P54759
SS
Gene name |
Epha7 (Ehk-3, Ehk3) |
Protein name |
Ephrin type-A receptor 7 |
Names |
EC 2.7.10.1 , EPH homology kinase 3 , EHK-3 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:171287 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.
Autoinhibitory domains (AIDs)
Target domain |
633-894 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
775-801 (Activation loop from InterPro)
Target domain |
633-894 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for P54759
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P54759-F1 | Predicted | AlphaFoldDB |
No variants for P54759
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P54759 | |||||
No associated diseases with P54759
13 regional properties for P54759
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 633 - 894 | IPR000719 |
| domain | Ephrin receptor ligand binding domain | 32 - 210 | IPR001090 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 633 - 888 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class V, conserved site | 186 - 206 | IPR001426-1 |
| conserved_site | Tyrosine-protein kinase, receptor class V, conserved site | 250 - 270 | IPR001426-2 |
| domain | Sterile alpha motif domain | 920 - 987 | IPR001660 |
| domain | Fibronectin type III | 331 - 441 | IPR003961-1 |
| domain | Fibronectin type III | 442 - 537 | IPR003961-2 |
| active_site | Tyrosine-protein kinase, active site | 754 - 766 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 639 - 665 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 633 - 890 | IPR020635 |
| domain | Ephrin receptor, transmembrane domain | 560 - 630 | IPR027936 |
| domain | Ephrin type-A receptor 7, ligand binding domain | 30 - 206 | IPR034283 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
10 GO annotations of cellular component
| Name | Definition |
|---|---|
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| glutamatergic synapse | A synapse that uses glutamate as a neurotransmitter. |
| hippocampal mossy fiber to CA3 synapse | One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell. |
| neuromuscular junction | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. |
| neuronal cell body | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| postsynaptic density membrane | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. |
| postsynaptic membrane | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. |
| postsynaptic specialization membrane | The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. |
| Schaffer collateral - CA1 synapse | A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. |
9 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| axon guidance receptor activity | Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. |
| chemorepellent activity | Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. |
| ephrin receptor activity | Combining with an ephrin receptor ligand to initiate a change in cell activity. |
| ephrin receptor binding | Binding to an ephrin receptor. |
| GPI-linked ephrin receptor activity | Combining with a GPI-anchored ephrin to initiate a change in cell activity. |
| growth factor binding | Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. |
| protein tyrosine kinase activity | Catalysis of the reaction |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
21 GO annotations of biological process
| Name | Definition |
|---|---|
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| branching morphogenesis of a nerve | The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron). |
| ephrin receptor signaling pathway | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| modulation of chemical synaptic transmission | Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. |
| negative chemotaxis | The directed movement of a motile cell or organism towards a lower concentration of a chemical. |
| negative regulation of collateral sprouting | Any process that stops, prevents, or reduces the frequency, rate or extent of collateral sprouting. |
| negative regulation of synapse assembly | Any process that stops, prevents, or reduces the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. |
| nephric duct morphogenesis | The process in which the anatomical structures of the nephric duct are generated and organized. A nephric duct is a tube that drains a primitive kidney. |
| neuron apoptotic process | Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| positive regulation of apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. |
| positive regulation of neuron apoptotic process | Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. |
