AiPD: Autoinhibited Protein Database

P55899

Gene name	FCGRT (FCRN)
Protein name	IgG receptor FcRn large subunit p51
Names	FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2217
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

37-107 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

37-107 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

26 structures for P55899

Entry ID	Method	Resolution	Chain	Position	Source
1EXU	X-ray	270 A	A	24-290	PDB
3M17	X-ray	260 A	A/C/E/G	24-290	PDB
3M1B	X-ray	310 A	A/C/E/G	24-290	PDB
4K71	X-ray	240 A	B/E	24-297	PDB
4N0F	X-ray	302 A	A/E/H/K	27-297	PDB
4N0U	X-ray	380 A	A	27-290	PDB
5BJT	X-ray	320 A	A/C/E/G	24-290	PDB
5BXF	X-ray	285 A	A/C	1-290	PDB
5WHK	X-ray	250 A	A	1-297	PDB
6C97	X-ray	200 A	A/C	24-297	PDB
6C98	X-ray	185 A	A/C	24-297	PDB
6C99	X-ray	200 A	A/C	24-297	PDB
6FGB	X-ray	290 A	A	24-365	PDB
6ILM	EM	340 A	E	28-290	PDB
6LA6	EM	239 A	E	28-290	PDB
6LA7	EM	282 A	E	28-290	PDB
6NHA	X-ray	238 A	A	24-296	PDB
6QIO	X-ray	195 A	B	24-297	PDB
6QIP	X-ray	245 A	B	24-297	PDB
6WNA	X-ray	240 A	A	27-290	PDB
6WOL	X-ray	249 A	A	24-290	PDB
7B5F	EM	290 A	G	24-290	PDB
7C9V	EM	330 A	E	28-290	PDB
7Q15	X-ray	330 A	A/C	1-297	PDB
7XXA	EM	309 A	E	28-290	PDB
AF-P55899-F1	Predicted				AlphaFoldDB

