P55144
SS
Gene name |
Tyro3 (Dtk, Rse, Tif) |
Protein name |
Tyrosine-protein kinase receptor TYRO3 |
Names |
EC 2.7.10.1 , Etk2/tyro3 , TK19-2 , Tyrosine-protein kinase DTK , Tyrosine-protein kinase RSE , Tyrosine-protein kinase TIF |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:22174 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Tyrosine-protein kinase receptor TYRO3 (Tyro3) is annotated based on its experimentally validated activation loop, which is expected to act as accessory element in the autoinhibition of Tyro3.
Autoinhibitory domains (AIDs)
Accessory elements
662-687 (Activation loop from InterPro)
Target domain |
508-785 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
4 structures for P55144
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 3QUP | X-ray | 190 A | A | 485-800 | PDB |
| 4FEQ | X-ray | 220 A | A | 485-800 | PDB |
| 4FF8 | X-ray | 240 A | A | 485-800 | PDB |
| AF-P55144-F1 | Predicted | AlphaFoldDB |
38 variants for P55144
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs243468327 | 13 | R>W | No | EVA | |
| rs3540655096 | 28 | S>A | No | EVA | |
| rs3388581073 | 106 | W>G | No | EVA | |
| rs3388575957 | 140 | V>M | No | EVA | |
| rs3388582225 | 160 | T>I | No | EVA | |
| rs3388584488 | 184 | G>E | No | EVA | |
| rs3388569998 | 228 | S>R | No | EVA | |
| rs3388581962 | 248 | C>Y | No | EVA | |
| rs3411268643 | 309 | G>A | No | EVA | |
| rs3388584475 | 328 | L>V | No | EVA | |
| rs3392113787 | 347 | P>H | No | EVA | |
| rs3388578085 | 363 | M>T | No | EVA | |
| rs3388573136 | 385 | C>* | No | EVA | |
| rs3388582201 | 385 | C>Y | No | EVA | |
| rs3413055369 | 395 | W>L | No | EVA | |
| rs3388573178 | 427 | L>F | No | EVA | |
| rs3388581344 | 529 | Q>E | No | EVA | |
| rs3388575201 | 532 | G>A | No | EVA | |
| rs3388582182 | 544 | A>D | No | EVA | |
| rs3392129501 | 550 | S>T | No | EVA | |
| rs864303851 | 570 | V>A | No | EVA | |
| rs3388573202 | 583 | K>E | No | EVA | |
| rs3388581071 | 618 | P>L | No | EVA | |
| rs3388574962 | 626 | M>I | No | EVA | |
| rs3388581060 | 638 | S>P | No | EVA | |
| rs3388583803 | 659 | V>M | No | EVA | |
| rs3388581950 | 679 | G>C | No | EVA | |
| rs3388573197 | 707 | A>T | No | EVA | |
| rs864302433 | 729 | A>P | No | EVA | |
| rs3392103484 | 739 | N>T | No | EVA | |
| rs3392138473 | 739 | N>Y | No | EVA | |
| rs3392088413 | 741 | L>R | No | EVA | |
| rs3388581968 | 748 | M>V | No | EVA | |
| rs3388574930 | 804 | T>S | No | EVA | |
| rs47863852 | 811 | V>F | No | EVA | |
| rs47863852 | 811 | V>L | No | EVA | |
| rs13459232 | 824 | G>S | No | EVA | |
| rs3388584947 | 830 | V>I | No | EVA |
No associated diseases with P55144
17 regional properties for P55144
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Flavodoxin-like | 523 - 536 | IPR001094-1 |
| domain | Flavodoxin-like | 570 - 581 | IPR001094-2 |
| domain | Flavodoxin-like | 646 - 656 | IPR001094-3 |
| domain | Flavodoxin-like | 670 - 689 | IPR001094-4 |
| domain | Oxidoreductase FAD/NAD(P)-binding | 1013 - 1125 | IPR001433 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 795 - 805 | IPR001709-1 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 940 - 947 | IPR001709-2 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 976 - 985 | IPR001709-3 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 1012 - 1031 | IPR001709-4 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 1042 - 1051 | IPR001709-5 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 1055 - 1066 | IPR001709-6 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 1087 - 1103 | IPR001709-7 |
| domain | Flavoprotein pyridine nucleotide cytochrome reductase | 1112 - 1120 | IPR001709-8 |
| domain | Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding | 754 - 981 | IPR003097 |
| domain | Nitric oxide synthase, N-terminal | 123 - 483 | IPR004030 |
| domain | Flavodoxin/nitric oxide synthase | 522 - 705 | IPR008254 |
| domain | FAD-binding domain, ferredoxin reductase-type | 758 - 1004 | IPR017927 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell surface | The external part of the cell wall and/or plasma membrane. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| phosphatidylinositol 3-kinase binding | Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction |
| virus receptor activity | Combining with a virus component and mediating entry of the virus into the cell. |
29 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic cell clearance | The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. |
| establishment of localization in cell | Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. |
