Descriptions

Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.

Autoinhibitory domains (AIDs)

Target domain

621-882 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

763-789 (Activation loop from InterPro)

Target domain

621-882 (Protein kinase domain)

Relief mechanism

Assay

Autoinhibited structure

Activated structure

17 structures for P54764

Entry ID Method Resolution Chain Position Source
2LW8 NMR - A 29-209 PDB
2WO1 X-ray 185 A A/B 30-202 PDB
2WO2 X-ray 245 A A 30-202 PDB
2WO3 X-ray 235 A A 30-202 PDB
3CKH X-ray 280 A A/B 29-209 PDB
3GXU X-ray 250 A A 29-203 PDB
4BK4 X-ray 365 A A/B 20-547 PDB
4BK5 X-ray 400 A A 20-547 PDB
4BKA X-ray 530 A A 20-547 PDB
4BKF X-ray 465 A A/B 20-547 PDB
4M4P X-ray 208 A A 27-543 PDB
4M4R X-ray 313 A A/C/E/G 27-543 PDB
4W4Z X-ray 241 A A/B/C/D 29-204 PDB
4W50 X-ray 242 A A/B/C/D 29-204 PDB
5JR2 X-ray 175 A A/B/C/D 29-204 PDB
7OFV X-ray 143 A A 29-209 PDB
AF-P54764-F1 Predicted AlphaFoldDB

