P53767
PR
Gene name |
Flt1 (Flt-1, Vegfr1) |
Protein name |
Vascular endothelial growth factor receptor 1 |
Names |
VEGFR-1, Fms-like tyrosine kinase 1, FLT-1, Tyrosine-protein kinase receptor FLT |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
|
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
(Annotation based on sequence homology with P35968)
The vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play crucial roles in vasculogenesis and angiogenesis. The unphosphorylated juxtamembrane region of VEGFR2 autoinhibits kinase activity by interacting with the activation loop in the kinase domain. Like other receptor tyrosine kinases, VEGFRs may have other autoinhibitory regions.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
1039-1064 (Activation loop)
Target domain |
827-1158 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for P53767
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53767-F1 | Predicted | AlphaFoldDB |
No variants for P53767
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P53767 | |||||
No associated diseases with P53767
27 regional properties for P53767
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 827 - 1158 | IPR000719 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 827 - 1154 | IPR001245 |
| conserved_site | Tyrosine-protein kinase, receptor class III, conserved site | 886 - 899 | IPR001824 |
| domain | Immunoglobulin subtype 2 | 44 - 114 | IPR003598-1 |
| domain | Immunoglobulin subtype 2 | 149 - 214 | IPR003598-2 |
| domain | Immunoglobulin subtype 2 | 243 - 318 | IPR003598-3 |
| domain | Immunoglobulin subtype 2 | 568 - 643 | IPR003598-4 |
| domain | Immunoglobulin subtype 2 | 673 - 738 | IPR003598-5 |
| domain | Immunoglobulin subtype | 38 - 127 | IPR003599-1 |
| domain | Immunoglobulin subtype | 143 - 224 | IPR003599-2 |
| domain | Immunoglobulin subtype | 237 - 327 | IPR003599-3 |
| domain | Immunoglobulin subtype | 344 - 425 | IPR003599-4 |
| domain | Immunoglobulin subtype | 439 - 553 | IPR003599-5 |
| domain | Immunoglobulin subtype | 562 - 656 | IPR003599-6 |
| domain | Immunoglobulin subtype | 667 - 749 | IPR003599-7 |
| domain | Immunoglobulin-like domain | 32 - 121 | IPR007110-1 |
| domain | Immunoglobulin-like domain | 230 - 327 | IPR007110-2 |
| domain | Immunoglobulin-like domain | 349 - 404 | IPR007110-3 |
| domain | Immunoglobulin-like domain | 428 - 549 | IPR007110-4 |
| domain | Immunoglobulin-like domain | 556 - 655 | IPR007110-5 |
| domain | Immunoglobulin-like domain | 661 - 747 | IPR007110-6 |
| active_site | Tyrosine-protein kinase, active site | 1018 - 1030 | IPR008266 |
| domain | Immunoglobulin I-set | 350 - 405 | IPR013098-1 |
| domain | Immunoglobulin I-set | 664 - 748 | IPR013098-2 |
| binding_site | Protein kinase, ATP binding site | 833 - 861 | IPR017441 |
| domain | Tyrosine-protein kinase, catalytic domain | 827 - 1154 | IPR020635 |
| domain | VEGFR-2, transmembrane domain | 753 - 787 | IPR041348 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| receptor complex | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| growth factor binding | Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. |
| identical protein binding | Binding to an identical protein or proteins. |
| placental growth factor receptor activity | Combining with placental growth factor (PlGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
| transmembrane receptor protein tyrosine kinase activity | Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. |
| vascular endothelial growth factor receptor activity | Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
42 GO annotations of biological process
| Name | Definition |
|---|---|
| aging | A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700). |
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| blood vessel morphogenesis | The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood. |
| branching involved in blood vessel morphogenesis | The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. |
| cell migration | The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms. |
| cellular response to hypoxia | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| cellular response to vascular endothelial growth factor stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. |
| embryonic morphogenesis | The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants. |
| female pregnancy | The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. |
| hematopoietic progenitor cell differentiation | The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells. |
| hyaloid vascular plexus regression | The developmental process in which the hyaloid vascular plexus is destroyed as a part of its normal progression. |