305 variants for P55899

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA9576097 rs201887538	3	V>I		No	ClinGen 1000Genomes ExAC gnomAD
CA406845602 rs1321677477	4	P>R		No	ClinGen TOPMed
CA309500782 rs865842679	5	R>W		No	ClinGen gnomAD
rs1601185712 CA406845612	6	P>S		No	ClinGen Ensembl
CA406845683 rs1457812213	10	A>P		No	ClinGen TOPMed
CA309500790 rs1014602885	10	A>V		No	ClinGen Ensembl
rs1221552740 CA406845717	13	L>I		No	ClinGen gnomAD
CA309500801 rs1020227408	15	L>F		No	ClinGen TOPMed
CA309500806 rs748687030	18	L>F		No	ClinGen ExAC gnomAD
CA9576098 rs748687030	18	L>V		No	ClinGen ExAC gnomAD
CA406845823 rs1568698281	20	G>E		No	ClinGen Ensembl
rs966015368 CA309500815	21	S>N		No	ClinGen TOPMed
rs977416239 CA309500817	22	L>P		No	ClinGen TOPMed
CA9576114 rs563156763	29	S>F		No	ClinGen ExAC gnomAD
CA406846959 rs1263757524	33	H>R		No	ClinGen TOPMed
CA406846966 rs1169990693	34	L>F		No	ClinGen TOPMed gnomAD
CA406846985 rs1353041751	35	T>I		No	ClinGen gnomAD
rs1348652644 CA406847000	36	A>V		No	ClinGen TOPMed
CA9576117 rs756598475	42	P>A		No	ClinGen ExAC gnomAD
CA406847129 rs1337482068	42	P>L		No	ClinGen TOPMed gnomAD
CA406847127 rs1337482068	42	P>Q		No	ClinGen TOPMed gnomAD
CA406847152 rs1282399994	43	G>E		No	ClinGen gnomAD
rs548622027 CA9576120	43	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9576121 rs774053349	45	P>A		No	ClinGen ExAC TOPMed gnomAD
CA406847192 rs1471192099	46	A>T		No	ClinGen TOPMed
rs745455322 CA9576122	46	A>V		No	ClinGen ExAC TOPMed gnomAD
CA406847370 rs1294405579	50	S>C		No	ClinGen gnomAD
rs771581989 CA9576123	52	W>C		No	ClinGen ExAC TOPMed gnomAD
CA9576126 rs764132164	55	P>L		No	ClinGen ExAC TOPMed gnomAD
rs764132164 CA309501455	55	P>R		No	ClinGen ExAC TOPMed gnomAD
rs776410571 CA9576127	56	Q>K		No	ClinGen ExAC TOPMed gnomAD
CA309501500 rs985172508	61	Y>H		No	ClinGen TOPMed
CA9576129 rs765121002	62	N>S		No	ClinGen ExAC TOPMed gnomAD
CA9576131 rs375492056	65	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA9576132 rs566716525	65	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406847762 rs1568698616	66	G>A		No	ClinGen Ensembl
CA406847742 rs1568698609	66	G>S		No	ClinGen Ensembl
rs1346962125 CA406847768	67	E>K		No	ClinGen gnomAD
rs756120751 CA9576134	68	A>V		No	ClinGen ExAC gnomAD
rs778398186 CA9576135	70	P>S		No	ClinGen ExAC gnomAD
CA9576136 rs151255924	71	C>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406848170 rs1283581624	80	V>M		No	ClinGen gnomAD
rs779188731 CA9576138	81	S>F		No	ClinGen ExAC gnomAD
rs745540437 CA9576139	86	K>R		No	ClinGen ExAC gnomAD
TCGA novel	90	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs771715578 CA9576141	91	L>M		No	ClinGen ExAC TOPMed gnomAD
rs558937033 CA9576142	94	K>E		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	95	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs571119864 CA309501620	95	E>K		No	ClinGen 1000Genomes
rs768039997 CA9576143	97	L>V		No	ClinGen ExAC TOPMed gnomAD
CA309501682 rs1053115692	100	E>G		No	ClinGen TOPMed gnomAD
CA406848632 rs1433490219	101	A>T		No	ClinGen TOPMed
CA9576144 rs776778260	103	K>Q		No	ClinGen ExAC gnomAD
rs1490955370 CA406848686	103	K>R		No	ClinGen gnomAD
CA406848701 rs1200387144	104	A>T		No	ClinGen gnomAD
CA406848705 rs1347515343	104	A>V		No	ClinGen TOPMed
CA9576146 rs761777508	105	L>F		No	ClinGen ExAC TOPMed gnomAD
CA9576147 rs201043787	106	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9576148 rs201043787	106	G>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1568698688	107	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406848780 rs1160378515	107	G>E		No	ClinGen gnomAD
rs1446108924 CA406848789	108	K>*		No	ClinGen TOPMed
rs577203568 CA9576169	109	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA406848987 rs1385630873	110	P>L		No	ClinGen gnomAD