923 variants for P54764

Variant ID(s) Position Change Description Diseaes Association Provenance
RCV002545874
RCV001878591
rs144149406
97 V>L Inborn genetic diseases [ClinVar] Yes ClinVar
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs375452175
RCV002005887
RCV002579626
466 R>Q Inborn genetic diseases [ClinVar] Yes ClinVar
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs774855923
RCV003167301
RCV001933892
COSM3391507
COSM3391508
573 R>W Variant assessed as Somatic; MODERATE impact. pancreas Inborn genetic diseases [NCI-TCGA, Cosmic, ClinVar] Yes NCI-TCGA Cosmic
cosmic curated
ClinVar
ExAC
NCI-TCGA
TOPMed
dbSNP
gnomAD
RCV002547965
RCV001894356
rs761654406
734 M>V Inborn genetic diseases [ClinVar] Yes ClinVar
ExAC
TOPMed
dbSNP
gnomAD
CA350407591
rs1553568456
RCV000655960
748 A>T atypical cerebral palsy [ClinVar] Yes ClinGen
ClinVar
Ensembl
dbSNP
RCV001992714
rs199889377
RCV002562935
852 A>V Inborn genetic diseases [ClinVar] Yes ClinVar
ExAC
TOPMed
dbSNP
gnomAD
COSM1016958
rs201040727
RCV002552109
RCV001880728
COSM1016957
946 V>M endometrium Inborn genetic diseases [Cosmic, ClinVar] Yes cosmic curated
ClinVar
1000Genomes
ExAC
TOPMed
dbSNP
gnomAD
rs939371167 3 G>E No gnomAD
rs746371733 4 I>V No ExAC
gnomAD
rs781578118 6 Y>C No ExAC
gnomAD
TCGA novel 6 Y>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 7 F>S Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1248253403 8 A>S No gnomAD
rs757596494 8 A>V No ExAC
gnomAD
COSM1405769
COSM1405770
9 L>P Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1264445058 9 L>V No TOPMed
gnomAD
rs1162358008 12 C>S No TOPMed
rs1008387910 13 L>F No TOPMed
rs1559300040 15 G>W No Ensembl
rs1694863385 17 C>* No Ensembl
rs1397108495
RCV001920140
17 C>S No ClinVar
dbSNP
gnomAD
rs1408458706 18 D>N No TOPMed
gnomAD
rs1408458706 18 D>Y No TOPMed
gnomAD
rs1041387439 20 V>A No TOPMed
gnomAD
rs765396923 21 T>I No ExAC
TOPMed
gnomAD
rs1307731541 22 G>C No TOPMed
gnomAD
rs756185018 22 G>D No ExAC
TOPMed
gnomAD
rs756185018 22 G>V No ExAC
TOPMed
gnomAD
rs1181064271 23 S>A No TOPMed
gnomAD
rs1694861916 24 R>K No gnomAD
rs767466254 24 R>W No ExAC
TOPMed
gnomAD
rs1201186843 25 V>I No TOPMed
gnomAD
rs773907283 26 Y>H No ExAC
TOPMed
gnomAD
rs1284439815 27 P>S No TOPMed
gnomAD
rs762381958 28 A>G No ExAC
gnomAD
rs763735444 28 A>P No ExAC
TOPMed
gnomAD
rs763735444 28 A>T No ExAC
TOPMed
gnomAD
rs1279318910 29 N>S No gnomAD
COSM1016998
COSM1016997
30 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
TCGA novel 31 V>= Variant assessed as Somatic; LOW impact. [NCI-TCGA] No NCI-TCGA
rs1574668112 31 V>A No Ensembl
rs1009852736 31 V>L No TOPMed
rs759008116 37 R>T No ExAC
gnomAD
rs777131300 38 S>C No ExAC
TOPMed
gnomAD
rs777131300 38 S>F No ExAC
TOPMed
gnomAD
rs1694743944 39 V>A No Ensembl
COSM4091865
COSM4091866
rs771415392
40 Q>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
gnomAD
rs201423814 41 G>A No ESP
ExAC
TOPMed
gnomAD
COSM122868
rs201423814
COSM122867
41 G>E upper_aerodigestive_tract [Cosmic] No cosmic curated
ESP
ExAC
TOPMed
gnomAD
COSM4091864
COSM4091863
42 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1290023348 43 L>F No gnomAD
TCGA novel 43 L>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM1531159
COSM1531160
COSM6157334
rs1308566551
COSM6157335
46 I>R lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] No cosmic curated
NCI-TCGA Cosmic
NCI-TCGA
gnomAD
rs1694743281 46 I>V No TOPMed
rs773695596 47 A>T No ExAC
TOPMed
gnomAD
rs772289765
RCV001899618
48 S>N No ClinVar
ExAC
TOPMed
dbSNP
gnomAD
rs748448148 48 S>R No ExAC
TOPMed
gnomAD
rs779224324 49 P>L No ExAC
TOPMed
gnomAD
rs1347222781 51 E>* No gnomAD
TCGA novel 52 G>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1574668029 53 G>R No Ensembl
rs762225060 58 S>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs1694562555 59 I>T No TOPMed
TCGA novel 59 I>W Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs774718510 60 M>I No ExAC
gnomAD
COSM3578194
COSM3578195
61 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM5861876
COSM5861875
62 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1253658594 64 N>H No gnomAD
COSM391256
COSM391257
64 N>I Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM5188853 64 N>K Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs965238814 65 T>I No TOPMed
gnomAD
rs965238814 65 T>K No TOPMed
gnomAD
rs1694562042 67 I>T No TOPMed
rs866953044 68 R>* No Ensembl
rs1419977273 68 R>Q No gnomAD
rs1429334984 69 T>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
COSM1016995
COSM1016996
70 Y>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs369440148 72 V>L No ESP
ExAC
gnomAD
rs139915472 74 N>H No ESP
ExAC
TOPMed
gnomAD
rs746991074 74 N>S No ExAC
TOPMed
gnomAD
rs1020746258 76 M>I No Ensembl
rs777531997 77 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs1574663492 81 N>S No Ensembl
COSM4091861
COSM4091862
85 R>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs374795790 85 R>G No ESP
ExAC
TOPMed
gnomAD
rs957961356 85 R>Q No TOPMed
gnomAD
rs1436338802 86 T>S No TOPMed
rs754695380 87 D>Y No ExAC
gnomAD
rs1222041854 88 W>C No gnomAD
rs755527453 91 R>G No ExAC
gnomAD
rs750966838 91 R>Q No ExAC
TOPMed
gnomAD
rs199555949 93 G>E No 1000Genomes
ExAC
TOPMed
gnomAD
rs199555949 93 G>V No 1000Genomes
ExAC
TOPMed
gnomAD
rs1453977925 94 A>S No gnomAD
rs1347356714 94 A>V No gnomAD
rs764546684 96 R>K No ExAC
TOPMed
gnomAD
rs775527820 97 V>A No ExAC
TOPMed
gnomAD
rs775527820 97 V>G No ExAC
TOPMed
gnomAD
rs1185509846 99 I>M No gnomAD
rs1307751766 99 I>T No gnomAD
rs1694557571 100 E>D No Ensembl
rs1694557642 100 E>Q No Ensembl
rs1694557486 102 K>N No TOPMed
TCGA novel 102 K>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 105 L>F Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1694557283 105 L>S No gnomAD
COSM4799033
COSM4799032
106 R>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM4799085
COSM4799084
106 R>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM4091857
COSM4091858
106 R>W Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1694557193 107 D>N No Ensembl
rs769949889 109 N>S No ExAC
TOPMed
gnomAD
rs2106209340 110 S>I No Ensembl
rs1255538022
COSM1205455
COSM1205454
112 P>L Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
TOPMed
gnomAD
rs745869814 113 G>S No ExAC
TOPMed
gnomAD
rs748076314 114 V>F No ExAC
TOPMed
gnomAD
rs748076314
COSM3407602
COSM3407601
114 V>I Variant assessed as Somatic; MODERATE impact. central_nervous_system [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
TOPMed
gnomAD
rs200482476 115 M>T No 1000Genomes
ExAC
TOPMed
TCGA novel 116 G>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs113596369 118 C>R No Ensembl
rs1694556067
COSM3045986
COSM3045987
121 T>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
TOPMed
rs1380003574 125 Y>C No gnomAD
rs1382467778 126 Y>C No gnomAD
rs1311349395
COSM4091856
COSM4091855
126 Y>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
gnomAD
rs371268826 127 Y>H No ESP
ExAC
TOPMed
gnomAD
rs371268826 127 Y>N No ESP
ExAC
TOPMed
gnomAD
COSM3838708
COSM3838709
rs2106209275
129 S>* Variant assessed as Somatic; HIGH impact. breast [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
Ensembl
TCGA novel 129 S>P Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs369898036 131 N>D No ESP
TOPMed
gnomAD
rs2106209268 132 D>E No Ensembl
TCGA novel 132 D>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1366582871 132 D>N No TOPMed
gnomAD
TCGA novel 133 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs749843233
COSM1405768
COSM1405767
135 R>C Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
gnomAD
rs749843233 135 R>G No ExAC
gnomAD
rs1013909979 135 R>H No TOPMed
gnomAD
rs924587124 137 I>T No TOPMed
gnomAD
TCGA novel 139 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
RCV002000319
rs2106209238
140 N>K No ClinVar
Ensembl
dbSNP
rs550952508 141 Q>* No 1000Genomes
rs550952508 141 Q>E No 1000Genomes
rs2106209230 142 F>I No Ensembl
rs767039863 143 V>F No ExAC
TOPMed
rs757903625 144 K>R No ExAC
gnomAD
COSM3391514
rs752080176
COSM3391513
145 I>T pancreas [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs764577079 146 D>E No ExAC
gnomAD
rs2106209212 147 T>S No Ensembl
rs1221547125 148 I>V No TOPMed
gnomAD
rs2106209207 149 A>V No Ensembl
rs2106209200 150 A>V No Ensembl
rs1224682977 151 D>Y No gnomAD
rs2106209198 152 E>* No Ensembl
TCGA novel 152 E>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1694553037 159 I>M No Ensembl
rs1559295681 159 I>T No Ensembl
rs1694553217 159 I>V No TOPMed
gnomAD
rs1036542307 162 R>K No Ensembl
rs1442624725 164 M>L No gnomAD
rs113138543 169 E>G No Ensembl
rs1250363178 169 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
rs2106209146 170 I>M No Ensembl
rs1398999744 171 R>Q No gnomAD
rs942232541 171 R>W No TOPMed
gnomAD
rs2106209131 172 D>N No Ensembl
rs1356547451 173 V>A No TOPMed
gnomAD
rs2106209123 173 V>I No Ensembl
COSM250924
COSM250925
rs1694551025
174 G>E liver [Cosmic] No cosmic curated
gnomAD
rs2106209119 174 G>R No Ensembl
rs1694550894 175 P>A No TOPMed
rs776646746 177 S>G No ExAC
TOPMed
gnomAD
rs770968962 178 K>Q No ExAC
gnomAD
rs761790381 178 K>T No ExAC
gnomAD
rs1472671633 179 K>R No TOPMed
rs1168581485 180 G>V No gnomAD
rs1168636665 180 G>W No gnomAD
