AiPD: Autoinhibited Protein Database

P53671

Gene name	LIMK2
Protein name	LIM domain kinase 2
Names	LIMK-2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3985
EC number	2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

241-334 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

241-334 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

468-511 (Activation loop from InterPro)

Target domain	331-608 (Protein kinase domain)
Relief mechanism
Assay

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

7 structures for P53671

Entry ID	Method	Resolution	Chain	Position	Source
1X6A	NMR	-	A	62-129	PDB
4TPT	X-ray	260 A	A/B	330-632	PDB
5NXD	X-ray	190 A	A/B	330-632	PDB
7QHG	X-ray	145 A	A/B	330-632	PDB
8GI4	X-ray	206 A	A/B/C/D/E/F/G/H	130-250	PDB
8WSW	X-ray	250 A	A/B/C/D	330-632	PDB
AF-P53671-F1	Predicted				AlphaFoldDB

473 variants for P53671

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1486913765 CA411238155	2	S>C		No	ClinGen gnomAD
CA10190229 rs780556610	3	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	5	A>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA323267562 rs969888787	5	A>T		No	ClinGen TOPMed
rs1167570802 CA411238196	5	A>V		No	ClinGen gnomAD
rs749303634 CA10190230	6	G>S		No	ClinGen ExAC gnomAD
rs148900540 CA10190250	8	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA411232931 rs1413964832	9	V>A		No	ClinGen TOPMed gnomAD
rs1413964832 CA411232926	9	V>D		No	ClinGen TOPMed gnomAD
rs752846979 CA10190251	11	R>G		No	ClinGen ExAC gnomAD
CA323243183 rs1024462531	12	C>R		No	ClinGen TOPMed gnomAD
CA411233059 rs1222341612	13	P>L		No	ClinGen TOPMed gnomAD
rs1222341612 CA411233052	13	P>Q		No	ClinGen TOPMed gnomAD
CA10190252 rs758586443	16	G>A		No	ClinGen ExAC TOPMed gnomAD
CA411233135 rs758586443	16	G>E		No	ClinGen ExAC TOPMed gnomAD
CA10190253 rs777860928	17	D>H		No	ClinGen ExAC gnomAD
CA10190254 rs746761018	18	H>Y		No	ClinGen ExAC gnomAD
rs770871986 CA10190255	19	I>F		No	ClinGen ExAC gnomAD
CA10190256 rs143570231	22	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA10190257 rs367645806	23	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA411233300 rs1243809616	24	I>L		No	ClinGen TOPMed
rs1358858195 CA411233306	24	I>R		No	ClinGen TOPMed
rs1433136921 CA411233318	25	W>*		No	ClinGen TOPMed
CA10190258 rs769184921	25	W>L		No	ClinGen ExAC gnomAD
rs1018365552 CA323243227	25	W>R		No	ClinGen TOPMed gnomAD
CA411233338 rs1175386769	27	R>T		No	ClinGen gnomAD
rs762386096 CA10190260	29	V>A		No	ClinGen ExAC gnomAD
CA411233366 rs1373592440	29	V>F		No	ClinGen gnomAD
CA411233362 rs1373592440	29	V>I		No	ClinGen gnomAD
CA411233379 rs1329281834	30	N>H		No	ClinGen gnomAD
CA10190261 rs768290994	30	N>S		No	ClinGen ExAC TOPMed gnomAD
CA411233407 COSM282428 rs1279238051	31	E>K	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1367946333 CA411233432	32	T>A		No	ClinGen TOPMed
COSM1256494 CA411233467 rs995881074	33	W>*	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
rs995881074 CA323243281	33	W>C		No	ClinGen gnomAD
CA411233461 rs1410432969	33	W>S		No	ClinGen gnomAD
CA411233482 rs1236620924	34	H>L		No	ClinGen gnomAD
rs5997917 CA10190263 VAR_034069	35	G>S		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1390264677 CA411233527	36	S>C		No	ClinGen TOPMed
CA411233545 rs1436474228	37	C>*		No	ClinGen gnomAD
CA10190265 rs754336982	37	C>R		No	ClinGen ExAC gnomAD
CA411233547 rs1436474228	37	C>W		No	ClinGen gnomAD
rs1201980587 CA411233554	38	F>V		No	ClinGen gnomAD
CA10190267 rs765675081	39	R>Q		No	ClinGen ExAC gnomAD
rs760091365 CA10190266	39	R>W		No	ClinGen ExAC TOPMed gnomAD
rs759302784 CA10190349	44	Q>R		No	ClinGen ExAC gnomAD
rs1349601025 CA411241440	45	D>G		No	ClinGen TOPMed
VAR_042249 CA10190350 rs35923988	45	D>N		No	ClinGen UniProt 1000Genomes ExAC TOPMed dbSNP gnomAD
TCGA novel	47	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10190351 rs775402074	48	T>A		No	ClinGen ExAC TOPMed gnomAD
rs1234109907 CA411241511	48	T>I		No	ClinGen TOPMed gnomAD
CA323262383 rs1053089955	49	N>D		No	ClinGen TOPMed
rs1447323172 CA411241544	49	N>K		No	ClinGen TOPMed
rs1312981583 CA411241529	49	N>S		No	ClinGen TOPMed
rs1176957466 CA411241639	52	Y>C		No	ClinGen TOPMed gnomAD
CA10190353 rs764106716	53	E>Q		No	ClinGen ExAC gnomAD
CA411241693 rs1220938866	54	K>R		No	ClinGen gnomAD
