P53778
SS
Gene name |
MAPK12 (ERK6, SAPK3) |
Protein name |
Mitogen-activated protein kinase 12 |
Names |
MAP kinase 12 , MAPK 12 , EC 2.7.11.24 , Extracellular signal-regulated kinase 6 , ERK-6 , Mitogen-activated protein kinase p38 gamma , MAP kinase p38 gamma , Stress-activated protein kinase 3 |
Species |
Homo sapiens (Human) |
KEGG Pathway |
hsa:6300 |
EC number |
2.7.11.24: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
MAPK1 encodes Mitogen-activated protein kinase 1, and is involved in diverse cellular responses by phosphorylating cytoplasmic and nuclear proteins. Unlike other MAP kinases, MAPK1 activates via dual phosphorylation of Thr-186 and Tyr-193 within the activation lip, and mutations at Q105 alone were sufficient for autoactivation. Additionally, in the inactive form, L76, Q10 and I87 form a structural unit that restrains intramolecular autophosphorylation by preventing interactions between activation lip residues and the catalytic base (D149) needed for phosphoryl transfer. Mutations at L76, I87 and additionally S153 increased basal specific activity via autophosphorylation of Thr-186 and Tyr-193.
Autoinhibitory domains (AIDs)
Target domain |
27-311 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
170-190 (Activation loop from InterPro)
Target domain |
27-311 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
170-190 (Activation loop from InterPro)
Target domain |
27-311 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Emrick MA et al. (2006) "The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity", Proceedings of the National Academy of Sciences of the United States of America, 103, 18101-6
- Emrick MA et al. (2001) "Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations", The Journal of biological chemistry, 276, 46469-79
Autoinhibited structure
Activated structure
5 structures for P53778
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1CM8 | X-ray | 240 A | A/B | 1-367 | PDB |
| 4QUM | X-ray | 252 A | B | 182-190 | PDB |
| 6UNA | X-ray | 255 A | A/B | 7-367 | PDB |
| 7CGA | X-ray | 315 A | A/B/C/D | 9-353 | PDB |
| AF-P53778-F1 | Predicted | AlphaFoldDB |
401 variants for P53778
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
|
CA412137736 rs1601648108 |
2 | S>N | No |
ClinGen Ensembl |
|
|
rs1487368723 CA412137732 |
2 | S>R | No |
ClinGen gnomAD |
|
|
rs1159855321 CA412137721 |
3 | S>F | No |
ClinGen TOPMed |
|
|
CA412137701 rs752884897 |
5 | P>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310892 rs752884897 |
5 | P>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310890 rs755390786 |
7 | A>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs755390786 CA325505705 |
7 | A>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412137665 rs1340516937 |
8 | R>H | No |
ClinGen gnomAD |
|
|
CA412137661 rs1340516937 |
8 | R>L | No |
ClinGen gnomAD |
|
|
rs867383439 CA325505697 |
11 | F>L | No |
ClinGen Ensembl |
|
|
CA412137600 rs200538586 |
13 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA412137602 rs200538586 |
13 | R>G | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1465168100 CA412137597 |
13 | R>H | No |
ClinGen TOPMed gnomAD |
|
|
rs1465168100 CA412137595 |
13 | R>L | No |
ClinGen TOPMed gnomAD |
|
|
CA10310889 rs200538586 |
13 | R>S | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs868525288 CA325505690 |
14 | Q>H | No |
ClinGen Ensembl |
|
|
rs1429961404 CA412137565 |
15 | E>D | No |
ClinGen gnomAD |
|
|
rs1286495477 CA412137550 |
17 | T>N | No |
ClinGen gnomAD |
|
|
CA325505682 rs867860805 |
18 | K>N | No |
ClinGen gnomAD |
|
|
CA412137542 rs1274404574 |
18 | K>Q | No |
ClinGen TOPMed |
|
|
CA10310887 rs763361878 |
18 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA10310886 rs772911113 |
19 | T>M | No |
ClinGen ExAC gnomAD |
|
|
rs868013627 CA412137501 CA325505665 |
21 | W>C | No |
ClinGen gnomAD |
|
|
rs868283081 CA325505669 |
21 | W>L | No |
ClinGen Ensembl |
|
|
rs761370755 CA325505658 |
22 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA412137499 rs1323595745 |
22 | E>K | No |
ClinGen gnomAD |
|
|
CA412137473 rs1310817773 |
24 | R>C | No |
ClinGen gnomAD |
|
|
rs776449594 CA412137471 |
24 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs776449594 CA10310881 |
24 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1224677427 CA412137468 |
25 | A>T | No |
ClinGen gnomAD |
|
|
CA412137461 rs1183544107 |
25 | A>V | No |
ClinGen TOPMed |
|
|
CA412137456 rs1332303479 |
26 | V>A | No |
ClinGen TOPMed gnomAD |
|
|
rs768138341 CA10310880 |
26 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412137434 rs1406866295 |
28 | R>P | No |
ClinGen gnomAD |
|
| TCGA novel | 29 | D>H | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs1338625341 CA412137430 |
29 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA412137427 rs1338625341 |
29 | D>Y | No |
ClinGen TOPMed gnomAD |
|
|
rs760525509 CA10310877 |
31 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs772106264 CA10310875 |
32 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310876 rs775145151 |
32 | P>S | No |
ClinGen ExAC gnomAD |
|
|
CA412137356 rs1244376929 |
33 | V>M | No |
ClinGen gnomAD |
|
|
CA10310871 rs769891752 |
35 | S>L | No |
ClinGen ExAC gnomAD |
|
|
rs777870827 CA10310872 |
35 | S>P | No |
ClinGen ExAC gnomAD |
|
|
CA412137302 rs1307381668 |
36 | G>D | No |
ClinGen gnomAD |
|
|
rs1383630854 CA412137268 |
38 | Y>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1239609579 CA412137278 |
38 | Y>H | No |
ClinGen gnomAD |
|
|
CA412137220 rs1293978747 |
41 | V>G | No |
ClinGen TOPMed |
|
|
rs1569144724 CA412137209 |
42 | C>Y | No |
ClinGen Ensembl |
|
|
CA10310864 rs752024173 |
43 | S>L | No |
ClinGen ExAC gnomAD |
|
|
CA412137119 rs780265256 |
46 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412137116 rs1338164513 |
47 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs759018144 CA10310862 |
48 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412137098 rs759018144 |
48 | R>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1425063604 CA412137086 |
49 | T>A | No |
ClinGen gnomAD |
|
|
rs1392488952 CA412137079 |
49 | T>S | No |
ClinGen gnomAD |
|
|
CA325505580 rs897386852 |
50 | G>S | No |
ClinGen TOPMed gnomAD |
|
|
rs866780075 CA325505576 |
51 | A>V | No |
ClinGen TOPMed |
|
|
rs1479120045 CA412137008 |
54 | A>T | No |
ClinGen gnomAD |
|
|
CA412136989 rs1008492127 |
55 | I>L | No |
ClinGen TOPMed gnomAD |
|
|
CA325505570 rs371313399 |
55 | I>M | No |
ClinGen ESP TOPMed gnomAD |
|
|
rs1008492127 CA325505573 |
55 | I>V | No |
ClinGen TOPMed gnomAD |
|
|
CA412136933 rs1386400549 |
56 | K>N | No |
ClinGen TOPMed |
|
|
rs751003209 CA10310861 |
56 | K>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1208247995 CA412136925 |
57 | K>N | No |
ClinGen TOPMed gnomAD |
|
|
rs761424358 CA10310860 |
57 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA10310859 rs761424358 |
57 | K>T | No |
ClinGen ExAC gnomAD |
|
|
rs753334645 CA10310858 |
58 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs1346601274 CA412136905 |
59 | Y>H | No |
ClinGen gnomAD |
|
|
rs775404891 CA412136888 |
60 | R>G | No |
ClinGen ExAC gnomAD |
|
|
rs771733687 CA10310854 |
60 | R>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs771733687 CA412136883 |
60 | R>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412136886 rs771733687 |
60 | R>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310855 rs775404891 |
60 | R>W | No |
ClinGen ExAC gnomAD |
|
|
CA10310853 RCV000894380 rs558276175 |
61 | P>L | No |
ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD |
|
|
rs770795073 CA10310851 |
63 | Q>K | No |
ClinGen ExAC gnomAD |
|
|
rs748227933 CA10310850 |
64 | S>F | No |
ClinGen ExAC gnomAD |
|
|
rs1463576627 CA412136805 |
65 | E>D | No |
ClinGen gnomAD |
|
|
CA412136816 rs1172275644 |
65 | E>Q | No |
ClinGen TOPMed gnomAD |
|
|
rs781124093 CA325505537 |
66 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs781124093 CA412136788 |
66 | L>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310849 rs781124093 |
66 | L>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412136778 rs1468769319 |
67 | F>L | No |
ClinGen TOPMed |
|
|
CA325505533 rs868745928 |
67 | F>L | No |
ClinGen Ensembl |
|
|
rs1398602859 CA412136772 |
68 | A>S | No |
ClinGen gnomAD |
|
|
CA10310848 rs368055751 |
69 | K>M | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA412136754 rs1248752237 |
69 | K>Q | No |
ClinGen gnomAD |
|
|
rs1451310440 CA412136743 |
70 | R>C | No |
ClinGen gnomAD |
|
|
CA412136745 rs1451310440 |
70 | R>G | No |
ClinGen gnomAD |
|
|
rs940879577 CA325505527 |
70 | R>L | No |
ClinGen TOPMed |
|
|
rs780286516 CA10310846 |
71 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs1251515204 CA412136731 |
71 | A>T | No |
ClinGen gnomAD |
|
|
CA10310847 rs780286516 |
71 | A>V | No |
ClinGen ExAC gnomAD |
|
|
rs1257375594 CA412136694 |
73 | R>C | No |
ClinGen gnomAD |
|
|
CA412136667 rs1232250071 |
74 | E>D | No |
ClinGen gnomAD |
|
|
CA412136684 rs1346872229 |
74 | E>Q | No |
ClinGen gnomAD |
|
|
rs138533200 CA10310845 |
76 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10310844 rs750761400 |
76 | R>H | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs750761400 CA412136640 |
76 | R>L | No |
ClinGen ExAC gnomAD |
|
|
CA412136616 rs1331266721 |
78 | L>F | No |
ClinGen gnomAD |
|
|
rs753446680 CA10310841 |
79 | K>R | No |
ClinGen ExAC gnomAD |
|
|
CA412136547 rs1477889223 |
81 | M>I | No |
ClinGen gnomAD |
|
|
CA10310840 CA10310839 rs373855209 |
81 | M>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs752323718 CA10310838 |
82 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412136535 rs752323718 |
82 | R>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310837 rs767106347 |
82 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs774063558 CA10310835 |
83 | H>Q | No |
ClinGen ExAC gnomAD |
|
|
rs372395330 CA10310836 |
83 | H>Y | No |
ClinGen ESP ExAC gnomAD |
|
|
rs568278596 CA10310834 |
84 | E>D | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA412136482 rs776817643 CA10310832 |
85 | N>K | No |
ClinGen ExAC gnomAD |
|
|
CA10310833 rs762861308 |
85 | N>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
| TCGA novel | 86 | V>A | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10310801 rs747677073 |
86 | V>L | No |
ClinGen ExAC gnomAD |
|
|
CA10310799 rs143795417 |
87 | I>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA412135511 rs1601644065 |
87 | I>S | No |
ClinGen Ensembl |
|
|
rs201816702 CA10310798 COSM3424267 |
88 | G>R | large_intestine Variant assessed as Somatic; 4.621e-05 impact. [Cosmic, NCI-TCGA] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD |
|
rs373525981 CA10310797 |
90 | L>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10310796 rs758145134 |