TCGA novel 181 F>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 181 F>V Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs774222133 182 Y>H No ExAC
gnomAD
rs2106209089 184 A>S No Ensembl
TCGA novel 184 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 186 Q>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1170306799 187 D>E No gnomAD
rs768468113 187 D>G No ExAC
gnomAD
rs748965921 189 G>R No ExAC
gnomAD
rs1694549055 192 I>S No Ensembl
rs1051141160 193 A>P No Ensembl
COSM1205452
COSM1205453
193 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1449807402 195 V>I No gnomAD
rs112444976 196 S>P No Ensembl
rs756804453 198 R>C No ExAC
TOPMed
gnomAD
rs756804453 198 R>G No ExAC
TOPMed
gnomAD
rs184759178
COSM1016991
COSM1016992
198 R>H Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
1000Genomes
NCI-TCGA
gnomAD
rs756804453 198 R>S No ExAC
TOPMed
gnomAD
rs1694547489 199 V>M No gnomAD
COSM3426128
rs1255584338
COSM3426129
200 F>L Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
gnomAD
rs1694547211 201 Y>H No gnomAD
TCGA novel 203 K>S Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs752143625 205 P>S No ExAC
TOPMed
gnomAD
rs1323748874 206 L>F No TOPMed
gnomAD
rs778357844 206 L>P No ExAC
gnomAD
rs753061954 208 V>F No ExAC
gnomAD
rs753061954 208 V>L No ExAC
gnomAD
RCV002009148
rs765633667
209 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ClinVar
ExAC
NCI-TCGA
TOPMed
dbSNP
gnomAD
COSM1725999
COSM1726000
rs759721341
209 R>H liver [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs759721341 209 R>L No ExAC
TOPMed
gnomAD
rs2106209015 210 N>S No Ensembl
rs1394481740 213 Q>E No TOPMed
gnomAD
TCGA novel 213 Q>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1694545401 213 Q>R No gnomAD
COSM4892796
COSM4892797
215 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs754072204 218 I>T No ExAC
TOPMed
gnomAD
rs1694544950 219 T>A No TOPMed
rs1431649558 221 A>P No TOPMed
gnomAD
rs1431649558
RCV002018640
221 A>S No ClinVar
TOPMed
dbSNP
gnomAD
rs766465905
COSM4681292
COSM4681291
223 T>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
TOPMed
gnomAD
rs766465905 223 T>R No ExAC
TOPMed
gnomAD
rs774273988 225 S>F No ExAC
gnomAD
COSM1718745
rs768519615
COSM1718746
228 E>K NS [Cosmic] No cosmic curated
ExAC
gnomAD
rs2106208991 229 V>I No Ensembl
COSM1177209
rs867613646
COSM1177210
230 R>* Variant assessed as Somatic; HIGH impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
Ensembl
NCI-TCGA
rs1420768724 230 R>Q No TOPMed
gnomAD
COSM6090784
COSM6090785
231 G>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs762933332 231 G>V No ExAC
gnomAD
rs1264539873 233 C>F No gnomAD
COSM3838706
COSM3838707
234 V>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
TCGA novel 234 V>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs769599505 235 N>H No ExAC
gnomAD
RCV001968884
rs745555273
235 N>S No ClinVar
ExAC
dbSNP
gnomAD
rs770569782 236 N>K No ExAC
TOPMed
gnomAD
rs780953547 236 N>S No ExAC
gnomAD
rs746462605 238 E>D No ExAC
TOPMed
gnomAD
TCGA novel
rs1245308570
239 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No TOPMed
NCI-TCGA
rs1694541955 239 E>K No Ensembl
rs1694541414 241 D>H No Ensembl
rs978524820 241 D>V No TOPMed
rs1453383325 243 P>A No gnomAD
rs1453383325 243 P>S No gnomAD
rs1694541046 244 K>T No gnomAD
COSM1405766
COSM1405765
245 M>C Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs2106208933 246 Y>C No Ensembl
COSM4091854
COSM4091853
249 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM4091851
COSM4091852
255 V>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1574662874 255 V>G No Ensembl
rs1694540524 256 P>R No Ensembl
rs758898289 257 I>T No ExAC
gnomAD
rs1022709550 259 N>S No TOPMed
rs779199200 263 N>K No ExAC
TOPMed
gnomAD
rs766517365 264 A>G No ExAC
TOPMed
gnomAD
rs368252272 264 A>P No ESP
ExAC
TOPMed
gnomAD
rs368252272 264 A>S No ESP
ExAC
TOPMed
gnomAD
rs368252272 264 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
TCGA novel 265 G>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1694539033 268 E>D No Ensembl
rs1694539154 268 E>K No Ensembl
rs762835852 269 R>G No ExAC
TOPMed
gnomAD
rs35084379
VAR_042135
269 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No UniProt
ExAC
NCI-TCGA
TOPMed
dbSNP
gnomAD
COSM1016989
rs762835852
COSM1016990
RCV001913924
269 R>W endometrium [Cosmic] No cosmic curated
ClinVar
ExAC
TOPMed
dbSNP
gnomAD
rs1694538560 270 S>G No gnomAD
rs1694538424 270 S>N No TOPMed
gnomAD
rs941541780 271 G>E No TOPMed
COSM4583242
COSM4583243
rs981128868
271 G>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
TOPMed
gnomAD
rs1207205117 274 Q>K No TOPMed
gnomAD
rs1694537539 275 A>T No TOPMed
rs1234704615 276 C>Y No gnomAD
RCV001994453
rs1196771519
277 K>R No ClinVar
TOPMed
dbSNP
gnomAD
COSM1016987
COSM1016988
279 G>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM3578184
rs1457488118
COSM3578185
279 G>R Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
gnomAD
rs200631562 280 Y>C No ExAC
TOPMed
gnomAD
rs200631562 280 Y>S No ExAC
TOPMed
gnomAD
TCGA novel 281 Y>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1205794130 281 Y>F No gnomAD
rs1692478520 282 K>N No TOPMed
rs781434654 283 A>G No ExAC
gnomAD
rs146488160 283 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs757297693 284 L>F No ExAC
TOPMed
gnomAD
rs1254867384 284 L>P No gnomAD
rs757297693 284 L>V No ExAC
TOPMed
gnomAD
rs766030392 285 S>P No ExAC
gnomAD
rs1382673990 286 T>A No TOPMed
rs200225096 286 T>K No ESP
ExAC
TOPMed
gnomAD
rs200225096
RCV000899544
286 T>M No ClinVar
ESP
ExAC
TOPMed
dbSNP
gnomAD
COSM3578182
COSM3578183
287 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1230632265 287 D>V No TOPMed
gnomAD
TCGA novel 288 A>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1324719136 288 A>V No gnomAD
rs1375509458 289 T>A No TOPMed
gnomAD
rs1692476783 289 T>I No Ensembl
rs973610366 291 A>G No TOPMed
gnomAD
rs973610366 291 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs1175746778 292 K>E No TOPMed
gnomAD
rs1574615884 293 C>S No Ensembl
rs2106157591 294 P>L No Ensembl
rs1401818376 296 H>Y No gnomAD
COSM442382
COSM442383
299 S>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1692475685 300 V>A No TOPMed
rs1692475469 302 E>K No TOPMed
COSM1565043
COSM1565044
303 G>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs145605677 303 G>A No ESP
rs377728125 304 A>V No ESP
TOPMed
rs1692475108 305 T>I No TOPMed
rs537081277
COSM5123795
COSM210124
306 S>L Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No cosmic curated
NCI-TCGA Cosmic
1000Genomes
ExAC
NCI-TCGA
TOPMed
gnomAD
rs1574615849 306 S>T No Ensembl
rs768017972 308 T>A No ExAC
gnomAD
rs1254055622 308 T>N No gnomAD
rs768017972 308 T>P No ExAC
gnomAD
rs768017972 308 T>S No ExAC
gnomAD
rs763497552 310 D>G No ExAC
TOPMed
gnomAD
rs1317445871 311 R>* No TOPMed
gnomAD
rs1317445871 311 R>G No TOPMed
gnomAD
rs375924623 311 R>L No ESP
ExAC
TOPMed
gnomAD
COSM1205457
rs375924623
COSM1205456
311 R>Q large_intestine [Cosmic] No cosmic curated
ESP
ExAC
TOPMed
gnomAD
rs59845374 312 G>S No Ensembl
rs1574615791 314 F>L No Ensembl
rs200748922 314 F>L No 1000Genomes
ExAC
gnomAD
rs1692472982 314 F>S No TOPMed
rs1692472692 315 R>G No TOPMed
rs1692472409 316 A>D No TOPMed
rs1480675044 316 A>T No TOPMed
rs1692472335 317 D>G No Ensembl
rs1692472259 318 N>D No gnomAD
rs185878065 318 N>K No 1000Genomes
ExAC
TOPMed
gnomAD
rs139457656 318 N>S No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs747169432 319 D>N No ExAC
TOPMed
gnomAD
rs1374932930 320 A>S No gnomAD
rs1302650060 321 A>V No gnomAD
rs977254277 322 S>C No TOPMed
gnomAD
rs977254277 322 S>F No TOPMed
gnomAD
rs1157433191 323 M>I No gnomAD
rs1419592564 324 P>L No gnomAD
rs1692471013 324 P>T No TOPMed
rs758506758 326 T>A No ExAC
gnomAD
rs1166938504 327 R>C No TOPMed
gnomAD
rs1420416308 328 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs1420416308 328 P>T No TOPMed
gnomAD
rs1164929779 329 P>L No TOPMed
rs1367956019 330 S>F No TOPMed
gnomAD
TCGA novel 331 A>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1691860174 331 A>T No TOPMed
rs555974208 333 L>P No Ensembl
rs777095910 334 N>I No ExAC
gnomAD
TCGA novel 336 I>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1425549452 338 N>D No gnomAD
rs747279418 338 N>K No ExAC
TOPMed
gnomAD
rs1691859063 339 V>I No gnomAD
rs1355448455 340 N>S No TOPMed
gnomAD
rs1267892853 341 E>K No gnomAD
rs1691856529 344 V>L No Ensembl
rs1301593446 349 S>N No TOPMed
gnomAD
rs1218892372 350 S>I No gnomAD
rs1691855972 351 P>S No Ensembl
COSM4933116
COSM4933115
351 P>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1276709569 353 N>Y No gnomAD
rs1559260345 356 G>D No Ensembl
COSM6026518
rs1011192300
COSM6026517
357 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
gnomAD
rs756184907
COSM269111
RCV002031471
COSM269110
357 R>H Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ClinVar
ExAC
NCI-TCGA
dbSNP
gnomAD
rs756184907
COSM3782128
COSM3782129
357 R>L pancreas [Cosmic] No cosmic curated
ExAC
gnomAD
rs1011192300 357 R>S No gnomAD
rs1559260327 360 I>T No Ensembl
rs2106141535 360 I>V No Ensembl
COSM230957
COSM230958
361 S>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1390161740 361 S>K No gnomAD
COSM1016983
COSM1016984
