AiPD: Autoinhibited Protein Database

P52735

Gene name	VAV2
Protein name	Guanine nucleotide exchange factor VAV2
Names	VAV-2
Species	Homo sapiens (Human)
KEGG Pathway	hsa:7410
EC number
Protein Class

Descriptions

The Vav family is a group of tyrosine phosphorylation-dependent guanine nucleotide exchange factors (GEFs) that activate members of the Rac and Rho families of guanosine triphosphatases (GTPases) downstream of protein tyrosine kinases. When the tyrosine residues within the acidic (Ac) region are non-phosphorylated, the CH domain and Ac region occlude the GTPase-binding site within DH domain. The interaction is stabilized by the interaction between the hydroxyl group of Tyr174 within Ac region and GTPase binding site as well as the interaction between CH domain and DH-PH domains. The Y174F mutant displays constitutive and phosphorylation-independent catalytic activity. In addition to the N-terminal autoinhibitory regions, the truncation of C-terminal SH3 domain also relives the autoinhibition. C-terminal SH3 domain interacts with DH-PH domains and the intramolecular interaction occludes the GTPase-binding site of DH domain.

Autoinhibitory domains (AIDs)

787-877 (C-terminal SH3 domain) SS

Target domain	198-376 (DH domain)
Relief mechanism	Partner binding, PTM
Assay

AID

787-877 (C-terminal SH3 domain)

Target domain

198-376 (DH domain)

Relief mechanism

Partner binding (Putative mechanism, binding of PRR-containing proteins to C-terminal SH3 domain), PTM (Lck-mediated phosphorylation at Tyr174)

Assay

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100

Aghazadeh B et al. (2000) "Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation", Cell, 102, 625-33

Barreira M et al. (2014) "The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins", Science signaling, 7, ra35

Yu B et al. (2010) "Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1", Cell, 140, 246-56

Rapley J et al. (2008) "Crucial structural role for the PH and C1 domains of the Vav1 exchange factor", EMBO reports, 9, 655-61

Autoinhibited structure

Activated structure

8 structures for P52735

Entry ID	Method	Resolution	Chain	Position	Source
2DLZ	NMR	-	A	663-767	PDB
2DM1	NMR	-	A	819-878	PDB
2LNW	NMR	-	A	659-771	PDB
2LNX	NMR	-	A	659-771	PDB
4ROJ	X-ray	195 A	A/B/C	667-782	PDB
7RNV	X-ray	215 A	A	665-774	PDB
7WFY	X-ray	245 A	C	659-771	PDB
AF-P52735-F1	Predicted				AlphaFoldDB