91 | D>N | No |
ClinGen ExAC |
|
|
CA10310794 rs369173418 |
92 | V>I | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
CA412135455 rs1569143397 |
93 | F>V | No |
ClinGen Ensembl |
|
|
rs1398562853 CA412135438 |
94 | T>A | No |
ClinGen gnomAD |
|
|
rs761799075 CA10310793 |
94 | T>I | No |
ClinGen ExAC gnomAD |
|
|
CA10310792 rs148981556 |
95 | P>S | No |
ClinGen ESP ExAC gnomAD |
|
|
CA325503349 rs148981556 |
95 | P>T | No |
ClinGen ESP ExAC gnomAD |
|
|
CA412135417 rs1164255210 |
96 | D>N | No |
ClinGen gnomAD |
|
|
CA412135410 rs1466181193 |
96 | D>V | No |
ClinGen gnomAD |
|
|
CA412135393 rs1425754679 |
97 | E>D | No |
ClinGen gnomAD |
|
|
rs759648659 CA10310790 |
98 | T>A | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1477392913 CA412135380 |
98 | T>I | No |
ClinGen gnomAD |
|
|
rs1161936001 CA412135335 |
102 | F>L | No |
ClinGen TOPMed |
|
|
CA10310785 rs34422484 |
103 | T>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10310784 rs34422484 VAR_042265 |
103 | T>M | No |
ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1045563517 CA325503321 |
104 | D>E | No |
ClinGen gnomAD |
|
|
rs1260582494 CA412135313 |
104 | D>N | No |
ClinGen gnomAD |
|
|
CA412134972 rs754871509 CA10310715 |
106 | Y>* | No |
ClinGen ExAC TOPMed |
|
|
CA10310716 rs756066514 |
106 | Y>* | No |
ClinGen ExAC |
|
|
rs201667359 CA10310714 |
108 | V>L | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10310713 rs778946810 |
109 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs757514255 CA10310712 |
110 | P>L | No |
ClinGen ExAC gnomAD |
|
|
CA325502648 rs867811954 |
110 | P>S | No |
ClinGen Ensembl |
|
|
CA10310709 rs756486889 |
112 | M>V | No |
ClinGen ExAC gnomAD |
|
|
rs1045279761 CA325502640 |
113 | G>V | No |
ClinGen Ensembl |
|
|
rs191191851 CA10310705 |
115 | D>N | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs200110495 CA10310704 |
115 | D>V | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA412134847 rs1272754232 |
117 | G>A | No |
ClinGen gnomAD |
|
|
CA412134841 rs1377156117 |
118 | K>E | No |
ClinGen gnomAD |
|
|
rs761670017 CA10310701 |
118 | K>N | No |
ClinGen ExAC gnomAD |
|
|
rs776280424 CA10310699 |
120 | M>V | No |
ClinGen ExAC gnomAD |
|
|
CA412134776 rs1325336554 |
122 | H>R | No |
ClinGen TOPMed |
|
|
CA412134785 rs1224429260 |
122 | H>Y | No |
ClinGen gnomAD |
|
|
rs1415407698 CA412134756 |
123 | E>G | No |
ClinGen gnomAD |
|
|
CA10310698 rs768689842 |
123 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs779930575 CA10310696 |
127 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA412134701 rs1467525101 |
128 | D>Y | No |
ClinGen Ensembl |
|
|
CA325502620 rs150223264 |
129 | R>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA412134690 rs1601642809 |
129 | R>Q | No |
ClinGen Ensembl |
|
|
rs150223264 CA10310695 |
129 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs777977620 CA10310693 |
130 | I>M | No |
ClinGen ExAC gnomAD |
|
|
rs546039180 CA10310694 |
130 | I>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA325502617 rs908215862 |
131 | Q>H | No |
ClinGen TOPMed gnomAD |
|
|
CA412134644 rs984169452 CA325502615 |
132 | F>L | No |
ClinGen TOPMed gnomAD |
|
|
CA412134637 rs931253980 |
133 | L>F | No |
ClinGen gnomAD |
|
|
CA325502613 rs931253980 |
133 | L>V | No |
ClinGen gnomAD |
|
|
CA412134618 rs753162308 |
134 | V>L | No |
ClinGen ExAC TOPMed |
|
|
rs753162308 CA10310691 |
134 | V>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed |
|
rs1277985447 CA412134605 |
135 | Y>H | No |
ClinGen gnomAD |
|
|
rs1249738488 CA412134478 |
140 | G>A | No |
ClinGen TOPMed |
|
|
rs375893058 CA10310688 |
140 | G>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs752037553 CA10310687 |
141 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA412134316 rs1217087190 |
145 | H>L | No |
ClinGen TOPMed |
|
|
CA412134323 rs1438710231 |
145 | H>Y | No |
ClinGen gnomAD |
|
|
rs144201280 CA10310649 |
146 | A>T | No |
ClinGen ESP ExAC gnomAD |
|
|
CA412134263 rs746411853 |
148 | G>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs746411853 CA10310646 |
148 | G>S | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412134233 rs1280851689 |
150 | I>N | No |
ClinGen gnomAD |
|
|
CA10310611 rs775873615 |
153 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412134026 rs1421021983 |
156 | P>R | No |
ClinGen gnomAD |
|
| TCGA novel | 157 | G>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
CA10310609 rs374797423 |
157 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10310607 rs771392509 |
159 | L>V | No |
ClinGen ExAC gnomAD |
|
|
rs1396825613 CA412133954 |
160 | A>V | No |
ClinGen TOPMed |
|
|
CA10310604 rs148670675 |
163 | E>K | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1217565976 CA412133871 |
164 | D>N | No |
ClinGen gnomAD |
|
|
rs766663292 CA10310603 |
165 | C>* | No |
ClinGen ESP ExAC TOPMed |
|
|
CA325502359 rs759318479 |
165 | C>G | No |
ClinGen gnomAD |
|
|
CA412133850 rs759318479 |
165 | C>R | No |
ClinGen gnomAD |
|
|
rs1569142420 CA412133840 |
165 | C>W | No |
ClinGen Ensembl |
|
|
CA412133818 rs1401558955 |
166 | E>G | No |
ClinGen TOPMed |
|
|
rs1259084256 CA412133835 |
166 | E>K | No |
ClinGen gnomAD |
|
|
rs1238422681 CA412133776 |
168 | K>N | No |
ClinGen gnomAD |
|
|
CA10310575 rs758229661 |
169 | I>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs761173302 CA10310602 |
