AiPD: Autoinhibited Protein Database

P55209

Gene name	NAP1L1 (NRP)
Protein name	Nucleosome assembly protein 1-like 1
Names	NAP-1-related protein, hNRP
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4673
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-68 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-68 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

4 structures for P55209

Entry ID	Method	Resolution	Chain	Position	Source
7BP5	X-ray	190 A	C	371-377	PDB
7UN3	EM	350 A	B/C	2-391	PDB
7UN6	EM	330 A	B/C	2-391	PDB
AF-P55209-F1	Predicted				AlphaFoldDB

230 variants for P55209

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1171644482 CA385800936	3	D>G		No	ClinGen gnomAD
rs1476464004 CA385800930	4	I>V		No	ClinGen gnomAD
rs1225132273 CA385800919	5	D>E		No	ClinGen TOPMed
CA6694031 rs781266736	5	D>N		No	ClinGen ExAC gnomAD
CA6694030 rs754821092	6	N>I		No	ClinGen ExAC gnomAD
rs1415843347 CA385800655	7	K>R		No	ClinGen gnomAD
rs371131424 CA6694012	9	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs371131424 CA6694011	9	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA385800591 rs1317846793	13	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs138832974 CA6694010	14	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA385800566 rs1382604262	15	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1051360355 CA239297915	17	D>G		No	ClinGen TOPMed
CA385800542 rs1235021865	17	D>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA385800544 rs1235021865	17	D>N		No	ClinGen TOPMed
CA385800540 rs1235021865	17	D>Y		No	ClinGen TOPMed
CA385800531 rs1565738536	18	D>N		No	ClinGen Ensembl
CA385800513 rs1176327761	19	V>I		No	ClinGen TOPMed
CA385800499 rs1280537442	20	E>G		No	ClinGen gnomAD
CA385800479 rs1444753619	22	V>L		No	ClinGen gnomAD
CA6694009 rs751339694	23	E>D		No	ClinGen ExAC gnomAD
rs201382128 CA239297901	25	E>G		No	ClinGen 1000Genomes
rs922184331	26	E>missing	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs758104500 CA6694007	27	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1474682550 CA385800421	28	G>A		No	ClinGen TOPMed gnomAD
rs754147495 CA6694006	30	E>Q		No	ClinGen ExAC gnomAD
rs141418050 CA239297889 COSM108409	31	T>K	skin [Cosmic]	No	ClinGen cosmic curated gnomAD
rs141418050 CA385800401	31	T>R		No	ClinGen gnomAD
rs764296493 CA6694005	32	K>E		No	ClinGen ExAC gnomAD
rs760749588 CA6694004	32	K>N		No	ClinGen ExAC gnomAD
rs1468378955 CA385800393	33	L>I		No	ClinGen gnomAD
CA385800379 rs1266051118	35	A>T		No	ClinGen gnomAD
rs1249867501 CA385800359	36	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA385800358 rs1290646596 COSM3417148	36	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA385800351 rs1480323361	37	Q>R		No	ClinGen TOPMed
CA6693972 rs752170912	40	V>A		No	ClinGen ExAC TOPMed gnomAD
rs373519196 CA385800325	41	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1470821285 CA385800301	44	Q>R		No	ClinGen gnomAD
TCGA novel	45	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385800293 rs1175261602	45	N>S		No	ClinGen TOPMed gnomAD
CA385800257 rs1428656822	50	A>V		No	ClinGen gnomAD
rs1421043986 CA385800250	52	L>V		No	ClinGen gnomAD
TCGA novel	53	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385800240 rs1184192683	53	Q>R		No	ClinGen gnomAD
TCGA novel	56	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6693968 rs765010364	58	G>D		No	ClinGen ExAC gnomAD
CA6693966 rs776398744	59	L>P		No	ClinGen ExAC TOPMed gnomAD
CA239296988 rs776398744	59	L>Q		No	ClinGen ExAC TOPMed gnomAD
rs1308229556 CA385800172	64	T>A		No	ClinGen gnomAD
