AiPD: Autoinhibited Protein Database

P52294

Gene name	KPNA1 (RCH2)
Protein name	Importin subunit alpha-5
Names	SCFR, Piebald trait protein, PBT, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, Karyopherin subunit alpha-1, Nucleoprotein interactor 1, NPI-1, RAG cohort protein 2, SRP1-beta
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3836
EC number
Protein Class

Descriptions

Importin subunit alpha functions in the nuclear transport of classical nuclear localization signal (cNLS)-containing cargo. Autoinhibition by the self-binding of IBB domain inhibits the NLS binding affinity by binding IBB domain to the NLS binding sites. In addition, the closed homodimerization works as an autoinhibition state when the IBB domian dissociates from the NLS binding sites.

Autoinhibitory domains (AIDs)

1-57 (IBB domain) SS

Target domain	114-515 (NLS-binding domain comprising armadillo (Arm) repeats)
Relief mechanism	Partner binding
Assay

AID

1-57 (IBB domain)

Target domain

114-515 (NLS-binding domain comprising armadillo (Arm) repeats)

Relief mechanism

Partner binding (importin-beta binding)

Assay

Accessory elements

No accessory elements

References

Kimoto C et al. (2015) "Functional characterization of importin α8 as a classical nuclear localization signal receptor", Biochimica et biophysica acta, 1853, 2676-83

Kobe B (1999) "Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha", Nature structural biology, 6, 388-97

Miyatake H et al. (2015) "Crystal structure of human importin-α1 (Rch1), revealing a potential autoinhibition mode involving homodimerization", PloS one, 10, e0115995

Catimel B et al. (2001) "Biophysical characterization of interactions involving importin-alpha during nuclear import", The Journal of biological chemistry, 276, 34189-98

Autoinhibited structure

Activated structure

5 structures for P52294

Entry ID	Method	Resolution	Chain	Position	Source
2JDQ	X-ray	220 A	A/B	66-512	PDB
3TJ3	X-ray	270 A	A/B	66-512	PDB
4B18	X-ray	252 A	A	66-512	PDB
6WX9	X-ray	280 A	A	73-538	PDB
AF-P52294-F1	Predicted				AlphaFoldDB