CA10190354 rs375786681	56	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA10190355 rs756826059	58	L>F		No	ClinGen ExAC gnomAD
CA10190357 rs750152301	61	P>A		No	ClinGen ExAC gnomAD
rs748859205 CA323262423	61	P>H		No	ClinGen ExAC TOPMed gnomAD
rs748859205 CA10190358	61	P>R		No	ClinGen ExAC TOPMed gnomAD
CA411241852 rs1188171176	62	K>N		No	ClinGen gnomAD
CA411241845 rs1601430033	62	K>R		No	ClinGen Ensembl
rs1415513799 CA411241886	64	Y>C		No	ClinGen gnomAD
rs1045529957 CA323262439	65	W>*		No	ClinGen TOPMed
CA10190359 rs554904269	65	W>*		No	ClinGen 1000Genomes ExAC gnomAD
rs1403039920 CA411241895	65	W>R		No	ClinGen gnomAD
rs1475434553 CA411241916	66	G>E		No	ClinGen TOPMed
CA411241913 rs1345334233	66	G>W		No	ClinGen gnomAD
rs748533181 CA10190360	67	K>N		No	ClinGen ExAC TOPMed gnomAD
CA323262444 rs905607840	67	K>T		No	ClinGen TOPMed
rs758762286 CA10190361	69	G>R		No	ClinGen ExAC gnomAD
CA10190362 rs778373418	73	H>N		No	ClinGen ExAC gnomAD
CA411242063 rs1568996154	74	G>E		No	ClinGen Ensembl
rs368850347 CA10190363	74	G>R		No	ClinGen ESP ExAC gnomAD
CA411242112 rs771084358	78	L>V		No	ClinGen ExAC
rs776696149 CA10190365	80	T>R		No	ClinGen ExAC TOPMed gnomAD
rs1228021091 CA411242200	83	F>S		No	ClinGen gnomAD
CA323262839 rs74759932	86	A>S		No	ClinGen Ensembl
rs775710676 CA10190387	88	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10190388 rs370469164	90	K>R		No	ClinGen ExAC gnomAD
rs1288179824 CA411242977	93	P>R		No	ClinGen gnomAD
CA323262844 rs547547048	95	C>Y		No	ClinGen Ensembl
TCGA novel	96	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10190391 rs761864296	99	M>V		No	ClinGen ExAC gnomAD
rs188450615 CA10190392	103	V>A		No	ClinGen 1000Genomes ExAC gnomAD
TCGA novel	104	I>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs772794184 CA10190393	105	I>T		No	ClinGen ExAC gnomAD
TCGA novel	107	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411243416 rs1273600757	108	G>R		No	ClinGen gnomAD
rs115033601 CA10190396	111	Y>F		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs202149781 CA323262878	116	H>L		No	ClinGen Ensembl
CA10190399 rs752006815	116	H>Y		No	ClinGen ExAC gnomAD
rs1237000645 CA411243698	118	T>I		No	ClinGen TOPMed gnomAD
rs1601430757 CA411243689	118	T>P		No	ClinGen Ensembl
rs1237000645 CA411243695	118	T>S		No	ClinGen TOPMed gnomAD
CA411243720 rs1200852580	119	L>H		No	ClinGen gnomAD
rs759301457 CA10190416	122	G>E		No	ClinGen ExAC gnomAD
CA10190415 rs370473616	122	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA10190417 rs764802452	123	K>R		No	ClinGen ExAC gnomAD
CA411244008 rs1374387813	124	C>G		No	ClinGen TOPMed
CA10190419 rs116294833	126	N>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs767971147 CA10190420	128	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1300645787 CA411244144	128	V>M		No	ClinGen gnomAD
CA411244166 rs1399817504	129	V>M		No	ClinGen gnomAD
CA10190422 rs750966369	131	A>E		No	ClinGen ExAC TOPMed gnomAD
CA10190421 rs750966369	131	A>V		No	ClinGen ExAC TOPMed gnomAD
CA323263354 rs377628882	133	M>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs971814417 CA323263348	133	M>V		No	ClinGen TOPMed
rs923107832 CA323263365	142	V>I		No	ClinGen TOPMed
rs879665211 CA323263394	143	Q>E		No	ClinGen Ensembl
CA411244416 rs1340186526	143	Q>R		No	ClinGen TOPMed
rs753998840 CA10190425	148	Y>*		No	ClinGen ExAC gnomAD
rs1601431514 CA411244451	148	Y>S		No	ClinGen Ensembl
rs1487146641 CA411244459	149	S>C		No	ClinGen gnomAD
rs555588151 CA10190426 COSM293551	151	T>M	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC gnomAD
rs1444340607 CA411244475	152	L>P		No	ClinGen gnomAD
CA10190428 rs747938973	153	I>M		No	ClinGen ExAC gnomAD
CA411244487 rs1568996807	154	S>Y		No	ClinGen Ensembl
rs375268249 CA323263448	155	M>I		No	ClinGen Ensembl
rs777833409 CA10190430	156	P>L		No	ClinGen ExAC gnomAD
TCGA novel	157	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411244513 rs1217051326	158	T>S		No	ClinGen TOPMed
CA10190432 rs770561524	161	G>D		No	ClinGen ExAC TOPMed gnomAD
CA10190435 rs371378655	163	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs745383774 CA10190434	163	R>W		No	ClinGen ExAC TOPMed gnomAD
CA10190436 rs370423192	166	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs142840455 CA10190438	167	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs761234126 CA10190440	169	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	170	E>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	171	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1568996866 CA411244606	173	C>Y		No	ClinGen Ensembl
