AiPD: Autoinhibited Protein Database

P53041

Gene name	PPP5C (PPP5)
Protein name	Serine/threonine-protein phosphatase 5
Names	PP5, Protein phosphatase T, PP-T, PPT
Species	Homo sapiens (Human)
KEGG Pathway	hsa:5536
EC number	3.1.3.16: Phosphoric monoester hydrolases
Protein Class	SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED (PTHR45668)

Descriptions

Protein phosphatase 5 (PP5) dephosphorylates a myriad of proteins involved in different signaling pathways and is implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, and cell survival. PP5 exhibits very low phosphatase activity, which can be stimulated >25-fold by proteolysis and binding of polyunsaturated fatty acids to its N-terminal tetratricopeptide repeat (TPR) domain. The TPR domain shields the active site from entry by protein substrates, and cleavage of the TPR domain or lipid binding to the TPR domain moves the TPR domain away from the active site, thereby activating PP5.

Autoinhibitory domains (AIDs)

Target domain	203-479 (Phosphatase domain)
Relief mechanism	Cleavage, Ligand binding
Assay	Deletion assay, Structural analysis

AID

28-129 (N-terminal tetratricopeptide repeat domains)

Target domain

203-479 (Phosphatase domain)

Relief mechanism

Cleavage (Proteolytic cleavage of TPR domain), Ligand binding (Binding of polyunsaturated fatty acid to the TPR domain)

Assay

Deletion assay, Structural analysis

Accessory elements

No accessory elements

References

Kang H et al. (2001) "Identification of amino acids in the tetratricopeptide repeat and C-terminal domains of protein phosphatase 5 involved in autoinhibition and lipid activation", Biochemistry, 40, 10485-90

Chen MX et al. (1997) "Activation of protein phosphatase 5 by limited proteolysis or the binding of polyunsaturated fatty acids to the TPR domain", FEBS letters, 400, 136-40

Oberoi J et al. (2016) "Structural and functional basis of protein phosphatase 5 substrate specificity", Proceedings of the National Academy of Sciences of the United States of America, 113, 9009-14

Cliff MJ et al. (2006) "Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90", Structure (London, England : 1993), 14, 415-26

Autoinhibited structure

Activated structure

23 structures for P53041

Entry ID	Method	Resolution	Chain	Position	Source
1A17	X-ray	245 A	A	16-181	PDB
1S95	X-ray	160 A	A/B	169-499	PDB
1WAO	X-ray	290 A	1/2/3/4	23-499	PDB
2BUG	NMR	-	A	19-147	PDB
3H60	X-ray	200 A	A/B	176-490	PDB
3H61	X-ray	145 A	A/D	176-490	PDB
3H62	X-ray	140 A	B/C	176-490	PDB
3H63	X-ray	130 A	A/C	176-490	PDB
3H64	X-ray	190 A	A/D	176-490	PDB
3H66	X-ray	259 A	A/B	176-490	PDB
3H67	X-ray	165 A	A/D	176-490	PDB
3H68	X-ray	150 A	A/D	176-490	PDB
3H69	X-ray	210 A	A/D	176-490	PDB
4ZVZ	X-ray	200 A	A/B/C/D	169-499	PDB
4ZX2	X-ray	123 A	A	169-499	PDB
5HPE	X-ray	227 A	A	175-499	PDB
5UI1	X-ray	196 A	A/B/C/D	169-499	PDB
5WG8	X-ray	165 A	A	169-499	PDB
7ZR5	EM	390 A	P	17-499	PDB
7ZR6	EM	420 A	P	17-499	PDB
8GAE	EM	330 A	E	1-499	PDB
8GFT	EM	380 A	E	1-499	PDB
AF-P53041-F1	Predicted				AlphaFoldDB