| forebrain cell migration | The orderly movement of a cell from one site to another at least one of which is located in the forebrain. |
| lymphocyte activation | A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. |
| natural killer cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell. |
| negative regulation of inflammatory response | Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. |
| negative regulation of innate immune response | Any process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response. |
| negative regulation of lymphocyte activation | Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation. |
| negative regulation of neuron apoptotic process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. |
| negative regulation of toll-like receptor signaling pathway | Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor signaling pathway. |
| nervous system development | The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. |
| neuron apoptotic process | Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. |
| neuron cellular homeostasis | The cellular homeostatic process that preserves a neuron in a stable, differentiated functional and structural state. |
| neuron migration | The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. |
| neuropeptide signaling pathway | A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. |
| ovulation cycle | The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years. |
| phagocytosis | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
| phosphatidylinositol 3-kinase/protein kinase B signal transduction | A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. |
| platelet activation | A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. |
| platelet aggregation | The adhesion of one platelet to one or more other platelets via adhesion molecules. |
| positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B. |
| positive regulation of viral life cycle | Any process that activates or increases the frequency, rate or extent of viral life cycle. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| secretion by cell | The controlled release of a substance by a cell. |
| spermatogenesis | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. |
| substrate adhesion-dependent cell spreading | The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vagina development | The reproductive developmental process whose specific outcome is the progression of the vagina over time, from its formation to the mature structure. |
68 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q98949 | TYRO3 | Tyrosine-protein kinase receptor TYRO3 | Gallus gallus (Chicken) | PR |
| P08581 | MET | Hepatocyte growth factor receptor | Homo sapiens (Human) | EV |
| P30530 | AXL | Tyrosine-protein kinase receptor UFO | Homo sapiens (Human) | PR |
| Q04912 | MST1R | Macrophage-stimulating protein receptor | Homo sapiens (Human) | EV |
| Q12866 | MERTK | Tyrosine-protein kinase Mer | Homo sapiens (Human) | EV |
| Q06418 | TYRO3 | Tyrosine-protein kinase receptor TYRO3 | Homo sapiens (Human) | SS |
| P34925 | RYK | Tyrosine-protein kinase RYK | Homo sapiens (Human) | PR |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q61006 | Musk | Muscle, skeletal receptor tyrosine-protein kinase | Mus musculus (Mouse) | SS |
| Q9Z138 | Ror2 | Tyrosine-protein kinase transmembrane receptor ROR2 | Mus musculus (Mouse) | SS |
| Q9Z139 | Ror1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 | Mus musculus (Mouse) | PR |
| Q62371 | Ddr2 | Discoidin domain-containing receptor 2 | Mus musculus (Mouse) | SS |
| Q03146 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Mus musculus (Mouse) | SS |
| P15209 | Ntrk2 | BDNF/NT-3 growth factors receptor | Mus musculus (Mouse) | SS |
| Q3UFB7 | Ntrk1 | High affinity nerve growth factor receptor | Mus musculus (Mouse) | SS |
| Q6VNS1 | Ntrk3 | NT-3 growth factor receptor | Mus musculus (Mouse) | SS |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P97793 | Alk | ALK tyrosine kinase receptor | Mus musculus (Mouse) | SS |
| Q9WTL4 | Insrr | Insulin receptor-related protein | Mus musculus (Mouse) | SS |
| Q60751 | Igf1r | Insulin-like growth factor 1 receptor | Mus musculus (Mouse) | SS |
| P15208 | Insr | Insulin receptor | Mus musculus (Mouse) | SS |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| Q60805 | Mertk | Tyrosine-protein kinase Mer | Mus musculus (Mouse) | SS |
| Q62190 | Mst1r | Macrophage-stimulating protein receptor | Mus musculus (Mouse) | SS |
| Q00993 | Axl | Tyrosine-protein kinase receptor UFO | Mus musculus (Mouse) | PR |
| P70424 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Mus musculus (Mouse) | SS |