| intracellular receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a receptor located within a cell. |
| liver regeneration | The regrowth of lost or destroyed liver. |
| monocyte chemotaxis | The movement of a monocyte in response to an external stimulus. |
| negative regulation of sprouting angiogenesis | Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis. |
| negative regulation of vascular endothelial cell proliferation | Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial cell proliferation. |
| negative regulation of vascular endothelial growth factor production | Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production. |
| peptidyl-tyrosine phosphorylation | The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. |
| positive regulation of angiogenesis | Any process that activates or increases angiogenesis. |
| positive regulation of cell migration | Any process that activates or increases the frequency, rate or extent of cell migration. |
| positive regulation of glial cell proliferation | Any process that activates or increases the rate or extent of glial cell proliferation. |
| positive regulation of hematopoietic progenitor cell differentiation | Any process that activates or increases the frequency, rate or extent of hematopoietic progenitor cell differentiation. |
| positive regulation of kinase activity | Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
| positive regulation of MAP kinase activity | Any process that activates or increases the frequency, rate or extent of MAP kinase activity. |
| positive regulation of MAPK cascade | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. |
| positive regulation of phosphatidylinositol 3-kinase activity | Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity. |
| positive regulation of phosphatidylinositol 3-kinase signaling | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade. |
| positive regulation of phospholipase C activity | Any process that increases the rate of phospholipase C activity. |
| positive regulation of smooth muscle cell proliferation | Any process that activates or increases the rate or extent of smooth muscle cell proliferation. |
| post-embryonic camera-type eye morphogenesis | The process in which the anatomical structures of the eye are generated and organized during post-embryonic development. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of smooth muscle contraction | Any process that modulates the frequency, rate or extent of smooth muscle contraction. |
| response to activity | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. |
| response to estradiol | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. |
| response to ethanol | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. |
| response to hypoxia | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. |
| sprouting angiogenesis | The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation. |
| transmembrane receptor protein tyrosine kinase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vascular endothelial growth factor receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vascular endothelial growth factor receptor-1 signaling pathway | The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-1 (VEGFR-1) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vascular endothelial growth factor signaling pathway | The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
83 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43481 | KIT | Mast/stem cell growth factor receptor Kit | Bos taurus (Bovine) | SS |
| Q06805 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Bos taurus (Bovine) | PR |
| Q06807 | TEK | Angiopoietin-1 receptor | Bos taurus (Bovine) | SS |
| Q28889 | KIT | Mast/stem cell growth factor receptor Kit | Felis catus (Cat) (Felis silvestris catus) | SS |
| P13369 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Felis catus (Cat) (Felis silvestris catus) | SS |
| P18460 | FGFR3 | Fibroblast growth factor receptor 3 | Gallus gallus (Chicken) | SS |
| P21804 | FGFR1 | Fibroblast growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| Q9PUF6 | PDGFRA | Platelet-derived growth factor receptor alpha | Gallus gallus (Chicken) | SS |
| Q08156 | KIT | Mast/stem cell growth factor receptor Kit | Gallus gallus (Chicken) | SS |
| P18461 | FGFR2 | Fibroblast growth factor receptor 2 | Gallus gallus (Chicken) | SS |
| Q8QHL3 | FLT1 | Vascular endothelial growth factor receptor 1 | Gallus gallus (Chicken) | SS |
| Q07407 | htl | Fibroblast growth factor receptor homolog 1 | Drosophila melanogaster (Fruit fly) | PR |
