856	IPR028889
domain	Ubiquitinyl hydrolase, variant UBP zinc finger	16 - 78	IPR041432
domain	Ubiquitin carboxyl-terminal hydrolase 5, UBA1 domain	655 - 702	IPR041812

		Description
EC Number	3.4.19.12	Omega peptidases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
cysteine-type deubiquitinase activity	An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated.
cysteine-type endopeptidase activity	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
ubiquitin binding	Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
zinc ion binding	Binding to a zinc ion (Zn).

Name	Definition
positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein deubiquitination	The removal of one or more ubiquitin groups from a protein.
protein K48-linked deubiquitination	A protein deubiquitination process in which a K48-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is removed from a protein.
ubiquitin-dependent protein catabolic process	The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q92995	USP13	Ubiquitin carboxyl-terminal hydrolase 13	Homo sapiens (Human)	PR
P45974	USP5	Ubiquitin carboxyl-terminal hydrolase 5	Homo sapiens (Human)	PR
P57080	Usp25	Ubiquitin carboxyl-terminal hydrolase 25	Mus musculus (Mouse)	SS
Q6A4J8	Usp7	Ubiquitin carboxyl-terminal hydrolase 7	Mus musculus (Mouse)	PR
F6V6I0	usp13	Ubiquitin carboxyl-terminal hydrolase 13	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR