P54754
SS
Gene name |
Ephb3 (Etk2, Mdk5, Sek4) |
Protein name |
Ephrin type-B receptor 3 |
Names |
EC 2.7.10.1 , Developmental kinase 5 , mDK-5 , Tyrosine-protein kinase receptor SEK-4 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13845 |
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
Ephrin type-B receptor 2 is a membrane-associated protein that mediates axon guidance, cell migration and morphogenesis. The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. The structure, supported by mutagenesis data, reveals that the juxtamembrane segment adopts a helical conformation that distorts the small lobe of the kinase domain, and blocks the activation segment from attaining an activated conformation. Phosphorylation of the conserved juxtamembrane tyrosines would relieve this autoinhibition by disturbing the association of the juxtamembrane segment with the kinase domain, while liberating phosphotyrosine sites for binding SH2 domains of target proteins.
Autoinhibitory domains (AIDs)
Target domain |
628-891 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
770-798 (Activation loop from InterPro)
Target domain |
628-891 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
Autoinhibited structure
Activated structure
1 structures for P54754
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P54754-F1 | Predicted | AlphaFoldDB |
52 variants for P54754
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389355965 | 35 | M>T | No | EVA | |
| rs3405781563 | 81 | N>D | No | EVA | |
| rs3389398189 | 100 | E>D | No | EVA | |
| rs3389423144 | 113 | N>I | No | EVA | |
| rs3389409886 | 154 | P>L | No | EVA | |
| rs3389405269 | 162 | D>Y | No | EVA | |
| rs3389368020 | 168 | T>I | No | EVA | |
| rs3406153268 | 219 | T>P | No | EVA | |
| rs3389408202 | 302 | T>A | No | EVA | |
| rs3552062421 | 303 | T>P | No | EVA | |
| rs3552200133 | 311 | T>P | No | EVA | |
| rs3389414730 | 318 | R>H | No | EVA | |
| rs3406153322 | 341 | N>I | No | EVA | |
| rs3406791851 | 342 | V>E | No | EVA | |
| rs3406680794 | 344 | E>* | No | EVA | |
| rs3406665674 | 349 | L>H | No | EVA | |
| rs3406680843 | 350 | E>D | No | EVA | |
| rs3406153354 | 353 | E>Q | No | EVA | |
| rs3389405664 | 368 | I>F | No | EVA | |
| rs3389409813 | 376 | S>T | No | EVA | |
| rs3389414678 | 446 | A>T | No | EVA | |
| rs3389355953 | 454 | L>V | No | EVA | |
| rs3389423069 | 481 | Y>* | No | EVA | |
| rs3389424709 | 489 | S>G | No | EVA | |
| rs3389424671 | 501 | N>K | No | EVA | |
| rs3389324564 | 510 | P>T | No | EVA | |
| rs3389368001 | 515 | V>I | No | EVA | |
| rs3389414738 | 547 | Q>L | No | EVA | |
| rs3389401047 | 600 | M>K | No | EVA | |
| rs3389400960 | 610 | E>A | No | EVA | |
| rs3389398208 | 613 | N>S | No | EVA | |
| rs3389398185 | 657 | V>L | No | EVA | |
| rs3389401293 | 680 | I>S | No | EVA | |
| rs3389324516 | 696 | V>L | No | EVA | |
| rs3389414716 | 698 | K>T | No | EVA | |
| rs3389417811 | 707 | E>K | No | EVA | |
| rs3389377114 | 721 | N>I | No | EVA | |
| rs3389401060 | 725 | F>I | No | EVA | |
| rs3389324529 | 779 | E>Q | No | EVA | |
| rs3389388013 | 792 | G>S | No | EVA | |
| rs3389324563 | 807 | Y>C | No | EVA | |
| rs3389409880 | 820 | G>W | No | EVA | |
| rs3389424636 | 845 | A>D | No | EVA | |
| rs3389401050 | 857 | D>G | No | EVA | |
| rs3406680793 | 894 | A>V | No | EVA | |
| rs3389405681 | 899 | V>F | No | EVA | |
| rs3406153296 | 905 | S>Y | No | EVA | |
| rs3389377099 | 922 | F>L | No | EVA | |
| rs3389414744 | 945 | G>E | No | EVA | |
| rs3389357945 | 953 | A>V | No | EVA | |
| rs3389424628 | 956 | T>S | No | EVA | |
| rs3389405310 | 985 | M>L | No | EVA |
No associated diseases with P54754
8 regional properties for P54754
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 191 - 450 | IPR000719 |
| domain | SH2 domain | 76 - 170 | IPR000980 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 192 - 441 | IPR001245 |
| domain | SH3 domain | 8 - 72 | IPR001452 |
| active_site | Tyrosine-protein kinase, active site | 308 - 320 | IPR008266 |
| binding_site | Protein kinase, ATP binding site | 197 - 219 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 191 - 441 | IPR020635 |
