P54936
SS
Gene name |
lin-2 (F17E5.1) |
Protein name |
Protein lin-2 |
Names |
Abnormal cell lineage protein 2 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F17E5.1 |
EC number |
|
Protein Class |
|
Descriptions
CAMK2D is a Calcium/Calmodulin (CaM)-dependent kinase II (CaMKII) that plays as a molecular switch of cellular signaling by transmitting Ca2+ signals in humans. The C-terminal helix bound to the substrate-binding site causes autoinhibited CaMKII.
Autoinhibitory domains (AIDs)
Target domain |
17-281 (Protein kinase domain) |
Relief mechanism |
Partner binding |
Assay |
|
Accessory elements
No accessory elements
References
- Rellos P et al. (2010) "Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation", PLoS biology, 8, e1000426
- Morlot C et al. (2007) "Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3", Acta crystallographica. Section D, Biological crystallography, 63, 961-8
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Akita T et al. (2018) "De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders", Annals of clinical and translational neurology, 5, 280-296
- Yang E et al. (1999) "Structural examination of autoregulation of multifunctional calcium/calmodulin-dependent protein kinase II", The Journal of biological chemistry, 274, 26199-208
- Özden C et al. (2022) "CaMKII binds both substrates and activators at the active site", Cell reports, 40, 111064
Autoinhibited structure
Activated structure
1 structures for P54936
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P54936-F1 | Predicted | AlphaFoldDB |
No variants for P54936
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P54936 | |||||
No associated diseases with P54936
12 regional properties for P54936
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 17 - 281 | IPR000719 |
| domain | SH3 domain | 633 - 717 | IPR001452 |
| domain | PDZ domain | 544 - 627 | IPR001478 |
| domain | L27 domain | 365 - 425 | IPR004172-1 |
| domain | L27 domain | 428 - 482 | IPR004172-2 |
| domain | Guanylate kinase-like domain | 774 - 946 | IPR008144 |
| domain | Guanylate kinase/L-type calcium channel beta subunit | 773 - 949 | IPR008145 |
| active_site | Tyrosine-protein kinase, active site | 142 - 154 | IPR008266 |
| domain | L27 domain, C-terminal | 374 - 423 | IPR014775-1 |
| domain | L27 domain, C-terminal | 430 - 478 | IPR014775-2 |
| conserved_site | Guanylate kinase, conserved site | 809 - 826 | IPR020590 |
| domain | Tyrosine-protein kinase, catalytic domain | 17 - 281 | IPR020635 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell junction | A cellular component that forms a specialized region of connection between two or more cells, or between a cell and the extracellular matrix, or between two membrane-bound components of a cell, such as flagella. |
| cell-cell junction | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| calmodulin binding | Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. |
| insulin-like growth factor receptor binding | Binding to an insulin-like growth factor receptor. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| signaling receptor binding | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| egg-laying behavior | A reproductive behavior that results in the deposition of eggs (either fertilized or not) upon a surface or into a medium such as water. |
| gamma-aminobutyric acid receptor clustering | The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane. |
| positive regulation of vulval development | Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. |
| post-embryonic development | The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development. |
| protein localization to basolateral plasma membrane | Any process in which a protein is transported to, or maintained in, basolateral regions of the plasma membrane. |
| regulation of neurotransmitter secretion | Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell. |
33 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHJ9 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Bos taurus (Bovine) | SS |
| Q2HJF7 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Bos taurus (Bovine) | SS |
| Q5ZKI0 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II delta chain | Gallus gallus (Chicken) | SS |
| Q00168 | CaMKII | Calcium/calmodulin-dependent protein kinase type II alpha chain | Drosophila melanogaster (Fruit fly) | SS |
| Q24210 | CASK | Peripheral plasma membrane protein CASK | Drosophila melanogaster (Fruit fly) | SS |
| Q9NZW5 | PALS2 | Protein PALS2 | Homo sapiens (Human) | PR |