CA9576170 rs544444357	111	Y>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs753884697 CA9576171	112	T>I		No	ClinGen ExAC gnomAD
CA406849016 rs1601186998	112	T>P		No	ClinGen Ensembl
CA406849074 rs1490571310	115	G>D		No	ClinGen TOPMed
rs765755605 CA9576174	119	C>*		No	ClinGen ExAC gnomAD
CA406849173 rs750871998	120	E>K		No	ClinGen ExAC gnomAD
CA9576175 rs750871998	120	E>Q		No	ClinGen ExAC gnomAD
CA406849280 rs1296773569	123	P>L		No	ClinGen TOPMed
CA406849259 rs1309576545	123	P>S		No	ClinGen TOPMed
rs1027136550 CA309501961	124	D>N		No	ClinGen TOPMed gnomAD
CA406849321 rs977467479	125	N>D		No	ClinGen Ensembl
CA309501970 rs977467479	125	N>H		No	ClinGen Ensembl
CA9576176 rs758794510	125	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1396854985 CA406849381	127	S>A		No	ClinGen gnomAD
TCGA novel	127	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780275784 CA9576177	129	P>A		No	ClinGen ExAC gnomAD
rs1454015050 CA406849501	130	T>A		No	ClinGen gnomAD
CA9576178 rs751281836	130	T>I		No	ClinGen ExAC gnomAD
CA406849529 rs1230163488	131	A>S		No	ClinGen TOPMed gnomAD
CA406849523 rs1230163488	131	A>T		No	ClinGen TOPMed gnomAD
rs1270924261 CA406849539	131	A>V		No	ClinGen gnomAD
CA9576180 rs140458678	132	K>M		No	ClinGen ESP ExAC TOPMed
RCV000951155 rs150420714 COSM239850 CA9576181	132	K>N	prostate [Cosmic]	No	ClinGen cosmic curated ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA406849585 rs140458678	132	K>R		No	ClinGen ESP ExAC TOPMed
CA406849605 rs1601187116	133	F>C		No	ClinGen Ensembl
CA9576183 rs777861971	133	F>L		No	ClinGen ExAC gnomAD
CA406849717 rs1204194307	138	E>K		No	ClinGen gnomAD
rs1421832028 CA406849745	139	E>*		No	ClinGen gnomAD
CA406849754 rs1568698932	139	E>V		No	ClinGen Ensembl
rs1356009302 CA406849794	141	M>R		No	ClinGen TOPMed
CA9576186 rs773997430	144	D>N		No	ClinGen ExAC gnomAD
rs760999604 CA9576187	147	Q>H		No	ClinGen ExAC TOPMed gnomAD
CA406849989 rs1474891146	147	Q>L		No	ClinGen gnomAD
rs965231176 CA309502084	148	G>R		No	ClinGen TOPMed gnomAD
CA9576189 rs776785568	148	G>V		No	ClinGen ExAC TOPMed gnomAD
CA9576190 rs548660464	149	T>I		No	ClinGen 1000Genomes ExAC gnomAD
rs765233786 CA9576191	151	G>D		No	ClinGen ExAC gnomAD
rs75776802 CA309502102	152	G>W		No	ClinGen Ensembl
rs1568698968 CA406850181	153	D>E		No	ClinGen Ensembl
rs773834526 CA9576192	153	D>Y		No	ClinGen ExAC gnomAD
CA406850212 rs1326030891	154	W>*		No	ClinGen gnomAD
rs1217649925 CA406850260	155	P>R		No	ClinGen TOPMed gnomAD
CA406850236 rs1216992482	155	P>S		No	ClinGen gnomAD
CA406850306 rs1223056651	157	A>V		No	ClinGen gnomAD
rs766812943 CA9576194	160	I>V		No	ClinGen ExAC gnomAD
rs751836833 CA9576195	161	S>R		No	ClinGen ExAC gnomAD
rs1191034149 CA406850472	163	R>Q		No	ClinGen gnomAD
CA406850465 rs1487863691	163	R>W	Variant assessed as Somatic; 4.782e-05 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9576196 rs755325686	164	W>C		No	ClinGen ExAC gnomAD
CA406850487 rs1601187287	164	W>G		No	ClinGen Ensembl
rs932442681 CA309502147	168	D>E		No	ClinGen Ensembl
rs921214557 CA309502142	168	D>H		No	ClinGen Ensembl
TCGA novel	170	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767296631 CA9576197	170	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9576200 rs777412760 CA406850717	172	N>K		No	ClinGen ExAC gnomAD
CA406850728 rs1159690332	173	K>R		No	ClinGen TOPMed gnomAD
TCGA novel	176	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406850783 rs1305186351	176	T>S		No	ClinGen gnomAD
TCGA novel rs1601187375 CA406850836	180	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA9576205 rs373482955	183	P>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9576206 rs554770888	183	P>L		No	ClinGen ExAC TOPMed gnomAD
COSM1395257 CA9576204 rs373482955	183	P>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA406850914 rs1601187401	184	H>P		No	ClinGen Ensembl