rs1011743787 CA323263516	174	S>F		No	ClinGen Ensembl
CA411244610 rs1256338338	174	S>P		No	ClinGen gnomAD
CA10190443 rs755048324	175	N>S		No	ClinGen ExAC gnomAD
CA411244627 rs765469850	176	Y>*		No	ClinGen ExAC TOPMed gnomAD
rs1246012090 CA411244625	176	Y>C		No	ClinGen TOPMed
rs752914428 CA10190445	177	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1260143570 CA411244639	178	T>I		No	ClinGen TOPMed
CA10190446 rs758256959	182	V>M		No	ClinGen ExAC TOPMed
rs746806038 CA10190449	184	E>Q		No	ClinGen ExAC
CA10190458 rs761037866	187	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs773495668 CA10190457	187	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1166087607 CA411245612	188	M>I		No	ClinGen TOPMed
CA411245673 rs1256208548	191	S>N		No	ClinGen TOPMed gnomAD
rs1223155092 CA411245724	194	N>S		No	ClinGen gnomAD
TCGA novel	195	R>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs5997927 CA411245739	196	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs371699959 CA10190461	197	A>S		No	ClinGen 1000Genomes ESP ExAC gnomAD
rs371699959 CA10190462	197	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA gnomAD
CA323265148 rs200565424	197	A>V		No	ClinGen Ensembl
CA10190463 rs752962006	199	H>Y		No	ClinGen ExAC gnomAD
rs200312431 CA10190464	203	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
COSM1196754 COSM1196753 rs200312431 CA10190465	203	R>G	lung [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs751350349 CA10190466 COSM1256493 COSM1256492	203	R>H	lung Variant assessed as Somatic; 0.0 impact. oesophagus central_nervous_system [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs757149319 CA10190467	208	N>S		No	ClinGen ExAC TOPMed gnomAD
rs376569162 CA323265189	211	P>L		No	ClinGen ESP TOPMed gnomAD
rs369493707 CA10190469	212	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	212	V>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10190470 rs34930775 VAR_042250	213	R>C		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs779494391 CA10190471	213	R>H		No	ClinGen ExAC gnomAD
CA10190472 rs779494391	213	R>L		No	ClinGen ExAC gnomAD
rs1275994563 CA411246017	214	T>A		No	ClinGen TOPMed
CA411246024 rs1235770219	214	T>I		No	ClinGen TOPMed
rs768236818 COSM229389 CA10190473	216	R>*	skin [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs768236818 CA411246036	216	R>G		No	ClinGen ExAC TOPMed gnomAD
rs115204987 CA411246038	216	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10190474 rs115204987	216	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs115736350 CA10190476	218	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10190478 rs760029773	219	E>K		No	ClinGen ExAC gnomAD
CA411246275 rs1601434065	220	V>G		No	ClinGen Ensembl
rs1489439369 CA411246269	220	V>L		No	ClinGen TOPMed gnomAD
rs115240632 CA323265464	221	E>K		No	ClinGen 1000Genomes
CA10190495 rs746258617	222	D>E		No	ClinGen ExAC gnomAD
CA10190496 rs770151744	223	A>S		No	ClinGen ExAC TOPMed
rs776172043 CA10190497	224	I>V		No	ClinGen ExAC gnomAD
CA323265472 rs968035921	225	S>I		No	ClinGen TOPMed
rs1474431245 CA411246401	226	Q>H		No	ClinGen TOPMed
rs575869944 CA411246416	227	T>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs575869944 CA10190498 COSM1153989	227	T>M	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs575869944 CA411246414	227	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1239899737 CA411246467	230	T>S		No	ClinGen TOPMed
rs1162777467 CA411246504	232	Q>H		No	ClinGen gnomAD
rs1180888920 CA411246532	234	L>V		No	ClinGen Ensembl
rs774700203 CA10190500	237	H>R		No	ClinGen ExAC gnomAD
rs1601434144 CA411246607	238	D>A		No	ClinGen Ensembl
rs762005629 CA10190501	239	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA10190503 rs370089296	240	V>I		No	ClinGen ExAC TOPMed gnomAD
rs370089296 CA10190504	240	V>L		No	ClinGen ExAC TOPMed gnomAD
CA411246649 rs1568997950	241	S>F		No	ClinGen Ensembl
rs899634625 CA323265559	241	S>P		No	ClinGen gnomAD
TCGA novel	242	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA10190507 rs200731336	243	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs571170200 CA10190508	243	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs148743159 CA323265604	247	L>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs887228775 CA411246760	248	R>L		No	ClinGen TOPMed gnomAD