| domain | PTK6, SH2 domain | 75 - 174 | IPR035846 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| axon guidance receptor activity | Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. |
| ephrin receptor activity | Combining with an ephrin receptor ligand to initiate a change in cell activity. |
| transmembrane-ephrin receptor activity | Combining with a transmembrane ephrin to initiate a change in cell activity. |
20 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| axon guidance | The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| axonal fasciculation | The collection of axons into a bundle of rods, known as a fascicle. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. |
| central nervous system projection neuron axonogenesis | Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region. |
| corpus callosum development | The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres. |
| dendritic spine development | The process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. |
| dendritic spine morphogenesis | The process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. |
| digestive tract morphogenesis | The process in which the anatomical structures of the digestive tract are generated and organized. The digestive tract is the anatomical structure through which food passes and is processed. |
| ephrin receptor signaling pathway | The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| positive regulation of synapse assembly | Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| regulation of axonogenesis | Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron. |
| regulation of cell-cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. |
| regulation of GTPase activity | Any process that modulates the rate of GTP hydrolysis by a GTPase. |
| retinal ganglion cell axon guidance | The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. |
| roof of mouth development | The biological process whose specific outcome is the progression of the roof of the mouth from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure. The roof of the mouth is the partition that separates the nasal and oral cavities. |
| substrate adhesion-dependent cell spreading | The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
| thymus development | The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components. |
| urogenital system development | The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure. |
49 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P28693 | EPHB2 | Ephrin type-B receptor 2 | Gallus gallus (Chicken) | PR |
| Q07496 | EPHA4 | Ephrin type-A receptor 4 | Gallus gallus (Chicken) | SS |
| Q07494 | EPHB1 | Ephrin type-B receptor 1 | Gallus gallus (Chicken) | SS |
| Q07497 | EPHB5 | Ephrin type-B receptor 5 | Gallus gallus (Chicken) | PR |
| P29318 | EPHA3 | Ephrin type-A receptor 3 | Gallus gallus (Chicken) | SS |
| O42422 | EPHA7 | Ephrin type-A receptor 7 | Gallus gallus (Chicken) | SS |
| P54755 | EPHA5 | Ephrin type-A receptor 5 | Gallus gallus (Chicken) | SS |
| Q07498 | EPHB3 | Ephrin type-B receptor 3 | Gallus gallus (Chicken) | SS |
| P0C0K6 | EPHB6 | Ephrin type-B receptor 6 | Pan troglodytes (Chimpanzee) | SS |
| P29322 | EPHA8 | Ephrin type-A receptor 8 | Homo sapiens (Human) | SS |
| P21709 | EPHA1 | Ephrin type-A receptor 1 | Homo sapiens (Human) | SS |
| P54764 | EPHA4 | Ephrin type-A receptor 4 | Homo sapiens (Human) | SS |
| P29320 | EPHA3 | Ephrin type-A receptor 3 | Homo sapiens (Human) | PR |
| P54760 | EPHB4 | Ephrin type-B receptor 4 | Homo sapiens (Human) | SS |
| P29317 | EPHA2 | Ephrin type-A receptor 2 | Homo sapiens (Human) | SS |
| Q15375 | EPHA7 | Ephrin type-A receptor 7 | Homo sapiens (Human) | SS |
| Q5JZY3 | EPHA10 | Ephrin type-A receptor 10 | Homo sapiens (Human) | SS |
| P29323 | EPHB2 | Ephrin type-B receptor 2 | Homo sapiens (Human) | EV |
| Q9UF33 | EPHA6 | Ephrin type-A receptor 6 | Homo sapiens (Human) | SS |
| P54762 | EPHB1 | Ephrin type-B receptor 1 | Homo sapiens (Human) | SS |
| P54756 | EPHA5 | Ephrin type-A receptor 5 | Homo sapiens (Human) | SS |
| O15197 | EPHB6 | Ephrin type-B receptor 6 | Homo sapiens (Human) | SS |
| P54753 | EPHB3 | Ephrin type-B receptor 3 | Homo sapiens (Human) | SS |