287 variants for P53041

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs1392436618 CA406457720	2	A>T		No	ClinGen gnomAD
rs1460002870 CA406457749	6	G>S		No	ClinGen gnomAD
rs1338176488 CA406457763	8	R>G		No	ClinGen gnomAD
CA406457765 rs564387287	8	R>K		No	ClinGen 1000Genomes ExAC gnomAD
CA9527857 rs564387287	8	R>T		No	ClinGen 1000Genomes ExAC gnomAD
CA9527858 rs760601651	9	T>I		No	ClinGen ExAC gnomAD
CA406457773 rs760601651	9	T>S		No	ClinGen ExAC gnomAD
rs970913527 CA309049143	11	C>R		No	ClinGen gnomAD
CA406457789 rs1294744355	12	A>T		No	ClinGen gnomAD
rs376984861 CA9527862	13	E>D		No	ClinGen ESP ExAC TOPMed
rs376984861 CA9527861	13	E>D		No	ClinGen ESP ExAC TOPMed
CA309049150 rs780864843	13	E>Q		No	ClinGen Ensembl
COSM998407 CA9527865 rs150667064	14	P>H	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs150667064 CA9527866	14	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA9527867 rs150667064	14	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA9527864 rs764757552	14	P>S		No	ClinGen ExAC TOPMed gnomAD
CA406457800 rs764757552	14	P>T		No	ClinGen ExAC TOPMed gnomAD
rs781518780 CA9527870	15	P>H		No	ClinGen ExAC TOPMed gnomAD
CA9527871 rs781518780	15	P>R		No	ClinGen ExAC TOPMed gnomAD
CA9527869 rs755378932	15	P>S		No	ClinGen ExAC gnomAD
CA406457808 rs1260218275	16	R>L		No	ClinGen gnomAD
rs1260218275 CA406457807	16	R>Q		No	ClinGen gnomAD
rs1186347547 CA406457806	16	R>W		No	ClinGen gnomAD
CA406457816 rs1452919587	17	D>E		No	ClinGen TOPMed
CA406457810 rs989233752	17	D>H		No	ClinGen TOPMed gnomAD
CA309049177 rs989233752	17	D>N		No	ClinGen TOPMed gnomAD
CA9527874 rs749397645	19	P>L		No	ClinGen ExAC gnomAD
CA9527875 rs770899505	20	P>A		No	ClinGen ExAC TOPMed gnomAD
CA9527876 rs775634557	21	A>P		No	ClinGen ExAC gnomAD
rs760656600 CA9527877	21	A>V		No	ClinGen ExAC TOPMed gnomAD
CA406457846 rs1431156400	22	D>E		No	ClinGen gnomAD
rs1288140755 CA406457850	23	G>E		No	ClinGen gnomAD
rs1311341547 CA406457874	27	R>Q		No	ClinGen TOPMed
CA406457873 rs1345005397	27	R>W		No	ClinGen gnomAD
rs1240868302 CA406457879	28	A>P		No	ClinGen TOPMed
CA309049207 rs993200202	33	T>S		No	ClinGen TOPMed
CA9527880 rs761449755	34	Q>E		No	ClinGen ExAC gnomAD
CA9527881 rs764956390	34	Q>R		No	ClinGen ExAC gnomAD
CA309049214 rs1027396456	37	D>E		No	ClinGen TOPMed
rs750033061 CA9527882	37	D>N		No	ClinGen ExAC gnomAD
CA406457972 rs1200786120	41	A>T		No	ClinGen gnomAD
CA406458005 rs906188983	43	D>E		No	ClinGen TOPMed gnomAD
CA9527906 rs553624039	45	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs553624039 CA406458014	45	E>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs753187342 CA9527907	46	N>D		No	ClinGen ExAC gnomAD
rs1216832107 CA406458047	49	K>N		No	ClinGen gnomAD
rs1275255719 CA406458041	49	K>Q		No	ClinGen TOPMed
rs372875234 CA9527910	52	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA406458074 rs1224913770	53	Q>*		No	ClinGen gnomAD