rs887228775 COSM1153990 CA323265618	248	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs777504070 CA10190511	248	R>W		No	ClinGen ExAC TOPMed gnomAD
rs533636256 CA323265627	249	L>P		No	ClinGen 1000Genomes
rs756541241 CA10190513	250	E>G		No	ClinGen ExAC gnomAD
rs1481955268 CA411246781	250	E>K		No	ClinGen gnomAD
CA411246807 rs1441432345	251	A>G		No	ClinGen gnomAD
rs1238326749 CA411246801	251	A>S		No	ClinGen TOPMed gnomAD
rs749866123 CA411246817	252	R>P		No	ClinGen ExAC gnomAD
CA10190515 rs749866123	252	R>Q		No	ClinGen ExAC gnomAD
rs201919044 CA10190514	252	R>W		No	ClinGen ExAC TOPMed gnomAD
CA411246841 rs774503661	254	A>P		No	ClinGen ExAC TOPMed gnomAD
rs774503661 CA10190517	254	A>T		No	ClinGen ExAC TOPMed gnomAD
rs553589149 CA10190518	254	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
TCGA novel	258	Q>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA411246926 rs1332125123	258	Q>R		No	ClinGen gnomAD
CA10190520 rs773511360	259	N>D		No	ClinGen ExAC TOPMed gnomAD
CA411246942 rs1468542716	259	N>S		No	ClinGen TOPMed
rs1368662581 CA411246970	261	G>E		No	ClinGen gnomAD
CA411246967 rs1309205779	261	G>R		No	ClinGen TOPMed gnomAD
CA411246976 rs766224494	262	H>P		No	ClinGen ExAC TOPMed gnomAD
CA10190522 rs766224494	262	H>R		No	ClinGen ExAC TOPMed gnomAD
CA411246992 rs776548315	264	H>Q		No	ClinGen ExAC TOPMed gnomAD
rs140409562 CA10190524	265	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1294813824 CA411247056	268	T>I		No	ClinGen TOPMed
rs1568998089 CA411247047	268	T>S		No	ClinGen Ensembl
CA10190525 rs765174488	271	T>I		No	ClinGen ExAC TOPMed gnomAD
CA411247104 rs765174488	271	T>N		No	ClinGen ExAC TOPMed gnomAD
CA10190526 rs752101247	272	K>R		No	ClinGen ExAC gnomAD
CA411247158 rs1478202225 COSM1213402 COSM1213401	273	E>D	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
CA411247177 rs1568998112	274	N>T		No	ClinGen Ensembl
rs763622489 CA10190528	275	L>V		No	ClinGen ExAC TOPMed gnomAD
rs751273863 CA10190529	277	G>E		No	ClinGen ExAC gnomAD
CA323265720 rs992327983	277	G>R		No	ClinGen Ensembl
rs1439030461 CA411247306	280	R>K		No	ClinGen TOPMed
rs749671783 CA10190532	281	R>K		No	ClinGen ExAC gnomAD
COSM1153992 rs755482329 CA10190533	282	R>C	endometrium Variant assessed as Somatic; 9.702e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA323265732 rs544622991	282	R>H		No	ClinGen gnomAD
rs1046954174 CA323265735	283	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
COSM1153993 rs777847145 CA10190554	286	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs370892426 COSM1592933 CA10190555 COSM1033425	286	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA323270882 rs777847145	286	R>S		No	ClinGen ExAC TOPMed gnomAD
CA411249394 rs1356855924	287	S>N		No	ClinGen Ensembl
CA411249408 rs1158484065	289	S>G		No	ClinGen TOPMed
CA10190556 rs771093451	290	I>N		No	ClinGen ExAC gnomAD
rs981186393 CA323270893	291	S>C		No	ClinGen TOPMed gnomAD
rs201035171 CA323270902	293	S>P		No	ClinGen Ensembl
CA411249443 rs745634132	294	P>L		No	ClinGen ExAC gnomAD
CA10190558 rs745634132	294	P>R		No	ClinGen ExAC gnomAD
CA411249449 rs1182112845	295	G>A		No	ClinGen TOPMed
rs1311412340 CA411249451	296	P>A		No	ClinGen gnomAD
CA10190560 VAR_042251 rs34875793	296	P>R		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
CA411249459 rs1317231624	297	S>T		No	ClinGen gnomAD
CA411249468 rs1207465844	298	S>F		No	ClinGen TOPMed
CA323270914 rs200526623	299	P>T		No	ClinGen 1000Genomes
CA411249488 rs1259559279	301	E>D		No	ClinGen TOPMed
rs763014809 CA10190561	302	P>S		No	ClinGen ExAC TOPMed gnomAD
CA411249513 rs1449599007	306	S>C		No	ClinGen gnomAD
CA10190562 rs768481780	307	R>C		No	ClinGen ExAC gnomAD
rs149963749 CA10190563	307	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1240836662 CA411249525	308	D>N		No	ClinGen gnomAD
rs769771373 CA323270924	311	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA411249550 rs1264748302	311	R>H		No	ClinGen TOPMed gnomAD
CA411249555 rs1568999613	312	S>P		No	ClinGen Ensembl
rs759969796 CA10190567	315	L>F		No	ClinGen ExAC gnomAD
COSM1714285 rs765703194 COSM1714284 CA411249579	316	R>C	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs765703194 CA10190568	316	R>G		No	ClinGen ExAC TOPMed gnomAD
