AiPD: Autoinhibited Protein Database

Gene name	Dnajc2 (Mida1, Zrf1)
Protein name	DnaJ homolog subfamily C member 2
Names	Mouse Id associate 1, MIDA1, Zuotin-related factor 1
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:22791
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

15-103 (Predicted disordered autoinhibitory region) PR

15-103 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P54103-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3395157040	4	L>P	No	EVA
rs3395270799	9	E>A	No	EVA
rs3388728281	73	F>Y	No	EVA
rs3388738891	74	P>T	No	EVA
rs3388743982	118	H>D	No	EVA
rs3395220942	170	S>Y	No	EVA
rs3395271695	171	K>H	No	EVA
rs3388745382	197	N>I	No	EVA
rs3388743940	200	K>Q	No	EVA
rs3388728306	247	I>N	No	EVA
rs3388745731	296	K>R	No	EVA
rs3388752388	354	Q>R	No	EVA
rs3388741412	382	K>N	No	EVA
rs3388728365	404	R>*	No	EVA
rs3388743159	404	R>SE*	No	EVA
rs3388731285	422	M>I	No	EVA
rs244433106	433	M>I	No	EVA
rs3388738894	496	A>V	No	EVA
rs3395296577	515	D>P	No	EVA
rs31976986	581	A>S	No	EVA
rs3388743225	587	R>K	No	EVA

Type	Name	Position	InterPro Accession
domain	SANT/Myb domain	450 - 509	IPR001005-1
domain	SANT/Myb domain	546 - 602	IPR001005-2
domain	DnaJ domain	87 - 161	IPR001623
domain	SANT domain	549 - 604	IPR017884
domain	Myb domain	546 - 604	IPR017930
conserved_site	DnaJ domain, conserved site	138 - 157	IPR018253
domain	Ribosome-associated complex head domain	339 - 427	IPR032003

		Description
EC Number
Subcellular Localization	Nucleus Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
nucleolus	A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
histone binding	Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
Hsp70 protein binding	Binding to a Hsp70 protein, heat shock proteins around 70kDa in size.
ribosome binding	Binding to a ribosome.
ubiquitin modification-dependent histone binding	Binding to a histone protein in which a residue has been modified by ubiquitination.

Name	Definition
'de novo' cotranslational protein folding	The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated.
chromatin organization	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
DNA replication	The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
negative regulation of cell growth	Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
negative regulation of DNA biosynthetic process	Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.
positive regulation of DNA-templated transcription	Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
regulation of translational fidelity	Any process that modulates the ability of the translational apparatus to interpret the genetic code.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P32527	ZUO1	Zuotin	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	EV
Q99543	DNAJC2	DnaJ homolog subfamily C member 2	Homo sapiens (Human)	PR
Q7TQ20	Dnajc2	DnaJ homolog subfamily C member 2	Rattus norvegicus (Rat)	PR
P34454	F54F2.9	Uncharacterized protein F54F2.9	Caenorhabditis elegans	PR
F4KGY6	RVE1	Protein REVEILLE 1	Arabidopsis thaliana (Mouse-ear cress)	PR
F4K5X6	RVE2	Protein REVEILLE 2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q6NWJ4	dnajc2	DnaJ homolog subfamily C member 2	Danio rerio (Zebrafish) (Brachydanio rerio)	PR