| Q03145 | Epha2 | Ephrin type-A receptor 2 | Mus musculus (Mouse) | PR |
| Q60629 | Epha5 | Ephrin type-A receptor 5 | Mus musculus (Mouse) | SS |
| Q60750 | Epha1 | Ephrin type-A receptor 1 | Mus musculus (Mouse) | SS |
| P54761 | Ephb4 | Ephrin type-B receptor 4 | Mus musculus (Mouse) | PR |
| O09127 | Epha8 | Ephrin type-A receptor 8 | Mus musculus (Mouse) | SS |
| Q61772 | Epha7 | Ephrin type-A receptor 7 | Mus musculus (Mouse) | SS |
| Q8CBF3 | Ephb1 | Ephrin type-B receptor 1 | Mus musculus (Mouse) | SS |
| Q03137 | Epha4 | Ephrin type-A receptor 4 | Mus musculus (Mouse) | SS |
| Q8BYG9 | Epha10 | Ephrin type-A receptor 10 | Mus musculus (Mouse) | SS |
| O08644 | Ephb6 | Ephrin type-B receptor 6 | Mus musculus (Mouse) | PR |
| P54763 | Ephb2 | Ephrin type-B receptor 2 | Mus musculus (Mouse) | SS |
| Q62413 | Epha6 | Ephrin type-A receptor 6 | Mus musculus (Mouse) | SS |
| P29319 | Epha3 | Ephrin type-A receptor 3 | Mus musculus (Mouse) | SS |
| P54757 | Epha5 | Ephrin type-A receptor 5 | Rattus norvegicus (Rat) | SS |
| P54759 | Epha7 | Ephrin type-A receptor 7 | Rattus norvegicus (Rat) | SS |
| P09759 | Ephb1 | Ephrin type-B receptor 1 | Rattus norvegicus (Rat) | SS |
| P0C0K7 | Ephb6 | Ephrin type-B receptor 6 | Rattus norvegicus (Rat) | SS |
| O08680 | Epha3 | Ephrin type-A receptor 3 | Rattus norvegicus (Rat) | SS |
| O61460 | vab-1 | Ephrin receptor 1 | Caenorhabditis elegans | SS |
| Q9LMN7 | WAK5 | Wall-associated receptor kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LSV3 | WAKL16 | Putative wall-associated receptor kinase-like 16 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M342 | WAKL15 | Wall-associated receptor kinase-like 15 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8VZJ9 | CRCK2 | Calmodulin-binding receptor-like cytoplasmic kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O73878 | ephb4b | Ephrin type-B receptor 4b | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13146 | epha3 | Ephrin type-A receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O13147 | ephb3 | Ephrin type-B receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGARPPPGL | LPLLAPLLLP | LLLPAGCWAL | EETLMDTKWV | TSELAWTSHP | ESGWEEVSGY |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DEAMNPIRTY | QVCNVRESSQ | NNWLRTGFIW | RREVQRVYVE | LKFTVRDCNS | IPNIPGSCKE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TFNLFYYEAD | SDVASASSPF | WMENPYVKVD | TIAPDESFSR | LDAGRVNTKV | RSFGPLSKAG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FYLAFQDQGA | CMSLISVRAF | YKKCASTTAG | FALFPETLTG | AEPTSLVIAP | GTCIANAVEV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SVPLKLYCNG | DGEWMVPVGA | CTCATGHEPA | AKESQCRACP | PGSYKAKQGE | GPCLPCPPNS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RTTSPAASIC | TCHNNFYRAD | SDSADSACTT | VPSPPRGVIS | NVNETSLILE | WSEPRDLGGR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DDLLYNVICK | KCRGSSGAGG | PATCSRCDDN | VEFVPRQLGL | TERRVHISHL | LAHTRYTFEV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| QAVNGVSGKS | PLPPRYAAVN | ITTNQAAPSE | VPTLHLHSSS | GSSLTLSWAP | PERPNGVILD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| YEMKYFEKSK | GIASTVTSQK | NSVQLDGLQP | DARYVVQVRA | RTVAGYGQYS | HPAEFETTSE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RGSGAQQLQE | QLPLIVGSTV | AGFVFMVVVV | VIALVCLRKQ | RHGPDAEYTE | KLQQYIAPGM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KVYIDPFTYE | DPNEAVREFA | KEIDVSCVKI | EEVIGAGEFG | EVCRGRLKLP | GRREVFVAIK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TLKVGYTERQ | RRDFLSEASI | MGQFDHPNII | RLEGVVTKSR | PVMILTEFME | NCALDSFLRL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NDGQFTVIQL | VGMLRGIAAG | MKYLSEMNYV | HRDLAARNIL | VNSNLVCKVS | DFGLSRFLED |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DPSDPTYTSS | LGGKIPIRWT | APEAIAYRKF | TSASDVWSYG | IVMWEVMSYG | ERPYWDMSNQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DVINAVEQDY | RLPPPMDCPT | ALHQLMLDCW | VRDRNLRPKF | SQIVNTLDKL | IRNAASLKVT |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ASAPSGMSQP | LLDRTVPDYT | TFTTVGDWLD | AIKMGRYKES | FVGAGFASFD | LVAQMTAEDL |
| 970 | 980 | 990 | |||
| LRIGVTLAGH | QKKILCSIQD | MRLQMNQTLP | VQV |