CA10190569 rs374529513	316	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA10190570 rs533618507	317	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs751598902 CA10190572	318	S>T		No	ClinGen ExAC gnomAD
rs757369218 CA10190573	319	S>G		No	ClinGen ExAC gnomAD
CA10190574 rs781371685	320	S>N		No	ClinGen ExAC TOPMed gnomAD
rs781371685 CA411249604	320	S>T		No	ClinGen ExAC TOPMed gnomAD
CA10190575 rs746144967	321	Y>C		No	ClinGen ExAC TOPMed gnomAD
rs1267229874 CA411249623	323	Q>*		No	ClinGen TOPMed gnomAD
CA10190576 rs769469177	324	Q>E		No	ClinGen ExAC gnomAD
CA10190577 rs779831503	324	Q>R		No	ClinGen ExAC gnomAD
CA411249637 rs1447360917	325	I>F		No	ClinGen gnomAD
rs142176216 CA323270960	325	I>N		No	ClinGen ESP TOPMed gnomAD
CA411249650 rs1238079205 COSM1415824 COSM1415825	327	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
COSM1415822 rs749049788 COSM1415823 CA10190578	327	R>W	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs145908769 CA10190579	328	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA411249690 rs1347395200	333	H>R		No	ClinGen gnomAD
CA10190580 rs187649083	335	E>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs771753332 CA10190582	338	G>A		No	ClinGen ExAC gnomAD
CA323270975 rs200133582	338	G>R		No	ClinGen 1000Genomes
CA411249726 rs1236896560	339	K>R		No	ClinGen gnomAD
CA411249740 rs1419060906	341	F>S		No	ClinGen TOPMed gnomAD
CA411249777 rs1342938634	346	I>M		No	ClinGen TOPMed gnomAD
rs1157827472 CA411249775	346	I>T		No	ClinGen gnomAD
rs201466946 COSM1153995 CA10190583	346	I>V	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs1477976906 CA411249799	348	V>M		No	ClinGen gnomAD
CA411249837 rs749067206	353	T>K		No	ClinGen ExAC gnomAD
rs749067206 CA10190596	353	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA323271430 rs970077897	355	K>I		No	ClinGen Ensembl
CA411249859 rs1403014622	357	M>L		No	ClinGen gnomAD
rs114127458 COSM168694 COSM1592932 CA10190600	364	R>*	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA10190601 rs772143318	364	R>L		No	ClinGen ExAC gnomAD
rs772143318 CA411249912	364	R>Q		No	ClinGen ExAC gnomAD
rs138769386 CA10190602	365	C>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
rs928612661 CA323271454	366	D>E		No	ClinGen Ensembl
rs1341351770 CA411249928	367	E>K		No	ClinGen gnomAD
CA411249969 rs1314746294	372	T>I		No	ClinGen TOPMed
CA411249998 rs1601439108	376	E>D		No	ClinGen Ensembl
CA411251036 rs1202218591	377	V>L		No	ClinGen gnomAD
CA10190622 rs373258619	380	M>V		No	ClinGen ESP ExAC gnomAD
CA411251115 rs1258591161	381	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA323271740 rs2229874 VAR_050149	381	R>H		No	ClinGen UniProt ExAC TOPMed dbSNP gnomAD
CA10190623 rs2229874	381	R>L		No	ClinGen ExAC TOPMed gnomAD
rs777892659 CA10190624	382	S>T		No	ClinGen ExAC gnomAD
TCGA novel	384	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs746497960 CA10190625	386	P>S		No	ClinGen ExAC gnomAD
rs376760049 CA10190626	387	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1418677021 CA411251225	389	L>P		No	ClinGen TOPMed
CA411251253 rs1402237296	392	I>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs776335007 CA10190627	392	I>T		No	ClinGen ExAC TOPMed gnomAD
CA411251312 rs1304630427	397	K>R		No	ClinGen gnomAD
CA411251378 rs1452488319	402	N>Y		No	ClinGen TOPMed gnomAD
rs1379496757 CA411251441	406	E>D		No	ClinGen gnomAD
rs1315924941 CA411251500	410	G>E		No	ClinGen gnomAD
rs762187095 CA10190632	410	G>W		No	ClinGen ExAC gnomAD
TCGA novel	411	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA323271789 rs890335349	411	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA10190633 rs767968950	411	G>S		No	ClinGen ExAC TOPMed gnomAD
CA411251517 rs1269917703	412	T>S		No	ClinGen TOPMed
CA411251532 rs1459612817	413	L>P		No	ClinGen gnomAD
CA411251538 rs1320349775	414	K>E		No	ClinGen TOPMed
rs1215604794 CA411251580	416	F>C		No	ClinGen TOPMed
CA411251572 rs1178302472	416	F>L		No	ClinGen Ensembl
CA411251589 rs1238726323	417	L>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
VAR_042252 rs35422808 CA10190636	418	R>C		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs147975203 CA10190637 COSM1033432 COSM1592931	418	R>H	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA10190638 rs759621133	419	S>N		No	ClinGen ExAC TOPMed gnomAD
