P55854
SS
Gene name |
SUMO3 (SMT3A, SMT3H1) |
Protein name |
Small ubiquitin-related modifier 3 |
Names |
SUMO-3 , SMT3 homolog 1 , SUMO-2 , Ubiquitin-like protein SMT3A , Smt3A |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:6612 |
EC number |
|
Protein Class |
|
Descriptions
The N-terminal region of SUMO1 functions as an autoinhibition domain by blocking its binding to the phosphorylated SIMs of PML and Daxx. This autoinhibition is relieved by zinc, which stabilizes the complex between SUMO1 and a phospho-mimetic form of the SIM of PML, suggesting a paralog specific function of SUMO1 in regulating SUMO1-SIM interactions required for PML-NB formation and function.
Autoinhibitory domains (AIDs)
Target domain |
15-92 (Ubiquitin-like domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
66 variants for P55854
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs1487230296 | 2 | S>Y | No | gnomAD | |
| rs1208231096 | 4 | E>* | No |
TOPMed gnomAD |
|
| rs1208231096 | 4 | E>K | No |
TOPMed gnomAD |
|
| rs1031147238 | 5 | K>T | No | TOPMed | |
| rs1286372218 | 6 | P>S | No | gnomAD | |
| rs1339835599 | 9 | G>S | No |
TOPMed gnomAD |
|
| rs1296527851 | 9 | G>V | No | gnomAD | |
| rs774531863 | 12 | T>A | No |
TOPMed gnomAD |
|
| rs762992147 | 12 | T>I | No |
ExAC TOPMed gnomAD |
|
| rs770045480 | 16 | H>N | No |
ExAC gnomAD |
|
| rs2083229576 | 17 | I>F | No | Ensembl | |
| rs1434560759 | 17 | I>M | No |
TOPMed gnomAD |
|
| rs1350148484 | 22 | A>V | No | gnomAD | |
| rs1427365426 | 24 | Q>R | No | gnomAD | |
| rs566847807 | 26 | G>S | No |
1000Genomes TOPMed gnomAD |
|
| rs1601217294 | 28 | V>M | No | Ensembl | |
| rs1488216430 | 35 | R>K | No | gnomAD | |
| rs1370248529 | 36 | H>Y | No | TOPMed | |
| rs778485624 | 37 | T>A | No |
ExAC gnomAD |
|
|
COSM4102014 COSM4102013 rs1482161206 |
37 | T>M | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA Cosmic NCI-TCGA gnomAD |
| rs778485624 | 37 | T>P | No |
ExAC gnomAD |
|
|
rs750770742 COSM1228009 |
38 | P>L | Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] | No |
NCI-TCGA Cosmic cosmic curated ExAC NCI-TCGA gnomAD |
| rs750770742 | 38 | P>Q | No |
ExAC gnomAD |
|
|
rs1051311 VAR_052692 |
38 | P>S | No |
UniProt dbSNP |
|
| rs1284579051 | 43 | M>I | No |
TOPMed gnomAD |
|
| rs752104087 | 43 | M>L | No |
ExAC gnomAD |
|
| rs373252768 | 47 | C>* | No |
ESP ExAC TOPMed gnomAD |
|
| rs780223287 | 55 | R>K | No |
ExAC gnomAD |
|
| rs2083195379 | 60 | R>M | No | Ensembl | |
| rs148679100 | 61 | F>L | No |
ESP ExAC TOPMed gnomAD |
|
| rs1430979239 | 62 | D>N | No | gnomAD | |
| rs1196466794 | 63 | G>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No |
NCI-TCGA gnomAD |
| rs1357768591 | 64 | Q>* | No |
TOPMed gnomAD |
|
| rs922287509 | 66 | I>S | No | Ensembl | |
| rs761729322 | 66 | I>V | No |
ExAC TOPMed gnomAD |
|
| rs751308919 | 67 | N>D | No |
ExAC gnomAD |
|
| rs972414276 | 69 | T>I | No | gnomAD | |
| rs972414276 | 69 | T>S | No | gnomAD | |
| rs1342135623 | 70 | D>G | No | gnomAD | |
| rs1203436216 | 70 | D>N | No | gnomAD | |
| rs939967587 | 71 | T>A | No | Ensembl | |
| rs2083195054 | 71 | T>N | No | TOPMed | |
| rs764098178 | 74 | Q>H | No |
ExAC gnomAD |
|
| rs1323654763 | 75 | L>P | No | gnomAD | |
| rs1226263799 | 76 | E>G | No | gnomAD | |
| rs1022901054 | 77 | M>I | No | Ensembl | |
| rs775935007 | 79 | D>E | No |
ExAC gnomAD |
|
| rs1224653134 | 80 | E>D | No | gnomAD | |
| rs770438614 | 80 | E>K | No |
ExAC gnomAD |
|
| rs1296335710 | 82 | T>A | No |
TOPMed gnomAD |
|
| rs751362750 | 83 | I>M | No |
ExAC TOPMed gnomAD |
|
| rs896059407 | 86 | F>S | No | Ensembl | |
| rs2083181476 | 90 | T>M | No | TOPMed | |
| TCGA novel | 91 | G>* | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| TCGA novel | 91 | G>R | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1451977950 | 93 | V>M | No |
TOPMed gnomAD |
|
|
RCV000972349 rs112870818 |
94 | P>L | No |
ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
| rs777914527 | 96 | S>G | No |