rs746496742 CA6693964	65	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs775502634 CA6693963	66	Y>D		No	ClinGen ExAC gnomAD
rs1392772370 CA385800152	67	I>T		No	ClinGen TOPMed
CA239296969 rs369213223	67	I>V		No	ClinGen ESP
rs533316083 CA6693935	72	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA6693934 rs757764434	72	R>K		No	ClinGen ExAC gnomAD
CA6693933 rs757764434	72	R>T		No	ClinGen ExAC gnomAD
rs760213536 CA6693930	73	V>I		No	ClinGen ExAC TOPMed gnomAD
CA6693931 rs760213536	73	V>L		No	ClinGen ExAC TOPMed gnomAD
rs901789996 CA239293071	74	V>F		No	ClinGen TOPMed
rs1329988229 CA385799706	82	K>R		No	ClinGen gnomAD
CA385799696 rs1318343714	83	N>K		No	ClinGen gnomAD
rs61345007 CA239293067	84	L>V		No	ClinGen Ensembl
CA385799642 rs1272725622	88	C>Y		No	ClinGen TOPMed
CA6693928 rs766956337	92	E>G		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	93	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1457026995 CA385799556	94	K>T		No	ClinGen gnomAD
CA385799525 rs11541044	96	Y>C		No	ClinGen TOPMed
CA239293060 rs11541044	96	Y>S		No	ClinGen TOPMed
rs151041773 CA6693927	98	E>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs1489731631 CA385799488	99	V>I		No	ClinGen TOPMed
CA6693925 rs770846357	101	D>Y		No	ClinGen ExAC gnomAD
CA385799403 rs1478747276	105	K>Q		No	ClinGen TOPMed
rs1259547504 CA385799383	106	Y>C		No	ClinGen gnomAD
CA385799339 rs1207919622	110	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	111	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385799326 rs1461598536	111	Q>R		No	ClinGen gnomAD
TCGA novel	113	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs903682058 CA239292854	123	A>V		No	ClinGen TOPMed
CA6693903 rs375997066	124	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1283319708 CA385799096	128	T>A		No	ClinGen gnomAD
rs3208349 CA385799081	129	E>D		No	ClinGen TOPMed
CA6693902 rs762912465	129	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	131	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1233154670 CA605833320	132	C>*		No	ClinGen gnomAD
rs1183525394 CA385798998	136	P>T		No	ClinGen gnomAD
rs1435661407 CA385798984	137	D>G		No	ClinGen gnomAD
rs1237452360 CA385798989	137	D>H		No	ClinGen TOPMed gnomAD
CA239292835 rs963413074	139	E>G		No	ClinGen Ensembl
CA6693899 rs761604507	139	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1222536736 CA385798952	140	D>G		No	ClinGen gnomAD
rs775642438 CA6693898	142	I>S		No	ClinGen ExAC gnomAD
CA385798929 rs1309279978	142	I>V		No	ClinGen TOPMed gnomAD
rs953811464 CA239290816	146	L>M		No	ClinGen Ensembl
rs1367102866 CA385798269	147	K>E		No	ClinGen gnomAD
rs1164459256 CA385798233	151	K>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs746028914 CA385798229	152	I>N		No	ClinGen ExAC TOPMed gnomAD
CA6693854 rs746028914	152	I>T		No	ClinGen ExAC TOPMed gnomAD
CA385798214 rs1414426439	154	D>G		No	ClinGen gnomAD
CA385798191 rs1180167484	156	K>I		No	ClinGen TOPMed gnomAD
CA6693853 CA385798174 rs1059143	157	K>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs770239693 CA6693850 CA6693849	158	D>E		No	ClinGen ExAC gnomAD
TCGA novel	158	D>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs545018387 CA6693851	158	D>N		No	ClinGen 1000Genomes ExAC gnomAD
rs1211567960 CA385798166	158	D>V		No	ClinGen gnomAD
CA385798143 rs1264657913	160	E>A		No	ClinGen gnomAD
CA385798111 rs762407693	163	D>H		No	ClinGen ExAC gnomAD
rs762407693 CA6693848	163	D>N		No	ClinGen ExAC gnomAD
CA239290763 rs921955083	165	K>R		No	ClinGen TOPMed gnomAD
rs1320306329 CA385798031	169	E>D		No	ClinGen TOPMed
