P53166
PR
Gene name |
MRH4 (YGL064C) |
Protein name |
ATP-dependent RNA helicase MRH4, mitochondrial |
Names |
Mitochondrial RNA helicase 4 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGL064C |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P53166
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P53166-F1 | Predicted | AlphaFoldDB |
9 variants for P53166
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-383192 | 7 | P>Q | No | SGRP | |
| s07-383189 | 8 | V>A | No | SGRP | |
| s07-383013 | 67 | P>S | strain: DBY947 [UniProt] | No | SGRP |
| s07-382842 | 124 | L>I | No | SGRP | |
| s07-382821 | 131 | T>P | No | SGRP | |
| s07-382580 | 211 | H>R | No | SGRP | |
| s07-382536 | 226 | T>S | No | SGRP | |
| s07-381900 | 438 | P>S | strain: DBY947 [UniProt] | No | SGRP |
| s07-381800 | 471 | L>W | No | SGRP |
No associated diseases with P53166
5 regional properties for P53166
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 12 - 264 | IPR000719 |
| domain | NAF domain | 294 - 351 | IPR004041 |
| active_site | Serine/threonine-protein kinase, active site | 130 - 142 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 18 - 41 | IPR017441 |
| domain | NAF/FISL domain | 291 - 315 | IPR018451 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial matrix | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| mitochondrial ribosomal large subunit rRNA binding | Binding to a mitochondrial large ribosomal subunit RNA (LSU rRNA). |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| mitochondrial large ribosomal subunit assembly | The aggregation, arrangement and bonding together of a set of components to form a mitochondrial large ribosomal subunit. |
| RNA metabolic process | The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
17 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P10081 | TIF2 | ATP-dependent RNA helicase eIF4A | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P15424 | MSS116 | ATP-dependent RNA helicase MSS116, mitochondrial | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q03532 | HAS1 | ATP-dependent RNA helicase HAS1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q06218 | DBP9 | ATP-dependent RNA helicase DBP9 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P20448 | HCA4 | ATP-dependent RNA helicase HCA4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P32892 | DRS1 | ATP-dependent RNA helicase DRS1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P21372 | PRP5 | Pre-mRNA-processing ATP-dependent RNA helicase PRP5 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | EV |
| P45818 | ROK1 | ATP-dependent RNA helicase ROK1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q29S22 | DDX47 | Probable ATP-dependent RNA helicase DDX47 | Bos taurus (Bovine) | PR |
| Q9H0S4 | DDX47 | Probable ATP-dependent RNA helicase DDX47 | Homo sapiens (Human) | PR |
| Q9CWX9 | Ddx47 | Probable ATP-dependent RNA helicase DDX47 | Mus musculus (Mouse) | PR |
| Q7Y183 | RH10 | DEAD-box ATP-dependent RNA helicase 10 | Oryza sativa subsp japonica (Rice) | PR |
| Q8L4E9 | Os07g0633500 | DEAD-box ATP-dependent RNA helicase 36 | Oryza sativa subsp japonica (Rice) | PR |
| P34668 | ZK686.2 | Putative ATP-dependent RNA helicase ZK686.2 | Caenorhabditis elegans | PR |
| P34580 | T26G10.1 | Putative ATP-dependent RNA helicase T26G10.1 | Caenorhabditis elegans | PR |
| Q9SA27 | RH36 | DEAD-box ATP-dependent RNA helicase 36 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q8GY84 | RH10 | DEAD-box ATP-dependent RNA helicase 10 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSLFFKPVIS | PQWSFPVLLK | IGVRSYAGGP | RTKHKGNSPL | ASVPTGSSNK | NRKQKAKGKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GNKKNDPDQA | FNFGEYGGLK | KDVEMNMDST | NKLIQKISNF | DQLLILPPVR | DAVKEIISKE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SLKLQDSRKK | TSENIIPSPI | QTVAIKRISK | NLMDPKLQIH | AIAAETGSGK | TMAYLIPLID |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YLKRQELETP | ELWETLRKNV | LIRSIILVPT | HELVDQVYET | VSKTKTLLGL | NSFKWDKATS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YRDLLENIKN | RIDILVTTPG | KLLNLFSIRM | ITRPDKVLSK | VGFVVLDEAD | TLLDRSWLEE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| THSAIKRIPN | INHLIFCSAT | IPQEFNKTMQ | RLFPTVVPIM | TPRLHKLPFA | LDFKVINSAL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SPFKGSKIKA | LAQTLYAISN | DDTEPGFEKR | CIIFVNEKKN | VPEIVNLLNK | KFGHNAIGLT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GEDTFEERSE | KIMPFLSPPR | PLSEVVAQST | SPPTSLKKFE | IPDSNIVIGK | LKNTNSNGTA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PSNKSLHVLV | TTDLMARGLN | FKGVRNVVLY | DVPKTSIDLI | HRVGRTARMK | QGGRVFMLTD |
| 550 | 560 | ||||
| SKTKSWAKAL | PKIIKKHQRL | S |