| positive regulation of protein phosphorylation | Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. |
| regulation of cell-cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process | Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis. |
| regulation of ERK1 and ERK2 cascade | Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| regulation of peptidyl-tyrosine phosphorylation | Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. |
| regulation of postsynapse organization | Any process that modulates the physical form of a postsynapse. |
| regulation of protein autophosphorylation | Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues. |
| retinal ganglion cell axon guidance | The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. |
52 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| O15197 | EPHB6 | Ephrin type-B receptor 6 | Homo sapiens (Human) | SS |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| P54754 | Ephb3 | Ephrin type-B receptor 3 | Mus musculus (Mouse) | SS |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q03137 | Epha4 | Ephrin type-A receptor 4 | Mus musculus (Mouse) | SS |
| O09127 | Epha8 | Ephrin type-A receptor 8 | Mus musculus (Mouse) | SS |
| Q8CBF3 | Ephb1 | Ephrin type-B receptor 1 | Mus musculus (Mouse) | SS |
| Q8BYG9 | Epha10 | Ephrin type-A receptor 10 | Mus musculus (Mouse) | SS |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| P29319 | Epha3 | Ephrin type-A receptor 3 | Mus musculus (Mouse) | SS |
| Q62413 | Epha6 | Ephrin type-A receptor 6 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54763 | Ephb2 | Ephrin type-B receptor 2 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| O08644 | Ephb6 | Ephrin type-B receptor 6 | Mus musculus (Mouse) | PR |
| Q61772 | Epha7 | Ephrin type-A receptor 7 | Mus musculus (Mouse) | SS |
| P54757 | Epha5 | Ephrin type-A receptor 5 | Rattus norvegicus (Rat) | SS |
| P09759 | Ephb1 | Ephrin type-B receptor 1 | Rattus norvegicus (Rat) | SS |
| O08680 | Epha3 | Ephrin type-A receptor 3 | Rattus norvegicus (Rat) | SS |
| P0C0K7 | Ephb6 | Ephrin type-B receptor 6 | Rattus norvegicus (Rat) | SS |
| O61460 | vab-1 | Ephrin receptor 1 | Caenorhabditis elegans | SS |
| Q3E8W4 | ANX2 | Receptor-like protein kinase ANXUR2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FLW0 | At5g24010 | Probable receptor-like protein kinase At5g24010 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M345 | LECRK42 | L-type lectin-domain containing receptor kinase IV.2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SCZ4 | FER | Receptor-like protein kinase FERONIA | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVVQTRYPSW | IILCYIWLLG | FAHTGEAQAA | KEVLLLDSKA | QQTELEWISS | PPSGWEEISG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LDENYTPIRT | YQVCQVMEPN | QNNWLRTNWI | SKGNAQRIFV | ELKFTLRDCN | SLPGVLGTCK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETFNLYYYET | DYDTGRNIRE | NLYVKIDTIA | ADESFTQGDL | GERKMKLNTE | VREIGPLSKK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GFYLAFQDVG | ACIALVSVKV | YYKKCWSIIE | NLAVFPDTVT | GSEFSSLVEV | RGTCVSSAEE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EAENSPRMHC | SAEGEWLVPI | GKCICKAGYQ | QKGDTCEPCG | RRFYKSSSQD | LQCSRCPTHS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FSDREGSSRC | ECEDGYYRAP | SDPPYVACTR | PPSAPQNLIF | NINQTTVSLE | WSPPADNGGR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NDVTYRILCK | RCSWEQGECV | PCGSNIGYMP | QQTGLEDNYV | TVMDLLAHAN | YTFEVEAVNG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VSDLSRSQRL | FAAVSITTGQ | AAPSQVSGVM | KERVLQRSVE | LSWQEPEHPN | GVITEYEIKY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YEKDQRERTY | STLKTKSTSA | SINNLKPGTV | YVFQIRAFTA | AGYGNYSPRL | DVATLEEASG |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KMFEATAVSS | EQNPVIIIAV | VAVAGTIILV | FMVFGFIIGR | RHCGYSKADQ | EGDEELYFHF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KFPGTKTYID | PETYEDPNRA | VHQFAKELDA | SCIKIERVIG | AGEFGEVCSG | RLKLPGKRDV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| AVAIKTLKVG | YTEKQRRDFL | CEASIMGQFD | HPNVVHLEGV | VTRGKPVMIV | IEFMENGALD |
| 730 | 740 | 750 | 760 | 770 | 780 |
| AFLRKHDGQF | TVIQLVGMLR | GIAAGMRYLA | DMGYVHRDLA | ARNILVNSNL | VCKVSDFGLS |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RVIEDDPEAV | YTTTGGKIPV | RWTAPEAIQY | RKFTSASDVW | SYGIVMWEVM | SYGERPYWDM |
| 850 | 860 | 870 | 880 | 890 | 900 |
| SNQDVIKAIE | EGYRLPAPMD | CPAGLHQLML | DCWQKERAER | PKFEQIVGIL | DKMIRNPSSL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| KTPLGTCSRP | ISPLLDQSTP | DFTAFCSVGE | WLQAIKMERY | KDNFTAAGYN | SLESVARMTI |
| 970 | 980 | 990 | |||
| DDVMSLGITL | VGHQKKIMSS | IQTMRAQMLH | LHGTGIQV |