169 | I>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs373887039 CA325502223 |
169 | I>V | No |
ClinGen ESP TOPMed |
|
|
CA10310573 rs779060916 |
170 | L>P | No |
ClinGen ExAC gnomAD |
|
|
CA10310571 rs752875210 |
171 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs368240751 CA10310569 |
173 | G>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs535912053 CA10310566 COSM3800283 |
175 | A>P | Variant assessed as Somatic; 0.0 impact. urinary_tract [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA gnomAD |
|
CA412132979 rs1337122058 |
176 | R>G | No |
ClinGen gnomAD |
|
|
rs1311378977 CA412132954 |
177 | Q>* | No |
ClinGen TOPMed |
|
|
rs1300715503 CA412132913 |
179 | D>G | No |
ClinGen gnomAD |
|
|
CA412132919 rs1372694244 |
179 | D>N | No |
ClinGen gnomAD |
|
|
CA412132893 rs1171868969 |
180 | S>G | No |
ClinGen Ensembl |
|
|
CA325502158 rs954522941 |
180 | S>R | No |
ClinGen TOPMed |
|
|
CA412132876 rs1569142184 |
181 | E>K | No |
ClinGen Ensembl |
|
|
rs565963616 CA325502153 |
185 | Y>* | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1370931385 CA412132770 |
185 | Y>F | No |
ClinGen gnomAD |
|
|
CA10310562 rs762283204 |
186 | V>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1394725031 CA412132728 |
187 | V>A | No |
ClinGen gnomAD |
|
|
CA412132698 rs1455116484 |
188 | T>I | No |
ClinGen TOPMed |
|
|
CA10310560 rs112567753 |
189 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs149914576 CA10310561 |
189 | R>W | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1171914628 COSM1035387 CA412132648 |
191 | Y>C | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA gnomAD |
|
rs541009038 CA325502135 |
192 | R>Q | No |
ClinGen TOPMed |
|
|
rs147362308 CA10310558 |
192 | R>W | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
| TCGA novel | 193 | A>D | Variant assessed as Somatic; impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs758565790 CA325502127 |
194 | P>S | No |
ClinGen Ensembl |
|
|
rs745733708 CA10310556 |
195 | E>K | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs778829977 CA10310555 |
196 | V>D | No |
ClinGen ExAC gnomAD |
|
|
CA412132424 rs1460991272 |
200 | W>S | No |
ClinGen TOPMed gnomAD |
|
|
CA10310553 rs2230823 |
202 | R>C | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs138065172 CA10310552 |
202 | R>H | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10310550 rs371441235 |
204 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10310548 rs766690172 |
205 | Q>R | No |
ClinGen ExAC gnomAD |
|
|
rs758531977 CA10310547 |
206 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412132283 rs1601641476 |
207 | V>M | No |
ClinGen Ensembl |
|
|
rs766968717 CA10310520 |
209 | I>V | No |
ClinGen ExAC gnomAD |
|
|
rs1291861758 CA412132162 |
210 | W>C | No |
ClinGen gnomAD |
|
|
rs1337552675 CA412132173 |
210 | W>L | No |
ClinGen gnomAD |
|
|
rs774158025 CA10310518 |
211 | S>T | No |
ClinGen ExAC gnomAD |
|
|
rs762907698 CA412132148 |
212 | V>L | No |
ClinGen ExAC gnomAD |
|
|
rs762907698 CA10310516 |
212 | V>M | No |
ClinGen ExAC gnomAD |
|
|
rs886409501 CA325501844 |
213 | G>D | No |
ClinGen TOPMed |
|
|
rs1428764495 CA412132138 |
213 | G>S | No |
ClinGen gnomAD |
|
|
CA10310515 rs772869234 |
214 | C>R | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs374984773 CA10310513 |
214 | C>S | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10310512 rs772160186 |
214 | C>W | No |
ClinGen ExAC gnomAD |
|
|
rs374984773 CA10310514 |
214 | C>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10310510 rs370098873 |
216 | M>V | No |
ClinGen ESP ExAC gnomAD |
|
|
rs779174381 CA10310509 |
217 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310507 rs754282586 |
218 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA412132063 rs1180635241 |
219 | M>K | No |
ClinGen gnomAD |
|
|
rs777972164 CA10310506 |
220 | I>L | No |
ClinGen ExAC gnomAD |
|
|
rs377211551 CA10310505 |
224 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs768008775 CA10310503 |
225 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1569141906 CA412131969 |
226 | F>L | No |
ClinGen Ensembl |
|
|
CA10310502 rs200047423 |
227 | K>E | No |
ClinGen 1000Genomes ExAC gnomAD |
|
|
CA412131947 rs1304695219 |
228 | G>A | No |
ClinGen TOPMed |
|
|
CA10310501 rs751107042 |
229 | S>G | No |
ClinGen ExAC gnomAD |
|
|
VAR_042266 rs35396905 CA10310499 |
230 | D>N | No |
ClinGen UniProt ExAC TOPMed dbSNP gnomAD |
|
|
CA10310498 rs148359556 |
231 | H>Y | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10310464 rs780657283 |
233 | D>E | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310466 rs375314561 |
233 | D>N | No |
ClinGen ESP ExAC gnomAD |
|
|
CA412131886 rs375314561 |
233 | D>Y | No |
ClinGen ESP ExAC gnomAD |
|
|
rs1385560206 CA412131873 |
234 | Q>K | No |
ClinGen TOPMed |
|
|
CA412131866 rs1323364567 |
234 | Q>P | No |
ClinGen TOPMed |
|
|
rs1286073530 CA412131821 |
237 | E>D | No |
ClinGen TOPMed |
|
|
rs1216584206 CA412131812 |
238 | I>T | No |
ClinGen gnomAD |
|
|
CA325501621 rs769749669 |
239 | M>I | No |
ClinGen Ensembl |
|
|
CA412131799 rs1327970473 |
239 | M>T | No |
ClinGen TOPMed |
|
|
rs756912295 CA10310460 |
240 | K>E | No |
ClinGen ExAC gnomAD |
|
|
CA412131754 rs1227593089 |
242 | T>M | No |
ClinGen TOPMed gnomAD |
|
|
rs1035286596 CA325501614 |
243 | G>E | No |
ClinGen Ensembl |
|
|
rs2066776 CA412131733 |