rs369398391 CA9527911	53	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs1462431375 CA406458080	54	A>S		No	ClinGen gnomAD
rs758539597 CA9527914	55	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1601411917 CA406458091	56	E>K		No	ClinGen Ensembl
rs748007218 CA9527916	59	P>T		No	ClinGen ExAC gnomAD
CA406458158 rs1427646791	65	Y>C		No	ClinGen TOPMed
rs1409429150 COSM1242707 CA406458155	65	Y>H	oesophagus [Cosmic]	No	ClinGen cosmic curated gnomAD
rs945371698 CA309052439	68	R>H		No	ClinGen TOPMed
COSM273147 CA309052442 rs866767367	71	A>T	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA9527918 rs772906552	72	Y>F		No	ClinGen ExAC gnomAD
rs369676905 CA9527920	74	R>C		No	ClinGen ESP ExAC gnomAD
CA9527921 rs773931053	74	R>H		No	ClinGen ExAC TOPMed gnomAD
CA9527922 rs759100480	78	Y>C		No	ClinGen ExAC gnomAD
rs1218908445 CA406458260	81	A>S		No	ClinGen Ensembl
CA9527924 rs776101874	81	A>V		No	ClinGen ExAC gnomAD
CA9527926 rs764610621	83	G>R		No	ClinGen ExAC
CA9527928 rs757637994	87	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA406458294 rs1195123440	87	R>W		No	ClinGen gnomAD
CA9527930 rs750671327	88	A>T		No	ClinGen ExAC gnomAD
rs758593717 CA9527931	89	I>T		No	ClinGen ExAC gnomAD
CA406458303 rs1470400986	89	I>V		No	ClinGen gnomAD
rs780262606 CA9527932	90	E>K		No	ClinGen ExAC gnomAD
CA406458315 rs1279038378	91	L>M		No	ClinGen TOPMed
CA406458326 rs1319474798	92	D>E		No	ClinGen gnomAD
COSM1394757 CA309052504 rs370743592	101	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP TOPMed gnomAD
CA406458396 rs1028814909	102	R>P		No	ClinGen TOPMed
rs1028814909 CA309052508	102	R>Q		No	ClinGen TOPMed
rs1346884244 CA406458395	102	R>W		No	ClinGen gnomAD
rs1279938654 CA406458411	105	S>G		No	ClinGen TOPMed
CA406458423 rs1342490108	106	N>K		No	ClinGen TOPMed gnomAD
CA9527935 rs777704129	106	N>S		No	ClinGen ExAC gnomAD
rs749045957 CA9527936	113	R>Q		No	ClinGen ExAC gnomAD
rs1284707017 CA406458467	113	R>W		No	ClinGen TOPMed gnomAD
rs1191454123 CA406458476	114	A>V		No	ClinGen gnomAD
CA9527938 rs774053368	115	A>T		No	ClinGen ExAC gnomAD
rs771616939 CA9527940	117	R>Q		No	ClinGen ExAC gnomAD
CA9527942 rs760192092	120	E>K		No	ClinGen ExAC gnomAD
rs1418368236 CA406458519	121	T>M		No	ClinGen TOPMed gnomAD
CA406461597 rs1466723067	127	P>L		No	ClinGen TOPMed
rs576127473 CA406461624	128	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406461634 rs576127473	128	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs972521478 CA309072333 COSM4154262	128	H>R	kidney [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA406461600 rs1338386202	128	H>Y		No	ClinGen gnomAD
CA309072353 rs774142342	130	K>M		No	ClinGen Ensembl
rs1186609696 CA406461693	131	D>V		No	ClinGen TOPMed
CA9527980 rs780778872	133	K>N		No	ClinGen ExAC TOPMed gnomAD