685 variants for P52735

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs780603223 CA5316362	3	Q>R		No	ClinGen ExAC gnomAD
CA5316361 rs755617330	4	W>*		No	ClinGen ExAC gnomAD
rs1379988829 CA375437387	4	W>G		No	ClinGen gnomAD
rs749929702 CA5316360	7	C>Y		No	ClinGen ExAC gnomAD
CA375437351 rs1204773538	9	R>C		No	ClinGen gnomAD
rs1436731913 CA375437341	10	W>C		No	ClinGen gnomAD
CA375437327 rs1212967741	12	I>M		No	ClinGen gnomAD
rs780522786 CA5316359	12	I>V		No	ClinGen ExAC gnomAD
CA5316358 rs756938235	14	C>G		No	ClinGen ExAC gnomAD
rs751150439 CA5316357	15	K>E		No	ClinGen ExAC gnomAD
rs762723809 CA5316355	18	P>L		No	ClinGen ExAC gnomAD
CA375437292 rs763889584	18	P>S		No	ClinGen ExAC TOPMed gnomAD
rs763889584 CA5316356	18	P>T		No	ClinGen ExAC TOPMed gnomAD
CA5316354 rs375205296	19	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs765191899 CA5316353	20	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1436628922 CA375437276	21	H>D		No	ClinGen gnomAD
CA375437266 rs773370672	22	R>L		No	ClinGen ExAC TOPMed gnomAD
CA5316351 rs773370672	22	R>P		No	ClinGen ExAC TOPMed gnomAD
CA5316350 rs772210977	24	V>A		No	ClinGen ExAC TOPMed gnomAD
CA5316348 rs774697864	26	P>L		No	ClinGen ExAC gnomAD
rs762139216 CA5316349	26	P>S		No	ClinGen ExAC
rs1177442941 CA375437237	27	S>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1469267301 CA375437233	28	A>S		No	ClinGen gnomAD
rs769205991 CA5316347	29	V>A		No	ClinGen ExAC TOPMed gnomAD
CA375437225 rs769205991	29	V>G		No	ClinGen ExAC TOPMed gnomAD
CA375437229 rs1249027124	29	V>M		No	ClinGen gnomAD
CA375437207 rs1433420969	32	D>G		No	ClinGen TOPMed
CA5316343 rs746323400	32	D>N		No	ClinGen ExAC gnomAD
CA375437202 rs1177697543	33	L>V		No	ClinGen TOPMed
TCGA novel	38	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375437159 rs1224572536	40	G>R		No	ClinGen gnomAD
CA201023284 rs1005902006	41	V>F		No	ClinGen TOPMed
rs751271227 CA5316340	44	C>G		No	ClinGen ExAC TOPMed gnomAD
CA375437121 rs1416764705	46	L>V		No	ClinGen gnomAD
rs1312810374 CA375437109	48	H>R		No	ClinGen gnomAD
CA5316339 rs777399618	48	H>Y		No	ClinGen ExAC gnomAD
rs1347343718 CA375437097	50	L>I		No	ClinGen TOPMed gnomAD
CA375437096 rs1347343718	50	L>V		No	ClinGen TOPMed gnomAD
CA375437087 rs1160242481	51	S>C		No	ClinGen TOPMed gnomAD
rs1160242481 CA375437086	51	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA375437088 rs1160242481	51	S>Y		No	ClinGen TOPMed gnomAD
rs1362367447 CA375437080	52	P>L		No	ClinGen gnomAD
rs754947202 CA5316335	55	I>V		No	ClinGen ExAC TOPMed gnomAD
CA375437057 rs1258422004	56	D>G		No	ClinGen TOPMed
rs1486783663 CA375437051	57	L>F		No	ClinGen gnomAD
CA375437053 rs1486783663	57	L>I		No	ClinGen gnomAD
CA201023235 rs368115750	59	D>N		No	ClinGen ESP TOPMed
CA5316332 rs767762962	60	I>V		No	ClinGen ExAC gnomAD
rs774751146 CA5316330	62	F>L		No	ClinGen ExAC TOPMed gnomAD
rs764386956 CA5316329	64	P>T		No	ClinGen ExAC TOPMed gnomAD
rs146348137 CA201023175	65	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1288396300 CA375436956	69	F>L		No	ClinGen TOPMed
CA375436950 rs1205114199	69	F>L		No	ClinGen gnomAD
rs201449931 CA201016648	75	I>T		No	ClinGen 1000Genomes
rs1235547692 CA375436905	76	R>C		No	ClinGen gnomAD
COSM1460893 COSM1460892 CA375436904 rs1330882032	76	R>H	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1344676875 CA375436876	80	K>N		No	ClinGen TOPMed
CA5316299 rs778422054	83	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA201016626 rs541209983	84	D>N		No	ClinGen gnomAD
CA5316296 rs561589068	86	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA375436835 rs1174175420	86	F>Y		No	ClinGen gnomAD
rs756154202 CA5316295	91	S>G		No	ClinGen ExAC TOPMed gnomAD
rs1421061147 CA375436789	92	E>D		No	ClinGen gnomAD
CA375436760 rs1482106215	97	F>L		No	ClinGen gnomAD
CA375436750 rs879500661	98	D>A		No	ClinGen Ensembl
rs879500661 CA201016617	98	D>V		No	ClinGen Ensembl
COSM1460890 CA375436732 COSM1460891 rs1158306898	101	D>N	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs765350604 CA5316290	102	V>M		No	ClinGen ExAC gnomAD
rs754226739 CA5316288	103	R>*		No	ClinGen ExAC TOPMed gnomAD
CA5316287 rs766660632 COSM1106526 COSM1598123	103	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA5316286 rs761181020	104	D>G		No	ClinGen ExAC gnomAD
CA201008970 rs143480779	110	S>A		No	ClinGen 1000Genomes
rs1469565534 CA375436112	110	S>F		No	ClinGen gnomAD
CA5316255 rs755033891	111	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
COSM76983 CA5316254 rs199806132	111	A>V	ovary Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA375436105 rs1227993424	112	V>L		No	ClinGen TOPMed gnomAD
CA5316252 rs756519675	113	S>L		No	ClinGen ExAC TOPMed gnomAD
CA375436101 rs1443070807	113	S>T		No	ClinGen TOPMed
rs1324443921 CA375436078	116	S>F		No	ClinGen gnomAD
rs1388590237 CA375436063	119	S>G		No	ClinGen gnomAD
TCGA novel	119	S>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757707681 CA5316249	119	S>N		No	ClinGen ExAC gnomAD
rs1390062805 CA375436057	120	I>V		No	ClinGen gnomAD
rs763756887 CA5316247	121	A>S		No	ClinGen ExAC gnomAD
rs763756887 CA5316248	121	A>T		No	ClinGen ExAC gnomAD
COSM1582793 COSM1582794 rs564658959 CA5316246	121	A>V	stomach [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
TCGA novel	122	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA201008948 rs973702754	122	Q>R		No	ClinGen Ensembl
TCGA novel	123	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs552496774 CA5316244	123	N>I		No	ClinGen 1000Genomes ExAC gnomAD
CA5316243 rs759182638	125	G>E		No	ClinGen ExAC TOPMed gnomAD
rs776325440 CA5316242	126	I>V		No	ClinGen ExAC gnomAD
TCGA novel	128	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1236806892 CA375435147	128	P>T		No	ClinGen TOPMed gnomAD
CA375435136 rs1207824569	129	F>C		No	ClinGen gnomAD
COSM1701902 COSM1701903 CA5316211 rs1325408097	130	P>S	skin [Cosmic]	No	ClinGen cosmic curated TOPMed
rs753191819 CA5316209	131	S>L		No	ClinGen ExAC gnomAD
CA375435128 rs1270255113	131	S>T		No	ClinGen gnomAD
rs1204274924 CA375435122	132	E>Q		No	ClinGen Ensembl
TCGA novel	136	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs374867136 CA5316205	139	D>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs540258929 CA5316206	139	D>N	Variant assessed as Somatic; 4.665e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA5316203 rs750247928	141	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1588242556 CA375435049	142	Y>S		No	ClinGen Ensembl
CA375435043 rs761751112	143	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5316200 rs774257474	143	R>H		No	ClinGen ExAC gnomAD
CA375435041 rs774257474 COSM48838	143	R>L	lung [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs774257474 CA375435042	143	R>P		No	ClinGen ExAC gnomAD
rs761751112 CA5316201	143	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1466845014 CA375435037	144	S>N		No	ClinGen TOPMed
CA375435012 rs1192829034	147	E>D		No	ClinGen gnomAD
CA375434999 rs1413060227	150	D>N		No	ClinGen TOPMed gnomAD
CA200991081 rs973290261	151	E>K		No	ClinGen TOPMed gnomAD
CA375436633 rs1167880867	156	E>*		No	ClinGen gnomAD