244 | T>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs2066776 CA10310456 VAR_012002 |
244 | T>M | No |
ClinGen UniProt ESP ExAC TOPMed dbSNP gnomAD |
|
|
rs1289006154 CA412131714 |
245 | P>L | No |
ClinGen gnomAD |
|
|
rs1251050892 CA412131720 |
245 | P>S | No |
ClinGen TOPMed |
|
|
rs141322209 CA10310454 |
246 | P>L | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD |
|
rs1454842467 CA412131708 |
246 | P>S | No |
ClinGen gnomAD |
|
|
rs994844264 CA325501590 |
247 | A>V | No |
ClinGen gnomAD |
|
|
CA412131690 rs1419088981 |
248 | E>K | No |
ClinGen gnomAD |
|
|
rs1249910714 CA412131662 |
249 | F>L | No |
ClinGen TOPMed |
|
|
CA412131645 rs1474387101 |
251 | Q>* | No |
ClinGen gnomAD |
|
|
rs776952708 CA10310449 |
252 | R>Q | No |
ClinGen ExAC gnomAD |
|
|
CA10310450 rs368431064 |
252 | R>W | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310447 rs747318970 |
254 | Q>* | No |
ClinGen ExAC TOPMed |
|
|
CA412131602 rs1208083339 |
254 | Q>P | No |
ClinGen gnomAD |
|
|
CA10310446 COSM1035384 rs780708607 |
255 | S>N | Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated ExAC NCI-TCGA gnomAD |
|
rs1397753103 CA412131565 |
256 | D>G | No |
ClinGen TOPMed |
|
|
CA412131573 rs1231217204 |
256 | D>N | No |
ClinGen gnomAD |
|
|
CA412131551 rs1270918989 |
257 | E>G | No |
ClinGen gnomAD |
|
|
rs766170277 CA10310412 |
258 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA10310411 rs757414638 |
259 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs1394963059 CA412131462 |
260 | N>H | No |
ClinGen TOPMed |
|
|
CA10310410 rs753961967 |
260 | N>S | No |
ClinGen ExAC gnomAD |
|
|
rs368005916 CA10310409 |
261 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA325501487 rs1129881 |
261 | Y>N | No |
ClinGen Ensembl |
|
|
CA10310408 rs760950890 |
262 | M>T | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1226051304 CA412131421 |
263 | K>T | No |
ClinGen TOPMed |
|
|
CA412131382 rs1300601766 |
265 | L>P | No |
ClinGen gnomAD |
|
|
rs145695654 CA10310406 |
265 | L>V | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1601640521 CA412131349 |
267 | E>A | No |
ClinGen Ensembl |
|
|
rs774930213 COSM1417054 CA10310404 |
267 | E>K | large_intestine [Cosmic] | No |
ClinGen cosmic curated ExAC TOPMed gnomAD |
|
rs774930213 CA412131352 |
267 | E>Q | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310402 rs140876255 |
269 | E>K | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10310400 rs769472123 |
271 | K>E | No |
ClinGen ExAC gnomAD |
|
|
rs1187211689 CA412131256 |
272 | D>N | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed |
|
CA10310397 rs780659710 |
273 | F>L | No |
ClinGen ExAC gnomAD |
|
|
CA10310396 rs754815553 |
274 | A>V | No |
ClinGen ExAC gnomAD |
|
|
CA412131191 rs1477693654 |
275 | S>F | No |
ClinGen gnomAD |
|
|
CA325501453 rs980347044 |
276 | I>M | No |
ClinGen TOPMed gnomAD |
|
|
rs145222937 CA10310395 |
278 | T>I | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs139620386 CA10310394 |
280 | A>T | No |
ClinGen ESP ExAC TOPMed |
|
|
CA412131097 rs2066770 |
281 | S>R | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1250654121 CA412131092 |
282 | P>S | No |
ClinGen TOPMed gnomAD |
|
|
rs1250654121 CA412131088 |
282 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
rs754013665 CA10310392 |
283 | L>P | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310367 rs763251061 |
284 | A>G | No |
ClinGen ExAC gnomAD |
|
|
rs1052023441 CA325501334 |
285 | V>L | No |
ClinGen Ensembl |
|
|
CA10310366 rs750939832 |
286 | N>D | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310365 rs565620467 |
288 | L>V | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10310364 rs761451320 |
289 | E>K | No |
ClinGen ExAC gnomAD |
|
|
rs550397425 CA10310363 |
291 | M>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA412130403 rs1387802745 |
292 | L>V | No |
ClinGen gnomAD |
|
|
rs1169472963 CA412130396 |
293 | V>M | No |
ClinGen gnomAD |
|
|
rs1366630695 CA412130385 |
294 | L>M | No |
ClinGen TOPMed |
|
|
rs760278888 CA10310361 |
294 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs760278888 CA10310362 |
294 | L>Q | No |
ClinGen ExAC gnomAD |
|
|
rs775233790 CA10310360 |
295 | D>V | No |
ClinGen ExAC gnomAD |
|
|
CA10310358 COSM3390300 rs200832605 |
296 | A>T | pancreas [Cosmic] | No |
ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD |
|
CA10310357 rs779064840 |
296 | A>V | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA325501267 rs914979130 |
297 | E>Q | No |
ClinGen Ensembl |
|
|
rs200947001 CA10310354 |
299 | R>L | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs200947001 CA10310355 |
299 | R>Q | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10310353 rs755043439 |
301 | T>M | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412130300 rs1272061993 |
304 | E>A | No |
ClinGen gnomAD |
|
|
rs202172571 CA10310350 |
304 | E>K | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10310349 rs367576600 |
305 | A>V | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10310347 rs762203850 |
306 | L>P | No |
ClinGen ExAC gnomAD |
|
|
rs1183818104 CA412130270 |
307 | A>G | No |
ClinGen gnomAD |
|
|
rs963460056 CA325501181 |
308 | H>R | No |
ClinGen Ensembl |
|
|
rs559897016 CA10310345 |
309 | P>L | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA412130247 rs1347956140 |
309 | P>S | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen NCI-TCGA TOPMed gnomAD |
|
