P54755

SS
Gene name
EPHA5 (CEK7)
Protein name
Ephrin type-A receptor 5
Names
EC 2.7.10.1 , EPH-like kinase 7 , EK7 , cEK7
Species
Gallus gallus (Chicken)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.

Autoinhibitory domains (AIDs)

625-651 (Juxtamembrane domain) SS

Target domain

651-912 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

793-819 (Activation loop from InterPro)

Target domain

651-912 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P54755

Entry ID Method Resolution Chain Position Source
AF-P54755-F1 Predicted AlphaFoldDB

No variants for P54755

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P54755

No associated diseases with P54755

12 regional properties for P54755

Type Name Position InterPro Accession
domain Protein kinase domain 651 - 912 IPR000719
domain Ephrin receptor ligand binding domain 36 - 214 IPR001090
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 651 - 908 IPR001245
conserved_site Tyrosine-protein kinase, receptor class V, conserved site 190 - 210 IPR001426-1
conserved_site Tyrosine-protein kinase, receptor class V, conserved site 252 - 272 IPR001426-2
domain Sterile alpha motif domain 938 - 1005 IPR001660
domain Fibronectin type III 333 - 443 IPR003961-1
domain Fibronectin type III 444 - 538 IPR003961-2
active_site Tyrosine-protein kinase, active site 772 - 784 IPR008266
binding_site Protein kinase, ATP binding site 657 - 683 IPR017441
domain Tyrosine-protein kinase, catalytic domain 651 - 908 IPR020635
domain Ephrin receptor, transmembrane domain 551 - 648 IPR027936

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Cell projection, axon
  • Cell projection, dendrite
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
dendrite A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GPI-linked ephrin receptor activity Combining with a GPI-anchored ephrin to initiate a change in cell activity.
transmembrane-ephrin receptor activity Combining with a transmembrane ephrin to initiate a change in cell activity.

6 GO annotations of biological process

Name Definition
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
ephrin receptor signaling pathway The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
hippocampus development The progression of the hippocampus over time from its initial formation until its mature state.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of GTPase activity Any process that modulates the rate of GTP hydrolysis by a GTPase.