| Q61527 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Mus musculus (Mouse) | SS |
| Q61526 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Mus musculus (Mouse) | SS |
| Q01279 | Egfr | Epidermal growth factor receptor | Mus musculus (Mouse) | SS |
| Q01887 | Ryk | Tyrosine-protein kinase RYK | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| P16056 | Met | Hepatocyte growth factor receptor | Mus musculus (Mouse) | PR |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| Q2QLE0 | MET | Hepatocyte growth factor receptor | Sus scrofa (Pig) | PR |
| P57097 | Mertk | Tyrosine-protein kinase Mer | Rattus norvegicus (Rat) | SS |
| H2KZU7 | svh-2 | Tyrosine-protein kinase receptor svh-2 | Caenorhabditis elegans | SS |
| C0LGI2 | At1g67720 | Probable LRR receptor-like serine/threonine-protein kinase At1g67720 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P43298 | TMK1 | Receptor protein kinase TMK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8LPS5 | SERK5 | Somatic embryogenesis receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94C77 | At4g34220 | Receptor protein kinase-like protein At4g34220 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LRP3 | At3g17420 | Probable receptor-like protein kinase At3g17420 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O64556 | At2g19230 | Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At2g19230 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q6XAT2 | ERL2 | LRR receptor-like serine/threonine-protein kinase ERL2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q3E991 | PRK6 | Pollen receptor-like kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q94AG2 | SERK1 | Somatic embryogenesis receptor kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9XIC7 | SERK2 | Somatic embryogenesis receptor kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGJ1 | At1g74360 | Probable LRR receptor-like serine/threonine-protein kinase At1g74360 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q93ZS4 | NIK3 | Protein NSP-INTERACTING KINASE 3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGQ4 | MDIS2 | Protein MALE DISCOVERER 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| C0LGX1 | At5g65240 | Probable LRR receptor-like serine/threonine-protein kinase At5g65240 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q0WR59 | At5g10020 | Probable inactive receptor kinase At5g10020 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LFG1 | At3g53590 | Putative leucine-rich repeat receptor-like serine/threonine-protein kinase At3g53590 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FXF2 | RKF1 | Probable LRR receptor-like serine/threonine-protein kinase RFK1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9YI66 | tyro3 | Tyrosine-protein kinase receptor TYRO3 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MALRRSMGWP | GLRPLLLAGL | ASLLLPGSAA | AGLKLMGAPV | KMTVSQGQPV | KLNCSVEGME |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DPDIHWMKDG | TVVQNASQVS | ISISEHSWIG | LLSLKSVERS | DAGLYWCQVK | DGEETKISQS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VWLTVEGVPF | FTVEPKDLAV | PPNAPFQLSC | EAVGPPEPVT | IYWWRGLTKV | GGPAPSPSVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NVTGVTQRTE | FSCEARNIKG | LATSRPAIVR | LQAPPAAPFN | TTVTTISSYN | ASVAWVPGAD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GLALLHSCTV | QVAHAPGEWE | ALAVVVPVPP | FTCLLRNLAP | ATNYSLRVRC | ANALGPSPYG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DWVPFQTKGL | APARAPQNFH | AIRTDSGLIL | EWEEVIPEDP | GEGPLGPYKL | SWVQENGTQD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ELMVEGTRAN | LTDWDPQKDL | ILRVCASNAI | GDGPWSQPLV | VSSHDHAGRQ | GPPHSRTSWV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PVVLGVLTAL | ITAAALALIL | LRKRRKETRF | GQAFDSVMAR | GEPAVHFRAA | RSFNRERPER |
| 490 | 500 | 510 | 520 | 530 | 540 |
| IEATLDSLGI | SDELKEKLED | VLIPEQQFTL | GRMLGKGEFG | SVREAQLKQE | DGSFVKVAVK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MLKADIIASS | DIEEFLREAA | CMKEFDHPHV | AKLVGVSLRS | RAKGRLPIPM | VILPFMKHGD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LHAFLLASRI | GENPFNLPLQ | TLVRFMVDIA | CGMEYLSSRN | FIHRDLAARN | CMLAEDMTVC |
| 670 | 680 | 690 | 700 | 710 | 720 |
| VADFGLSRKI | YSGDYYRQGC | ASKLPVKWLA | LESLADNLYT | VHSDVWAFGV | TMWEIMTRGQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| TPYAGIENAE | IYNYLIGGNR | LKQPPECMEE | VYDLMYQCWS | ADPKQRPSFT | CLRMELENIL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GHLSVLSTSQ | DPLYINIERA | EQPTESGSPE | VHCGERSSSE | AGDGSGVGAV | GGIPSDSRYI |
| 850 | 860 | 870 | |||
| FSPGGLSESP | GQLEQQPESP | LNENQRLLLL | QQGLLPHSSC |