CA412130246 rs1347956140 |
309 | P>T | No |
ClinGen TOPMed gnomAD |
|
|
CA10310344 rs760174056 |
310 | Y>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs775287258 CA10310343 |
312 | E>K | No |
ClinGen ExAC gnomAD |
|
|
CA412130212 rs775287258 |
312 | E>Q | No |
ClinGen ExAC gnomAD |
|
|
CA10310342 rs771850986 |
313 | S>A | No |
ClinGen ExAC gnomAD |
|
|
CA10310341 rs759466661 |
313 | S>F | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs770945104 CA412130174 |
315 | H>N | Variant assessed as Somatic; impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA TOPMed gnomAD |
|
CA10310339 rs770945104 |
315 | H>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs200321773 CA10310337 |
316 | D>N | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA10310334 rs140312551 |
317 | T>M | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA10310335 rs140312551 |
317 | T>R | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs556084921 CA325501151 |
317 | T>S | No |
ClinGen 1000Genomes TOPMed gnomAD |
|
|
rs201016559 CA10310331 |
318 | E>G | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs976183321 CA325501136 |
319 | D>G | No |
ClinGen TOPMed |
|
|
CA10310330 rs149438446 |
319 | D>Y | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
CA325501130 rs754315556 |
321 | P>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310329 rs754315556 |
321 | P>L | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1220917943 CA412130061 |
321 | P>S | No |
ClinGen gnomAD |
|
|
rs1292784226 CA412130035 |
323 | V>I | No |
ClinGen gnomAD |
|
|
CA412130020 rs1330801681 |
324 | Q>E | No |
ClinGen gnomAD |
|
|
CA10310327 rs764596006 |
324 | Q>H | No |
ClinGen ExAC gnomAD |
|
|
rs1305752167 CA412129976 |
325 | K>N | No |
ClinGen gnomAD |
|
|
rs139984390 CA10310326 |
326 | Y>C | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
CA412129965 rs139984390 |
326 | Y>F | No |
ClinGen ESP ExAC TOPMed gnomAD |
|
|
rs555010998 CA10310324 |
327 | D>A | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
CA10310323 rs759235816 |
327 | D>E | No |
ClinGen ExAC gnomAD |
|
|
rs752245784 CA10310325 |
327 | D>Y | No |
ClinGen ExAC gnomAD |
|
|
rs947527083 CA325501098 |
329 | S>F | No |
ClinGen Ensembl |
|
|
CA412129880 rs766106806 |
332 | D>N | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA10310321 rs766106806 |
332 | D>Y | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs769765600 CA10310318 |
333 | V>A | No |
ClinGen ExAC gnomAD |
|
|
CA10310319 rs773024220 |
333 | V>I | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1054886574 CA10310315 |
335 | R>C | No |
ClinGen TOPMed gnomAD |
|
|
rs1054886574 CA10310316 |
335 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
rs747147908 CA10310314 |
335 | R>H | No |
ClinGen ExAC TOPMed gnomAD |
|
|
rs1281216459 CA412129827 |
336 | T>S | No |
ClinGen gnomAD |
|
|
CA325501067 rs150677711 |
338 | D>E | No |
ClinGen ESP |
|
|
rs1300419273 CA412129806 |
338 | D>N | No |
ClinGen TOPMed gnomAD |
|
|
CA412129773 rs1224159118 |
340 | W>* | No |
ClinGen gnomAD |
|
|
CA10310312 rs772319839 |
342 | R>C | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412129714 rs1206908988 |
342 | R>H | No |
ClinGen gnomAD |
|
|
rs1273368509 CA412129711 |
343 | V>I | No |
ClinGen gnomAD |
|
|
CA10310163 rs562826406 |
344 | T>I | No |
ClinGen 1000Genomes ExAC TOPMed |
|
|
CA412129702 rs562826406 |
344 | T>S | No |
ClinGen 1000Genomes ExAC TOPMed |
|
|
rs780815449 CA10310165 |
344 | T>S | No |
ClinGen ExAC |
|
|
CA412129683 rs1258243960 |
347 | E>* | No |
ClinGen TOPMed gnomAD |
|
|
CA412129680 rs1231558733 |
347 | E>V | No |
ClinGen TOPMed gnomAD |
|
|
rs1159298322 CA412129669 |
349 | L>F | No |
ClinGen TOPMed |
|
|
rs1330937971 CA412129665 |
350 | S>R | No |
ClinGen gnomAD |
|
|
CA412129656 rs1365182586 |
351 | F>L | No |
ClinGen TOPMed |
|
|
rs746965360 CA325497953 |
353 | P>A | No |
ClinGen ExAC TOPMed |
|
|
CA325497949 rs755382069 |
353 | P>L | No |
ClinGen gnomAD |
|
|
CA10310162 rs746965360 |
353 | P>S | No |
ClinGen ExAC TOPMed |
|
|
rs544707425 CA412129637 |
354 | P>S | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs544707425 CA10310161 |
354 | P>T | No |
ClinGen 1000Genomes ExAC TOPMed gnomAD |
|
|
rs1307517554 CA412129633 |
355 | R>G | No |
ClinGen TOPMed gnomAD |
|
|
CA10310160 rs138582408 |
355 | R>Q | No |
ClinGen 1000Genomes ESP ExAC TOPMed gnomAD |
|
|
rs1307517554 COSM1417050 CA412129632 |
355 | R>W | Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic] | No |
ClinGen cosmic curated NCI-TCGA TOPMed gnomAD |
|
CA412129627 rs1404303754 |
356 | Q>* | No |
ClinGen gnomAD |
|
|
CA10310159 rs753955809 |
356 | Q>R | No |
ClinGen ExAC TOPMed gnomAD |
|
| rs1184072475 | 359 | A>P | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No | NCI-TCGA |
|
rs778107816 CA10310158 |
359 | A>T | No |
ClinGen ExAC gnomAD |
|
|
CA412129597 rs1337740173 |
361 | V>F | No |
ClinGen TOPMed |
|
|
CA10310157 rs756261585 |
361 | V>G | No |
ClinGen ExAC TOPMed gnomAD |
|
|
CA412129589 rs1187678837 |
362 | S>F | No |
ClinGen gnomAD |
|
|
rs1263617959 CA412129578 |
364 | E>* | No |
ClinGen TOPMed |
|
|
CA10310154 rs759840185 |
364 | E>D | No |
ClinGen ExAC gnomAD |
|
|
CA412129572 rs1488156743 |
365 | T>A | No |
ClinGen TOPMed |
|
|
CA10310153 rs747209953 |
365 | T>M | Variant assessed as Somatic; 0.0 impact. [NCI-TCGA] | No |
ClinGen ExAC NCI-TCGA gnomAD |
|
rs1437402973 CA412129550 |
