P54767

PR
Gene name
Protein name
Glutamate decarboxylase
Names
GAD, ERT D1
Species
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
KEGG Pathway
EC number
4.1.1.15: Carboxy-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-66 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P54767

Entry ID Method Resolution Chain Position Source
AF-P54767-F1 Predicted AlphaFoldDB

No variants for P54767

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54767

No associated diseases with P54767

3 regional properties for P54767

Type Name Position InterPro Accession
domain 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 236 - 557 IPR002073
domain HD/PDEase domain 309 - 485 IPR003607
conserved_site 3'5'-cyclic nucleotide phosphodiesterase, conserved site 352 - 363 IPR023174

Functions

Description
EC Number 4.1.1.15 Carboxy-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
calmodulin binding Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
glutamate decarboxylase activity Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

1 GO annotations of biological process

Name Definition
glutamate catabolic process The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q04792 GAD1 Glutamate decarboxylase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P69908 gadA Glutamate decarboxylase alpha Escherichia coli (strain K12) PR
P69910 gadB Glutamate decarboxylase beta Escherichia coli (strain K12) EV
Q9ZPS3 GAD4 Glutamate decarboxylase 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q42521 GAD1 Glutamate decarboxylase 1 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LSH2 GAD5 Glutamate decarboxylase 5 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVLTTTSIRD SEESLHCTFA SRYVQEPLPK FKMPKKSMPK EAAYQIVNDE LMLDGNPRLN
70 80 90 100 110 120
LASFVSTWME PECDKLIMSS INKNYVDMDE YPVTTELQNR CVNMLAHLFH APVGDDETAV
130 140 150 160 170 180
GVGTVGSSEA IMLAGLAFKR KWQSKRKAEG KPFDKPNIVT GANVQVCWEK FARYFEVELK
190 200 210 220 230 240
EVKLKEGYYV MDPAKAVEIV DENTICVAAI LGSTLTGEFE DVKLLNELLT KKNKETGWET
250 260 270 280 290 300
PIHVDAASGG FIAPFLWPDL EWDFRLPLVK SINVSGHKYG LVYAGVGWVI WRSKEDLPDE
310 320 330 340 350 360
LVFHINYLGS DQPTFTLNFS KGSYQIIAQY YQLIRLGFEG YKNVMKNCLS NAKVLTEGIT
370 380 390 400 410 420
KMGRFDIVSK DVGVPVVAFS LRDSSKYTVF EVSEHLRRFG WIVPAYTMPP DAEHIAVLRV
430 440 450 460 470 480
VIREDFSHSL AERLVSDIEK ILSELDTQPP RLPTKAVRVT AEEVRDDKGD GLHHFHMDTV
490 500
ETQKDIIKHW RKIAGKKTSG VC