363 N>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1316327295 363 N>Y No TOPMed
COSM1565048 364 V>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs781087709 367 K>R No ExAC
TOPMed
gnomAD
rs1168279571
RCV001904783
369 C>R No ClinVar
dbSNP
gnomAD
rs895132449 369 C>S No TOPMed
gnomAD
rs895132449 369 C>Y No TOPMed
gnomAD
rs756952113
VAR_042136
COSM21131
370 G>E urinary_tract a bladder carcinoma NOS sample; somatic mutation [Cosmic, UniProt] No cosmic curated
UniProt
ExAC
dbSNP
gnomAD
COSM1405758
rs1307844419
COSM1405757
370 G>R Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
gnomAD
TCGA novel 371 A>missing Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs201391619 371 A>D No gnomAD
rs1206616391 371 A>S No TOPMed
gnomAD
rs1206616391 371 A>T No TOPMed
gnomAD
rs1431328286 372 G>D No TOPMed
gnomAD
rs939425780 372 G>S No Ensembl
rs1431328286 372 G>V No TOPMed
gnomAD
rs1278101088 373 D>N No TOPMed
rs763670422 374 P>A No ExAC
gnomAD
rs867434076 374 P>L No gnomAD
rs758033751 375 S>I No ExAC
TOPMed
gnomAD
rs758033751 375 S>N No ExAC
TOPMed
gnomAD
RCV001943212
rs752271799
378 R>L No ClinVar
ExAC
dbSNP
gnomAD
rs752271799 378 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
gnomAD
rs199971007 379 P>L No 1000Genomes
ExAC
TOPMed
gnomAD
rs199971007 379 P>R No 1000Genomes
ExAC
TOPMed
gnomAD
rs1346215997 379 P>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
gnomAD
rs1691850395 381 G>R No TOPMed
gnomAD
rs1691850110 382 S>N No TOPMed
rs978585578 383 G>R No TOPMed
rs760885287 383 G>V No ExAC
gnomAD
COSM3972045
COSM3972044
384 V>A Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1307815156 384 V>D No gnomAD
rs773586125 385 H>R No ExAC
TOPMed
gnomAD
rs1374756921 387 T>N No TOPMed
gnomAD
rs1691848737 390 Q>L No gnomAD
rs1691848737 390 Q>R No gnomAD
rs1330990969 392 G>A No gnomAD
rs1330990969 392 G>D No gnomAD
rs1330990969 392 G>V No gnomAD
rs1470407288 393 L>F No gnomAD
TCGA novel 394 K>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1402681482 395 T>I No gnomAD
rs772477067
RCV001886148
397 K>E No ClinVar
ExAC
dbSNP
gnomAD
COSM3045928
COSM21144
rs868224085
VAR_042137
399 S>F Variant assessed as Somatic; MODERATE impact. skin a metastatic melanoma sample; somatic mutation [NCI-TCGA, Cosmic, UniProt] No NCI-TCGA Cosmic
cosmic curated
UniProt
Ensembl
NCI-TCGA
dbSNP
RCV002005886
rs1464493300
400 I>V No ClinVar
TOPMed
dbSNP
gnomAD
rs768831751 402 D>E No ExAC
gnomAD
COSM1016981
rs2106141367
COSM1016982
RCV002048253
404 L>I Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ClinVar
Ensembl
dbSNP
rs745837888 404 L>P No ExAC
gnomAD
rs1177672725 405 A>V No gnomAD
rs780950065 406 H>P No ExAC
gnomAD
rs780950065 406 H>R No ExAC
gnomAD
rs1691846302 407 T>A No Ensembl
rs2106141337
TCGA novel
RCV001983273
407 T>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ClinVar
NCI-TCGA
Ensembl
dbSNP
COSM3578172
COSM3578173
409 Y>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
TCGA novel 410 T>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1314884263 412 E>Q No TOPMed
gnomAD
rs1287445533 414 W>* No gnomAD
TCGA novel 415 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1691845909 418 G>R No TOPMed
rs1691845838 419 V>M No TOPMed
gnomAD
TCGA novel 421 K>N Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1274741785 423 N>H No gnomAD
rs752325084 423 N>K No ExAC
TOPMed
gnomAD
rs758087110 423 N>S No ExAC
TOPMed
gnomAD
rs1342425992 424 P>S No gnomAD
rs910879210 426 P>T No Ensembl
rs764751712 427 D>N No ExAC
TOPMed
gnomAD
rs764751712 427 D>Y No ExAC
TOPMed
gnomAD
rs1159235217 428 Q>P No TOPMed
gnomAD
rs915257202 430 V>A No TOPMed
gnomAD
rs754376727 431 S>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
gnomAD
rs537001502 433 T>A No 1000Genomes
ExAC
TOPMed
gnomAD
TCGA novel 435 T>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1238780896 435 T>S No gnomAD
rs1442266098 439 A>V No gnomAD
rs189733468
COSM1531164
COSM6157339
COSM1531163
COSM6157338
441 P>S lung Variant assessed as Somatic; MODERATE impact. [Cosmic, NCI-TCGA] No cosmic curated
NCI-TCGA Cosmic
1000Genomes
gnomAD
rs189733468 441 P>T No 1000Genomes
gnomAD
rs1318816546 443 S>C No gnomAD
rs971898806 445 A>T No TOPMed
rs1259007158 446 L>S No TOPMed
gnomAD
rs779608005 448 Q>R No ExAC
gnomAD
TCGA novel 451 E>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1269584121 452 V>I No TOPMed
gnomAD
rs1351145874 454 R>I No TOPMed
gnomAD
rs768014459 455 Y>C No ExAC
gnomAD
rs1172365521 456 S>R No gnomAD
rs1400486676 456 S>R No gnomAD
rs1192322375 460 A>V No TOPMed
gnomAD
rs1245084455 461 W>C No gnomAD
rs764163455 461 W>L No ExAC
gnomAD
rs1691013384 462 L>M No Ensembl
rs75793991 463 E>G No Ensembl
rs763223548 465 D>H No ExAC
TOPMed
gnomAD
rs763223548 465 D>N No ExAC
TOPMed
gnomAD
rs1458390610 465 D>V No gnomAD
RCV002004743
rs199981171
466 R>W No ClinVar
ESP
ExAC
TOPMed
dbSNP
gnomAD
TCGA novel 468 N>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs2106118873 468 N>S No Ensembl
rs980508885 470 V>G No Ensembl
TCGA novel 470 V>G Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 476 V>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs766357479 478 Y>C No Ensembl
rs1303799779 483 Q>* No TOPMed
gnomAD
rs1303799779 483 Q>E No TOPMed
gnomAD
rs1303799779 483 Q>K No TOPMed
gnomAD
rs1167402539 484 N>D No gnomAD
rs774050484 485 E>D No ExAC
TOPMed
gnomAD
rs767504649 485 E>K No ExAC
gnomAD
rs368046283 486 R>Q No ESP
ExAC
TOPMed
gnomAD
TCGA novel 487 S>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1156866186 488 Y>C No TOPMed
gnomAD
rs1443433118 489 R>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
gnomAD
COSM1405752
COSM1405751
489 R>P Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs775171156 490 I>V No ExAC
TOPMed
gnomAD
rs1191568368 491 V>A No gnomAD
rs927390651 492 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs1690966051
COSM3838705
COSM173357
492 R>W Variant assessed as Somatic; MODERATE impact. large_intestine breast [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
Ensembl
rs184634347 494 A>T No 1000Genomes
ExAC
gnomAD
TCGA novel
rs780837109
495 A>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
ExAC
gnomAD
rs780837109 495 A>T No ExAC
gnomAD
rs757905726 497 N>D No ExAC
gnomAD
rs747496763 497 N>S No ExAC
gnomAD
rs1237246170 498 T>A No gnomAD
rs758747802 502 G>D No ExAC
gnomAD
COSM1405750 503 L>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1377489193 504 N>S No gnomAD
rs1312612580 505 P>A No gnomAD
TCGA novel 505 P>L Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1312612580 505 P>S No gnomAD
rs552992707 506 L>F No 1000Genomes
ExAC
gnomAD
rs552992707 506 L>V No 1000Genomes
ExAC
gnomAD
RCV002040032
rs2106117855
509 Y>C No ClinVar
Ensembl
dbSNP
rs1250926714 512 H>R No gnomAD
rs1427659031 513 V>M No TOPMed
gnomAD
rs1553572100 514 R>* No TOPMed
COSM3972043
COSM3972042
514 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1197783524 515 A>G No gnomAD
TCGA novel 518 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM1016976
COSM1016975
520 G>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1186891230 521 Y>C No TOPMed
gnomAD
rs1690962352 525 S>G No TOPMed
rs1690962224 526 E>V No Ensembl
TCGA novel 527 P>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1553572091 529 E>D No Ensembl
rs1690961418 531 T>A No Ensembl
rs775020442 531 T>K No ExAC
gnomAD
rs2106117784 532 T>I No Ensembl
rs868844423 534 T>A No gnomAD
rs762788015 535 V>A No ExAC
gnomAD
rs752604578 536 P>L No ExAC
TOPMed
gnomAD
rs752604578 536 P>R No ExAC
TOPMed
gnomAD
rs776382226 538 R>P No ExAC
TOPMed
gnomAD
rs776382226
COSM122865
COSM122866
538 R>Q upper_aerodigestive_tract [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs759284589 538 R>W No ExAC
TOPMed
gnomAD
rs556830861 540 I>T No 1000Genomes
ExAC
TOPMed
gnomAD
rs770567769 540 I>V No ExAC
TOPMed
gnomAD
rs1370326372 541 G>A No gnomAD
rs1690921142 542 D>V No gnomAD
rs772581007 543 G>A No ExAC
TOPMed
gnomAD
rs1449240150 544 A>V No gnomAD
rs1690920441 546 S>T No TOPMed
gnomAD
rs1690920013 547 T>I No gnomAD
rs1690920149 547 T>S No gnomAD
rs779294936 548 V>A No ExAC
TOPMed
gnomAD
rs779294936 548 V>D No ExAC
TOPMed
gnomAD
rs2106116869 548 V>I No Ensembl
COSM5134546 550 L>missing Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs768964879 554 S>L No ExAC
TOPMed
gnomAD
rs1183713443 557 V>A No gnomAD
rs1251795181 558 V>M No gnomAD
rs1458779447 560 V>A No gnomAD
COSM3695300
COSM3695301
560 V>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1178896117 560 V>L No gnomAD
COSM4091841
COSM4091842
563 L>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1248873615 564 I>V No gnomAD
TCGA novel 566 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1195527152 568 V>F No TOPMed
gnomAD
rs780185882 569 I>V No ExAC
gnomAD
rs756163696 570 S>R No ExAC
TOPMed
gnomAD
COSM3709447
COSM3709448
rs781128122
571 R>Q liver [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs371177966 571 R>W No ESP
ExAC
TOPMed
gnomAD
COSM5723643
COSM5723642
rs764646085
573 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
gnomAD
COSM4091840
COSM4091839
574 S>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
TCGA novel 574 S>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs997617273 577 S>T No gnomAD