rs768101611 CA9527979	133	K>R		No	ClinGen ExAC gnomAD
rs747623831 CA9527981	136	Y>C		No	ClinGen ExAC gnomAD
CA9527982 rs770432613	141	K>R		No	ClinGen ExAC gnomAD
rs372807877 CA9527985	142	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs374447988 CA9527986	143	V>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406461952 rs1264469452	144	K>R		No	ClinGen gnomAD
rs767583912 COSM1262895 CA9527988	150	R>Q	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs199924972 CA9527987	150	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA9527990 rs760680208	153	A>T		No	ClinGen ExAC TOPMed gnomAD
rs765157979 CA309072412	153	A>V		No	ClinGen Ensembl
rs558480632 CA9527991	155	D>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406462073 rs558480632	155	D>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406462084 rs1401701802	156	E>K		No	ClinGen TOPMed
CA309072434 rs61578656	157	H>L		No	ClinGen Ensembl
rs1225480213 CA406462097	157	H>N		No	ClinGen gnomAD
CA9527994 rs571962821	158	K>R		No	ClinGen 1000Genomes ExAC gnomAD
CA406462125 rs1311897521	159	R>C		No	ClinGen TOPMed gnomAD
CA9527995 rs751265952	159	R>H		No	ClinGen ExAC TOPMed gnomAD
CA406462140 rs780928951	161	V>L		No	ClinGen ExAC TOPMed gnomAD
rs780928951 CA9527997 COSM998412	161	V>M	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs747678273 CA9527998	162	V>A		No	ClinGen ExAC gnomAD
CA406462177 rs1261779030	164	S>L		No	ClinGen gnomAD
rs373836899 CA9528000	167	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA406462215 rs771245335	168	E>*		No	ClinGen ExAC gnomAD
CA406462221 rs1346776368	168	E>D		No	ClinGen gnomAD
CA9528002 rs771245335	168	E>K		No	ClinGen ExAC gnomAD
rs1454204524 CA406462244	170	M>T		No	ClinGen gnomAD
rs1320568707 CA406462772	171	T>I		No	ClinGen gnomAD
CA406462781 rs1234251272	172	I>V		No	ClinGen gnomAD
CA406462855 rs1601435417	176	Y>D		No	ClinGen Ensembl
CA9528033 rs767394593	176	Y>F		No	ClinGen ExAC gnomAD
CA406462882 rs1177713673	177	S>G		No	ClinGen TOPMed gnomAD
CA406462885 rs1236137603	177	S>N		No	ClinGen gnomAD
rs547427875 CA406462895	177	S>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA406462897 rs1163798018	178	G>R		No	ClinGen gnomAD
CA309073085 rs779264630	178	G>V		No	ClinGen Ensembl
CA406462916 rs1303095171	179	P>S		No	ClinGen TOPMed
CA406462957 rs1403648313	182	E>K		No	ClinGen gnomAD
rs1219807209 CA406462976	183	D>H		No	ClinGen TOPMed
rs760429710 CA9528035	183	D>V		No	ClinGen ExAC gnomAD
rs1272145503 CA406462990	184	G>D		No	ClinGen gnomAD
CA9528036 rs146574618	184	G>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA9528037 rs753395451	186	V>A		No	ClinGen ExAC gnomAD
CA9528038 rs756665798	188	I>V		No	ClinGen ExAC gnomAD
rs750891321 CA9528040	195	M>I		No	ClinGen ExAC gnomAD
rs750891321 CA9528041	195	M>I		No	ClinGen ExAC gnomAD
rs1297672900 CA406463141	195	M>V		No	ClinGen TOPMed
CA406463188 rs1284090326	196	Q>R		No	ClinGen gnomAD
