P55853
SS
Gene name |
smo-1 (smt3, sumo, K12C11.2) |
Protein name |
Small ubiquitin-related modifier |
Names |
SUMO , Ubiquitin-like protein SMT3 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_K12C11.2 |
EC number |
|
Protein Class |
|
Descriptions
The N-terminal region of SUMO1 functions as an autoinhibition domain by blocking its binding to the phosphorylated SIMs of PML and Daxx. This autoinhibition is relieved by zinc, which stabilizes the complex between SUMO1 and a phospho-mimetic form of the SIM of PML, suggesting a paralog specific function of SUMO1 in regulating SUMO1-SIM interactions required for PML-NB formation and function.
Autoinhibitory domains (AIDs)
Target domain |
13-90 (Ubiquitin-like domain) |
Relief mechanism |
Ligand binding |
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
2 structures for P55853
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 5XQM | NMR | - | A | 1-90 | PDB |
| AF-P55853-F1 | Predicted | AlphaFoldDB |
No variants for P55853
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P55853 | |||||
No associated diseases with P55853
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| PML body | A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection. |
| septin ring | A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| protein tag activity | A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. |
| ubiquitin-like protein ligase binding | Binding to a ubiquitin-like protein ligase, such as ubiquitin-ligase. |
14 GO annotations of biological process
| Name | Definition |
|---|---|
| embryo development ending in birth or egg hatching | The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. |
| mitotic metaphase chromosome alignment | The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis. |
| mitotic sister chromatid separation | The process in which sister chromatids are physically detached from each other during mitosis. |
| multicellular organismal locomotion | Locomotion in a multicellular organism, i.e. self-propelled movement of a multicellular organism from one location to another. |
| muscle cell cellular homeostasis | The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state. |
| negative regulation of DNA-templated transcription | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| nematode larval development | The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew. |
| positive regulation of nematode male tail tip morphogenesis | Any process that activates or increases the frequency, rate or extent of nematode male tail tip morphogenesis. |
| protein localization to chromosome | Any process in which a protein is transported to, or maintained at, a specific location on a chromosome. |
| protein sumoylation | The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein. |
| regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
| regulation of protein stability | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. |
| synaptonemal complex disassembly | The controlled breakdown of a synaptonemal complex. |
34 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12306 | SMT3 | Ubiquitin-like protein SMT3 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | SS |
| Q17QV3 | SUMO3 | Small ubiquitin-related modifier 3 | Bos taurus (Bovine) | SS |
| Q5E9D1 | SUMO1 | Small ubiquitin-related modifier 1 | Bos taurus (Bovine) | SS |
| Q5ZJM9 | SUMO2 | Small ubiquitin-related modifier 2 | Gallus gallus (Chicken) | SS |
| Q5ZHQ1 | SUMO3 | Small ubiquitin-related modifier 3 | Gallus gallus (Chicken) | SS |
| Q8QGH2 | SUMO1 | Small ubiquitin-related modifier 1 | Gallus gallus (Chicken) | SS |
| Q9VCP1 | CG4449 | Uncharacterized protein CG4449 | Drosophila melanogaster (Fruit fly) | PR |
| Q6EEV6 | SUMO4 | Small ubiquitin-related modifier 4 | Homo sapiens (Human) | SS |
| P61956 | SUMO2 | Small ubiquitin-related modifier 2 | Homo sapiens (Human) | SS |
| P63165 | SUMO1 | Small ubiquitin-related modifier 1 | Homo sapiens (Human) | EV |
| P55854 | SUMO3 | Small ubiquitin-related modifier 3 | Homo sapiens (Human) | SS |
| G2XKQ0 | SUMO1P1 | Small ubiquitin-related modifier 5 | Homo sapiens (Human) | SS |
| Q9Z172 | Sumo3 | Small ubiquitin-related modifier 3 | Mus musculus (Mouse) | SS |
| P61957 | Sumo2 | Small ubiquitin-related modifier 2 | Mus musculus (Mouse) | SS |
| P63166 | Sumo1 | Small ubiquitin-related modifier 1 | Mus musculus (Mouse) | SS |
| P61958 | SUMO2 | Small ubiquitin-related modifier 2 | Sus scrofa (Pig) | SS |
| A7WLH8 | SUMO1 | Small ubiquitin-related modifier 1 | Sus scrofa (Pig) | SS |
| Q5XIF4 | Sumo3 | Small ubiquitin-related modifier 3 | Rattus norvegicus (Rat) | SS |
| P61959 | Sumo2 | Small ubiquitin-related modifier 2 | Rattus norvegicus (Rat) | SS |
| Q5I0H3 | Sumo1 | Small ubiquitin-related modifier 1 | Rattus norvegicus (Rat) | SS |
| P55857 | SUMO1 | Small ubiquitin-related modifier 1 | Oryza sativa subsp. japonica (Rice) | SS |
| B3H5R8 | SUMO8 | Putative small ubiquitin-related modifier 8 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| P55852 | SUMO1 | Small ubiquitin-related modifier 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8VZI7 | SUMO5 | Small ubiquitin-related modifier 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FKC5 | SUMO4 | Putative small ubiquitin-related modifier 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FLP5 | SUMO3 | Small ubiquitin-related modifier 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q3E8A8 | SUMO7 | Putative small ubiquitin-related modifier 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9FLP6 | SUMO2 | Small ubiquitin-related modifier 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q28H04 | sumo2 | Small ubiquitin-related modifier 2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q6DEP7 | sumo1 | Small ubiquitin-related modifier 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| Q6NV25 | sumo3l | Small ubiquitin-related modifier 3-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6DI05 | sumo3 | Small ubiquitin-related modifier 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6DHL4 | sumo2 | Small ubiquitin-related modifier 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q7SZR5 | sumo1 | Small ubiquitin-related modifier 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADDAAQAGD | NAEYIKIKVV | GQDSNEVHFR | VKYGTSMAKL | KKSYADRTGV | AVNSLRFLFD |
| 70 | 80 | 90 | |||
| GRRINDDDTP | KTLEMEDDDV | IEVYQEQLGG | F |