368 | L>C | No |
ClinGen TOPMed |
1 associated diseases with P53778
Without disease ID
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.24 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| MAP kinase activity | Catalysis of the reaction |
| protein serine kinase activity | Catalysis of the reactions |
| protein serine/threonine kinase activity | Catalysis of the reactions |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| intracellular signal transduction | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. |
| MAPK cascade | An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers |
| muscle organ development | The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work. |
| myoblast differentiation | The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers. |
| negative regulation of cell cycle | Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle. |
| peptidyl-serine phosphorylation | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. |
| positive regulation of muscle cell differentiation | Any process that activates or increases the frequency, rate or extent of muscle cell differentiation. |
| positive regulation of peptidase activity | Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
| signal transduction in response to DNA damage | A cascade of processes induced by the detection of DNA damage within a cell. |
91 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P32485 | HOG1 | Mitogen-activated protein kinase HOG1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| A5PKJ4 | MAPK7 | Mitogen-activated protein kinase 7 | Bos taurus (Bovine) | SS |
| Q3T0N5 | MAPK13 | Mitogen-activated protein kinase 13 | Bos taurus (Bovine) | SS |
| P46196 | MAPK1 | Mitogen-activated protein kinase 1 | Bos taurus (Bovine) | SS |
| Q5F3W3 | MAPK6 | Mitogen-activated protein kinase 6 | Gallus gallus (Chicken) | SS |
| Q95NE7 | MAPK14 | Mitogen-activated protein kinase 14 | Pan troglodytes (Chimpanzee) | SS |
| Q9N272 | MAPK13 | Mitogen-activated protein kinase 13 | Pan troglodytes (Chimpanzee) | SS |
| Q9W354 | Erk7 | Extracellular signal-regulated kinase 7 | Drosophila melanogaster (Fruit fly) | SS |
| P40417 | rl | Mitogen-activated protein kinase ERK-A | Drosophila melanogaster (Fruit fly) | SS |
| P83100 | p38c | Putative mitogen-activated protein kinase 14C | Drosophila melanogaster (Fruit fly) | SS |
| O62618 | p38a | Mitogen-activated protein kinase p38a | Drosophila melanogaster (Fruit fly) | SS |
| O61443 | p38b | Mitogen-activated protein kinase p38b | Drosophila melanogaster (Fruit fly) | SS |
| P20794 | MAK | Serine/threonine-protein kinase MAK | Homo sapiens (Human) | PR |
| Q9UQ07 | MOK | MAPK/MAK/MRK overlapping kinase | Homo sapiens (Human) | PR |
| Q8TD08 | MAPK15 | Mitogen-activated protein kinase 15 | Homo sapiens (Human) | SS |
| P45984 | MAPK9 | Mitogen-activated protein kinase 9 | Homo sapiens (Human) | SS |
| P45983 | MAPK8 | Mitogen-activated protein kinase 8 | Homo sapiens (Human) | EV |
| P53779 | MAPK10 | Mitogen-activated protein kinase 10 | Homo sapiens (Human) | EV |
| Q9UBE8 | NLK | Serine/threonine-protein kinase NLK | Homo sapiens (Human) | SS |
| P27361 | MAPK3 | Mitogen-activated protein kinase 3 | Homo sapiens (Human) | SS |
| P28482 | MAPK1 | Mitogen-activated protein kinase 1 | Homo sapiens (Human) | EV |
| P31152 | MAPK4 | Mitogen-activated protein kinase 4 | Homo sapiens (Human) | SS |
| Q16659 | MAPK6 | Mitogen-activated protein kinase 6 | Homo sapiens (Human) | SS |
| Q13164 | MAPK7 | Mitogen-activated protein kinase 7 | Homo sapiens (Human) | SS |
| O15264 | MAPK13 | Mitogen-activated protein kinase 13 | Homo sapiens (Human) | SS |
| Q15759 | MAPK11 | Mitogen-activated protein kinase 11 | Homo sapiens (Human) | SS |
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | Homo sapiens (Human) | SS |
| Q9Z1B7 | Mapk13 | Mitogen-activated protein kinase 13 | Mus musculus (Mouse) | SS |
| P47811 | Mapk14 | Mitogen-activated protein kinase 14 | Mus musculus (Mouse) | SS |
| Q61532 | Mapk6 | Mitogen-activated protein kinase 6 | Mus musculus (Mouse) | SS |
| Q63844 | Mapk3 | Mitogen-activated protein kinase 3 | Mus musculus (Mouse) | SS |
| P63085 | Mapk1 | Mitogen-activated protein kinase 1 | Mus musculus (Mouse) | SS |
| Q9WVS8 | Mapk7 | Mitogen-activated protein kinase 7 | Mus musculus (Mouse) | SS |
| Q9WUI1 | Mapk11 | Mitogen-activated protein kinase 11 | Mus musculus (Mouse) | SS |
| Q80Y86 | Mapk15 | Mitogen-activated protein kinase 15 | Mus musculus (Mouse) | SS |
| Q6P5G0 | Mapk4 | Mitogen-activated protein kinase 4 | Mus musculus (Mouse) | SS |
| O08911 | Mapk12 | Mitogen-activated protein kinase 12 | Mus musculus (Mouse) | SS |
| P70618 | Mapk14 | Mitogen-activated protein kinase 14 | Rattus norvegicus (Rat) | SS |
| Q9WTY9 | Mapk13 | Mitogen-activated protein kinase 13 | Rattus norvegicus (Rat) | SS |
| P63086 | Mapk1 | Mitogen-activated protein kinase 1 | Rattus norvegicus (Rat) | SS |
| Q9Z2A6 | Mapk15 | Mitogen-activated protein kinase 15 | Rattus norvegicus (Rat) | SS |
| P27704 | Mapk6 | Mitogen-activated protein kinase 6 | Rattus norvegicus (Rat) | SS |
| P21708 | Mapk3 | Mitogen-activated protein kinase 3 | Rattus norvegicus (Rat) | SS |
| Q63454 | Mapk4 | Mitogen-activated protein kinase 4 | Rattus norvegicus (Rat) | SS |
| P0C865 | Mapk7 | Mitogen-activated protein kinase 7 | Rattus norvegicus (Rat) | SS |