COSM5109355 579 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1475171456 580 K>N No gnomAD
rs1690587950 581 Q>E No TOPMed
rs1264602413 581 Q>H No gnomAD
rs1690587779 583 A>T No gnomAD
rs1356824377 583 A>V No TOPMed
gnomAD
COSM476967
rs371063790
COSM476966
586 E>G kidney [Cosmic] No cosmic curated
ESP
ExAC
TOPMed
gnomAD
rs780293673 588 H>Q No TOPMed
rs770032654 588 H>Y No ExAC
TOPMed
gnomAD
COSM3045912
COSM3045913
592 G>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs911843392 592 G>V No TOPMed
rs1690499304 593 V>A No Ensembl
rs375822609 593 V>I No ESP
ExAC
TOPMed
gnomAD
rs1690499210 594 R>T No TOPMed
rs772225365 595 T>I No ExAC
gnomAD
rs1690498611 597 V>A No TOPMed
rs779793006 598 D>G No ExAC
gnomAD
TCGA novel 598 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs755954200 599 P>S No ExAC
gnomAD
rs755954200 599 P>T No ExAC
gnomAD
rs373017524 601 T>K No 1000Genomes
ESP
ExAC
gnomAD
rs373017524 601 T>M No 1000Genomes
ESP
ExAC
gnomAD
rs922888117 602 Y>D No TOPMed
rs1439654910 602 Y>S No gnomAD
rs750174534 603 E>K No ExAC
TOPMed
gnomAD
rs1158819805 604 D>V No TOPMed
gnomAD
COSM3578164
COSM3578165
605 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs934865278 607 Q>E No TOPMed
rs1690496887 608 A>G No Ensembl
rs1408714826 608 A>T No gnomAD
COSM3695299
COSM3695298
rs978543585
610 R>* Variant assessed as Somatic; HIGH impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
TOPMed
rs376651409 610 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
NCI-TCGA
TOPMed
gnomAD
rs757835718 613 A>T No ExAC
gnomAD
rs1479077799 614 K>R No gnomAD
rs1559242911 616 I>V No gnomAD
COSM3909679
COSM3909680
617 D>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1328946873 617 D>N No TOPMed
gnomAD
rs765720231 618 A>T No ExAC
TOPMed
gnomAD
rs1690495560 618 A>V No TOPMed
gnomAD
rs1443537232 619 S>F No TOPMed
gnomAD
rs760082018 619 S>P No ExAC
gnomAD
rs1443537232 619 S>Y No TOPMed
gnomAD
rs993030458 620 C>* No Ensembl
rs1329778859 620 C>G No TOPMed
rs1238575951 620 C>Y No gnomAD
rs1690494689 621 I>L No TOPMed
rs754191255 623 I>T No ExAC
TOPMed
gnomAD
TCGA novel 624 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs10498111 625 K>N No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
TCGA novel 625 K>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 626 V>L Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs773524736 627 I>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
gnomAD
rs1690493866 628 G>R No Ensembl
rs1349459325 629 V>A No gnomAD
COSM4826312
COSM4826313
634 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1574566652 636 C>Y No Ensembl
rs904777556 639 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
gnomAD
rs147566564
RCV001985262
639 R>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ClinVar
ESP
ExAC
NCI-TCGA
TOPMed
dbSNP
gnomAD
rs904777556 639 R>S No TOPMed
gnomAD
rs1690473468 641 K>R No Ensembl
rs1043256637 642 V>A No TOPMed
gnomAD
rs377053299 644 G>D No ESP
gnomAD
rs377053299 644 G>V No ESP
gnomAD
rs1574566617 646 R>S No Ensembl
rs1392603148 647 E>D No TOPMed
gnomAD
TCGA novel 648 I>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1255388465 648 I>V No gnomAD
rs1187109573 649 C>S No TOPMed
gnomAD
rs1187109573 649 C>Y No TOPMed
gnomAD
TCGA novel 651 A>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs2106105779 652 I>V No 1000Genomes
rs1690471892 653 K>T No Ensembl
rs2106105764 658 G>D No Ensembl
rs1690470673 659 Y>F No Ensembl
rs1690470590 660 T>A No TOPMed
COSM6090787
COSM6090786
664 R>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs975672638 666 D>G No Ensembl
rs759416479 667 F>L No ExAC
gnomAD
rs1463272908 669 S>R No gnomAD
rs1690470137 671 A>V No Ensembl
rs770725465 673 I>T No ExAC
TCGA novel 674 M>I Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1252090836 674 M>I No TOPMed
rs777537789 678 D>G No ExAC
gnomAD
rs1293269800 679 H>N No gnomAD
rs372198896 680 P>L No ESP
ExAC
TOPMed
gnomAD
rs372198896 680 P>R No ESP
ExAC
TOPMed
gnomAD
rs367921954 682 I>V No ESP
TOPMed
rs754610340
RCV001972268
684 H>R No ClinVar
ExAC
TOPMed
dbSNP
gnomAD
rs751025331 688 V>M No ExAC
gnomAD
rs751734937 695 V>L No ExAC
TOPMed
gnomAD
rs1332294584 698 I>V No gnomAD
COSM4420707
COSM4420708
699 T>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs764320268 700 E>D No ExAC
gnomAD
COSM6157341
COSM6157340
701 Y>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1296426407 702 M>V No gnomAD
rs758544317 703 E>D No ExAC
gnomAD
rs1461387354 703 E>G No TOPMed
gnomAD
COSM1692052
rs868069433
COSM1692051
703 E>K skin [Cosmic] No cosmic curated
Ensembl
rs1174899151 705 G>V No gnomAD
COSM1016971
COSM1016972
706 S>Y Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs752811601 709 A>S No ExAC
TOPMed
gnomAD
rs752811601 709 A>T No ExAC
TOPMed
gnomAD
rs746968633 710 F>L No TOPMed
rs1690263805 712 R>W No gnomAD
rs370645355 717 R>I No ESP
ExAC
TOPMed
gnomAD
rs1207145160 717 R>S No gnomAD
rs962061446 719 T>I No TOPMed
gnomAD
rs1690246342 724 V>G No TOPMed
rs2106099085 726 M>I No Ensembl
rs1014919480 726 M>K No TOPMed
gnomAD
rs1690245918 727 L>F No gnomAD
rs1690245918 727 L>I No gnomAD
COSM216558
COSM216557
rs376275374
728 R>C Variant assessed as Somatic; MODERATE impact. pancreas large_intestine endometrium breast [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs750370585 728 R>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs1166784898 729 G>S No TOPMed
gnomAD
rs1690245194 730 I>M No gnomAD
rs767546349 730 I>T No ExAC
gnomAD
rs751412916 734 M>T No ExAC
gnomAD
rs1382416246 735 K>T No TOPMed
gnomAD
rs1307216138 737 L>* No Ensembl
rs200282869 738 S>C No ESP
ExAC
TOPMed
gnomAD
COSM1016969
COSM1016970
738 S>P Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs762721061 739 D>G No ExAC
gnomAD
COSM4091836
COSM4091835
739 D>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1690244612 739 D>Y No TOPMed
rs775243880 740 M>V No ExAC
rs1176036722 741 S>G No TOPMed
gnomAD
rs1690244206 742 Y>* No TOPMed
rs769432864 742 Y>H No ExAC
TOPMed
gnomAD
rs1690244113 743 V>L No TOPMed
COSM3578161
COSM3578160
745 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
TCGA novel 745 R>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs898646182 747 L>R No Ensembl
rs1163445850 747 L>V No TOPMed
gnomAD
rs139589907 749 A>S No ESP
ExAC
TOPMed
gnomAD
rs139589907 749 A>T No ESP
ExAC
TOPMed
gnomAD
rs1340049984 749 A>V No TOPMed
gnomAD
rs771507400 750 R>W No ExAC
TOPMed
gnomAD
rs1690243162 754 V>A No TOPMed
TCGA novel 755 N>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1445335675 756 S>N No gnomAD
rs1261355406 758 L>F No gnomAD
rs1690242716 759 V>F No Ensembl
rs147794174 760 C>F No ESP
TOPMed
rs1271994410 761 K>N No TOPMed
gnomAD
TCGA novel 762 V>C Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs778222160 763 S>C No ExAC
TOPMed
gnomAD
rs778222160 763 S>F No ExAC
TOPMed
gnomAD
COSM3578156
COSM3578157
rs1218746876
764 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
TOPMed
COSM720564
COSM720565
765 F>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs543108757 766 G>V No 1000Genomes
ExAC
gnomAD
rs56159060 769 R>* No ExAC
TOPMed
gnomAD
rs755176786 769 R>Q No ExAC
gnomAD
rs1690241060 771 L>V No gnomAD
rs1432352843 772 E>D No gnomAD
COSM337101
COSM337102
773 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1324152290 774 D>H No TOPMed
gnomAD
rs1324152290 774 D>N No TOPMed
gnomAD
rs200730212 775 P>L No 1000Genomes
ExAC
TOPMed
gnomAD
rs1260836606 777 A>G No TOPMed
gnomAD
rs200518563 778 A>V No Ensembl
TCGA novel 779 Y>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1690239618 781 T>A No TOPMed
rs1369769739 783 G>S No TOPMed
gnomAD
COSM1405746
COSM1405745
784 G>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs904937574 785 K>N No Ensembl
rs1690164810 787 P>S No TOPMed
rs1690164569 788 I>N No Ensembl
rs1690164647 788 I>V No TOPMed
rs199606862 789 R>L No 1000Genomes
ExAC
TOPMed
gnomAD
rs199606862 789 R>Q No 1000Genomes
ExAC
TOPMed
gnomAD
rs1690164481
TCGA novel
789 R>W Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
Ensembl
COSM6090789
COSM6090788
790 W>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs760041934 791 T>A No ExAC
gnomAD
rs772762078 792 A>E No ExAC
TOPMed
gnomAD
rs772762078 792 A>G No ExAC
TOPMed
gnomAD
rs2106096655 792 A>P No Ensembl
TCGA novel 793 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
COSM1016967
COSM1016968
795 A>T Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1206570737 797 A>V No gnomAD
TCGA novel
rs1690163499
799 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
rs914099718
COSM1251291
COSM1251290
799 R>H Variant assessed as Somatic; MODERATE impact. oesophagus [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
TOPMed
gnomAD
rs1690163243 804 A>G No TOPMed
rs1429208033 804 A>T No gnomAD
COSM4852227
rs1273295450
COSM4852228
805 S>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
NCI-TCGA
TOPMed
gnomAD
COSM1614427
COSM1614426
809 S>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1297542266 812 I>V No TOPMed
rs775509386 813 V>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
gnomAD
rs769931238 814 M>T No ExAC
gnomAD
rs1690162639 814 M>V No TOPMed
rs1218233138 815 W>L No gnomAD
rs1690162269 818 M>I No TOPMed
gnomAD
COSM1016965
rs781417898