TCGA novel	184	H>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1270515624 CA406850936	185	R>C		No	ClinGen gnomAD
CA9576208 rs200294618	185	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9576209 rs145251123	187	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406850970 rs1264611909	188	E>Q		No	ClinGen gnomAD
rs759996121 CA9576210	189	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA406850993 rs1160447854	190	L>M		No	ClinGen TOPMed gnomAD
CA9576212 rs766823478	193	G>C		No	ClinGen ExAC TOPMed gnomAD
CA9576214 rs759988303	194	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9576215 rs140957263	194	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9576216 rs140957263	194	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9576219 CA309502310 rs753321487	195	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1601187487 CA406851060	196	N>T		No	ClinGen Ensembl
CA309511195 rs868060040	202	P>A		No	ClinGen Ensembl
rs1289505049 CA406855846	202	P>L		No	ClinGen TOPMed gnomAD
CA9576266 rs780596384	203	P>H		No	ClinGen ExAC TOPMed gnomAD
CA406855869 rs780596384	203	P>L		No	ClinGen ExAC TOPMed gnomAD
rs780596384 CA9576265	203	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1031342092 CA309511210	204	S>C		No	ClinGen TOPMed gnomAD
rs1378221933 CA406855961	205	M>I		No	ClinGen TOPMed gnomAD
rs1177979004 CA406855948	205	M>T		No	ClinGen TOPMed gnomAD
CA9576268 rs757472733	205	M>V		No	ClinGen ExAC TOPMed gnomAD
rs779240739 CA9576269	206	R>C	Variant assessed as Somatic; 4.765e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
COSM3835383 rs1163474595 CA406855986	206	R>H	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA9576270 rs141886822	207	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1389228142 CA406856097	209	A>S		No	ClinGen TOPMed
rs1401612604 CA406856105	209	A>V		No	ClinGen gnomAD
rs1446659989 CA406856116	210	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9576273 rs747515242	210	R>Q		No	ClinGen ExAC gnomAD
rs981686219 CA406856133	211	P>A		No	ClinGen TOPMed gnomAD
rs768959760 CA309511261	211	P>L		No	ClinGen ExAC gnomAD
CA9576274 rs768959760	211	P>R		No	ClinGen ExAC gnomAD
rs981686219 CA309511249	211	P>S		No	ClinGen TOPMed gnomAD
CA9576275 rs777030957	212	S>G		No	ClinGen ExAC gnomAD
rs1258755172 CA406856156	212	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA406856162 rs1370269878	212	S>R		No	ClinGen TOPMed
CA309511283 rs928505166	214	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA309511297 rs939434904	217	S>F		No	ClinGen TOPMed gnomAD
CA9576277 rs769515663	218	V>M		No	ClinGen ExAC TOPMed gnomAD
rs772799298 CA9576278	220	T>S		No	ClinGen ExAC gnomAD
rs1367480794 CA406856494	222	S>C		No	ClinGen gnomAD
CA406856540 rs1471623069	222	S>R		No	ClinGen gnomAD
CA406856550 rs1169330758	223	A>P		No	ClinGen gnomAD
rs1169330758 CA406856553	223	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA406856722 rs765804676	227	Y>*		No	ClinGen ExAC TOPMed gnomAD
CA406856708 rs1601199416	227	Y>S		No	ClinGen Ensembl
CA9576281 rs774335339	228	P>L		No	ClinGen ExAC gnomAD
rs759499665 CA9576282	229	P>L		No	ClinGen ExAC TOPMed gnomAD
rs752571484 CA406856909	234	R>L		No	ClinGen ExAC TOPMed gnomAD
rs752571484 CA9576284	234	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9576283 rs767260789	234	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA9576286 rs147601685	237	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9576287 rs147601685	237	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9576285 rs147973476	237	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs370645883 CA309511359	238	N>S		No	ClinGen gnomAD
rs1347064601 CA406857050	239	G>W		No	ClinGen gnomAD
rs780268860 CA9576290	242	A>P		No	ClinGen ExAC TOPMed gnomAD