rs200479334 CA309073134	198	Y>C		No	ClinGen 1000Genomes
CA406463220 rs1377715409	198	Y>H		No	ClinGen gnomAD
rs1203032024 CA406463240	199	K>E		No	ClinGen TOPMed gnomAD
CA309073144 rs11550353	199	K>N		No	ClinGen Ensembl
CA9528043 rs747333739	200	D>E		No	ClinGen ExAC gnomAD
rs1318086699 CA406463283	201	Q>E		No	ClinGen gnomAD
CA9528044 rs768868888	206	R>Q		No	ClinGen ExAC gnomAD
rs1197655107 CA406463381	206	R>W		No	ClinGen TOPMed gnomAD
CA309073154 rs199770924	209	A>V		No	ClinGen 1000Genomes
CA406464504 rs1463860862	212	I>L		No	ClinGen gnomAD
rs1304434605 CA406464516	214	V>I		No	ClinGen gnomAD
CA406464527 rs1395392400	215	Q>H		No	ClinGen gnomAD
rs202039197 CA309077628	215	Q>R		No	ClinGen gnomAD
rs762514080 CA9528093	219	V>I		No	ClinGen ExAC gnomAD
CA309077635 rs1033418818	221	S>F		No	ClinGen TOPMed
rs1212613290 CA406464600	227	V>M		No	ClinGen TOPMed gnomAD
CA9528094 rs190089663	229	T>I		No	ClinGen 1000Genomes ExAC gnomAD
rs1235930072 CA406464639	233	E>K		No	ClinGen TOPMed
rs764524071 CA9528119	234	T>I		No	ClinGen ExAC gnomAD
CA309077960 rs200850133	235	E>G		No	ClinGen 1000Genomes
rs1379239319 CA406464675	236	K>E		No	ClinGen TOPMed
rs1440218576 CA406464751	241	G>E		No	ClinGen TOPMed
CA406464789 rs1392611532	244	H>R		No	ClinGen TOPMed
rs1385439258 CA406464817	246	Q>H		No	ClinGen gnomAD
CA9528120 rs754162823	246	Q>K		No	ClinGen ExAC gnomAD
CA9528122 rs762149325	247	F>L		No	ClinGen ExAC TOPMed gnomAD
CA406464898 rs1354971770	252	N>S		No	ClinGen gnomAD
CA406464921 rs1458741886	254	F>L		No	ClinGen TOPMed
rs761049173 CA309077976	254	F>L		No	ClinGen ExAC gnomAD
rs758489583 CA9528124 COSM998414	255	E>K	large_intestine endometrium [Cosmic]	No	ClinGen cosmic curated ExAC
CA309078000 rs374372568	258	G>S		No	ClinGen ESP TOPMed gnomAD
CA406465028 rs1246923687	262	E>D		No	ClinGen gnomAD
rs1568576445 CA406465025	262	E>G		No	ClinGen Ensembl
rs151202020 CA309078025	263	T>I		No	ClinGen ESP TOPMed
rs1462772169 CA406465051	264	N>K		No	ClinGen TOPMed gnomAD
CA406465053 rs1487988358	265	P>S		No	ClinGen gnomAD
CA309078952 rs374452643	276	G>A		No	ClinGen ESP TOPMed gnomAD
CA406465525 rs374452643	276	G>V		No	ClinGen ESP TOPMed gnomAD
CA406465528 rs1314792871	277	S>A		No	ClinGen TOPMed
rs779638817 CA9528153	282	V>A		No	ClinGen ExAC gnomAD
CA9528152 rs757897686	282	V>M		No	ClinGen ExAC gnomAD
CA406465584 rs1210758763	286	L>F		No	ClinGen gnomAD
CA9528156 rs777265109	288	G>S		No	ClinGen ExAC TOPMed gnomAD
CA9528157 rs370192243	289	F>Y		No	ClinGen ESP ExAC TOPMed gnomAD
CA309079012 rs774269286	291	L>V		No	ClinGen Ensembl
rs1477627523 CA406465623	292	L>V		No	ClinGen gnomAD
rs1203448736 CA406465718	304	H>N		No	ClinGen TOPMed
rs773652625 CA9528178	307	D>N		No	ClinGen ExAC gnomAD
rs771200975 CA9528180	308	N>S		No	ClinGen ExAC gnomAD
CA406465769 rs1368613338	310	N>K		No	ClinGen gnomAD