| Q96JB8 | MPP4 | MAGUK p55 subfamily member 4 | Homo sapiens (Human) | PR |
| Q14168 | MPP2 | MAGUK p55 subfamily member 2 | Homo sapiens (Human) | PR |
| Q13555 | CAMK2G | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Homo sapiens (Human) | EV |
| Q13557 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Homo sapiens (Human) | EV |
| Q13554 | CAMK2B | Calcium/calmodulin-dependent protein kinase type II subunit beta | Homo sapiens (Human) | EV |
| Q9UQM7 | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Homo sapiens (Human) | EV |
| Q00013 | MPP1 | 55 kDa erythrocyte membrane protein | Homo sapiens (Human) | PR |
| O14936 | CASK | Peripheral plasma membrane protein CASK | Homo sapiens (Human) | EV |
| Q9WV34 | Mpp2 | MAGUK p55 subfamily member 2 | Mus musculus (Mouse) | PR |
| O88910 | Mpp3 | MAGUK p55 subfamily member 3 | Mus musculus (Mouse) | PR |
| Q6P7F1 | Mpp4 | MAGUK p55 subfamily member 4 | Mus musculus (Mouse) | PR |
| Q8BVD5 | Mpp7 | MAGUK p55 subfamily member 7 | Mus musculus (Mouse) | PR |
| Q9JLB0 | Pals2 | Protein PALS2 | Mus musculus (Mouse) | PR |
| Q923T9 | Camk2g | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Mus musculus (Mouse) | SS |
| P11798 | Camk2a | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Mus musculus (Mouse) | PR |
| Q6PHZ2 | Camk2d | Calcium/calmodulin-dependent protein kinase type II subunit delta | Mus musculus (Mouse) | SS |
| P28652 | Camk2b | Calcium/calmodulin-dependent protein kinase type II subunit beta | Mus musculus (Mouse) | SS |
| P70290 | Mpp1 | 55 kDa erythrocyte membrane protein | Mus musculus (Mouse) | PR |
| O70589 | Cask | Peripheral plasma membrane protein CASK | Mus musculus (Mouse) | SS |
| Q95266 | CAMK2D | Calcium/calmodulin-dependent protein kinase type II subunit delta | Sus scrofa (Pig) | SS |
| Q9QYH1 | Mpp4 | MAGUK p55 subfamily member 4 | Rattus norvegicus (Rat) | PR |
| P15791 | Camk2d | Calcium/calmodulin-dependent protein kinase type II subunit delta | Rattus norvegicus (Rat) | SS |
| P11275 | Camk2a | Calcium/calmodulin-dependent protein kinase type II subunit alpha | Rattus norvegicus (Rat) | PR |
| P11730 | Camk2g | Calcium/calmodulin-dependent protein kinase type II subunit gamma | Rattus norvegicus (Rat) | SS |
| O62305 | unc-43 | Calcium/calmodulin-dependent protein kinase type II | Caenorhabditis elegans | EV |
| Q6DGS3 | camk2d2 | Calcium/calmodulin-dependent protein kinase type II delta 2 chain | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q6DEH3 | camk2d1 | Calcium/calmodulin-dependent protein kinase type II delta 1 chain | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRELDPDESN | LLLDEQLSIR | DVIEQGPFSN | VYRILHGPSN | RKFLLRSINL | NLFRQHTGLG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FEEIDEEIRI | CQNLQHPYIC | RLEKTINSVH | YRHIIFENME | GNDICFEIVQ | RASNGFVFSE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YVVSHYTRQL | LDALDYCHTR | KIVHRDVRPH | NLVLASKDTS | APLKLCGFGV | AKDLSEIGGS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MACGRVGVPQ | FMAPEIVRKD | RVSCSSDIWS | SGVVLFLLLA | GRLPFSGSTS | DIYERIMQTD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VDVDGYMPNI | SESARNLVRR | MLNADPSKRI | SAKEALNHEW | IRDKEHMASR | KHMNDVIDQM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RRYNESRKLK | SNVLSAVNSG | RFDETTPRQD | TPQTAFVDGS | SPGGDCCHRG | ESSSNDAAEP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PADKDLSGAY | KVLGSLDAIN | SLLDPNSYKP | GSTTFQKIHD | DGSVRNLLRL | YDKIKALPCE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PVVTEVDTST | LRKETLNQID | GLLGPSPEAL | ELRQLLNSPH | LASCVQALDV | VVCEIRDPKN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EASGSGDKEG | NCVSSDPAPA | YLNGGVLPLG | AQRAGTSFEH | FNQSAVHTSY | DEEEEELYDC |
| 550 | 560 | 570 | 580 | 590 | 600 |
| MSRLRLVQFQ | KDTQEPMGIT | LKVNEDGRCF | VARIMHGGMI | HRQATLHVGD | EIREINGMSV |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ANRSVESLQE | MLRDARGQVT | FKIIPSYRSA | PPACEIFVRA | QFDYEPSQDD | LIPCPQAGIP |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FKTGDILQVI | SKDDHNWWQA | RFVSSFPSIG | NSSNAQRSNQ | QQVAGLIPSP | ELQEWRTACL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AMERSKNTCN | THCMWFNKKK | KYYTTKYLQK | HSALFDQLDL | VTYEEVMRLS | QYRRKTLVLL |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GAHGVGRRHI | KNTLIHRHPN | RFAYPIPHTT | RPPRKDEVDG | KHYYFVTNEQ | MMADIQNNEY |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LEYGTHEESM | YGTKLETIRN | IHKSGKIAIL | DVEPQALKVL | RTAEYSPFVV | FIAAPNLQGM |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QDPDGSLEKL | LNESDVLRQA | FGHLFDFIIT | NSDIDDTIAQ | LERLVEKLPA | YPQWLPVTWV |
| Y |