P53994

PR
Gene name
Rab2a (Rab2)
Protein name
Ras-related protein Rab-2A
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:59021
EC number
3.6.5.2: Acting on GTP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

147-212 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P53994

Entry ID Method Resolution Chain Position Source
AF-P53994-F1 Predicted AlphaFoldDB

3 variants for P53994

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388670186 57 L>F No EVA
rs3388652811 148 T>N No EVA
rs3388666387 154 S>P No EVA

No associated diseases with P53994

1 regional properties for P53994

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 7 - 161 IPR005225

Functions

Description
EC Number 3.6.5.2 Acting on GTP; involved in cellular and subcellular movement
Subcellular Localization
  • Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor ; Cytoplasmic side
  • Melanosome
  • Endoplasmic reticulum membrane ; Lipid-anchor ; Cytoplasmic side
  • Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side
  • Cytoplasmic vesicle, secretory vesicle, acrosome
  • Cytoplasmic vesicle, autophagosome membrane ; Lipid-anchor ; Cytoplasmic side
  • Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
acrosomal vesicle A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
anchored component of synaptic vesicle membrane The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
endoplasmic reticulum-Golgi intermediate compartment membrane The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

3 GO annotations of molecular function

Name Definition
GDP binding Binding to GDP, guanosine 5'-diphosphate.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

3 GO annotations of biological process

Name Definition
Golgi organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

13 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q6IMM1 DNAJC27 DnaJ homolog subfamily C member 27 Gallus gallus (Chicken) PR
Q90965 RAB2A Ras-related protein Rab-2A Gallus gallus (Chicken) PR
P61105 RAB2A Ras-related protein Rab-2A Canis lupus familiaris (Dog) (Canis familiaris) PR
Q8WUD1 RAB2B Ras-related protein Rab-2B Homo sapiens (Human) PR
P61019 RAB2A Ras-related protein Rab-2A Homo sapiens (Human) PR
Q8CFP6 Dnajc27 DnaJ homolog subfamily C member 27 Mus musculus (Mouse) PR
Q8BHC1 Rab39b Ras-related protein Rab-39B Mus musculus (Mouse) PR
Q91ZR1 Rab4b Ras-related protein Rab-4B Mus musculus (Mouse) PR
P46638 Rab11b Ras-related protein Rab-11B Mus musculus (Mouse) PR
P62492 Rab11a Ras-related protein Rab-11A Mus musculus (Mouse) PR
Q6IML7 Dnajc27 DnaJ homolog subfamily C member 27 Rattus norvegicus (Rat) PR
P05712 Rab2a Ras-related protein Rab-2A Rattus norvegicus (Rat) PR
Q6IMK3 dnajc27 DnaJ homolog subfamily C member 27 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMITI DGKQIKLQIW
70 80 90 100 110 120
DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW LEDARQHSNS NMVIMLIGNK
130 140 150 160 170 180
SDLESRREVK KEEGEAFARE HGLIFMETSA KTASNVEEAF INTAKEIYEK IQEGVFDINN
190 200 210
EANGIKIGPQ HAATNASHGS NQGGQQAGGG CC