rs1242249589 CA406465790	313	Y>C		No	ClinGen gnomAD
CA9528182 rs759682571	314	G>S		No	ClinGen ExAC gnomAD
rs1452420186 CA406465807	316	E>K		No	ClinGen gnomAD
rs1052895749 CA309081167	319	V>G		No	ClinGen Ensembl
CA406465843 rs1321779694	321	A>T		No	ClinGen TOPMed
CA406465872 rs1265574791	325	A>S		No	ClinGen TOPMed
rs190295738 CA9528185	325	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9528186 rs765046094	326	Q>E		No	ClinGen ExAC gnomAD
rs375447747 CA9528188	326	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA9528187 rs750238426	326	Q>L		No	ClinGen ExAC gnomAD
rs201851594 CA9528189	327	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751223842 CA9528190	329	E>K		No	ClinGen ExAC gnomAD
CA9528192 rs780868078	331	F>Y		No	ClinGen ExAC gnomAD
CA406465924 rs1253543852	333	E>K		No	ClinGen gnomAD
CA9528194 rs756645743	336	E>A		No	ClinGen ExAC gnomAD
rs1601446465 CA406465990	342	Q>P		No	ClinGen Ensembl
rs1203726026 CA406466006	344	I>T		No	ClinGen gnomAD
CA9528200 rs772234226	344	I>V		No	ClinGen ExAC gnomAD
rs571000092 CA9528202	346	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9528203 rs769827065	347	K>Q		No	ClinGen ExAC gnomAD
rs1198028020 CA406466061	351	M>L		No	ClinGen TOPMed
CA406466076 rs1306094175	353	G>R		No	ClinGen TOPMed gnomAD
CA309081530 rs938866403	357	S>G		No	ClinGen Ensembl
CA9528234 rs750800832	359	D>E		No	ClinGen ExAC TOPMed gnomAD
CA9528235 rs780293038	360	G>C		No	ClinGen ExAC TOPMed gnomAD
CA9528236 rs780293038	360	G>S		No	ClinGen ExAC TOPMed gnomAD
rs755178312 CA9528237	361	V>I		No	ClinGen ExAC gnomAD
CA406466165 rs748188415	366	I>M		No	ClinGen ExAC TOPMed gnomAD
CA406466167 rs1260657606 COSM3105218	367	R>Q	breast [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA9528240 rs771003117	367	R>W		No	ClinGen ExAC gnomAD
CA406466184 rs1378077754	369	I>M		No	ClinGen gnomAD
CA406466182 rs1178038759	369	I>T		No	ClinGen TOPMed gnomAD
CA9528242 rs745727929	370	E>K		No	ClinGen ExAC gnomAD
CA406466194 rs1171806958	371	R>Q		No	ClinGen gnomAD
rs947012848 CA309081564	373	R>*		No	ClinGen Ensembl
rs771963783 CA9528243 COSM1194576	373	R>Q	lung [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA406466238 rs1288502118	378	S>A		No	ClinGen gnomAD
rs775265798 CA9528244	378	S>L		No	ClinGen ExAC gnomAD
rs964222283 CA309082922	390	Q>*		No	ClinGen Ensembl
CA406466364 rs1432369422	391	P>S		No	ClinGen gnomAD
rs776989579 CA9528318	393	N>Y		No	ClinGen ExAC gnomAD
CA406455567 rs1459485768	394	G>W		No	ClinGen gnomAD
CA9528320 rs765379704	395	R>H		No	ClinGen ExAC TOPMed gnomAD
COSM1262896 rs750428975 CA9528321	396	S>L	oesophagus [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA406455605 rs1156419988 COSM998417	400	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs373786217 CA309049074	400	R>W		No	ClinGen ESP TOPMed
CA309049091 rs1037787942	401	G>S		No	ClinGen TOPMed