rs546183608 CA5316171	156	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs1282762869 CA375436632	156	E>G		No	ClinGen TOPMed
TCGA novel	156	E>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5316170 rs769233434	157	D>G		No	ClinGen ExAC
CA375436606 rs377547961	160	D>H		No	ClinGen ESP ExAC gnomAD
CA5316168 rs377547961	160	D>N		No	ClinGen ESP ExAC gnomAD
rs144953516 COSM1106524 COSM1598124 CA5316166	162	V>I	endometrium [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA5316164 rs757095462	163	P>L		No	ClinGen ExAC TOPMed gnomAD
rs757095462 CA5316165	163	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs267602159 CA200991070	163	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs763759757 CA5316162	165	E>K		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	166	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752522017 CA5316160	168	G>E		No	ClinGen ExAC gnomAD
rs1199450170 CA375436545	169	D>G		No	ClinGen TOPMed
TCGA novel	170	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5316157 rs773614765	170	D>N		No	ClinGen ExAC gnomAD
CA375436531 rs1229773234	171	I>N		No	ClinGen TOPMed gnomAD
rs762083852 CA5316155	173	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA375436512 rs1407871213	174	D>N		No	ClinGen gnomAD
rs774782605 CA5316154	176	I>V		No	ClinGen ExAC gnomAD
CA375436483 rs1303256900	178	V>M		No	ClinGen gnomAD
rs1360085814 CA375436469	180	V>M		No	ClinGen Ensembl
CA200991041 rs947002482	184	M>V		No	ClinGen TOPMed
rs1361068811 CA375436404	187	Y>H		No	ClinGen TOPMed
CA5316112 CA200990138 rs765520477	188	M>I		No	ClinGen ExAC TOPMed gnomAD
CA375436394 rs1210124682	188	M>T		No	ClinGen TOPMed
CA200990140 rs971509748	188	M>V		No	ClinGen Ensembl
rs760052704 CA5316111	189	Q>P		No	ClinGen ExAC gnomAD
rs1232623564 CA375436372	190	K>E		No	ClinGen TOPMed gnomAD
rs1232623564 CA375436373	190	K>Q		No	ClinGen TOPMed gnomAD
CA5316081 rs775377110	191	M>I		No	ClinGen ExAC gnomAD
CA5316080 rs769651196	195	E>K		No	ClinGen ExAC gnomAD
CA375436315 rs1327297349	197	D>E		No	ClinGen gnomAD
CA5316078 rs777730106	200	N>T		No	ClinGen ExAC gnomAD
CA375436287 rs1316516211	201	C>Y		No	ClinGen Ensembl
rs1234687506 CA375436237	208	E>G		No	ClinGen gnomAD
CA5316074 rs755389222	210	E>D		No	ClinGen ExAC gnomAD
CA5316075 rs779080016	210	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA375436201 rs1588206252	213	Y>*		No	ClinGen Ensembl
rs754228976 CA5316073	214	Y>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs756590609 CA5316071	215	R>C		No	ClinGen ExAC TOPMed gnomAD
CA5316070 rs750925866	215	R>H		No	ClinGen ExAC gnomAD
rs750925866 CA375436190	215	R>L		No	ClinGen ExAC gnomAD
CA375436186 rs1401551520	216	T>I		No	ClinGen TOPMed
rs1279682174 CA375436166	219	D>G		No	ClinGen gnomAD
rs774196526 CA200989632	220	I>M		No	ClinGen ExAC TOPMed gnomAD
rs573725166 CA5316068	220	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA375436149 rs1564368166	222	K>Q		No	ClinGen Ensembl
CA375435992 rs1250209692	223	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1189441446 CA375435987	224	Y>H		No	ClinGen gnomAD
CA5316041 rs770926917	225	M>I		No	ClinGen ExAC TOPMed gnomAD
rs375010179 CA200989024	225	M>V		No	ClinGen ESP TOPMed gnomAD
rs1056608217 CA200989022	226	S>I		No	ClinGen gnomAD
CA375435961 rs1291614851	227	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs760535339 CA5316040	227	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs760535339 CA375435965	227	P>T		No	ClinGen ExAC TOPMed gnomAD
rs546008982 CA5316037	229	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5316036 rs780290287	229	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs546008982 CA5316038	229	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA5316033 rs781370355	231	V>G		No	ClinGen ExAC gnomAD
CA5316035 rs746265076	231	V>L		No	ClinGen ExAC TOPMed gnomAD
CA5316034 rs746265076	231	V>M		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	232	L>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	232	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757844156 CA5316032	233	S>I		No	ClinGen ExAC gnomAD
COSM1624683 rs200521072 COSM1624682 CA5316031	234	P>L	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
rs200521072 CA200989010	234	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs368899494 CA375435926	235	A>E		No	ClinGen ExAC gnomAD
rs1301212214 CA375435927	235	A>T		No	ClinGen gnomAD
CA5316029 rs368899494	235	A>V	Variant assessed as Somatic; 4.672e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs759066470 CA5316026	236	D>A		No	ClinGen ExAC gnomAD
CA5316027 rs759066470	236	D>G		No	ClinGen ExAC gnomAD
rs766101488 CA5316024	237	M>V		No	ClinGen ExAC TOPMed gnomAD
rs377331945 CA5316023	238	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1268880253 CA375435905	239	A>P		No	ClinGen gnomAD
rs1220883003 CA375435898	240	V>L		No	ClinGen gnomAD
CA5315989 rs199616982	246	D>G		No	ClinGen 1000Genomes ExAC gnomAD
CA5315990 rs530224752	246	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA375435838 rs1258667667	247	L>M		No	ClinGen gnomAD
CA375435808 rs1462613393	251	H>R		No	ClinGen gnomAD
rs1210059973 CA375435801	252	H>R		No	ClinGen TOPMed gnomAD
rs767232783 CA5315986	252	H>Y		No	ClinGen ExAC gnomAD
rs1356296947 CA375435768	257	A>T		No	ClinGen gnomAD
CA375435749 rs1342081307	259	D>E		No	ClinGen gnomAD
CA375435756 rs1168963554	259	D>N		No	ClinGen TOPMed gnomAD
CA375435753 rs1236759493	259	D>V		No	ClinGen gnomAD
rs757231721 CA375435748	260	V>L		No	ClinGen ExAC gnomAD
rs757231721 CA5315985	260	V>M		No	ClinGen ExAC gnomAD
TCGA novel	261	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5315984 rs751439753	261	S>T		No	ClinGen ExAC gnomAD
rs759504644 CA375435737	262	V>L		No	ClinGen ExAC TOPMed gnomAD
CA5315982 rs759504644	262	V>M		No	ClinGen ExAC TOPMed gnomAD
CA375435729 rs1319388006	263	M>T		No	ClinGen TOPMed
rs1385733713 CA375435720	264	V>G		No	ClinGen gnomAD
rs777044584 CA5315981	264	V>M		No	ClinGen ExAC gnomAD
CA375435719 rs1564365196	265	G>R		No	ClinGen Ensembl
rs143919789 CA5315979	266	G>D		No	ClinGen 1000Genomes ExAC gnomAD
CA375435707 rs1165943219	267	S>G		No	ClinGen gnomAD
CA5315977 rs147505589	268	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA5315978 rs773720874	268	T>P		No	ClinGen ExAC gnomAD
TCGA novel	270	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375435673 rs1177409077	272	V>A		No	ClinGen TOPMed gnomAD
rs1177409077 CA375435672	272	V>G		No	ClinGen TOPMed gnomAD
rs1202807126 CA375435655	275	D>G		No	ClinGen gnomAD
CA5315974 rs768260214	275	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA375435656 rs768260214	275	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs907198234 CA200988544	278	E>G		No	ClinGen TOPMed
CA375435626 rs1453601686	279	R>G		No	ClinGen TOPMed
CA5315972 rs779498711	279	R>M		No	ClinGen ExAC gnomAD
CA375435608 rs1204960790	280	L>I		No	ClinGen gnomAD
rs1376631871 CA375435591	282	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5315938 rs752628002	283	Y>H		No	ClinGen ExAC gnomAD
rs1347264164 CA375435582	284	G>R		No	ClinGen gnomAD
CA5315936 rs756227922	285	E>D		No	ClinGen ExAC gnomAD
CA375435561 rs1379248664	287	C>R		No	ClinGen TOPMed