CA411251608 rs1304652355	419	S>R		No	ClinGen TOPMed
CA10190639 rs759621133	419	S>T		No	ClinGen ExAC TOPMed gnomAD
CA411251626 rs752503455	420	M>L		No	ClinGen ExAC TOPMed gnomAD
rs752503455 CA10190640	420	M>V		No	ClinGen ExAC TOPMed gnomAD
CA411251701 rs141613754	421	D>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs141613754 CA10190652	421	D>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs146397913 CA10190653	422	P>A		No	ClinGen ESP ExAC gnomAD
CA411251717 rs1177359333	422	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA411251744 rs1311218047	424	P>S		No	ClinGen TOPMed
CA411251776 rs1421798320	426	Q>*		No	ClinGen TOPMed gnomAD
rs1408659463 CA411251798	427	Q>L		No	ClinGen gnomAD
rs1408659463 CA411251799	427	Q>R		No	ClinGen gnomAD
rs1328808591 CA411251802	428	K>Q		No	ClinGen gnomAD
rs753018095 CA10190657	428	K>R		No	ClinGen ExAC TOPMed gnomAD
rs762828667 CA10190658	430	R>M		No	ClinGen ExAC gnomAD
rs764047994 CA10190659	430	R>S		No	ClinGen ExAC gnomAD
CA10190661 rs138454239	436	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs1453240789 CA411251924	438	G>R		No	ClinGen TOPMed
CA323273334 rs989742133	441	Y>C		No	ClinGen TOPMed
rs958250426 CA323273329	441	Y>H		No	ClinGen TOPMed
CA411252421 rs1192523012	442	L>F		No	ClinGen gnomAD
rs755603688 CA10190681	442	L>V		No	ClinGen ExAC gnomAD
CA10190682 rs765937785	444	S>P		No	ClinGen ExAC gnomAD
rs753347553 COSM726611 CA10190683 COSM1149432	445	M>V	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA323273352 rs904459217	446	C>R		No	ClinGen TOPMed gnomAD
rs778661802 CA10190685	450	R>Q		No	ClinGen ExAC gnomAD
CA10190684 rs530553008	450	R>W		No	ClinGen ExAC gnomAD
CA323273362 rs368377617	451	D>H		No	ClinGen ESP
rs1398631355 CA411252573	454	S>L		No	ClinGen gnomAD
rs1438692567 CA411252591	455	H>Q		No	ClinGen gnomAD
CA10190688 rs781537713	456	N>S		No	ClinGen ExAC TOPMed
CA10190689 rs746444460	458	L>F		No	ClinGen ExAC
rs770430583 CA10190690	459	I>V		No	ClinGen ExAC gnomAD
TCGA novel	461	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1284199360 CA411253277	462	D>N		No	ClinGen gnomAD
rs143007905 CA10190707	464	T>S		No	ClinGen ESP ExAC gnomAD
rs1392523963 CA411253330	466	V>M		No	ClinGen TOPMed
CA10190708 rs746250163	468	A>S		No	ClinGen ExAC gnomAD
rs866823812 CA323273855	468	A>V		No	ClinGen Ensembl
CA411253480 rs1262630792	474	R>Q		No	ClinGen TOPMed gnomAD
CA411253477 rs1166020585	474	R>W		No	ClinGen gnomAD
CA10190711 rs780736822	476	I>L		No	ClinGen ExAC gnomAD
rs780736822 CA10190710	476	I>V		No	ClinGen ExAC gnomAD
rs1248782926 CA411253512	477	V>M		No	ClinGen gnomAD
rs146120713 CA411253616	483	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
rs768828867 CA10190712	483	A>S		No	ClinGen ExAC gnomAD
CA10190713 rs146120713	483	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs758927568 CA323273876	485	M>V		No	ClinGen gnomAD
rs1481237772 CA411253676	487	K>M		No	ClinGen gnomAD
rs553269007 CA10190714	488	A>S		No	ClinGen 1000Genomes ExAC gnomAD
rs553269007 CA10190715	488	A>T		No	ClinGen 1000Genomes ExAC gnomAD
rs1428061792 CA411253685	488	A>V		No	ClinGen gnomAD
CA10190716 rs772931048	489	T>A		No	ClinGen ExAC gnomAD
CA411253708 rs1394014794	490	T>I		No	ClinGen gnomAD
rs760496514 CA10190717	490	T>P		No	ClinGen ExAC gnomAD
CA10190718 rs770827714	493	R>C		No	ClinGen ExAC TOPMed gnomAD
CA323273888 COSM1535258 rs946756010 COSM1535257	493	R>H	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA10190720 rs567200775	496	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10190721 rs764868585	496	R>H		No	ClinGen ExAC TOPMed gnomAD
rs535765873 CA411253820	498	N>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA10190724 rs763863787	499	D>G		No	ClinGen ExAC gnomAD
CA10190723 rs762609949	499	D>N		No	ClinGen ExAC TOPMed gnomAD
CA10190726 rs756585652	500	R>C		No	ClinGen ExAC gnomAD
CA10190727 rs780683920	500	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1196853074 CA411253862	501	K>R		No	ClinGen gnomAD
rs755005373 CA10190729	502	K>E		No	ClinGen ExAC gnomAD
CA10190730 rs778980962	503	R>C		No	ClinGen ExAC gnomAD
CA10190731 rs139813773	503	R>H		No	ClinGen ESP ExAC gnomAD
rs772300294 CA10190732	504	Y>C		No	ClinGen ExAC gnomAD
rs555986857 CA323273928	511	Y>C		No	ClinGen 1000Genomes