COSM1016966
819 S>L Variant assessed as Somatic; MODERATE impact. endometrium [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
ExAC
NCI-TCGA
gnomAD
rs1350485081 820 Y>C No TOPMed
gnomAD
COSM1405744
rs1436714812
COSM1405743
821 G>R Variant assessed as Somatic; MODERATE impact. large_intestine [NCI-TCGA, Cosmic] No NCI-TCGA Cosmic
cosmic curated
NCI-TCGA
gnomAD
COSM6090790
COSM6090791
821 G>W Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs887747697 822 E>D No gnomAD
rs754661415 823 R>K No ExAC
TOPMed
gnomAD
rs754661415 823 R>T No ExAC
TOPMed
gnomAD
rs374909341 826 W>* No ESP
COSM3578153
COSM3578152
827 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1690161099 828 M>I No Ensembl
rs923374395 828 M>V No TOPMed
COSM4091831
COSM4091832
829 S>P Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1424977340 829 S>Y No gnomAD
rs766001735 830 N>H No ExAC
gnomAD
rs1690160787 831 Q>K No TOPMed
rs1690160714 831 Q>R No TOPMed
rs1421658409 833 V>A No TOPMed
rs1690029458 834 I>M No TOPMed
rs1690029328 837 I>V No TOPMed
TCGA novel 838 E>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1690029067 839 E>G No TOPMed
TCGA novel 839 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1180843498 840 G>D No gnomAD
rs779866081 842 R>L No ExAC
TOPMed
gnomAD
rs779866081 842 R>Q No ExAC
TOPMed
gnomAD
rs560055932
COSM210116
842 R>W large_intestine [Cosmic] No cosmic curated
ExAC
gnomAD
rs1574555246 843 L>F No Ensembl
COSM3909675
COSM3909676
844 P>L Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1385989739 844 P>R No TOPMed
rs780716002 844 P>T No ExAC
gnomAD
RCV001978346
rs752075336
845 P>A No ClinVar
ExAC
TOPMed
dbSNP
gnomAD
rs1690027812 845 P>L No gnomAD
COSM3578151
rs752075336
COSM3578150
845 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
TOPMed
gnomAD
rs752075336 845 P>T No ExAC
TOPMed
gnomAD
COSM5106516 846 P>S Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1215288334 847 M>V No gnomAD
rs1690027586 848 D>N No TOPMed
rs1308099274 851 I>L No TOPMed
gnomAD
rs1212957127 851 I>M No TOPMed
gnomAD
rs764568007 851 I>T No ExAC
TOPMed
gnomAD
rs1308099274 851 I>V No TOPMed
gnomAD
rs1326256676 855 Q>* No gnomAD
rs1326256676 855 Q>K No gnomAD
COSM1016964
COSM1016963
857 M>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs2106092371 857 M>L No Ensembl
rs1056023957 859 D>G No TOPMed
rs776926049 860 C>G No ExAC
gnomAD
rs1690026382 860 C>Y No Ensembl
rs771148130 863 K>T No ExAC
gnomAD
rs773418289 864 E>G No ExAC
gnomAD
rs1464119769 865 R>K No TOPMed
gnomAD
rs749224993 866 S>N No ExAC
TOPMed
gnomAD
COSM1016961
COSM1016962
867 D>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs745528063 867 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
rs745528063 867 D>Y No ExAC
TOPMed
gnomAD
TCGA novel 868 R>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs780769305
COSM4133514
COSM4133515
869 P>A thyroid [Cosmic] No cosmic curated
ExAC
TOPMed
gnomAD
rs780769305 869 P>S No ExAC
TOPMed
gnomAD
rs756889351 871 F>S No ExAC
gnomAD
rs756889351 871 F>Y No ExAC
gnomAD
rs868613699 872 G>V No Ensembl
rs751138156 876 N>K No ExAC
TOPMed
gnomAD
rs1293446223 877 M>V No gnomAD
rs1409366211 878 L>W No gnomAD
TCGA novel 879 D>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1690024791 880 K>R No Ensembl
rs777306913 881 L>F No ExAC
gnomAD
rs142296640 883 R>C Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ESP
ExAC
NCI-TCGA
TOPMed
gnomAD
rs765523420 883 R>H Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
TOPMed
gnomAD
TCGA novel 883 R>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1388271957 884 N>D No TOPMed
gnomAD
rs1292899369 884 N>I No gnomAD
rs1292899369 884 N>S No gnomAD
rs755335356 885 P>L No ExAC
TOPMed
gnomAD
rs755335356 885 P>R No ExAC
TOPMed
gnomAD
rs1690023641 886 N>S No TOPMed
rs1574555040 887 S>R No Ensembl
rs754240886 889 K>R No ExAC
gnomAD
rs1690023294 890 R>G No TOPMed
gnomAD
rs374390918 890 R>T No ESP
ExAC
TOPMed
gnomAD
COSM256189
COSM256190
891 T>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1448349123 891 T>S No gnomAD
rs1395369294 892 G>E No gnomAD
rs1294073843 893 T>A No TOPMed
rs142860268
RCV001887600
893 T>M No ClinVar
1000Genomes
ExAC
TOPMed
dbSNP
gnomAD
rs1294073843 893 T>S No TOPMed
rs767587519 895 S>I No ExAC
TOPMed
gnomAD
rs760466873 895 S>R No TOPMed
gnomAD
rs767587519 895 S>T No ExAC
TOPMed
gnomAD
COSM6157342
COSM6157343
896 S>= Variant assessed as Somatic; LOW impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1689919724 898 P>L No gnomAD
rs61731200
RCV000964895
899 N>K No ClinVar
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs759439482 900 T>I No ExAC
TOPMed
gnomAD
rs759439482 900 T>N No ExAC
TOPMed
gnomAD
rs1689918963 901 A>T No TOPMed
rs1158764547 901 A>V No TOPMed
gnomAD
TCGA novel
rs2106089212
903 L>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
Ensembl
rs1689918329 904 D>H No Ensembl
COSM1631860
COSM1631861
904 D>N Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1689918056 905 P>R No gnomAD
TCGA novel 905 P>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs377085774 905 P>T No ESP
ExAC
TOPMed
gnomAD
rs1689917918 906 S>N No Ensembl
rs772862033 907 S>C No ExAC
gnomAD
rs1689917491 908 P>R No Ensembl
COSM1692048
COSM1692047
909 E>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs868141918 911 S>F No Ensembl
RCV002031457
rs1689917240
912 A>missing No ClinVar
dbSNP
rs771609248 913 V>A No ExAC
gnomAD
rs1441906445 913 V>M No gnomAD
rs1207092426 914 V>L No gnomAD
rs778250722 915 S>L No ExAC
gnomAD
rs1227712057 917 G>A No gnomAD
rs780599857 918 D>N No ExAC
TOPMed
gnomAD
rs780599857 918 D>Y No ExAC
TOPMed
gnomAD
TCGA novel 919 W>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1242040961 919 W>L No gnomAD
COSM4397735
COSM4397736
920 L>F Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
COSM1016959
COSM1016960
920 L>P Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs2106089119 921 Q>* No Ensembl
rs1574552530 921 Q>P No Ensembl
rs1689915934 922 A>V No Ensembl
rs1339336870 923 I>T No gnomAD
rs1689915858 923 I>V No Ensembl
rs1689915615
TCGA novel
924 K>E Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TOPMed
rs1237562136 925 M>T No TOPMed
gnomAD
COSM4843829
rs750627059
COSM4843830
927 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ExAC
NCI-TCGA
TOPMed
gnomAD
rs569400142 927 R>W No ExAC
TOPMed
gnomAD
rs2106089087
RCV001892730
928 Y>C No ClinVar
Ensembl
dbSNP
rs781538913 930 D>N No ExAC
TOPMed
gnomAD
rs1468078506 930 D>V No TOPMed
rs1462291653 931 N>K No gnomAD
COSM4091829
COSM4091830
932 F>V Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs150029140 934 A>G No ESP
ExAC
TOPMed
gnomAD
rs764137404 935 A>V No ExAC
TOPMed
gnomAD
rs1295241749 936 G>S No gnomAD
rs1689913828 940 L>I No TOPMed
gnomAD
rs1689913747 941 E>A No TOPMed
gnomAD
rs753706663 943 V>A No ExAC
gnomAD
rs753706663 943 V>G No ExAC
gnomAD
RCV001979527
rs560424392
945 H>Q No ClinVar
1000Genomes
ExAC
TOPMed
dbSNP
gnomAD
COSM32815 948 Q>* Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs775135616 950 D>N No ExAC
gnomAD
rs76959649 952 A>E No Ensembl
rs1310363964 952 A>P No gnomAD
TCGA novel
rs1689898687
953 R>G Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
gnomAD
VAR_049721
rs35341687
953 R>K No UniProt
ExAC
TOPMed
dbSNP
gnomAD
rs35341687
RCV002046534
953 R>T No ClinVar
ExAC
TOPMed
dbSNP
gnomAD
rs1174520420 954 I>T No gnomAD
rs1369980968 954 I>V No gnomAD
COSM4091828
COSM4091827
955 G>D Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1689897780 957 T>I No TOPMed
rs771163279 957 T>P No ExAC
gnomAD
rs1689897530 958 A>V No Ensembl
rs747243818 959 I>V No ExAC
TOPMed
gnomAD
rs1689896933 960 T>A No Ensembl
rs748264251 960 T>M Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No ExAC
NCI-TCGA
gnomAD
rs750286180 961 H>Y No ExAC
gnomAD
TCGA novel 962 Q>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
TCGA novel 963 N>K Variant assessed as Somatic; HIGH impact. [NCI-TCGA] No NCI-TCGA
rs1689896266 963 N>S No TOPMed
TCGA novel 967 S>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs2106088567 967 S>R No Ensembl
rs376541020 968 S>R No ESP
ExAC
TOPMed
gnomAD
TCGA novel 971 A>S Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1425015958 972 M>I No TOPMed
rs757397148 972 M>T No TOPMed
gnomAD
rs202216669 973 R>* No 1000Genomes
ExAC
TOPMed
gnomAD
rs140023331 973 R>L No ESP
ExAC
gnomAD
COSM5514912
COSM5514913
rs140023331
973 R>Q Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
ESP
ExAC
NCI-TCGA
gnomAD
rs141897098
RCV001959442
974 T>I No ClinVar
ESP
ExAC
TOPMed
dbSNP
gnomAD
COSM1016955
COSM1016956
976 M>I Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA Cosmic
rs1689894452 976 M>T No Ensembl
rs1689894026 978 Q>H No TOPMed
rs764606763 980 H>L No ExAC
rs373468133 980 H>Q No ESP
ExAC
TOPMed
gnomAD
rs138231669 981 G>S No ESP
ExAC
gnomAD
TCGA novel 982 R>K Variant assessed as Somatic; MODERATE impact. [NCI-TCGA] No NCI-TCGA
rs1559234426 983 M>I No Ensembl
rs747438072 984 V>F No ExAC
TOPMed
gnomAD
rs747438072 984 V>I No ExAC
TOPMed
gnomAD
rs141387215 986 V>F No 1000Genomes
ESP
ExAC
TOPMed
gnomAD
RCV001863492
rs141387215
986 V>I No ClinVar
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs779080753 987 V>C No ExAC
TOPMed
gnomAD
rs779080753 987 V>W No ExAC
TOPMed
gnomAD