rs1290753677 CA375435559	287	C>Y		No	ClinGen gnomAD
rs376443625 CA5315935	289	H>R		No	ClinGen ESP ExAC gnomAD
rs1335528002 CA375435539	290	M>V		No	ClinGen TOPMed gnomAD
rs141016276 CA5315934	292	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1598126 COSM1106520 CA5315932 rs751902643	293	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs764471379 CA5315931	293	A>V		No	ClinGen ExAC TOPMed gnomAD
CA5315930 rs763501246	294	Q>*		No	ClinGen ExAC gnomAD
rs775944049 CA5315929	295	N>D		No	ClinGen ExAC gnomAD
CA5315928 rs769359624	296	T>A		No	ClinGen ExAC gnomAD
TCGA novel	296	T>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375435489 rs1469479782	297	L>P		No	ClinGen gnomAD
CA375435482 rs1189308670	298	N>K		No	ClinGen gnomAD
rs759032620 CA5315927	298	N>S		No	ClinGen ExAC gnomAD
rs1462841236 CA375435478	299	Q>*		No	ClinGen gnomAD
CA375435474 rs1394793750	299	Q>H		No	ClinGen gnomAD
CA5315926 rs776146802	300	L>F		No	ClinGen ExAC gnomAD
rs1291650134 CA375435465	301	L>Q		No	ClinGen TOPMed
CA375435459 rs1321493519	302	A>D		No	ClinGen gnomAD
CA375435457 rs1321493519	302	A>V		No	ClinGen gnomAD
CA375435447 rs1350540931	304	R>Q		No	ClinGen TOPMed gnomAD
rs150680379 CA5315924	304	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA375435423 rs1564357856	307	F>C		No	ClinGen Ensembl
TCGA novel	311	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5315922 rs568453790	312	E>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5315886 rs754343989	313	E>K		No	ClinGen ExAC gnomAD
CA375435364 rs1441178732	314	C>G		No	ClinGen TOPMed
TCGA novel	314	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765842927 CA5315885	315	T>I		No	ClinGen ExAC TOPMed gnomAD
rs34769896 CA200983250	316	L>M		No	ClinGen Ensembl
CA375435350 rs1588187554	316	L>R		No	ClinGen Ensembl
CA5315882 rs767286250	321	G>R		No	ClinGen ExAC TOPMed gnomAD
CA375435281 rs1346890694	326	Q>R		No	ClinGen gnomAD
rs148077598 CA5315881	328	L>V		No	ClinGen ESP ExAC TOPMed
CA5315880 rs143721504	330	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1428046965 CA375435255	331	V>I		No	ClinGen TOPMed gnomAD
rs768549731 CA5315879	332	P>A		No	ClinGen ExAC gnomAD
TCGA novel	334	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762839518 CA5315878	334	Q>R		No	ClinGen ExAC gnomAD
rs775492722 CA5315877	335	R>K		No	ClinGen ExAC gnomAD
rs770973334 CA5315876	336	V>L		No	ClinGen ExAC gnomAD
CA375435205 rs1261055802	338	K>N		No	ClinGen gnomAD
rs1457518292 CA375435193	340	H>Y		No	ClinGen TOPMed
rs1239641767 CA375435181	342	L>V		No	ClinGen TOPMed
rs1305365070 CA375435164	344	K>M		No	ClinGen gnomAD
rs752565749 CA5315840	345	E>D		No	ClinGen ExAC gnomAD
CA5315841 rs372614789	345	E>K		No	ClinGen ESP ExAC gnomAD
CA5315839 rs764890175	346	L>F		No	ClinGen ExAC gnomAD
CA5315838 rs759515348	347	L>V		No	ClinGen ExAC gnomAD
CA375434964 rs1260003591	348	S>N		No	ClinGen gnomAD
CA375434963 rs1260003591	348	S>T		No	ClinGen gnomAD
rs61761612 CA5315837	349	H>L		No	ClinGen ExAC TOPMed gnomAD
CA5315836 rs767645931	350	S>Y		No	ClinGen ExAC gnomAD
CA5315835 rs367789551	351	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA375434932 rs749425031	353	R>L		No	ClinGen ExAC TOPMed gnomAD
CA5315832 rs749425031	353	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA5315833 rs200570910	353	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA375434910 rs1367813154	357	Q>E		No	ClinGen gnomAD
rs201146753 CA5315828	358	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5315827 rs757780660	359	L>P		No	ClinGen ExAC gnomAD
CA200982865 rs1004482095	367	Q>R		No	ClinGen TOPMed gnomAD
rs754562539 CA5315804	370	A>V		No	ClinGen ExAC gnomAD
rs766115923 CA5315802	371	M>I		No	ClinGen ExAC gnomAD
CA375434800 rs1176170688	371	M>L		No	ClinGen TOPMed
rs1386577376 CA375434791	372	Y>H		No	ClinGen TOPMed
rs756096553 CA5315801	373	I>V		No	ClinGen ExAC gnomAD
rs752765700 COSM3413431 COSM3413432 CA5315797	378	R>Q	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed
CA5315798 rs142018797	378	R>W	Variant assessed as Somatic; 9.24e-05 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA375434734 rs1234422985	380	K>R		No	ClinGen gnomAD
rs765560617 CA5315796	381	E>Q		No	ClinGen ExAC gnomAD
rs759792457 CA5315795	382	T>A		No	ClinGen ExAC gnomAD
rs761281648 CA5315792	391	S>N		No	ClinGen ExAC gnomAD
rs369424247 CA200981611	392	S>C		No	ClinGen ESP TOPMed gnomAD
rs369424247 CA375434646	392	S>F		No	ClinGen ESP TOPMed gnomAD
CA5315789 rs747621286	393	I>M		No	ClinGen ExAC gnomAD
CA5315790 rs138063876	393	I>V		No	ClinGen ESP ExAC gnomAD
TCGA novel	395	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778358319 CA5315788	396	L>S		No	ClinGen ExAC gnomAD
rs145444804 CA5315761	398	V>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs1244385929 CA375434400	398	V>M		No	ClinGen gnomAD
CA375434383 rs1488229094	400	L>R		No	ClinGen gnomAD
CA5315760 rs755102034	401	E>G		No	ClinGen ExAC gnomAD
rs754168996 CA5315759	402	E>K		No	ClinGen ExAC TOPMed gnomAD
CA375434371 rs1359711568	402	E>V		No	ClinGen gnomAD
CA200980826 rs267602158	410	G>R		No	ClinGen Ensembl
rs1226172352 CA375434304	412	L>V		No	ClinGen gnomAD
CA5315757 rs756289741	415	R>Q		No	ClinGen ExAC gnomAD
rs1363424884 COSM1701901 CA375434285 COSM1701900	415	R>W	skin [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA5315755 rs767906649	416	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA375434274 rs1366492152	417	I>T		No	ClinGen gnomAD
rs375096471 CA5315754	417	I>V		No	ClinGen ESP ExAC gnomAD
rs774837732 CA5315753	419	N>S		No	ClinGen ExAC TOPMed gnomAD
rs1588175826 CA375434257	420	H>N		No	ClinGen Ensembl
CA5315752 rs763654070	421	T>I		No	ClinGen ExAC gnomAD
rs574299407 CA5315750	423	Q>E		No	ClinGen 1000Genomes ExAC gnomAD
CA5315749 rs745475435	424	D>E		No	ClinGen ExAC TOPMed gnomAD
rs776337749 CA5315747	425	R>M		No	ClinGen ExAC TOPMed gnomAD
CA200980478 rs935832395	426	Y>*		No	ClinGen Ensembl
CA200980476 rs768507686	428	F>L		No	ClinGen Ensembl
CA5315710 rs760360468	433	V>A		No	ClinGen ExAC gnomAD
rs771963894 CA375434013	435	I>M		No	ClinGen ExAC TOPMed gnomAD
CA375434026 rs1267642044	435	I>V		No	ClinGen TOPMed
CA5315706 rs761914102	436	V>I		No	ClinGen ExAC gnomAD
CA5315709 rs762688041	437	C>*		No	ClinGen ExAC
rs768420549 CA5315704	439	R>G		No	ClinGen ExAC TOPMed gnomAD
CA5315703 rs138761889	439	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs768420549 CA5315705	439	R>W		No	ClinGen ExAC TOPMed gnomAD
rs781095040 CA5315702	440	K>R		No	ClinGen ExAC gnomAD
CA5315700 rs747209081	443	S>G		No	ClinGen ExAC gnomAD
rs56296048 CA375433890	444	Y>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs758756932 CA5315698	445	E>D		No	ClinGen ExAC gnomAD
rs1402193576 CA375433870	446	L>F		No	ClinGen gnomAD
CA375433821 rs1301583073	449	I>N		No	ClinGen TOPMed gnomAD
rs949387662 CA200980456 CA375433788	451	E>D		No	ClinGen TOPMed gnomAD
CA5315695 rs755369467	451	E>K		No	ClinGen ExAC gnomAD
rs1486130935 CA375433671 CA375433670	459	D>E		No	ClinGen TOPMed gnomAD
CA5315689 rs761718058	459	D>N		No	ClinGen ExAC gnomAD
rs773952259 CA5315688	460	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA375433634 rs1228990434	462	M>L		No	ClinGen TOPMed