CA6693847 rs548972699	173	T>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	175	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs747372763 CA6693845	175	F>L		No	ClinGen ExAC gnomAD
CA6693844 rs779740648	176	K>N		No	ClinGen ExAC gnomAD
CA6693843 rs771736072	177	N>S		No	ClinGen ExAC gnomAD
CA6693842 rs745410509	179	D>E		No	ClinGen ExAC gnomAD
TCGA novel	180	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	181	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778516837 CA6693841	182	S>G		No	ClinGen ExAC gnomAD
CA6693840 rs756672048	184	M>T		No	ClinGen ExAC gnomAD
rs1157210938 CA385797838	186	Q>H		No	ClinGen gnomAD
CA6693818 rs756095253	187	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1404632983 CA385797727	189	D>G		No	ClinGen TOPMed gnomAD
rs147850219 CA239290287	191	P>L		No	ClinGen ESP TOPMed
CA385797585 rs754675420	195	H>Q		No	ClinGen ExAC TOPMed gnomAD
CA239290275 rs760252000	195	H>R		No	ClinGen Ensembl
rs1295900723 CA385797521	199	I>T		No	ClinGen gnomAD
CA385797492 rs1434780188	201	V>L		No	ClinGen gnomAD
rs765375395 CA6693813	205	D>H		No	ClinGen ExAC gnomAD
CA6693812 rs757389249	205	D>V		No	ClinGen ExAC TOPMed gnomAD
CA385797367 rs1169249380	206	A>V		No	ClinGen gnomAD
TCGA novel	208	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6693811 rs753894554	209	P>R		No	ClinGen ExAC gnomAD
rs543207974 CA6693809	210	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1183772220 CA385796496	214	L>F		No	ClinGen gnomAD
TCGA novel	215	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs754020203 CA6693793	217	H>R		No	ClinGen ExAC gnomAD
CA385796462 rs1257921760	219	E>Q		No	ClinGen TOPMed gnomAD
CA385796451 rs1193263971	220	P>H		No	ClinGen TOPMed
rs749935267 CA6693791	221	N>D		No	ClinGen ExAC gnomAD
CA239289693 rs749935267	221	N>H		No	ClinGen ExAC gnomAD
rs564692682 CA6693790	221	N>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	225	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6693789 rs767903442	227	E>K		No	ClinGen ExAC gnomAD
CA385796397 rs1230381161	228	V>A		No	ClinGen gnomAD
CA239289669 rs944132783	228	V>M		No	ClinGen Ensembl
CA239289664 rs912712188	230	T>S		No	ClinGen Ensembl
TCGA novel	231	K>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385796345 rs1480056476	236	R>G		No	ClinGen gnomAD
rs1321383420 CA385796300	242	S>Y		No	ClinGen gnomAD
TCGA novel	246	S>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385796232 rs1300565985	252	I>V		No	ClinGen TOPMed
rs1471373982 CA385796210	255	C>R		No	ClinGen gnomAD
rs772947683 CA6693784	255	C>Y		No	ClinGen ExAC gnomAD
rs769436819 CA6693783 COSM1606643	256	T>A	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA6693751 rs748296565	258	C>F		No	ClinGen ExAC TOPMed gnomAD
rs1174687563 CA385796179	258	C>G		No	ClinGen gnomAD
CA385796165 rs1322722967	260	I>V		No	ClinGen TOPMed
CA385796155 rs1448028635	261	D>G		No	ClinGen gnomAD
CA6693750 rs781158577	264	K>E		No	ClinGen ExAC gnomAD
rs755033455 CA6693749	268	V>I		No	ClinGen ExAC TOPMed gnomAD
CA385796098 rs1220741912	269	T>S		No	ClinGen TOPMed
CA6693748 rs780704549	270	L>F		No	ClinGen ExAC gnomAD
TCGA novel	272	T>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs991746233 CA239289414	274	K>E		No	ClinGen TOPMed
rs991746233 CA385796067	274	K>Q		No	ClinGen TOPMed
CA6693746 rs758892896	274	K>R		No	ClinGen ExAC TOPMed gnomAD
CA385796053 rs1483369924 COSM75555	276	K>Q	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1245551239 COSM1364251 CA385796049	276	K>R	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs750799874 CA6693744	282	R>C		No	ClinGen ExAC gnomAD
CA239289402 rs866387925	282	R>H		No	ClinGen TOPMed
CA385795998 rs1341204537	283	G>V		No	ClinGen gnomAD