COSM1206936 rs780268860 CA9576289	242	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1459800562 CA406857188	243	G>V		No	ClinGen TOPMed
CA406857228 rs781510967	244	T>I		No	ClinGen ExAC gnomAD
CA9576291 rs543194840	244	T>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs781510967 CA9576292	244	T>S		No	ClinGen ExAC gnomAD
rs374238496 CA9576294	245	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA406857292 rs900437297	246	Q>*		No	ClinGen gnomAD
rs900437297 CA309511461	246	Q>E		No	ClinGen gnomAD
rs772852184 CA9576295	246	Q>H		No	ClinGen ExAC gnomAD
CA406857329 rs1400495409	247	G>D		No	ClinGen TOPMed gnomAD
rs771380652 CA309511479	248	D>N		No	ClinGen Ensembl
rs1168003686 CA406857398	250	G>S		No	ClinGen TOPMed gnomAD
CA406857443 rs770480388	251	P>H		No	ClinGen ExAC TOPMed gnomAD
rs770480388 CA406857450	251	P>L		No	ClinGen ExAC TOPMed gnomAD
rs770480388 CA9576297	251	P>R		No	ClinGen ExAC TOPMed gnomAD
rs1192351481 CA406857471	252	N>S		No	ClinGen TOPMed
CA9576300 rs767515922	259	A>S		No	ClinGen ExAC gnomAD
rs767515922 CA9576301	259	A>T		No	ClinGen ExAC gnomAD
CA406857663 rs1331792548	259	A>V		No	ClinGen gnomAD
CA9576303 rs763978019 COSM1252307	260	S>L	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs758671395 CA9576305	261	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	261	S>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754962611 CA9576308	264	T>A		No	ClinGen ExAC gnomAD
rs748534641 CA9576310	266	K>E		No	ClinGen ExAC gnomAD
CA406857979 rs1230139775	267	S>T		No	ClinGen TOPMed
rs756533874 CA9576311	268	G>S		No	ClinGen ExAC gnomAD
rs573657624 CA309511606	269	D>N		No	ClinGen 1000Genomes gnomAD
CA9576314 rs770605164	271	H>Q		No	ClinGen ExAC gnomAD
rs1418061908 CA406858235	272	H>L		No	ClinGen gnomAD
CA406858277 rs1368383274	273	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA9576316 rs745400633	274	C>R		No	ClinGen ExAC TOPMed gnomAD
CA309511617 rs1004298228	276	I>V		No	ClinGen Ensembl
CA9576318 rs181621260	280	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs777748221 CA9576319	280	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA406858679 rs995470892	283	A>P		No	ClinGen gnomAD
rs995470892 CA309511684	283	A>T		No	ClinGen gnomAD
rs558897527 CA9576321	283	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9576324 rs751671400	284	Q>E		No	ClinGen ExAC gnomAD
rs1172109872 CA406858760	285	P>L		No	ClinGen TOPMed
rs767485909 CA406858743	285	P>S		No	ClinGen ExAC TOPMed gnomAD
CA9576326 rs767485909	285	P>T		No	ClinGen ExAC TOPMed gnomAD
rs753301457 CA9576327	286	L>F		No	ClinGen ExAC TOPMed gnomAD
rs1167172470 CA406858795	287	R>G		No	ClinGen gnomAD
rs11882842 CA309511736	287	R>K		No	ClinGen Ensembl
rs1601199820 CA406858846	288	V>G		No	ClinGen Ensembl
CA406858852 rs1350692360	289	E>K		No	ClinGen gnomAD
rs770697747 CA9576378	294	A>G		No	ClinGen ExAC gnomAD
rs1365785355 CA406859309	294	A>T		No	ClinGen TOPMed
CA9576379 rs775759872	295	K>M		No	ClinGen ExAC gnomAD
CA406859416 rs1467238023	297	S>C		No	ClinGen gnomAD
rs111846329 CA9576381	297	S>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9576380 rs111846329	297	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406859433 CA9576382 rs34522905	298	V>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9576383 rs34522905	298	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	300	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs141001122 CA9576386	300	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs766845001 CA9576387	301	V>A		No	ClinGen ExAC gnomAD
CA406859521 rs766845001	301	V>G		No	ClinGen ExAC gnomAD
rs552700082 CA309512529	304	V>I		No	ClinGen 1000Genomes
CA406859601 rs752280594	305	I>F		No	ClinGen ExAC gnomAD
rs752280594 CA9576391	305	I>V		No	ClinGen ExAC gnomAD
CA406859628 rs1459473819	306	G>D		No	ClinGen TOPMed gnomAD