rs201696320	519	N>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs201696320 CA10190736	519	N>K		No	ClinGen ExAC TOPMed gnomAD
rs1233256532 CA411254132	520	G>R		No	ClinGen TOPMed
rs780985585 CA10190758	521	K>R		No	ClinGen ExAC TOPMed gnomAD
CA411254258 rs1426936828	522	S>N		No	ClinGen gnomAD
CA411254275 rs1242652465	523	Y>C		No	ClinGen TOPMed
CA411254268 rs1245672683	523	Y>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA10190759 rs745675682	526	T>M		No	ClinGen ExAC gnomAD
CA411254366 rs1258369360	530	F>L		No	ClinGen gnomAD
rs748805795 CA10190762	533	G>E		No	ClinGen ExAC gnomAD
CA411254431 rs768335627	534	I>M		No	ClinGen ExAC TOPMed gnomAD
CA10190764 rs115349954	535	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA10190765 rs761489425	537	C>Y		No	ClinGen ExAC gnomAD
CA411254581 rs1356597041	540	I>T		No	ClinGen TOPMed gnomAD
rs1440445912 CA411254615	543	V>M		No	ClinGen TOPMed gnomAD
CA323275014 rs941930668	544	Y>C		No	ClinGen gnomAD
CA323275010 rs907566495	544	Y>H		No	ClinGen Ensembl
rs1320808783 CA411254759	554	L>P		No	ClinGen gnomAD
rs765588748 CA10190790	554	L>V		No	ClinGen ExAC gnomAD
CA323275030 rs750237299	557	G>D		No	ClinGen Ensembl
rs751602623 CA10190793	560	V>L		No	ClinGen ExAC TOPMed gnomAD
CA10190794 rs751602623	560	V>M		No	ClinGen ExAC TOPMed gnomAD
CA411254844 rs1601447889	561	K>Q		No	ClinGen Ensembl
rs1382893293 CA411254910	565	E>G		No	ClinGen TOPMed
CA411254947 rs1404858356	567	F>L		No	ClinGen gnomAD
CA323275043 rs937213685	568	V>I		No	ClinGen TOPMed
CA323275046 rs527658172	569	P>S		No	ClinGen Ensembl
rs779644268 CA10190798	571	D>N		No	ClinGen ExAC TOPMed gnomAD
rs753699445 CA10190799	572	C>F		No	ClinGen ExAC gnomAD
rs755843333 CA10190801	574	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1168342628 CA411255048	575	A>D		No	ClinGen gnomAD
CA411255039 rs1408785815	575	A>T		No	ClinGen gnomAD
rs777477587 CA10190805	578	P>L		No	ClinGen ExAC TOPMed gnomAD
CA10190804 rs771541571	578	P>S		No	ClinGen ExAC TOPMed gnomAD
rs946129705 CA323275082	581	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1413441757 CA411255228	588	P>R		No	ClinGen Ensembl
CA10190971 rs761085598	592	P>L		No	ClinGen ExAC TOPMed gnomAD
rs771265453 CA10190972	593	A>T		No	ClinGen ExAC gnomAD
CA10190973 rs374493189	595	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA323276472 rs962213087	600	S>F		No	ClinGen TOPMed gnomAD
CA411258904 rs1282623712	600	S>P		No	ClinGen gnomAD
CA411258939 rs1229079655	605	S>A		No	ClinGen gnomAD
CA10190976 rs149034313	605	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA10190977 rs149034313	605	S>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1444511890 CA411258982	611	L>P		No	ClinGen gnomAD
CA10190978 rs764290466	612	G>R		No	ClinGen ExAC
rs757509670 CA10190980	614	P>L		No	ClinGen ExAC gnomAD
CA411259023 rs1182251650	615	L>V		No	ClinGen gnomAD
CA323276483 rs952666415	616	P>S		No	ClinGen TOPMed
CA411259065 rs1386273010	618	E>D		No	ClinGen TOPMed
rs750250899 CA10190982	618	E>G		No	ClinGen ExAC gnomAD
CA411259056 rs1322870186	618	E>Q		No	ClinGen TOPMed
CA411259074 rs1397389857	619	L>P		No	ClinGen TOPMed
rs923536571 CA323276484	621	E>A		No	ClinGen TOPMed gnomAD
CA411259095 rs1455511637	621	E>Q		No	ClinGen gnomAD
rs1428003819 CA411259127	623	D>A		No	ClinGen TOPMed
rs771073476 CA10190983	623	D>H		No	ClinGen ExAC gnomAD
CA10190986 rs768337817	627	S>N		No	ClinGen ExAC TOPMed gnomAD
rs778621131 CA411259197	628	M>L		No	ClinGen ExAC gnomAD
CA10190988 rs747688288	628	M>T		No	ClinGen ExAC TOPMed gnomAD
CA10190987 rs778621131	628	M>V		No	ClinGen ExAC gnomAD
CA323276501 rs916433571	629	Q>P		No	ClinGen Ensembl
CA10190990 rs776822609	631	G>D		No	ClinGen ExAC gnomAD
rs377766847 CA10190989	631	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs776822609 CA411259276	631	G>V		No	ClinGen ExAC gnomAD
CA411259281 rs1199085400	632	L>V		No	ClinGen gnomAD
rs371070083 CA10190991	633	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA10190993 rs776036059	634	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs374240104 CA10190992	634	R>W		No	ClinGen ExAC TOPMed gnomAD
CA411259341 rs1180879988	635	D>Y		No	ClinGen gnomAD
CA411259373 rs1378130835	636	S>L		No	ClinGen gnomAD
rs1479001084 CA411259383	637	P>S		No	ClinGen TOPMed gnomAD
CA323276513 rs935290709	638	P>S		No	ClinGen TOPMed
rs751677107 CA10190996	639	P>S		No	ClinGen ExAC gnomAD