rs761404703 CA6693742	284	T>I		No	ClinGen ExAC gnomAD
CA239289389 rs960661050	286	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA385795976 rs1209754341	287	T>I		No	ClinGen TOPMed
rs763527475 CA6693740	294	N>D		No	ClinGen ExAC gnomAD
CA6693739 rs760165842	294	N>S		No	ClinGen ExAC TOPMed gnomAD
CA385795910 rs1420963303	297	F>L		No	ClinGen TOPMed
TCGA novel	301	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385795863 rs1165883900	304	P>S		No	ClinGen gnomAD
CA385795856 rs1425825717	305	E>A		No	ClinGen gnomAD
rs1265742986 CA385795832	307	P>A		No	ClinGen TOPMed gnomAD
rs1257717246 CA385795811	310	G>R		No	ClinGen TOPMed
CA6693709 rs375560258	313	D>E		No	ClinGen ESP ExAC gnomAD
rs1158338893 CA385795350	313	D>G		No	ClinGen TOPMed
CA6693708 rs772231209	315	D>A		No	ClinGen ExAC gnomAD
TCGA novel	318	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6693707 rs140491195	318	A>T		No	ClinGen ESP ExAC
rs1245807211 CA385795312	319	I>V		No	ClinGen gnomAD
rs779412852 CA6693706	321	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1377513278 CA385795271	325	E>K		No	ClinGen gnomAD
CA6693705 rs757630325	331	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1470910169 CA385795226	331	R>H		No	ClinGen TOPMed
CA6693703 rs777338249	333	R>H		No	ClinGen ExAC TOPMed gnomAD
rs755732251 CA6693702	334	I>V		No	ClinGen ExAC gnomAD
rs539840959 CA6693700	337	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA239288188 rs15703	340	L>*		No	ClinGen Ensembl
rs751453919 CA6693698	341	Y>H		No	ClinGen ExAC gnomAD
rs1169051913 CA385795126	347	I>V		No	ClinGen TOPMed gnomAD
TCGA novel	348	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762708324 CA6693696	348	E>V		No	ClinGen ExAC TOPMed gnomAD
rs995352836 CA239288177	349	D>G		No	ClinGen TOPMed
rs1565714425 CA385795103	350	D>A		No	ClinGen Ensembl
CA6693695 rs144982900	353	D>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA6693669 rs774456411	354	Y>C		No	ClinGen ExAC gnomAD
TCGA novel	354	Y>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6693667 rs763537430	358	G>A		No	ClinGen ExAC
rs770875476 CA6693668	358	G>C		No	ClinGen ExAC gnomAD
rs770875476 CA385795032	358	G>S		No	ClinGen ExAC gnomAD
CA6693666 rs773531244	361	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	366	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs896846690 CA239287534	369	G>R		No	ClinGen TOPMed gnomAD
CA385794737 rs1453299502	370	D>G		No	ClinGen TOPMed
rs755806930 CA6693633	371	E>D		No	ClinGen ExAC gnomAD
TCGA novel	373	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA385794697 rs1188514752	375	P>L		No	ClinGen gnomAD
rs149910881 CA6693632	377	Y>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA6693631 rs766501750	378	D>G		No	ClinGen ExAC gnomAD
rs1444110658 CA385794673	379	P>A		No	ClinGen gnomAD
CA385794665 rs1278096426	380	K>M		No	ClinGen gnomAD
CA385794643 rs1292077637	381	K>R		No	ClinGen TOPMed gnomAD
rs749251203 CA6693614	382	D>N		No	ClinGen ExAC gnomAD
TCGA novel	383	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6693613 rs777782468	384	N>K		No	ClinGen ExAC gnomAD
CA385794616 rs1217574929	385	P>A		No	ClinGen gnomAD
rs1229565362 CA385794614	385	P>Q		No	ClinGen TOPMed
rs747880037 CA6693611	386	A>E		No	ClinGen ExAC gnomAD
rs747880037 CA6693612	386	A>G		No	ClinGen ExAC gnomAD
rs566985660 CA6693610	387	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs758582461 CA6693609	389	K>M		No	ClinGen ExAC gnomAD
rs758582461 CA385794583	389	K>R		No	ClinGen ExAC gnomAD
rs771762505 CA6693608	391	Q>*	Variant assessed as Somatic; 4.621e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD

No associated diseases with P55209

No regional properties for P55209

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P55209

Functions

		Description
EC Number
Subcellular Localization	Nucleus Melanosome Cytoplasm	Identified by mass spectrometry in melanosome fractions from stage I to stage IV
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
chromatin	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
melanosome	A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding	Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
histone chaperone activity	Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone).
RNA binding	Binding to an RNA molecule or a portion thereof.

6 GO annotations of biological process

Name	Definition
DNA replication	The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
nervous system development	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
nucleosome assembly	The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of neural precursor cell proliferation	Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
positive regulation of neurogenesis	Any process that activates or increases the frequency, rate or extent of neurogenesis, the generation of cells within the nervous system.

12 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q99457	NAP1L3	Nucleosome assembly protein 1-like 3	Homo sapiens (Human)	PR
Q01534	TSPY1	Testis-specific Y-encoded protein 1	Homo sapiens (Human)	PR
P0CV99	TSPY4	Testis-specific Y-encoded protein 4	Homo sapiens (Human)	PR
P0CV98	TSPY3	Testis-specific Y-encoded protein 3	Homo sapiens (Human)	PR
P0CW00	TSPY8	Testis-specific Y-encoded protein 8	Homo sapiens (Human)	PR
P0CW01	TSPY10	Testis-specific Y-encoded protein 10	Homo sapiens (Human)	PR
A6NKD2	TSPY2	Testis-specific Y-encoded protein 2	Homo sapiens (Human)	PR
Q8N831	TSPYL6	Testis-specific Y-encoded-like protein 6	Homo sapiens (Human)	PR
Q9H2G4	TSPYL2	Testis-specific Y-encoded-like protein 2	Homo sapiens (Human)	PR
P0DME0	SETSIP	Protein SETSIP	Homo sapiens (Human)	SS
Q01105	SET	Protein SET	Homo sapiens (Human)	SS
Q9H489	TSPY26P	Putative testis-specific Y-encoded-like protein 3	Homo sapiens (Human)	PR

10	20	30	40	50	60
MADIDNKEQS	ELDQDLDDVE	EVEEEETGEE	TKLKARQLTV	QMMQNPQILA	ALQERLDGLV
70	80	90	100	110	120
ETPTGYIESL	PRVVKRRVNA	LKNLQVKCAQ	IEAKFYEEVH	DLERKYAVLY	QPLFDKRFEI
130	140	150	160	170	180
INAIYEPTEE	ECEWKPDEED	EISEELKEKA	KIEDEKKDEE	KEDPKGIPEF	WLTVFKNVDL
190	200	210	220	230	240
LSDMVQEHDE	PILKHLKDIK	VKFSDAGQPM	SFVLEFHFEP	NEYFTNEVLT	KTYRMRSEPD
250	260	270	280	290	300
DSDPFSFDGP	EIMGCTGCQI	DWKKGKNVTL	KTIKKKQKHK	GRGTVRTVTK	TVSNDSFFNF
310	320	330	340	350	360
FAPPEVPESG	DLDDDAEAIL	AADFEIGHFL	RERIIPRSVL	YFTGEAIEDD	DDDYDEEGEE
370	380	390
ADEEGEEEGD	EENDPDYDPK	KDQNPAECKQ	Q