52 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q07494 EPHB1 Ephrin type-B receptor 1 Gallus gallus (Chicken) SS
O42422 EPHA7 Ephrin type-A receptor 7 Gallus gallus (Chicken) SS
P28693 EPHB2 Ephrin type-B receptor 2 Gallus gallus (Chicken) PR
P29318 EPHA3 Ephrin type-A receptor 3 Gallus gallus (Chicken) SS
Q07496 EPHA4 Ephrin type-A receptor 4 Gallus gallus (Chicken) SS
Q07497 EPHB5 Ephrin type-B receptor 5 Gallus gallus (Chicken) PR
Q07498 EPHB3 Ephrin type-B receptor 3 Gallus gallus (Chicken) SS
P0C0K6 EPHB6 Ephrin type-B receptor 6 Pan troglodytes (Chimpanzee) SS
P29322 EPHA8 Ephrin type-A receptor 8 Homo sapiens (Human) SS
P21709 EPHA1 Ephrin type-A receptor 1 Homo sapiens (Human) SS
P54764 EPHA4 Ephrin type-A receptor 4 Homo sapiens (Human) SS
P54753 EPHB3 Ephrin type-B receptor 3 Homo sapiens (Human) SS
P29320 EPHA3 Ephrin type-A receptor 3 Homo sapiens (Human) PR
P54760 EPHB4 Ephrin type-B receptor 4 Homo sapiens (Human) SS
P29317 EPHA2 Ephrin type-A receptor 2 Homo sapiens (Human) SS
Q15375 EPHA7 Ephrin type-A receptor 7 Homo sapiens (Human) SS
Q5JZY3 EPHA10 Ephrin type-A receptor 10 Homo sapiens (Human) SS
P29323 EPHB2 Ephrin type-B receptor 2 Homo sapiens (Human) EV
Q9UF33 EPHA6 Ephrin type-A receptor 6 Homo sapiens (Human) SS
P54762 EPHB1 Ephrin type-B receptor 1 Homo sapiens (Human) SS
O15197 EPHB6 Ephrin type-B receptor 6 Homo sapiens (Human) SS
P54756 EPHA5 Ephrin type-A receptor 5 Homo sapiens (Human) SS
P54754 Ephb3 Ephrin type-B receptor 3 Mus musculus (Mouse) SS
Q03145 Epha2 Ephrin type-A receptor 2 Mus musculus (Mouse) PR
Q03137 Epha4 Ephrin type-A receptor 4 Mus musculus (Mouse) SS
Q61772 Epha7 Ephrin type-A receptor 7 Mus musculus (Mouse) SS
O09127 Epha8 Ephrin type-A receptor 8 Mus musculus (Mouse) SS
Q8CBF3 Ephb1 Ephrin type-B receptor 1 Mus musculus (Mouse) SS
Q8BYG9 Epha10 Ephrin type-A receptor 10 Mus musculus (Mouse) SS
P29319 Epha3 Ephrin type-A receptor 3 Mus musculus (Mouse) SS
Q62413 Epha6 Ephrin type-A receptor 6 Mus musculus (Mouse) SS
Q60750 Epha1 Ephrin type-A receptor 1 Mus musculus (Mouse) SS
P54763 Ephb2 Ephrin type-B receptor 2 Mus musculus (Mouse) SS
P54761 Ephb4 Ephrin type-B receptor 4 Mus musculus (Mouse) PR
O08644 Ephb6 Ephrin type-B receptor 6 Mus musculus (Mouse) PR
Q60629 Epha5 Ephrin type-A receptor 5 Mus musculus (Mouse) SS
P54759 Epha7 Ephrin type-A receptor 7 Rattus norvegicus (Rat) SS
P09759 Ephb1 Ephrin type-B receptor 1 Rattus norvegicus (Rat) SS
P0C0K7 Ephb6 Ephrin type-B receptor 6 Rattus norvegicus (Rat) SS
O08680 Epha3 Ephrin type-A receptor 3 Rattus norvegicus (Rat) SS
P54757 Epha5 Ephrin type-A receptor 5 Rattus norvegicus (Rat) SS
O61460 vab-1 Ephrin receptor 1 Caenorhabditis elegans SS
Q7X8C5 WAKL2 Wall-associated receptor kinase-like 2 Arabidopsis thaliana (Mouse-ear cress) PR
Q9S9M2 WAKL4 Wall-associated receptor kinase-like 4 Arabidopsis thaliana (Mouse-ear cress) PR
Q9LMN7 WAK5 Wall-associated receptor kinase 5 Arabidopsis thaliana (Mouse-ear cress) PR
Q9C9L5 WAKL9 Wall-associated receptor kinase-like 9 Arabidopsis thaliana (Mouse-ear cress) PR
Q8VYA3 WAKL10 Wall-associated receptor kinase-like 10 Arabidopsis thaliana (Mouse-ear cress) PR
Q9M092 WAKL17 Wall-associated receptor kinase-like 17 Arabidopsis thaliana (Mouse-ear cress) PR
Q0WNY5 WAKL18 Wall-associated receptor kinase-like 18 Arabidopsis thaliana (Mouse-ear cress) PR
O13147 ephb3 Ephrin type-B receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
O73878 ephb4b Ephrin type-B receptor 4b Danio rerio (Zebrafish) (Brachydanio rerio) SS
O13146 epha3 Ephrin type-A receptor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MGLRGGGGRA GGPAPGWTCL LLCAALRSLL ASPGSEVNLL DSRTVMGDLG WIAYPKNGWE
70 80 90 100 110 120
EIGEVDENYA PIHTYQVCKV MEQNQNNWLL TSWISNEGRP ASSFELKFTL RDCNSLPGGL
130 140 150 160 170 180
GTCKETFNMY YFESDDEDGR NIRENQYIKI DTIAADESFT ELDLGDRVMK LNTEVRDVGP
190 200 210 220 230 240
LTKKGFYLAF QDVGACIALV SVRVYYKKCP SVIRNLARFP DTITGADSSQ LLEVSGVCVN
250 260 270 280 290 300
HSVTDEAPKM HCSAEGEWLV PIGKCLCKAG YEEKNNTCQV CRPGFFKASP HSPSCSKCPP
310 320 330 340 350 360
HSYTLDEAST SCLCEEHYFR RESDPPTMAC TRPPSAPRSA ISNVNETSVF LEWIPPADTG
370 380 390 400 410 420
GRKDVSYYIA CKKCNSHSGL CEACGSHVRY LPQQTGLKNT SVMMVDLLAH TNYTFEIEAV
430 440 450 460 470 480
NGVSDQNPGA RQFVSVNVTT NQAAPSPVSS VKKGKITKNS ISLSWQEPDR PNGIILEYEI
490 500 510 520 530 540
KYFEKDQETS YTIIKSKETA ITADGLKPGS AYVFQIRART AAGYGGFSRR FEFETSPVLA
550 560 570 580 590 600
ASSDQSQIPI IVVSVTVGVI LLAVVIGFLL SGSCCDHGCG WASSLRAVAY PSLIWRCGYS
610 620 630 640 650 660
KAKQDPEEEK MHFHNGHIKL PGVRTYIDPH TYEDPNQAVH EFAKEIEASC ITIERVIGAG
670 680 690 700 710 720
EFGEVCSGRL KLQGKREFPV AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP NIIHLEGVVT
730 740 750 760 770 780
KSKPVMIVTE YMENGSLDTF LKKNDGQFTV IQLVGMLRGI ASGMKYLSDM GYVHRDLAAR
790 800 810 820 830 840
NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAFRK FTSASDVWSY
850 860 870 880 890 900
GIVMWEVMSY GERPYWEMTN QDVIKAVEEG YRLPSPMDCP AALYQLMLDC WQKDRNSRPK
910 920 930 940 950 960
FDEIVSMLDK LIRNPSSLKT LVNASSRVSN LLVEHSPVGS GAYRSVGEWL EAIKMGRYTE
970 980 990 1000 1010
IFMENGYSSM DSVAQVTLED LRRLGVTLVG HQKKIMNSLQ EMKVQLVNGM VPL