rs1287802834 CA375433612	463	N>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs762753188 CA5315686	464	N>S		No	ClinGen ExAC gnomAD
TCGA novel	465	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375433578 rs1172044202	466	D>V		No	ClinGen gnomAD
rs201764323 CA5315684	467	V>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA375433575 rs150924742	467	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA5315685 rs150924742	467	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs777957288 CA5315682	468	K>Q		No	ClinGen ExAC gnomAD
rs1458249565 CA375433102	471	H>Y		No	ClinGen TOPMed gnomAD
CA200980170 rs935532382	472	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA5315604 rs764213656	478	G>A		No	ClinGen ExAC gnomAD
CA375432845 rs764213656	478	G>D		No	ClinGen ExAC gnomAD
rs186434110 COSM1155095 COSM1106516 CA5315605	478	G>S	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1320534584 CA375432823	480	Y>H		No	ClinGen gnomAD
CA375432788 rs1350620440	482	I>S		No	ClinGen gnomAD
rs1340851644 CA375432777	483	H>R		No	ClinGen TOPMed
rs1403666390 CA375432762	484	L>P		No	ClinGen gnomAD
rs767478307 CA200978320	486	G>E		No	ClinGen Ensembl
rs776987604 CA5315599	486	G>R		No	ClinGen ExAC gnomAD
rs771536985 CA5315594	499	M>T		No	ClinGen ExAC gnomAD
CA5315591 rs768234718	504	M>I		No	ClinGen ExAC TOPMed gnomAD
CA5315593 rs774008253	504	M>K		No	ClinGen ExAC TOPMed gnomAD
CA375432473 rs1218813414	504	M>L		No	ClinGen gnomAD
rs774008253 CA5315592	504	M>R		No	ClinGen ExAC TOPMed gnomAD
CA5315590 rs140877645	505	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs779854047 CA5315589	511	M>T		No	ClinGen ExAC gnomAD
CA375432242 rs1588169455	512	S>A		No	ClinGen Ensembl
rs144398774 CA5315564	515	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA5315562 rs150054284	520	N>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA375432126 rs1254038497	520	N>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA200977986 rs562583711	521	A>T		No	ClinGen 1000Genomes
rs1588169418 CA375432110	521	A>V		No	ClinGen Ensembl
CA375432085 rs1364781694	523	H>D		No	ClinGen gnomAD
CA375432037 rs1392794706	526	F>V		No	ClinGen Ensembl
CA5315559 rs184909763	528	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs750245667 CA200977983	530	T>M		No	ClinGen TOPMed gnomAD
CA375431967 rs750245667	530	T>R		No	ClinGen TOPMed gnomAD
rs191239028 CA5315556	532	D>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5315557 rs773904390	532	D>N		No	ClinGen ExAC gnomAD
rs1378997392 CA375431917	534	T>A		No	ClinGen TOPMed gnomAD
CA5315555 rs372445285	535	T>N		No	ClinGen ESP ExAC TOPMed gnomAD
CA375431895 rs1360828074	536	N>D		No	ClinGen gnomAD
rs1157646248 CA375431876	537	C>Y		No	ClinGen gnomAD
rs1451130243 CA375431850	539	A>T		No	ClinGen gnomAD
CA200977977 rs986093528	541	K>E		No	ClinGen Ensembl
TCGA novel	544	L>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759464787 CA5315551	544	L>F		No	ClinGen ExAC TOPMed gnomAD
CA375431762 rs1301910148	544	L>R		No	ClinGen TOPMed
CA375431345 rs1332516679	546	G>A		No	ClinGen TOPMed gnomAD
rs1332516679 CA375431346	546	G>D		No	ClinGen TOPMed gnomAD
CA200977786 rs969726282	547	T>I		No	ClinGen gnomAD
rs1385769740 CA375431327	549	Y>C		No	ClinGen gnomAD
CA375431312 rs1391688105	551	G>A		No	ClinGen gnomAD
rs202226819 CA5315520	553	M>T		No	ClinGen 1000Genomes ExAC
TCGA novel	553	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs757608619 CA5315521	553	M>V		No	ClinGen ExAC gnomAD
rs1471767990 CA375431276	556	K>R		No	ClinGen TOPMed
rs1167345356 CA375431262	558	G>C		No	ClinGen TOPMed
rs1024006695 CA200977780	558	G>D		No	ClinGen TOPMed gnomAD
CA375431258 rs758789048	559	V>F		No	ClinGen ExAC TOPMed gnomAD
CA5315518 rs758789048	559	V>I		No	ClinGen ExAC TOPMed gnomAD
CA5315515 rs754695036	560	G>A		No	ClinGen ExAC gnomAD
CA375431251 rs754695036	560	G>E		No	ClinGen ExAC gnomAD
CA5315516 rs376689003	560	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA5315513 rs766333869	561	A>S		No	ClinGen ExAC TOPMed gnomAD
rs766333869 CA5315514	561	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1251236031 CA375431226	564	E>G		No	ClinGen gnomAD
CA375431198 rs1348306895	568	V>A		No	ClinGen TOPMed gnomAD
rs1348306895 CA375431197	568	V>G		No	ClinGen TOPMed gnomAD
rs760558503 CA200977773	568	V>L		No	ClinGen ExAC gnomAD
CA5315512 rs760558503	568	V>M		No	ClinGen ExAC gnomAD
rs773103360 CA5315511	569	I>L		No	ClinGen ExAC gnomAD
CA375431187 rs1232395967	570	P>L		No	ClinGen TOPMed
CA200977770 rs374011637	570	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA5315510 rs374011637	570	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1256918027 CA375431165	573	K>N		No	ClinGen gnomAD
rs1232105362 CA375431155	575	T>A		No	ClinGen gnomAD
rs1352670554 CA375430541	577	P>L		No	ClinGen Ensembl
rs1412693042 CA375430546	577	P>S		No	ClinGen gnomAD
CA375430533 rs1310708370	578	A>E		No	ClinGen TOPMed gnomAD
CA5315481 rs776654627	580	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1414688677 CA375429963	581	D>N		No	ClinGen TOPMed gnomAD
rs776157987 CA375429938	582	A>P		No	ClinGen ExAC gnomAD
rs776157987 CA5315437	582	A>T		No	ClinGen ExAC gnomAD
rs745404223 COSM3395652 CA5315435 COSM3395651	584	G>R	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA5315434 rs146078250	585	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs548048956 CA5315433	585	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1348939836 CA375429815	588	G>R		No	ClinGen TOPMed gnomAD
COSM1727178 COSM1727179 rs749245786 CA5315408	590	K>N	liver [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs781187663 CA5315407	591	M>I		No	ClinGen ExAC TOPMed gnomAD
rs757372611 CA5315406	592	V>M		No	ClinGen ExAC gnomAD
rs1351582845 CA375429545	593	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA375429539 rs602990	594	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA375429537 rs1474814044	594	M>T		No	ClinGen gnomAD
VAR_045690 rs602990 CA5315404	594	M>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA375429526 rs1415417405	595	Q>*		No	ClinGen gnomAD
CA375429484 rs1588162619	597	Y>S		No	ClinGen Ensembl
rs948700593 CA200976015	598	H>R		No	ClinGen Ensembl
CA375429446 rs1478965365	599	G>D		No	ClinGen gnomAD
CA375429429 rs1588162602	600	N>T		No	ClinGen Ensembl
rs1262681533 CA375429413	601	P>S		No	ClinGen gnomAD
CA5315403 rs758647095	602	A>V		No	ClinGen ExAC gnomAD
CA200976012 rs917121261	603	P>A		No	ClinGen Ensembl
CA5315402 rs753165273	603	P>L		No	ClinGen ExAC gnomAD
CA5315401 rs765602760	604	P>L		No	ClinGen ExAC TOPMed gnomAD
rs148238092 CA5315398	605	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5315399 COSM1232203 rs148238092 COSM1232202	605	G>W	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA375429309 rs1484927694	608	V>A		No	ClinGen TOPMed
CA5315397 rs760181556	608	V>L		No	ClinGen ExAC gnomAD
rs772668402 CA5315396	610	T>I		No	ClinGen ExAC gnomAD
rs771733049 CA5315395	611	F>L		No	ClinGen ExAC gnomAD
CA5315394 rs747775389	612	Q>L		No	ClinGen ExAC
rs774081477 CA5315393	613	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs569003098 CA5315391	614	G>R		No	ClinGen ExAC TOPMed gnomAD
