P52490

PR
Gene name
UBC13 (YDR092W, YD6652.04)
Protein name
Ubiquitin-conjugating enzyme E2 13
Names
E2 ubiquitin-conjugating enzyme 13, Ubiquitin carrier protein 13, Ubiquitin-protein ligase 13
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDR092W
EC number
2.3.2.23: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for P52490

Entry ID Method Resolution Chain Position Source
1JAT X-ray 160 A A 2-153 PDB
1JBB X-ray 200 A A/B 1-153 PDB
2GMI X-ray 250 A A 1-152 PDB
4FH1 X-ray 261 A A 1-152 PDB
5OJW X-ray 200 A A 1-152 PDB
6ZHS X-ray 235 A B/C 1-153 PDB
6ZHT X-ray 230 A B 1-152 PDB
AF-P52490-F1 Predicted AlphaFoldDB

2 variants for P52490

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-630489 117 P>S No SGRP
s04-630568 143 W>L No SGRP

No associated diseases with P52490

2 regional properties for P52490

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 3 - 149 IPR000608
active_site Ubiquitin-conjugating enzyme, active site 76 - 91 IPR023313

Functions

Description
EC Number 2.3.2.23 Aminoacyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
fungal-type vacuole membrane The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
UBC13-MMS2 complex A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p.
ubiquitin conjugating enzyme complex Any complex that possesses ubiquitin conjugating enzyme activity.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.

5 GO annotations of biological process

Name Definition
free ubiquitin chain polymerization The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein.
postreplication repair The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication.
protein K63-linked ubiquitination A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
protein targeting to vacuolar membrane The process of directing proteins towards the vacuolar membrane; usually uses signals contained within the protein.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P21734 UBC1 Ubiquitin-conjugating enzyme E2 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P33296 UBC6 Ubiquitin-conjugating enzyme E2 6 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P35128 ben Ubiquitin-conjugating enzyme E2 N Drosophila melanogaster (Fruit fly) PR
10 20 30 40 50 60
MASLPKRIIK ETEKLVSDPV PGITAEPHDD NLRYFQVTIE GPEQSPYEDG IFELELYLPD
70 80 90 100 110 120
DYPMEAPKVR FLTKIYHPNI DRLGRICLDV LKTNWSPALQ IRTVLLSIQA LLASPNPNDP
130 140 150
LANDVAEDWI KNEQGAKAKA REWTKLYAKK KPE