rs367544623 CA9528325	410	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA406455690 rs1393085022	413	A>T		No	ClinGen TOPMed gnomAD
rs1601448223 CA406455695	413	A>V		No	ClinGen Ensembl
CA9528327 rs748914520	417	E>K		No	ClinGen ExAC TOPMed gnomAD
CA9528328 rs756813142	421	D>A		No	ClinGen ExAC gnomAD
CA406455752 rs778518975	421	D>E		No	ClinGen ExAC TOPMed gnomAD
CA9528330 rs745310619	425	R>C		No	ClinGen ExAC gnomAD
rs772647399 CA9528331	425	R>H		No	ClinGen ExAC gnomAD
CA406455787 rs1249721065	426	S>R		No	ClinGen TOPMed
COSM1221833 rs1320561842 CA406455796	428	E>K	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs769113694 CA9528334	430	K>R		No	ClinGen ExAC gnomAD
rs1179124938 CA406455818	431	A>P		No	ClinGen gnomAD
rs773354318 CA9528338	432	E>D		No	ClinGen ExAC gnomAD
rs765309737 CA9528337	432	E>K		No	ClinGen ExAC TOPMed gnomAD
CA9528340 rs767506672	435	E>K		No	ClinGen ExAC TOPMed gnomAD
CA9528342 rs775331289	439	G>R		No	ClinGen ExAC gnomAD
rs376107784 CA9528343	441	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs753540087 CA9528344	441	R>H		No	ClinGen ExAC TOPMed gnomAD
CA309049164 rs753540087	441	R>L		No	ClinGen ExAC TOPMed gnomAD
rs778377016 CA406456312	445	V>F		No	ClinGen ExAC TOPMed gnomAD
CA9528346 rs778377016	445	V>I		No	ClinGen ExAC TOPMed gnomAD
CA9528363 rs765007929	453	D>E		No	ClinGen ExAC gnomAD
CA406456547 rs1253824377	453	D>N		No	ClinGen TOPMed gnomAD
rs1454310589 CA406456563	455	M>L		No	ClinGen Ensembl
CA309050099 rs982049499	465	Q>R		No	ClinGen TOPMed
rs1239608683 CA406456720	467	S>P		No	ClinGen gnomAD
CA9528366 rs779740867	468	D>G		No	ClinGen ExAC gnomAD
rs148346594 CA406456740	470	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs148346594 CA9528367 COSM191072	470	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA406456737 rs1395689489	470	R>W		No	ClinGen gnomAD
rs1171866891 CA406456746	471	P>L		No	ClinGen gnomAD
CA406456749 rs1347121839	472	Q>*		No	ClinGen gnomAD
rs755554889 CA9528368	473	F>C		No	ClinGen ExAC TOPMed gnomAD
rs377014797 CA9528370	474	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA9528369 rs367960531	474	H>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9528372 rs778102010	478	A>E		No	ClinGen ExAC gnomAD
rs1176701252 CA406456818	480	P>L		No	ClinGen gnomAD
rs1476326852 CA406456831	482	P>L		No	ClinGen gnomAD
CA309050304 rs868432813	482	P>S		No	ClinGen Ensembl
CA406456838 rs776682862	483	N>K		No	ClinGen ExAC TOPMed gnomAD
rs141536166 CA9528400	484	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA309050310 rs890283050	488	A>T		No	ClinGen gnomAD
rs769703528 CA9528401	488	A>V		No	ClinGen ExAC gnomAD
rs376307768 CA9528403	492	T>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA406456899 rs1168449146	493	L>V		No	ClinGen TOPMed
CA309050329 rs769971834	498	M>V		No	ClinGen Ensembl
rs1601451066 CA406456936	499	M>L		No	ClinGen Ensembl