CA200975983 rs978842166	615	D>N		No	ClinGen TOPMed gnomAD
rs747112648 CA5315388	616	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA375429162 rs1554770506	617	L>F		No	ClinGen Ensembl
CA5315385 rs752960944	621	R>M		No	ClinGen ExAC TOPMed gnomAD
rs755378842 CA5315383	623	D>N		No	ClinGen ExAC TOPMed gnomAD
rs1194332682 CA375429054	624	P>S		No	ClinGen gnomAD
rs766939641 CA5315381	627	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1200959100 CA375429018	629	W>R		No	ClinGen gnomAD
CA375427983 rs1485961160	631	G>V		No	ClinGen TOPMed
rs749439328 CA5315348	632	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5315347 rs780462649	632	R>H		No	ClinGen ExAC TOPMed gnomAD
rs756485000 CA5315346	633	L>V	Variant assessed as Somatic; 9.266e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs137947314 CA5315345	635	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1209739418 CA375427868	641	Y>F		No	ClinGen gnomAD
CA375427853 rs1484446568	642	F>L		No	ClinGen TOPMed gnomAD
rs757658966 CA5315343	643	P>L		No	ClinGen ExAC gnomAD
rs752274958 CA5315339	651	P>S		No	ClinGen ExAC gnomAD
CA375427672 rs1175926019	652	V>G		No	ClinGen TOPMed
CA5315338 rs764920694	652	V>M		No	ClinGen ExAC gnomAD
rs745423288 CA200975353	653	D>E		No	ClinGen TOPMed gnomAD
CA375427643 rs1414405918	653	D>G		No	ClinGen gnomAD
rs776525103 CA5315336	654	G>R		No	ClinGen ExAC
CA375427612 rs1320441021	654	G>V		No	ClinGen gnomAD
rs766440261 CA5315335	655	R>G		No	ClinGen ExAC gnomAD
CA375427603 rs1564335031	655	R>K		No	ClinGen Ensembl
rs150295787	656	P>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs201540300 CA5315309	656	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA375427123 rs1372412547	657	P>A		No	ClinGen gnomAD
CA5315306 rs190108958	660	R>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5315305 rs190108958	660	R>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs770053214 CA5315307	660	R>W		No	ClinGen ExAC TOPMed gnomAD
CA5315304 rs145700399	661	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA200974609 rs955136607	662	P>L		No	ClinGen TOPMed
rs778142385 CA5315302	663	S>C		No	ClinGen ExAC gnomAD
CA5315300 rs147799977	664	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5315301 rs772588253	664	R>W		No	ClinGen ExAC TOPMed gnomAD
CA5315298 rs144269361	666	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA375426994 rs1454312993	666	I>V		No	ClinGen gnomAD
rs779956188 CA5315296	667	D>G		No	ClinGen ExAC gnomAD
CA5315297 rs142558070	667	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5315295 rs755866286	669	T>A		No	ClinGen ExAC TOPMed gnomAD
CA375426972 rs1348655623	669	T>S		No	ClinGen TOPMed
rs1272714390 CA375426969	670	A>P		No	ClinGen TOPMed gnomAD
CA375426958 rs1348710701	671	Y>C		No	ClinGen TOPMed gnomAD
rs752817573 CA5315291	672	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1217979822 CA375426953	672	P>S		No	ClinGen gnomAD
CA200974546 rs1046012161	673	W>S		No	ClinGen TOPMed
rs769246708 CA375426443	678	M>K		No	ClinGen ExAC gnomAD
CA5315264 rs769246708	678	M>T		No	ClinGen ExAC gnomAD
rs748829750 CA5315263	683	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs769373042 CA5315261	685	N>S		No	ClinGen ExAC gnomAD
rs769373042 CA375426196	685	N>T		No	ClinGen ExAC gnomAD
rs1310178015 CA375426172	686	L>V		No	ClinGen gnomAD
CA5315259 rs780909333	689	S>C		No	ClinGen ExAC TOPMed gnomAD
CA375426104 rs1588157572	689	S>P		No	ClinGen Ensembl
rs7875953 CA5315258	690	H>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs142993722 CA200973890	691	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs142993722 CA5315256	691	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA5315255 rs758279112	691	A>V		No	ClinGen ExAC TOPMed gnomAD
rs766448838 CA5315253	693	G>R		No	ClinGen ExAC TOPMed gnomAD
CA375425951 rs937643733	694	T>P		No	ClinGen Ensembl
rs937643733 CA200973840	694	T>S		No	ClinGen Ensembl
rs1471922738 CA375425802	699	E>V		No	ClinGen gnomAD
COSM1460879 rs1162980032 COSM1460878 CA375425776	700	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
COSM1598129 CA375425786 COSM1106512 rs1564332755	700	R>W	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated Ensembl NCI-TCGA
CA200973828 rs927504022	701	P>L		No	ClinGen Ensembl
CA5315251 rs750643570	702	A>S		No	ClinGen ExAC gnomAD
rs762272210 CA5315249	703	E>K		No	ClinGen ExAC gnomAD
rs764747022 CA5315247	704	A>T		No	ClinGen ExAC gnomAD
rs369246487 CA5315245	706	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA5315244 rs769335699	706	R>H		No	ClinGen ExAC TOPMed gnomAD
CA375425566 rs1266345573	709	I>M		No	ClinGen Ensembl
rs1029016039 CA200973796	709	I>V		No	ClinGen TOPMed
CA5315243 rs745312826	710	S>N		No	ClinGen ExAC gnomAD
CA375425535 rs1307709067	711	I>L		No	ClinGen gnomAD
rs1294299323 CA375425507	712	K>R		No	ClinGen gnomAD
CA5315200 rs751820840	714	N>H		No	ClinGen ExAC gnomAD
rs758798561 CA5315198	714	N>I		No	ClinGen ExAC TOPMed gnomAD
rs758798561 CA5315199	714	N>S		No	ClinGen ExAC TOPMed gnomAD
CA200970939 rs1012487581	720	I>V		No	ClinGen TOPMed
rs759935502 CA5315195	723	V>A		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	723	V>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765866512 CA5315193	725	K>R		No	ClinGen ExAC TOPMed gnomAD
rs760375847 CA5315191	731	I>N		No	ClinGen ExAC gnomAD
rs1411696176 CA375424038	732	T>I		No	ClinGen gnomAD
rs902666283 CA200970911	738	D>N		No	ClinGen TOPMed
rs140004145 CA200970909	739	S>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs140004145 CA5315188	739	S>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1186280431 CA375423905	739	S>I		No	ClinGen gnomAD
CA375423902 rs1199188591	739	S>R		No	ClinGen TOPMed
rs867032627 CA200970901	740	L>F		No	ClinGen Ensembl
rs749975481 CA375423525	743	L>F		No	ClinGen ExAC gnomAD
CA5315151 rs766933645	744	V>G		No	ClinGen ExAC
rs56300187 CA200969228	746	Y>*		No	ClinGen Ensembl
TCGA novel	746	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1588152493 CA375423492	746	Y>D		No	ClinGen Ensembl
CA375423438 rs1168032692	750	H>D		No	ClinGen gnomAD
CA5315148 rs763737747	750	H>L		No	ClinGen ExAC gnomAD
rs764218046 CA200969201	751	S>L		No	ClinGen Ensembl
rs1468809405 CA375423405	755	S>G		No	ClinGen gnomAD
CA5315146 rs775372990	755	S>N		No	ClinGen ExAC gnomAD
rs1283428476 CA375423368	760	D>Y		No	ClinGen gnomAD
CA375423359 rs1275345661	761	T>S		No	ClinGen gnomAD
CA200969106 rs773411427	762	T>I		No	ClinGen ExAC gnomAD
rs773411427 CA5315143	762	T>K		No	ClinGen ExAC gnomAD
rs1020408130 CA200969098	763	L>F		No	ClinGen TOPMed gnomAD
CA375423349 rs1295409239	763	L>P		No	ClinGen gnomAD
rs772034314 CA5315142	764	K>R		No	ClinGen ExAC gnomAD
TCGA novel	764	K>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs972602439 CA200969097	765	Y>*		No	ClinGen Ensembl
CA375423332 rs1274679832	766	P>A		No	ClinGen gnomAD
CA375423320 rs1366276670	767	Y>*		No	ClinGen gnomAD
TCGA novel	767	Y>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5315139 rs202215285	770	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5315140 rs774443032	770	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA5315138 rs749677179	771	E>G		No	ClinGen ExAC gnomAD