No associated diseases with P53671

3 regional properties for P53671

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	17 - 291	IPR000719
binding_site	Protein kinase, ATP binding site	23 - 46	IPR017441
domain	Serine/threonine-protein kinase OSR1/WNK, CCT domain	434 - 491	IPR024678

Functions

		Description
EC Number	2.7.11.1	Protein-serine/threonine kinases
Subcellular Localization	Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome ;
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cis-Golgi network	The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitotic spindle	A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
perinuclear region of cytoplasm	Cytoplasm situated near, or occurring around, the nucleus.

4 GO annotations of molecular function

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding	Binding to a metal ion.
protein serine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity	Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

11 GO annotations of biological process

Name	Definition
actin cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
astral microtubule organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.
cornea development in camera-type eye	The progression of the cornea over time, from its formation to the mature structure. The cornea is the transparent structure that covers the anterior of the eye.
establishment of vesicle localization	The directed movement of a vesicle to a specific location.
head development	The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.
negative regulation of cilium assembly	Any process that stops, prevents or reduces the frequency, rate or extent of cilium assembly.
phosphorylation	The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
positive regulation of protein localization to nucleus	Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
positive regulation of protein phosphorylation	Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
protein phosphorylation	The process of introducing a phosphate group on to a protein.
spermatogenesis	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.

27 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9Y616	IRAK3	Interleukin-1 receptor-associated kinase 3	Homo sapiens (Human)	PR
Q96S53	TESK2	Dual specificity testis-specific protein kinase 2	Homo sapiens (Human)	PR
P53667	LIMK1	LIM domain kinase 1	Homo sapiens (Human)	PR
Q8K4B2	Irak3	Interleukin-1 receptor-associated kinase 3	Mus musculus (Mouse)	PR
Q8CFA1	Irak2	Interleukin-1 receptor-associated kinase-like 2	Mus musculus (Mouse)	PR
Q8VCT9	Tesk2	Dual specificity testis-specific protein kinase 2	Mus musculus (Mouse)	PR
O54785	Limk2	LIM domain kinase 2	Mus musculus (Mouse)	PR
Q4QQS0	Irak2	Interleukin-1 receptor-associated kinase-like 2	Rattus norvegicus (Rat)	PR
Q924U5	Tesk2	Dual specificity testis-specific protein kinase 2	Rattus norvegicus (Rat)	PR
Q9ASQ5	CRCK3	Calmodulin-binding receptor-like cytoplasmic kinase 3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8LPS5	SERK5	Somatic embryogenesis receptor kinase 5	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8RWW0	ALE2	Receptor-like serine/threonine-protein kinase ALE2	Arabidopsis thaliana (Mouse-ear cress)	PR
P93050	BSH	Probable LRR receptor-like serine/threonine-protein kinase RKF3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LRP3	At3g17420	Probable receptor-like protein kinase At3g17420	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LSV3	WAKL16	Putative wall-associated receptor kinase-like 16	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9STF0	LECRKS3	Receptor like protein kinase S.3	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9SCZ4	FER	Receptor-like protein kinase FERONIA	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9M342	WAKL15	Wall-associated receptor kinase-like 15	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LYN6	At3g56050	Probable inactive receptor-like protein kinase At3g56050	Arabidopsis thaliana (Mouse-ear cress)	PR
Q8VZJ9	CRCK2	Calmodulin-binding receptor-like cytoplasmic kinase 2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0WNY5	WAKL18	Wall-associated receptor kinase-like 18	Arabidopsis thaliana (Mouse-ear cress)	PR
P43293	PBL11	Probable serine/threonine-protein kinase PBL11	Arabidopsis thaliana (Mouse-ear cress)	PR
Q94C25	At5g20050	Probable receptor-like protein kinase At5g20050	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FLW0	At5g24010	Probable receptor-like protein kinase At5g24010	Arabidopsis thaliana (Mouse-ear cress)	PR
Q3E8W4	ANX2	Receptor-like protein kinase ANXUR2	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9LTC0	PBL19	Probable serine/threonine-protein kinase PBL19	Arabidopsis thaliana (Mouse-ear cress)	PR
Q9FIL7	CRCK1	Calmodulin-binding receptor-like cytoplasmic kinase 1	Arabidopsis thaliana (Mouse-ear cress)	PR

10	20	30	40	50	60
MSALAGEDVW	RCPGCGDHIA	PSQIWYRTVN	ETWHGSCFRC	SECQDSLTNW	YYEKDGKLYC
70	80	90	100	110	120
PKDYWGKFGE	FCHGCSLLMT	GPFMVAGEFK	YHPECFACMS	CKVIIEDGDA	YALVQHATLY
130	140	150	160	170	180
CGKCHNEVVL	APMFERLSTE	SVQEQLPYSV	TLISMPATTE	GRRGFSVSVE	SACSNYATTV
190	200	210	220	230	240
QVKEVNRMHI	SPNNRNAIHP	GDRILEINGT	PVRTLRVEEV	EDAISQTSQT	LQLLIEHDPV
250	260	270	280	290	300
SQRLDQLRLE	ARLAPHMQNA	GHPHALSTLD	TKENLEGTLR	RRSLRRSNSI	SKSPGPSSPK
310	320	330	340	350	360
EPLLFSRDIS	RSESLRCSSS	YSQQIFRPCD	LIHGEVLGKG	FFGQAIKVTH	KATGKVMVMK
370	380	390	400	410	420
ELIRCDEETQ	KTFLTEVKVM	RSLDHPNVLK	FIGVLYKDKK	LNLLTEYIEG	GTLKDFLRSM
430	440	450	460	470	480
DPFPWQQKVR	FAKGIASGMA	YLHSMCIIHR	DLNSHNCLIK	LDKTVVVADF	GLSRLIVEER
490	500	510	520	530	540
KRAPMEKATT	KKRTLRKNDR	KKRYTVVGNP	YWMAPEMLNG	KSYDETVDIF	SFGIVLCEII
550	560	570	580	590	600
GQVYADPDCL	PRTLDFGLNV	KLFWEKFVPT	DCPPAFFPLA	AICCRLEPES	RPAFSKLEDS
610	620	630
FEALSLYLGE	LGIPLPAELE	ELDHTVSMQY	GLTRDSPP