P52487

PR
Gene name
Ubc84D (CG12799)
Protein name
Ubiquitin-conjugating enzyme E2-18 kDa
Names
E2 ubiquitin-conjugating enzyme 84D, Ubiquitin carrier protein, Ubiquitin-protein ligase
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG12799
EC number
2.3.2.23: Aminoacyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

100-153 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P52487

Entry ID Method Resolution Chain Position Source
AF-P52487-F1 Predicted AlphaFoldDB

No variants for P52487

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P52487

No associated diseases with P52487

4 regional properties for P52487

Type Name Position InterPro Accession
domain Ubiquitin-conjugating enzyme E2 4 - 154 IPR000608
domain Ubiquitin-associated domain 161 - 199 IPR015940
active_site Ubiquitin-conjugating enzyme, active site 80 - 96 IPR023313
domain Ubiquitin-conjugating enzyme E2-22kDa (UbcD4), UBA domain 163 - 198 IPR042614

Functions

Description
EC Number 2.3.2.23 Aminoacyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ubiquitin ligase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ubiquitin conjugating enzyme activity Isoenergetic transfer of ubiquitin from one protein to another via the reaction X-ubiquitin + Y -> Y-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
ubiquitin protein ligase binding Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.

2 GO annotations of biological process

Name Definition
protein polyubiquitination Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P35128 ben Ubiquitin-conjugating enzyme E2 N Drosophila melanogaster (Fruit fly) PR
P52486 Ubc4 Ubiquitin-conjugating enzyme E2-22 kDa Drosophila melanogaster (Fruit fly) PR
P25867 eff Ubiquitin-conjugating enzyme E2-17 kDa Drosophila melanogaster (Fruit fly) PR
Q9VX25 CG8188 Ubiquitin-conjugating enzyme E2 S Drosophila melanogaster (Fruit fly) SS
O14933 UBE2L6 Ubiquitin/ISG15-conjugating enzyme E2 L6 Homo sapiens (Human) PR
Q9LJD7 COP10 Constitutive photomorphogenesis protein 10 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MAATRRLTRE LSDLVEAKMS TLRNIESSDE SLLMWTGLLV PEKAPYNKGA FRIEINFPPQ
70 80 90 100 110 120
YPFMPPKILF KTKIYHPNVD EKGEVCLPII STDNWKPTTR TEQVLQALVA IVHNPEPEHP
130 140 150
LRSDLAEEFV REHKKFMKTA EEFTKKNAEK RPE