rs1428639992 CA375423302	771	E>K		No	ClinGen gnomAD
CA375423293 COSM1151240 rs1174972227 COSM753259	772	R>C	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA5315137 rs780374809	772	R>H		No	ClinGen ExAC TOPMed gnomAD
rs756680997 CA5315136	773	S>L		No	ClinGen ExAC TOPMed gnomAD
rs142833769 CA200969074	774	A>T		No	ClinGen ESP TOPMed gnomAD
rs781681211 CA375423278	775	S>A		No	ClinGen ExAC TOPMed gnomAD
CA375423279 rs781681211	775	S>P		No	ClinGen ExAC TOPMed gnomAD
rs781681211 CA5315134	775	S>T		No	ClinGen ExAC TOPMed gnomAD
CA5315132 rs751038492	776	R>G		No	ClinGen ExAC gnomAD
CA5315131 rs777588088	777	A>P		No	ClinGen ExAC gnomAD
CA375423260 rs1217927063	778	S>C		No	ClinGen gnomAD
rs200274692 CA5315130	778	S>P		No	ClinGen ExAC gnomAD
TCGA novel	779	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs765122995 CA375423250	780	R>G		No	ClinGen ExAC TOPMed gnomAD
CA5315126 rs767880414	780	R>Q		No	ClinGen ExAC gnomAD
rs765122995 CA5315127	780	R>W		No	ClinGen ExAC TOPMed gnomAD
rs866421862 CA200969024	781	S>C		No	ClinGen Ensembl
CA375422257 rs1456299174	785	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1294246832 CA375422187	788	Y>C		No	ClinGen TOPMed gnomAD
COSM455561 CA375422158 rs1215778665	789	N>S	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA375422085 rs1332532896	792	F>V		No	ClinGen TOPMed
CA5315099 rs531614938	792	F>Y		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs777028727 CA5315098	793	L>V		No	ClinGen ExAC TOPMed gnomAD
rs370841001 CA5315095	794	S>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA375422020 rs1458657832	795	P>S		No	ClinGen gnomAD
CA375421985 rs1328349315	797	G>C		No	ClinGen TOPMed
CA5315092 rs377647835	798	L>F		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	801	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs200411313 CA5315090	801	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	803	Q>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA375421866 rs1210783594	804	G>A		No	ClinGen gnomAD
rs749087475 CA5315088	804	G>S		No	ClinGen ExAC gnomAD
CA375421844 rs1206118288	806	S>T		No	ClinGen gnomAD
CA5315083 rs372641201	807	A>G		No	ClinGen ExAC TOPMed gnomAD
rs183141718 CA5315085	807	A>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA5315084 rs183141718	807	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs372641201 CA200966411	807	A>V		No	ClinGen ExAC TOPMed gnomAD
CA375421836 rs1373077557	808	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs758502385 CA5315082	809	F>L		No	ClinGen ExAC gnomAD
rs1588151280 CA375421811	811	S>L		No	ClinGen Ensembl
CA5315048 rs564689902	814	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA5315046 rs746931943	815	P>S		No	ClinGen ExAC gnomAD
CA5315045 rs191274326	816	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs202055327 CA5315044	816	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs780349466 CA5315042	817	V>I		No	ClinGen ExAC TOPMed gnomAD
COSM3774355 CA5315040 rs61751477 COSM3774356	818	I>M	kidney [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs148033881 CA5315039	819	G>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148033881 CA5315038	819	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
TCGA novel	821	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs934946882 CA200965647	823	A>T		No	ClinGen Ensembl
rs201135054 CA200965640	824	R>G		No	ClinGen Ensembl
rs978997426 CA200965639	825	Y>C		No	ClinGen Ensembl
CA5315034 rs774838611	828	A>S		No	ClinGen ExAC gnomAD
rs1415577020 CA375421583	829	A>T		No	ClinGen TOPMed
CA5315032 rs146994870	830	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs374240487 CA5315031	830	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA375421537 rs746743644	832	M>L		No	ClinGen ExAC TOPMed gnomAD
rs746743644 CA5315029	832	M>V		No	ClinGen ExAC TOPMed gnomAD
rs746362083 CA200965568	834	E>D		No	ClinGen TOPMed gnomAD
rs201638694 CA200965560	835	L>I		No	ClinGen 1000Genomes
COSM168874 CA5315027 rs771858287	836	S>L	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA200965538 rs371905656	837	L>M		No	ClinGen ESP
rs138753594 CA5315023	838	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs756471330 CA5315024	838	R>W		No	ClinGen ExAC TOPMed gnomAD
rs781497372 CA5315022	839	E>A		No	ClinGen ExAC TOPMed
rs1318958505 CA375421410	840	G>D		No	ClinGen gnomAD
CA5315021 CA5315020 rs764709519	841	D>E		No	ClinGen ExAC TOPMed gnomAD
CA5315018 rs145738821 COSM1145262 COSM608167	842	V>L	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs145738821 CA5315017	842	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	843	V>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5315016 rs375495204	844	R>K		No	ClinGen ExAC gnomAD
rs1471533924 CA375421320	846	Y>C		No	ClinGen gnomAD
rs1471533924 CA375421322	846	Y>S		No	ClinGen gnomAD
CA375421300 rs1391413151	847	S>R		No	ClinGen gnomAD
rs149037213 CA5315015	848	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs1448786149 CA375421291	848	R>H		No	ClinGen TOPMed gnomAD
rs1448786149 CA375421287	848	R>L		No	ClinGen TOPMed gnomAD
rs765980821 CA5315014	849	I>F		No	ClinGen ExAC TOPMed gnomAD
rs9722384 CA375421275	849	I>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs765980821 CA5315013	849	I>V		No	ClinGen ExAC TOPMed gnomAD
CA5315011 rs150483592	850	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs748032251 CA5315009	851	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1229876435 CA375421231	852	D>G		No	ClinGen gnomAD
rs1299832987 CA375421239	852	D>Y		No	ClinGen gnomAD
CA200965433 rs151297491	853	Q>*		No	ClinGen ESP TOPMed gnomAD
CA200965430 rs781431537	853	Q>L		No	ClinGen gnomAD
CA200965429 rs180805365	854	G>S		No	ClinGen 1000Genomes
CA375421171 rs1588150235	856	W>G		No	ClinGen Ensembl
rs1350779241 CA375421139	858	G>C		No	ClinGen gnomAD
CA5315004 rs757529218	859	E>K		No	ClinGen ExAC gnomAD
rs1057144078 CA200965413	860	T>I		No	ClinGen gnomAD
rs201927799 CA5315002	862	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765663291 CA5314999	863	R>G		No	ClinGen ExAC TOPMed gnomAD
rs1192809186 CA375421052	863	R>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1192809186 CA375421057	863	R>Q		No	ClinGen TOPMed gnomAD
CA5315000 rs765663291	863	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1564321914 CA375419452	866	W>G		No	ClinGen Ensembl
CA5314964 rs751377141	867	F>V		No	ClinGen ExAC gnomAD
rs762978617 CA5314962	868	P>S	Variant assessed as Somatic; 4.623e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs143833447 CA5314960	870	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs752528032 CA5314957	872	V>I		No	ClinGen ExAC TOPMed gnomAD
CA375419381 rs752528032	872	V>L		No	ClinGen ExAC TOPMed gnomAD
rs867276571 CA200961722	874	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1412357683 CA375419328	876	G>A		No	ClinGen gnomAD
rs1356034282 CA375419335	876	G>R		No	ClinGen TOPMed
rs748565136 CA5314956	877	I>N		No	ClinGen ExAC gnomAD
CA200961707 rs961760785	878	Q>R		No	ClinGen TOPMed
rs1564321774 CA375419281	879	Q>G		No	ClinGen Ensembl