COSM3692960 rs144900355 CA9576393	306	G>S	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs199588435 CA9576394	307	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA309512575 rs961720168	309	L>P		No	ClinGen TOPMed gnomAD
rs145875747 CA309512576	310	L>F		No	ClinGen ESP TOPMed gnomAD
rs973257707 CA309512578	310	L>P		No	ClinGen Ensembl
CA9576396 rs778656931	311	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs200666118 CA406859748	313	A>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200666118 COSM999317 CA9576398	313	A>V	Variant assessed as Somatic; 4.644e-05 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
rs1601200876 CA406859770	315	V>G		No	ClinGen Ensembl
rs748189145 CA9576400	315	V>I		No	ClinGen ExAC gnomAD
CA406859807 rs1259852571	317	G>*		No	ClinGen gnomAD
TCGA novel	317	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9576402 rs773658267	317	G>V		No	ClinGen ExAC TOPMed gnomAD
CA9576403 rs763500395	318	A>T		No	ClinGen ExAC gnomAD
CA406859861 rs1248119064	319	L>M		No	ClinGen TOPMed gnomAD
CA406859922 rs1187807513	321	W>C		No	ClinGen gnomAD
rs773899345	325	R>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1424918091 CA406860129	327	G>R		No	ClinGen gnomAD
rs142797093 CA9576408	329	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA406860474 rs766183044	331	P>A		No	ClinGen ExAC gnomAD
CA406860487 rs1485223386	331	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs766183044 CA9576442	331	P>S		No	ClinGen ExAC gnomAD
rs1246889776 CA406860500	332	W>*		No	ClinGen TOPMed
rs1036044883 CA309513105	333	I>M		No	ClinGen Ensembl
rs752908319 CA9576443	336	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs756324491 CA9576444	336	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs756324491 CA9576445	336	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1393639273 CA406860709	339	D>A		No	ClinGen gnomAD
rs757342904 CA9576447	339	D>N		No	ClinGen ExAC gnomAD
CA9576448 rs779632491	340	T>I		No	ClinGen ExAC gnomAD
rs779632491 CA9576449	340	T>S		No	ClinGen ExAC gnomAD
CA9576452 rs747296238	341	G>E		No	ClinGen ExAC gnomAD
CA9576451 rs775893397 CA406860760	341	G>R		No	ClinGen ExAC TOPMed gnomAD
rs776091911 CA9576454	342	V>A		No	ClinGen ExAC TOPMed gnomAD
CA9576456 rs146734541	343	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
CA9576455 rs146734541	343	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs894180076 CA309513152	345	P>H		No	ClinGen TOPMed gnomAD
CA309513157 rs894180076	345	P>L		No	ClinGen TOPMed gnomAD
CA406860913 rs1385756672	347	P>A		No	ClinGen TOPMed
TCGA novel	347	P>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs535861974 CA9576459	349	E>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs535861974 CA309513179	349	E>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs868581036 CA309513185	351	Q>*		No	ClinGen Ensembl
CA9576460 rs751398296	352	D>A		No	ClinGen ExAC gnomAD
rs1356505064 CA406862257	355	L>V		No	ClinGen gnomAD
rs754677554 CA9576461	356	K>E		No	ClinGen ExAC gnomAD
CA406862314 rs1251686144	356	K>R		No	ClinGen gnomAD
rs1459324123 CA406862336	357	D>N		No	ClinGen gnomAD
rs762437562 CA9576462	358	V>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	359	N>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757473780 CA9576465	360	V>A		No	ClinGen ExAC gnomAD
rs200786838 CA9576464	360	V>M		No	ClinGen ExAC TOPMed gnomAD
rs779118203 CA9576466	361	I>N		No	ClinGen ExAC gnomAD
rs779118203 CA9576467	361	I>T		No	ClinGen ExAC gnomAD
CA9576468 rs758976222	362	P>S		No	ClinGen ExAC TOPMed gnomAD
rs201395293 CA9576469	363	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA309513207 rs74973216	364	T>P		No	ClinGen Ensembl
CA9576471 COSM1681214 rs768835093	365	A>T	haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA406862652 rs1372406389	366	A>W		No	ClinGen gnomAD