No associated diseases with P54764

15 regional properties for P54764

Type Name Position InterPro Accession
domain Protein kinase domain 621 - 882 IPR000719
domain Ephrin receptor ligand binding domain 30 - 209 IPR001090
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 621 - 878 IPR001245
conserved_site Tyrosine-protein kinase, receptor class V, conserved site 185 - 205 IPR001426-1
conserved_site Tyrosine-protein kinase, receptor class V, conserved site 247 - 267 IPR001426-2
domain Sterile alpha motif domain 908 - 975 IPR001660
domain Fibronectin type III 328 - 439 IPR003961-1
domain Fibronectin type III 440 - 537 IPR003961-2
active_site Tyrosine-protein kinase, active site 742 - 754 IPR008266
domain Tyrosine-protein kinase ephrin type A/B receptor-like 269 - 306 IPR011641
binding_site Protein kinase, ATP binding site 627 - 653 IPR017441
domain Tyrosine-protein kinase, catalytic domain 621 - 878 IPR020635
domain Ephrin receptor, transmembrane domain 550 - 618 IPR027936
domain Ephrin type-A receptor 4, SAM domain 911 - 981 IPR030602
domain Ephrin type-A receptor 4, ligand binding domain 30 - 203 IPR034270

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Cell projection, axon
  • Cell projection, dendrite
  • Postsynaptic density membrane
  • Early endosome
  • Cell junction, adherens junction
  • Clustered upon activation and targeted to early endosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

19 GO annotations of cellular component

Name Definition
adherens junction A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
axon terminus Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
axonal growth cone The migrating motile tip of a growing nerve cell axon.
cell surface The external part of the cell wall and/or plasma membrane.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
dendritic shaft Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
early endosome membrane The lipid bilayer surrounding an early endosome.
filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
mitochondrial outer membrane The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
neuromuscular junction The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
perikaryon The portion of the cell soma (neuronal cell body) that excludes the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynaptic density membrane The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.
presynaptic membrane A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
Schaffer collateral - CA1 synapse A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.

12 GO annotations of molecular function

Name Definition
amyloid-beta binding Binding to an amyloid-beta peptide/protein.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DH domain binding Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.
ephrin receptor binding Binding to an ephrin receptor.
GPI-linked ephrin receptor activity Combining with a GPI-anchored ephrin to initiate a change in cell activity.
identical protein binding Binding to an identical protein or proteins.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
PH domain binding Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction
protein tyrosine kinase activity Catalysis of the reaction
protein tyrosine kinase binding Binding to protein tyrosine kinase.
transmembrane-ephrin receptor activity Combining with a transmembrane ephrin to initiate a change in cell activity.