| Q63538 | Mapk12 | Mitogen-activated protein kinase 12 | Rattus norvegicus (Rat) | SS |
| Q5ZCI1 | MPK10 | Mitogen-activated protein kinase 10 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5VP69 | MPK16 | Mitogen-activated protein kinase 16 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5SN53 | MPK8 | Mitogen-activated protein kinase 8 | Oryza sativa subsp. japonica (Rice) | SS |
| Q0E459 | MPK13 | Mitogen-activated protein kinase 13 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6Z437 | MPK3 | Mitogen-activated protein kinase 3 | Oryza sativa subsp. japonica (Rice) | SS |
| Q75KK8 | MPK14 | Mitogen-activated protein kinase 14 | Oryza sativa subsp. japonica (Rice) | SS |
| Q67C40 | MPK7 | Mitogen-activated protein kinase 7 | Oryza sativa subsp. japonica (Rice) | SS |
| Q6L5F7 | MPK17 | Mitogen-activated protein kinase 17 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5VN19 | MPK11 | Mitogen-activated protein kinase 11 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5Z859 | MPK4 | Mitogen-activated protein kinase 4 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5Z9J0 | MPK12 | Mitogen-activated protein kinase 12 | Oryza sativa subsp. japonica (Rice) | SS |
| Q53N72 | MPK15 | Mitogen-activated protein kinase 15 | Oryza sativa subsp. japonica (Rice) | SS |
| Q336X9 | MPK6 | Mitogen-activated protein kinase 6 | Oryza sativa subsp. japonica (Rice) | SS |
| Q5J4W4 | MPK2 | Mitogen-activated protein kinase 2 | Oryza sativa subsp. japonica (Rice) | SS |
| Q84UI5 | MPK1 | Mitogen-activated protein kinase 1 | Oryza sativa subsp. japonica (Rice) | SS |
| Q10N20 | MPK5 | Mitogen-activated protein kinase 5 | Oryza sativa subsp. japonica (Rice) | SS |
| Q11179 | mapk-15 | Mitogen-activated protein kinase 15 | Caenorhabditis elegans | SS |
| O44514 | pmk-3 | Mitogen-activated protein kinase pmk-3 | Caenorhabditis elegans | PR |
| P39745 | mpk-1 | Mitogen-activated protein kinase mpk-1 | Caenorhabditis elegans | SS |
| G5EBT1 | sma-5 | Mitogen-activated protein kinase sma-5 | Caenorhabditis elegans | SS |
| Q8MXI4 | pmk-2 | Mitogen-activated protein kinase pmk-2 | Caenorhabditis elegans | SS |
| Q17446 | pmk-1 | Mitogen-activated protein kinase pmk-1 | Caenorhabditis elegans | SS |
| Q39021 | MPK1 | Mitogen-activated protein kinase 1 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LM33 | MPK8 | Mitogen-activated protein kinase 8 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C5C0 | MPK18 | Mitogen-activated protein kinase 18 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39022 | MPK2 | Mitogen-activated protein kinase 2 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9C9U4 | MPK15 | Mitogen-activated protein kinase 15 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q84M93 | MPK17 | Mitogen-activated protein kinase 17 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39027 | MPK7 | Mitogen-activated protein kinase 7 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9SJG9 | MPK20 | Mitogen-activated protein kinase 20 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LUC3 | MPK19 | Mitogen-activated protein kinase 19 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LV37 | MPK9 | Mitogen-activated protein kinase 9 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| O23236 | MPK14 | Mitogen-activated protein kinase 14 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8W4J2 | MPK16 | Mitogen-activated protein kinase 16 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39023 | MPK3 | Mitogen-activated protein kinase 3 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39026 | MPK6 | Mitogen-activated protein kinase 6 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39025 | MPK5 | Mitogen-activated protein kinase 5 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q39024 | MPK4 | Mitogen-activated protein kinase 4 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M1Z5 | MPK10 | Mitogen-activated protein kinase 10 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8GYQ5 | MPK12 | Mitogen-activated protein kinase 12 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LMM5 | MPK11 | Mitogen-activated protein kinase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9LQQ9 | MPK13 | Mitogen-activated protein kinase 13 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9DGE1 | mapk14b | Mitogen-activated protein kinase 14B | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DGE2 | mapk14a | Mitogen-activated protein kinase 14A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O42376 | mapk12 | Mitogen-activated protein kinase 12 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSPPPARSG | FYRQEVTKTA | WEVRAVYRDL | QPVGSGAYGA | VCSAVDGRTG | AKVAIKKLYR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PFQSELFAKR | AYRELRLLKH | MRHENVIGLL | DVFTPDETLD | DFTDFYLVMP | FMGTDLGKLM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KHEKLGEDRI | QFLVYQMLKG | LRYIHAAGII | HRDLKPGNLA | VNEDCELKIL | DFGLARQADS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EMTGYVVTRW | YRAPEVILNW | MRYTQTVDIW | SVGCIMAEMI | TGKTLFKGSD | HLDQLKEIMK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VTGTPPAEFV | QRLQSDEAKN | YMKGLPELEK | KDFASILTNA | SPLAVNLLEK | MLVLDAEQRV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TAGEALAHPY | FESLHDTEDE | PQVQKYDDSF | DDVDRTLDEW | KRVTYKEVLS | FKPPRQLGAR |
| VSKETPL |