No associated diseases with P55899

4 regional properties for P55899

Type	Name	Position	InterPro Accession
conserved_site	Immunoglobulin/major histocompatibility complex, conserved site	273 - 279	IPR003006
domain	Immunoglobulin C1-set	216 - 285	IPR003597
domain	Immunoglobulin-like domain	202 - 289	IPR007110
domain	MHC class I-like antigen recognition-like	28 - 197	IPR011161

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Single-pass type I membrane protein Endosome membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
endosome membrane	The lipid bilayer surrounding an endosome.
external side of plasma membrane	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name	Definition
beta-2-microglobulin binding	Binding to beta-2-microglobulin.
IgG binding	Binding to an immunoglobulin of an IgG isotype.

1 GO annotations of biological process

Name	Definition
IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor	The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P15813	CD1D	Antigen-presenting glycoprotein CD1d	Homo sapiens (Human)	PR
P29017	CD1C	T-cell surface glycoprotein CD1c	Homo sapiens (Human)	PR
Q9BZM4	ULBP3	UL16-binding protein 3	Homo sapiens (Human)	PR
Q61559	Fcgrt	IgG receptor FcRn large subunit p51	Mus musculus (Mouse)	PR
P13599	Fcgrt	IgG receptor FcRn large subunit p51	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MGVPRPQPWA	LGLLLFLLPG	SLGAESHLSL	LYHLTAVSSP	APGTPAFWVS	GWLGPQQYLS
70	80	90	100	110	120
YNSLRGEAEP	CGAWVWENQV	SWYWEKETTD	LRIKEKLFLE	AFKALGGKGP	YTLQGLLGCE
130	140	150	160	170	180
LGPDNTSVPT	AKFALNGEEF	MNFDLKQGTW	GGDWPEALAI	SQRWQQQDKA	ANKELTFLLF
190	200	210	220	230	240
SCPHRLREHL	ERGRGNLEWK	EPPSMRLKAR	PSSPGFSVLT	CSAFSFYPPE	LQLRFLRNGL
250	260	270	280	290	300
AAGTGQGDFG	PNSDGSFHAS	SSLTVKSGDE	HHYCCIVQHA	GLAQPLRVEL	ESPAKSSVLV
310	320	330	340	350	360
VGIVIGVLLL	TAAAVGGALL	WRRMRSGLPA	PWISLRGDDT	GVLLPTPGEA	QDADLKDVNV

IPATA