43 GO annotations of biological process

Name Definition
adherens junction organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
adult walking behavior The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
cellular response to amyloid-beta Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
cochlea development The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.
corticospinal tract morphogenesis Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.
ephrin receptor signaling pathway The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
fasciculation of motor neuron axon The collection of motor neuron axons into a bundle of rods, known as a fascicle.
fasciculation of sensory neuron axon The collection of sensory neuron axons into a bundle of rods, known as a fascicle.
glial cell migration The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
motor neuron axon guidance The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
negative regulation of axon regeneration Any process that stops, prevents, or reduces the frequency, rate or extent of axon regeneration.
negative regulation of cell adhesion Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
negative regulation of cell migration Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
negative regulation of cellular response to hypoxia Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to hypoxia.
negative regulation of epithelial to mesenchymal transition Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
negative regulation of ERK1 and ERK2 cascade Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
negative regulation of long-term synaptic potentiation Any process that stops, prevents or reduces the frequency, rate or extent of long-term synaptic potentiation.
negative regulation of neuron projection development Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
negative regulation of proteolysis involved in protein catabolic process Any process that stops, prevents or reduces the frequency, rate or extent of proteolysis involved in protein catabolic process.
negative regulation of translation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
nephric duct morphogenesis The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney.
neuron projection fasciculation The collection of neuronal projections into a bundle of rods, known as a fascicle.
neuron projection guidance The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
peptidyl-tyrosine phosphorylation The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
positive regulation of amyloid-beta formation Any process that activates or increases the frequency, rate or extent of amyloid-beta formation.
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process.
positive regulation of cell adhesion Any process that activates or increases the frequency, rate or extent of cell adhesion.
positive regulation of cell migration Any process that activates or increases the frequency, rate or extent of cell migration.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of dendrite morphogenesis Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.
positive regulation of protein tyrosine kinase activity Any process that increases the rate, frequency, or extent of protein tyrosine kinase activity.
positive regulation of Rho guanyl-nucleotide exchange factor activity Any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
regulation of astrocyte differentiation Any process that modulates the frequency, rate or extent of astrocyte differentiation.
regulation of axonogenesis Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
regulation of dendritic spine morphogenesis Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.
regulation of modification of synaptic structure Any process that modulates the frequency, rate or extent of modification of synaptic structure.
regulation of synapse pruning Any process that modulates the frequency, rate or extent of synapse pruning.
synapse pruning A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.

49 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P28693 EPHB2 Ephrin type-B receptor 2 Gallus gallus (Chicken) PR
Q07494 EPHB1 Ephrin type-B receptor 1 Gallus gallus (Chicken) SS
Q07497 EPHB5 Ephrin type-B receptor 5 Gallus gallus (Chicken) PR
P29318 EPHA3 Ephrin type-A receptor 3 Gallus gallus (Chicken) SS
O42422 EPHA7 Ephrin type-A receptor 7 Gallus gallus (Chicken) SS
P54755 EPHA5 Ephrin type-A receptor 5 Gallus gallus (Chicken) SS
Q07498 EPHB3 Ephrin type-B receptor 3 Gallus gallus (Chicken) SS
Q07496 EPHA4 Ephrin type-A receptor 4 Gallus gallus (Chicken) SS
P0C0K6 EPHB6 Ephrin type-B receptor 6 Pan troglodytes (Chimpanzee) SS
P21709 EPHA1 Ephrin type-A receptor 1 Homo sapiens (Human) SS
P54760 EPHB4 Ephrin type-B receptor 4 Homo sapiens (Human) SS
P29317 EPHA2 Ephrin type-A receptor 2 Homo sapiens (Human) SS
Q15375 EPHA7 Ephrin type-A receptor 7 Homo sapiens (Human) SS
P54756 EPHA5 Ephrin type-A receptor 5 Homo sapiens (Human) SS
Q9UF33 EPHA6 Ephrin type-A receptor 6 Homo sapiens (Human) SS
P54762 EPHB1 Ephrin type-B receptor 1 Homo sapiens (Human) SS
P29322 EPHA8 Ephrin type-A receptor 8 Homo sapiens (Human) SS
P29320 EPHA3 Ephrin type-A receptor 3 Homo sapiens (Human) PR
P54753 EPHB3 Ephrin type-B receptor 3 Homo sapiens (Human) SS
Q5JZY3 EPHA10 Ephrin type-A receptor 10 Homo sapiens (Human) SS
O15197 EPHB6 Ephrin type-B receptor 6 Homo sapiens (Human) SS
P29323 EPHB2 Ephrin type-B receptor 2 Homo sapiens (Human) EV
P54754 Ephb3 Ephrin type-B receptor 3 Mus musculus (Mouse) SS
Q03145 Epha2 Ephrin type-A receptor 2 Mus musculus (Mouse) PR
Q61772 Epha7 Ephrin type-A receptor 7 Mus musculus (Mouse) SS
O09127 Epha8 Ephrin type-A receptor 8 Mus musculus (Mouse) SS
Q8CBF3 Ephb1 Ephrin type-B receptor 1 Mus musculus (Mouse) SS
Q8BYG9 Epha10 Ephrin type-A receptor 10 Mus musculus (Mouse) SS
Q60629 Epha5 Ephrin type-A receptor 5 Mus musculus (Mouse) SS
P29319 Epha3 Ephrin type-A receptor 3 Mus musculus (Mouse) SS
Q62413 Epha6 Ephrin type-A receptor 6 Mus musculus (Mouse) SS
Q60750 Epha1 Ephrin type-A receptor 1 Mus musculus (Mouse) SS
P54763 Ephb2 Ephrin type-B receptor 2 Mus musculus (Mouse) SS
P54761 Ephb4 Ephrin type-B receptor 4 Mus musculus (Mouse) PR
O08644 Ephb6 Ephrin type-B receptor 6 Mus musculus (Mouse) PR
Q03137 Epha4 Ephrin type-A receptor 4 Mus musculus (Mouse) SS
P54757 Epha5 Ephrin type-A receptor 5 Rattus norvegicus (Rat) SS
P54759 Epha7 Ephrin type-A receptor 7 Rattus norvegicus (Rat) SS
P09759 Ephb1 Ephrin type-B receptor 1 Rattus norvegicus (Rat) SS
P0C0K7 Ephb6 Ephrin type-B receptor 6 Rattus norvegicus (Rat) SS
O08680 Epha3 Ephrin type-A receptor 3 Rattus norvegicus (Rat) SS
O61460 vab-1 Ephrin receptor 1 Caenorhabditis elegans SS
Q8RWZ5 SD25 G-type lectin S-receptor-like serine/threonine-protein kinase SD2-5 Arabidopsis thaliana (Mouse-ear cress) PR
Q94AG2 SERK1 Somatic embryogenesis receptor kinase 1 Arabidopsis thaliana (Mouse-ear cress) PR
Q3E991 PRK6 Pollen receptor-like kinase 6 Arabidopsis thaliana (Mouse-ear cress) PR
Q9FXF2 RKF1 Probable LRR receptor-like serine/threonine-protein kinase RFK1 Arabidopsis thaliana (Mouse-ear cress) PR
O13147 ephb3 Ephrin type-B receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
O73878 ephb4b Ephrin type-B receptor 4b Danio rerio (Zebrafish) (Brachydanio rerio) SS
O13146 epha3 Ephrin type-A receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MAGIFYFALF SCLFGICDAV TGSRVYPANE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM
70 80 90 100 110 120
DEKNTPIRTY QVCNVMEPSQ NNWLRTDWIT REGAQRVYIE IKFTLRDCNS LPGVMGTCKE
130 140 150 160 170 180
TFNLYYYESD NDKERFIREN QFVKIDTIAA DESFTQVDIG DRIMKLNTEI RDVGPLSKKG
190 200 210 220 230 240
FYLAFQDVGA CIALVSVRVF YKKCPLTVRN LAQFPDTITG ADTSSLVEVR GSCVNNSEEK
250 260 270 280 290 300
DVPKMYCGAD GEWLVPIGNC LCNAGHEERS GECQACKIGY YKALSTDATC AKCPPHSYSV
310 320 330 340 350 360
WEGATSCTCD RGFFRADNDA ASMPCTRPPS APLNLISNVN ETSVNLEWSS PQNTGGRQDI
370 380 390 400 410 420
SYNVVCKKCG AGDPSKCRPC GSGVHYTPQQ NGLKTTKVSI TDLLAHTNYT FEIWAVNGVS
430 440 450 460 470 480
KYNPNPDQSV SVTVTTNQAA PSSIALVQAK EVTRYSVALA WLEPDRPNGV ILEYEVKYYE
490 500 510 520 530 540
KDQNERSYRI VRTAARNTDI KGLNPLTSYV FHVRARTAAG YGDFSEPLEV TTNTVPSRII
550 560 570 580 590 600
GDGANSTVLL VSVSGSVVLV VILIAAFVIS RRRSKYSKAK QEADEEKHLN QGVRTYVDPF
610 620 630 640 650 660
TYEDPNQAVR EFAKEIDASC IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT
670 680 690 700 710 720
DKQRRDFLSE ASIMGQFDHP NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV
730 740 750 760 770 780
IQLVGMLRGI GSGMKYLSDM SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT
790 800 810 820 830 840
TRGGKIPIRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG
850 860 870 880 890 900
YRLPPPMDCP IALHQLMLDC WQKERSDRPK FGQIVNMLDK LIRNPNSLKR TGTESSRPNT
910 920 930 940 950 960
ALLDPSSPEF SAVVSVGDWL QAIKMDRYKD NFTAAGYTTL EAVVHVNQED LARIGITAIT
970 980
HQNKILSSVQ AMRTQMQQMH GRMVPV