| Q6J9G0 | STYK1 | Tyrosine-protein kinase STYK1 | Homo sapiens (Human) | PR |
| P36888 | FLT3 | Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (Human) | EV |
| P16234 | PDGFRA | Platelet-derived growth factor receptor alpha | Homo sapiens (Human) | EV |
| P09619 | PDGFRB | Platelet-derived growth factor receptor beta | Homo sapiens (Human) | EV |
| P35916 | FLT4 | Vascular endothelial growth factor receptor 3 | Homo sapiens (Human) | SS |
| P35968 | KDR | Vascular endothelial growth factor receptor 2 | Homo sapiens (Human) | EV |
| P07333 | CSF1R | Macrophage colony-stimulating factor 1 receptor | Homo sapiens (Human) | SS |
| P10721 | KIT | Mast/stem cell growth factor receptor Kit | Homo sapiens (Human) | EV |
| P22455 | FGFR4 | Fibroblast growth factor receptor 4 | Homo sapiens (Human) | SS |
| P22607 | FGFR3 | Fibroblast growth factor receptor 3 | Homo sapiens (Human) | EV |
| P07949 | RET | Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (Human) | EV |
| P35590 | TIE1 | Tyrosine-protein kinase receptor Tie-1 | Homo sapiens (Human) | PR |
| Q02763 | TEK | Angiopoietin-1 receptor | Homo sapiens (Human) | SS |
| P11362 | FGFR1 | Fibroblast growth factor receptor 1 | Homo sapiens (Human) | EV |
| P21802 | FGFR2 | Fibroblast growth factor receptor 2 | Homo sapiens (Human) | EV |
| P17948 | FLT1 | Vascular endothelial growth factor receptor 1 | Homo sapiens (Human) | SS |
| Q03142 | Fgfr4 | Fibroblast growth factor receptor 4 | Mus musculus (Mouse) | PR |
| P05532 | Kit | Mast/stem cell growth factor receptor Kit | Mus musculus (Mouse) | PR |
| Q91V87 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Mus musculus (Mouse) | PR |
| P35917 | Flt4 | Vascular endothelial growth factor receptor 3 | Mus musculus (Mouse) | SS |
| P05622 | Pdgfrb | Platelet-derived growth factor receptor beta | Mus musculus (Mouse) | SS |
| P09581 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Mus musculus (Mouse) | SS |
| P35546 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Mus musculus (Mouse) | SS |
| Q06806 | Tie1 | Tyrosine-protein kinase receptor Tie-1 | Mus musculus (Mouse) | SS |
| Q00342 | Flt3 | Receptor-type tyrosine-protein kinase FLT3 | Mus musculus (Mouse) | SS |
| Q6J9G1 | Styk1 | Tyrosine-protein kinase STYK1 | Mus musculus (Mouse) | PR |
| P16092 | Fgfr1 | Fibroblast growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q61851 | Fgfr3 | Fibroblast growth factor receptor 3 | Mus musculus (Mouse) | PR |
| Q02858 | Tek | Angiopoietin-1 receptor | Mus musculus (Mouse) | SS |
| P35918 | Kdr | Vascular endothelial growth factor receptor 2 | Mus musculus (Mouse) | PR |
| P21803 | Fgfr2 | Fibroblast growth factor receptor 2 | Mus musculus (Mouse) | SS |
| P26618 | Pdgfra | Platelet-derived growth factor receptor alpha | Mus musculus (Mouse) | SS |
| P35969 | Flt1 | Vascular endothelial growth factor receptor 1 | Mus musculus (Mouse) | SS |
| Q2HWD6 | KIT | Mast/stem cell growth factor receptor Kit | Sus scrofa (Pig) | SS |
| Q7TQM3 | Fgfrl1 | Fibroblast growth factor receptor-like 1 | Rattus norvegicus (Rat) | PR |
| G3V9H8 | Ret | Proto-oncogene tyrosine-protein kinase receptor Ret | Rattus norvegicus (Rat) | SS |
| O08775 | Kdr | Vascular endothelial growth factor receptor 2 | Rattus norvegicus (Rat) | SS |
| P20786 | Pdgfra | Platelet-derived growth factor receptor alpha | Rattus norvegicus (Rat) | SS |
| Q04589 | Fgfr1 | Fibroblast growth factor receptor 1 | Rattus norvegicus (Rat) | SS |
| Q05030 | Pdgfrb | Platelet-derived growth factor receptor beta | Rattus norvegicus (Rat) | SS |
| Q498D6 | Fgfr4 | Fibroblast growth factor receptor 4 | Rattus norvegicus (Rat) | PR |
| Q91ZT1 | Flt4 | Vascular endothelial growth factor receptor 3 | Rattus norvegicus (Rat) | SS |
| Q62838 | Musk | Muscle, skeletal receptor tyrosine protein kinase | Rattus norvegicus (Rat) | SS |
| Q63474 | Ddr1 | Epithelial discoidin domain-containing receptor 1 | Rattus norvegicus (Rat) | SS |
| Q63604 | Ntrk2 | BDNF/NT-3 growth factors receptor | Rattus norvegicus (Rat) | SS |
| P35739 | Ntrk1 | High affinity nerve growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q03351 | Ntrk3 | NT-3 growth factor receptor | Rattus norvegicus (Rat) | SS |
| Q64716 | Insrr | Insulin receptor-related protein | Rattus norvegicus (Rat) | SS |
| P24062 | Igf1r | Insulin-like growth factor 1 receptor | Rattus norvegicus (Rat) | SS |
| P15127 | Insr | Insulin receptor | Rattus norvegicus (Rat) | SS |
| P57097 | Mertk | Tyrosine-protein kinase Mer | Rattus norvegicus (Rat) | SS |
| P97523 | Met | Hepatocyte growth factor receptor | Rattus norvegicus (Rat) | PR |