ExAC gnomAD |
|
| rs1383102257 | 96 | S>N | No |
TOPMed gnomAD |
|
|
COSM4102011 COSM4102012 |
98 | L>P | Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] | No | NCI-TCGA Cosmic |
| rs920114946 | 98 | L>Q | No |
TOPMed gnomAD |
|
| rs1191024116 | 100 | G>E | No | TOPMed | |
| rs780717596 | 101 | H>Q | Variant assessed as Somatic; HIGH impact. [NCI-TCGA] | No | NCI-TCGA |
| rs1461661809 | 101 | H>R | No | gnomAD | |
| rs2083181197 | 102 | S>G | No | Ensembl | |
| rs1601209647 | 103 | F>L | No | Ensembl |
No associated diseases with P55854
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| PML body | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein tag activity | A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. |
| ubiquitin-like protein ligase binding | Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of DNA binding | Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). |
| protein sumoylation | The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. |
| regulation of protein localization to nucleus | Any process that modulates the frequency, rate or extent of protein localization to nucleus. |
28 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q17QV3 | SUMO3 | Small ubiquitin-related modifier 3 | Bos taurus (Bovine) | SS |
| Q5E9D1 | SUMO1 | Small ubiquitin-related modifier 1 | Bos taurus (Bovine) | SS |
| Q5ZHQ1 | SUMO3 | Small ubiquitin-related modifier 3 | Gallus gallus (Chicken) | SS |
| Q5ZJM9 | SUMO2 | Small ubiquitin-related modifier 2 | Gallus gallus (Chicken) | SS |
| Q8QGH2 | SUMO1 | Small ubiquitin-related modifier 1 | Gallus gallus (Chicken) | SS |
| P61956 | SUMO2 | Small ubiquitin-related modifier 2 | Homo sapiens (Human) | SS |
| Q6EEV6 | SUMO4 | Small ubiquitin-related modifier 4 | Homo sapiens (Human) | SS |
| P63165 | SUMO1 | Small ubiquitin-related modifier 1 | Homo sapiens (Human) | EV |
| G2XKQ0 | SUMO1P1 | Small ubiquitin-related modifier 5 | Homo sapiens (Human) | SS |
| Q9Z172 | Sumo3 | Small ubiquitin-related modifier 3 | Mus musculus (Mouse) | SS |
| P61957 | Sumo2 | Small ubiquitin-related modifier 2 | Mus musculus (Mouse) | SS |
| P63166 | Sumo1 | Small ubiquitin-related modifier 1 | Mus musculus (Mouse) | SS |
| P61958 | SUMO2 | Small ubiquitin-related modifier 2 | Sus scrofa (Pig) | SS |
| Q5XIF4 | Sumo3 | Small ubiquitin-related modifier 3 | Rattus norvegicus (Rat) | SS |
| Q5I0H3 | Sumo1 | Small ubiquitin-related modifier 1 | Rattus norvegicus (Rat) | SS |
| P55857 | SUMO1 | Small ubiquitin-related modifier 1 | Oryza sativa subsp. japonica (Rice) | SS |
| P55853 | smo-1 | Small ubiquitin-related modifier | Caenorhabditis elegans | SS |
| P55852 | SUMO1 | Small ubiquitin-related modifier 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FKC5 | SUMO4 | Putative small ubiquitin-related modifier 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FLP5 | SUMO3 | Small ubiquitin-related modifier 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8VZI7 | SUMO5 | Small ubiquitin-related modifier 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| B3H5R8 | SUMO8 | Putative small ubiquitin-related modifier 8 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8A8 | SUMO7 | Putative small ubiquitin-related modifier 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FLP6 | SUMO2 | Small ubiquitin-related modifier 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q28H04 | sumo2 | Small ubiquitin-related modifier 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q6DI05 | sumo3 | Small ubiquitin-related modifier 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6NV25 | sumo3l | Small ubiquitin-related modifier 3-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SZR5 | sumo1 | Small ubiquitin-related modifier 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSEEKPKEGV | KTENDHINLK | VAGQDGSVVQ | FKIKRHTPLS | KLMKAYCERQ | GLSMRQIRFR |
| 70 | 80 | 90 | 100 | ||
| FDGQPINETD | TPAQLEMEDE | DTIDVFQQQT | GGVPESSLAG | HSF |