No associated diseases with P52735

14 regional properties for P52735

Type	Name	Position	InterPro Accession
domain	Protein kinase domain	621 - 884	IPR000719
domain	Ephrin receptor ligand binding domain	20 - 202	IPR001090
domain	Serine-threonine/tyrosine-protein kinase, catalytic domain	622 - 880	IPR001245
conserved_site	Tyrosine-protein kinase, receptor class V, conserved site	178 - 198	IPR001426-1
conserved_site	Tyrosine-protein kinase, receptor class V, conserved site	241 - 261	IPR001426-2
domain	Sterile alpha motif domain	910 - 977	IPR001660
domain	Fibronectin type III	324 - 434	IPR003961-1
domain	Fibronectin type III	435 - 530	IPR003961-2
active_site	Tyrosine-protein kinase, active site	742 - 754	IPR008266
domain	Tyrosine-protein kinase ephrin type A/B receptor-like	268 - 302	IPR011641
binding_site	Protein kinase, ATP binding site	627 - 653	IPR017441
domain	Tyrosine-protein kinase, catalytic domain	621 - 880	IPR020635
domain	Ephrin receptor, transmembrane domain	544 - 617	IPR027936
domain	Ephrin type-B receptor 2, ligand binding domain	19 - 196	IPR034238

Functions

		Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name	Definition
epidermal growth factor receptor binding	Binding to an epidermal growth factor receptor.
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
metal ion binding	Binding to a metal ion.
phosphotyrosine residue binding	Binding to a phosphorylated tyrosine residue within a protein.

14 GO annotations of biological process

Name	Definition
angiogenesis	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
cell migration	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues.
cellular response to xenobiotic stimulus	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
Fc-epsilon receptor signaling pathway	The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
Fc-gamma receptor signaling pathway involved in phagocytosis	An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
lamellipodium assembly	Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
platelet activation	A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
regulation of cell size	Any process that modulates the size of a cell.
regulation of GTPase activity	Any process that modulates the rate of GTP hydrolysis by a GTPase.
regulation of small GTPase mediated signal transduction	Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
signal transduction	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
small GTPase-mediated signal transduction	The series of molecular signals in which a small monomeric GTPase relays a signal.
vascular endothelial growth factor receptor signaling pathway	The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

8 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9NHV9	Vav	Protein vav	Drosophila melanogaster (Fruit fly)	SS
P15498	VAV1	Proto-oncogene vav	Homo sapiens (Human)	EV SS
Q9UKW4	VAV3	Guanine nucleotide exchange factor VAV3	Homo sapiens (Human)	SS
P27870	Vav1	Proto-oncogene vav	Mus musculus (Mouse)	EV
Q9R0C8	Vav3	Guanine nucleotide exchange factor VAV3	Mus musculus (Mouse)	SS
Q60992	Vav2	Guanine nucleotide exchange factor VAV2	Mus musculus (Mouse)	SS
P54100	Vav1	Proto-oncogene vav	Rattus norvegicus (Rat)	SS
Q45FX5	vav-1	Protein vav-1	Caenorhabditis elegans	SS

10	20	30	40	50	60
MEQWRQCGRW	LIDCKVLPPN	HRVVWPSAVV	FDLAQALRDG	VLLCQLLHNL	SPGSIDLKDI
70	80	90	100	110	120
NFRPQMSQFL	CLKNIRTFLK	VCHDKFGLRN	SELFDPFDLF	DVRDFGKVIS	AVSRLSLHSI
130	140	150	160	170	180
AQNKGIRPFP	SEETTENDDD	VYRSLEELAD	EHDLGEDIYD	CVPCEDGGDD	IYEDIIKVEV
190	200	210	220	230	240
QQPMIRYMQK	MGMTEDDKRN	CCLLEIQETE	AKYYRTLEDI	EKNYMSPLRL	VLSPADMAAV
250	260	270	280	290	300
FINLEDLIKV	HHSFLRAIDV	SVMVGGSTLA	KVFLDFKERL	LIYGEYCSHM	EHAQNTLNQL
310	320	330	340	350	360
LASREDFRQK	VEECTLKVQD	GKFKLQDLLV	VPMQRVLKYH	LLLKELLSHS	AERPERQQLK
370	380	390	400	410	420
EALEAMQDLA	MYINEVKRDK	ETLRKISEFQ	SSIENLQVKL	EEFGRPKIDG	ELKVRSIVNH
430	440	450	460	470	480
TKQDRYLFLF	DKVVIVCKRK	GYSYELKEII	ELLFHKMTDD	PMNNKDVKKS	HGKMWSYGFY
490	500	510	520	530	540
LIHLQGKQGF	QFFCKTEDMK	RKWMEQFEMA	MSNIKPDKAN	ANHHSFQMYT	FDKTTNCKAC
550	560	570	580	590	600
KMFLRGTFYQ	GYMCTKCGVG	AHKECLEVIP	PCKFTSPADL	DASGAGPGPK	MVAMQNYHGN
610	620	630	640	650	660
PAPPGKPVLT	FQTGDVLELL	RGDPESPWWE	GRLVQTRKSG	YFPSSSVKPC	PVDGRPPISR
670	680	690	700	710	720
PPSREIDYTA	YPWFAGNMER	QQTDNLLKSH	ASGTYLIRER	PAEAERFAIS	IKFNDEVKHI
730	740	750	760	770	780
KVVEKDNWIH	ITEAKKFDSL	LELVEYYQCH	SLKESFKQLD	TTLKYPYKSR	ERSASRASSR
790	800	810	820	830	840
SPASCASYNF	SFLSPQGLSF	ASQGPSAPFW	SVFTPRVIGT	AVARYNFAAR	DMRELSLREG
850	860	870
DVVRIYSRIG	GDQGWWKGET	NGRIGWFPST	YVEEEGIQ