| P06494 | Erbb2 | Receptor tyrosine-protein kinase erbB-2 | Rattus norvegicus (Rat) | SS |
| Q62956 | Erbb4 | Receptor tyrosine-protein kinase erbB-4 | Rattus norvegicus (Rat) | SS |
| Q62799 | Erbb3 | Receptor tyrosine-protein kinase erbB-3 | Rattus norvegicus (Rat) | SS |
| Q00495 | Csf1r | Macrophage colony-stimulating factor 1 receptor | Rattus norvegicus (Rat) | PR |
| Q17833 | old-1 | Tyrosine-protein kinase receptor old-1 | Caenorhabditis elegans | PR |
| Q19238 | F09A5.2 | Putative tyrosine-protein kinase F09A5.2 | Caenorhabditis elegans | SS |
| Q10656 | egl-15 | Myoblast growth factor receptor egl-15 | Caenorhabditis elegans | PR |
| P34892 | kin-16 | Receptor-like tyrosine-protein kinase kin-16 | Caenorhabditis elegans | PR |
| G5ED65 | ver-1 | Protein ver-1 | Caenorhabditis elegans | PR |
| Q8AXB3 | kdrl | Vascular endothelial growth factor receptor kdr-like | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5GIT4 | kdr | Vascular endothelial growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| O73791 | tek | Angiopoietin-1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90Z00 | fgfr1a | Fibroblast growth factor receptor 1-A | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JG38 | fgfr2 | Fibroblast growth factor receptor 2 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9I8N6 | csf1r | Macrophage colony-stimulating factor 1 receptor | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q90413 | fgfr4 | Fibroblast growth factor receptor 4 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q9DE49 | pdgfra | Platelet-derived growth factor receptor alpha | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q8JFR5 | kita | Mast/stem cell growth factor receptor kita | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| Q5MD89 | flt4 | Vascular endothelial growth factor receptor 3 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVSCWDTAVL | PCALLGCLLL | TGYCSGSKLK | GPELSLKGTQ | HVMQAGQTLF | LKCRGEAAHS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WSLPTTVSQE | DKKLSVTRSA | CGRNNRQFCS | TLTLNMAQAN | HTGLYSCRYL | PKSTSKEKKM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ESAIYIFVSD | AGSPFIEMHS | DIPKLVHMTE | GRELIIPCRV | TSPNITVTLK | KFPFDALTPD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GQRIAWDSRR | GFIIANATYK | EIGLLTCEAT | VNGHLYQTSY | LTHRQTNTIL | DVQISPPSPV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RFLRGQTLVL | NCTVTTDLNT | RVQMSWNYPG | KATKRASIRQ | RIDQSNPHSN | VFHSVLKINN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VESRDKGLYT | CRVKSGSSFR | TFNTSVHVYE | KGFISVKHRK | QQVQETIAGK | RSHRLSMKVK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AFPSPEVVWL | KDGVPATEKS | ARYSVHGYSL | IIKDVTAEDA | GDYTILLGIK | QSKLFRNLTA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TLIVNVKPQI | YEKSVSSLPS | PPLYPLGSRQ | VLTCTVYGIP | QPTIKWLWHP | CHYNHSKERN |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DFCFGSEESF | ILDSSSNIGN | RIEGITQRMM | VIEGTNKTVS | TLVVADSRTP | GSYSCKAFNK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IGTVERDIRF | YVTDVPNGFH | VSLEKIPTEG | EDLKLSCVVS | KFLYRDITWI | LLRTVNNRTM |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HHSISKQKMA | TTQDYSITLN | LVIKNVSLED | SGTYACRARN | IYTGEEILRK | TEVLVRDLEA |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PLLLQNLSDH | EVSISGSTTL | DCQARGVPAP | QITWFKNNHK | IQQEPGIILG | PGNSTLFIER |
| 730 | 740 | 750 | 760 | 770 | 780 |
| VTEEDEGVYR | CRATNQKGVV | ESSAYLTVQG | TSDKSNLELI | TLTCTCVAAT | LFWLLLTLFI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RKLKRSSSEV | KTDYLSIIMD | PDEVPLDEQC | ERLPYDASKW | EFARERLKLG | KSLGRGAFGK |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VVQASAFGIK | KSPTCRTVAV | KMLKEGATAS | EYKALMTELK | ILTHIGHHLN | VVNLLGACTK |
| 910 | 920 | 930 | 940 | 950 | 960 |
| QGGPLMVIVE | YCKYGNLSNY | LKSKRDFFCL | NKDAALHMEP | KKEKLEPDLE | QDQKPRLDSV |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| SSSESFTSSG | FQEDKSVSDV | EGGEDYSEIS | KQPLTMEDLI | SYSFQVARGM | EFLSSRKCIH |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| RDLAARNILL | SENNVVKICD | FGLARDIYKN | PDYVRRGDTR | LPLKWMAPES | IFDKVYSTKS |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| DVWSYGVLLW | EIFSLGGSPY | PGVQMDEDFC | SRLKEGMRMR | TPEYATPEIY | QIMLDCWHKD |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| PKERPRFAEL | VEKLGDLLQA | NVQQDGKDYI | PLNAILTRNS | GFTYSVPTFS | EDFFKDGFTD |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| PKFHSGSSDD | VRYVNAFKFM | SLERIKTFEE | LSPNATSMFE | DYHLDTSSLL | TSPLLKRFTW |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| TETKPKASMK | IDLRITSKSK | EAGLSDLPGP | SFCFSSCGHI | RPVRQEDEDD | PELGKESCCS |
| 1330 | |||||
| PPPDYNSVVL | YSSPPA |