No associated diseases with P53041

2 regional properties for P53041

Type	Name	Position	InterPro Accession
domain	Homeobox domain	184 - 248	IPR001356
conserved_site	Homeobox, conserved site	219 - 242	IPR017970

Functions

		Description
EC Number	3.1.3.16	Phosphoric monoester hydrolases
Subcellular Localization	Nucleus Cytoplasm Cell membrane	Predominantly nuclear (PubMed:15383005) But also present in the cytoplasm (PubMed:15383005) Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner (PubMed:19948726)
PANTHER Family	PTHR45668	SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED
PANTHER Subfamily	PTHR45668:SF5	SERINE_THREONINE-PROTEIN PHOSPHATASE 5
PANTHER Protein Class	protein phosphatase protein modifying enzyme
PANTHER Pathway Category	No pathway information available

7 GO annotations of cellular component

Name	Definition
chaperone complex	A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-containing complex	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

11 GO annotations of molecular function

Name	Definition
ADP binding	Binding to ADP, adenosine 5'-diphosphate.
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Hsp90 protein binding	Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size.
identical protein binding	Binding to an identical protein or proteins.
lipid binding	Binding to a lipid.
metal ion binding	Binding to a metal ion.
phosphatase activity	Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
phosphoprotein phosphatase activity	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
protein serine/threonine phosphatase activity	Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.
RNA binding	Binding to an RNA molecule or a portion thereof.
tau protein binding	Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.

11 GO annotations of biological process

Name	Definition
double-strand break repair	The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
MAPK cascade	An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
peptidyl-serine dephosphorylation	The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine.
peptidyl-threonine dephosphorylation	The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.
positive regulation of I-kappaB kinase/NF-kappaB signaling	Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.
response to arachidonic acid	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arachidonic acid stimulus.
response to lead ion	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
response to morphine	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
transcription, DNA-templated	The synthesis of an RNA transcript from a DNA template.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P53043	PPT1	Serine/threonine-protein phosphatase T	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
Q60676	Ppp5c	Serine/threonine-protein phosphatase 5	Mus musculus (Mouse)	SS
P53042	Ppp5c	Serine/threonine-protein phosphatase 5	Rattus norvegicus (Rat)	EV
Q9NES8	pph-5	Serine/threonine-protein phosphatase 5	Caenorhabditis elegans	EV
Q84XU2	PAPP5	Serine/threonine-protein phosphatase 5	Arabidopsis thaliana (Mouse-ear cress)	SS
Q84K11	PP5	Serine/threonine-protein phosphatase 5	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	PR

10	20	30	40	50	60
MAMAEGERTE	CAEPPRDEPP	ADGALKRAEE	LKTQANDYFK	AKDYENAIKF	YSQAIELNPS
70	80	90	100	110	120
NAIYYGNRSL	AYLRTECYGY	ALGDATRAIE	LDKKYIKGYY	RRAASNMALG	KFRAALRDYE
130	140	150	160	170	180
TVVKVKPHDK	DAKMKYQECN	KIVKQKAFER	AIAGDEHKRS	VVDSLDIESM	TIEDEYSGPK
190	200	210	220	230	240
LEDGKVTISF	MKELMQWYKD	QKKLHRKCAY	QILVQVKEVL	SKLSTLVETT	LKETEKITVC
250	260	270	280	290	300
GDTHGQFYDL	LNIFELNGLP	SETNPYIFNG	DFVDRGSFSV	EVILTLFGFK	LLYPDHFHLL
310	320	330	340	350	360
RGNHETDNMN	QIYGFEGEVK	AKYTAQMYEL	FSEVFEWLPL	AQCINGKVLI	MHGGLFSEDG
370	380	390	400	410	420
VTLDDIRKIE	RNRQPPDSGP	MCDLLWSDPQ	PQNGRSISKR	GVSCQFGPDV	TKAFLEENNL
430	440	450	460	470	480
DYIIRSHEVK	AEGYEVAHGG	RCVTVFSAPN	YCDQMGNKAS	YIHLQGSDLR	PQFHQFTAVP
490
HPNVKPMAYA	NTLLQLGMM