222 variants for P52294

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA354173217 rs1559755041	9	F>I		No	ClinGen Ensembl
rs1366468624 CA354173207	9	F>S		No	ClinGen TOPMed
rs1007278639 COSM202963 CA82793410	10	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
CA354173168 rs1245476506	12	K>Q		No	ClinGen gnomAD
CA354173158 rs1395445484	12	K>R		No	ClinGen TOPMed
rs748913434 CA82793403	13	S>T		No	ClinGen Ensembl
rs371255339 CA2571096	14	Y>*		No	ClinGen ESP ExAC gnomAD
rs748617707 CA2571094	16	N>S		No	ClinGen ExAC gnomAD
rs748617707 CA82793390	16	N>T		No	ClinGen ExAC gnomAD
CA354172987 rs1377270559	21	P>A		No	ClinGen gnomAD
rs1296470858 CA354172978	21	P>L		No	ClinGen TOPMed
rs1443873785 CA354172972	22	D>N		No	ClinGen gnomAD
rs1398957671 CA354172904	25	R>C		No	ClinGen gnomAD
CA354172871 rs1298039703	27	R>K		No	ClinGen gnomAD
rs1392446808 CA354172805	30	E>G		No	ClinGen TOPMed
CA354172781 rs1278018384	31	E>G		No	ClinGen gnomAD
rs1450402782 CA354172730	34	Q>*		No	ClinGen gnomAD
CA82793347 rs977703329	34	Q>H		No	ClinGen TOPMed gnomAD
rs1354135656 CA354172686	36	R>Q		No	ClinGen TOPMed
rs1165031085 CA354165601	45	F>C		No	ClinGen TOPMed
CA354165605 rs1199757102	45	F>L		No	ClinGen gnomAD
rs1419253160 CA354165594	46	K>R		No	ClinGen TOPMed
rs1434807039 CA354165588 COSM1037145	47	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1265244880 CA354165570	50	V>I		No	ClinGen TOPMed gnomAD
CA2571072 COSM1616800 rs147411710	52	T>I	liver [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs1473598243 CA354165553	53	A>S		No	ClinGen gnomAD
CA2571071 rs776559438	54	E>A		No	ClinGen ExAC TOPMed gnomAD
CA354165540 rs1392330060	55	E>Q		No	ClinGen TOPMed
CA2571070 rs766198475	57	T>S		No	ClinGen ExAC
rs760748553 CA2571068	60	E>V		No	ClinGen ExAC gnomAD
rs771734934 CA354165488	62	M>K		No	ClinGen ExAC TOPMed gnomAD
rs771734934 CA354165487	62	M>R		No	ClinGen ExAC TOPMed gnomAD
rs771734934 CA2571065	62	M>T		No	ClinGen ExAC TOPMed gnomAD
CA2571066 rs376809268	62	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA354165470 rs1216337317	64	D>E		No	ClinGen gnomAD
rs1299772157 CA354165473	64	D>G		No	ClinGen gnomAD
rs774157849 CA2571063	68	H>R		No	ClinGen ExAC gnomAD
CA354165369 rs4678193	73	S>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs4678193 VAR_050002 CA2571062	73	S>N		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA354165371 rs4678193	73	S>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1384575990 CA354165331	75	M>I		No	ClinGen gnomAD
CA354165334 rs1278219654	75	M>T		No	ClinGen TOPMed
rs1281829451 CA354165343	75	M>V		No	ClinGen TOPMed gnomAD
CA82769768 rs919044782	77	M>I		No	ClinGen Ensembl
CA354165302 rs1440873553	77	M>V		No	ClinGen TOPMed
CA354165272 rs1467611873	78	A>V		No	ClinGen gnomAD
rs749610817 CA2571061	79	P>L		No	ClinGen ExAC TOPMed gnomAD
rs749610817 CA82769758	79	P>Q		No	ClinGen ExAC TOPMed gnomAD
CA354164980 rs1458590147	81	G>D		No	ClinGen gnomAD
CA2571034 rs747062327	81	G>R		No	ClinGen ExAC gnomAD
CA354164955 rs1406308896	85	S>Y		No	ClinGen gnomAD
rs777960890 CA2571032	88	I>T		No	ClinGen ExAC gnomAD
CA2571031 rs758503638	89	E>G		No	ClinGen ExAC
rs148747467 CA2571030	91	I>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1311619259 CA354164843	91	I>M		No	ClinGen Ensembl
rs755983475 CA2571028	94	K>E		No	ClinGen ExAC TOPMed gnomAD
rs1380902025 CA354164783	96	P>A		No	ClinGen gnomAD
CA2571027 rs750299072	99	Q>*		No	ClinGen ExAC gnomAD
CA354164707 rs1402583431	101	S>L		No	ClinGen gnomAD
rs767556130 CA2571026	103	T>I		No	ClinGen ExAC gnomAD
CA354164678 rs1409319585	104	Q>E		No	ClinGen gnomAD
CA354164186 rs1477987119	115	N>S		No	ClinGen TOPMed
rs759237459 CA2570994	118	I>V		No	ClinGen ExAC
rs77145751 CA82765233	119	D>A		No	ClinGen Ensembl
rs766764778 CA2570992	122	I>V		No	ClinGen ExAC gnomAD
CA354164133 rs1576309261	123	S>T		No	ClinGen Ensembl
rs1282209759 CA354164124	124	T>I		No	ClinGen gnomAD
rs761024788 CA2570991	127	V>I		No	ClinGen ExAC gnomAD
CA354164086 rs1345837457	131	F>L		No	ClinGen TOPMed gnomAD
rs772509476 CA2570989	134	F>L		No	ClinGen ExAC gnomAD
rs1298649358 CA354164043	137	R>*		No	ClinGen TOPMed gnomAD
rs1400654022 COSM1037139 CA354164042	137	R>Q	endometrium [Cosmic]	No	ClinGen cosmic curated TOPMed
CA354164036 rs1316779695	138	K>T		No	ClinGen TOPMed
CA354164031 rs1007284107	139	E>K		No	ClinGen TOPMed gnomAD
CA82765223 rs1007284107	139	E>Q		No	ClinGen TOPMed gnomAD
CA354164013 rs773610445	141	C>S		No	ClinGen ExAC gnomAD
CA2570987 rs773610445	141	C>Y		No	ClinGen ExAC gnomAD
rs1376923123 CA354189717	156	S>L		No	ClinGen gnomAD
CA354189651 rs1349514246	161	Q>H		No	ClinGen TOPMed
CA2570964 rs746790022	163	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA2570963 rs777480696	164	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1437578416 CA354189586	165	V>A		No	ClinGen gnomAD
CA354189524 rs1367853255	168	A>T		No	ClinGen gnomAD
CA354189247 rs1560029680	181	E>Q		No	ClinGen Ensembl
rs1417215460 CA354189166	184	D>H		No	ClinGen gnomAD
CA354189124 rs1191732792	186	Q>L		No	ClinGen gnomAD
rs1226877931 CA354188357	189	A>V		No	ClinGen gnomAD
CA354188347 rs1169648359	190	V>A		No	ClinGen TOPMed
CA354188146 rs1281751321	202	M>T		No	ClinGen TOPMed gnomAD
rs142101334 CA2570939	202	M>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1560027975 CA354188131	203	C>S		No	ClinGen Ensembl
rs748761403 CA2570938	205	D>H		No	ClinGen ExAC gnomAD
rs1330826298 CA354188069	206	Y>C		No	ClinGen TOPMed
CA2570937 rs763240529	209	D>A		No	ClinGen ExAC gnomAD
CA2570936 rs755745102	211	N>S		No	ClinGen ExAC gnomAD
rs138305574 CA2570934	212	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA2570933 rs757709546	214	P>L		No	ClinGen ExAC gnomAD
rs764664928 CA2570931	215	P>R		No	ClinGen ExAC gnomAD
rs145892619 CA2570932	215	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs775027981 CA2570916 COSM294510	225	R>C	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
COSM167717 CA354187647 rs1189764467	225	R>H	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
CA2570915 rs769193108	227	T>A		No	ClinGen ExAC gnomAD
rs1461057765 CA354187602	228	M>I		No	ClinGen gnomAD
CA354187611 rs1461152078	228	M>T		No	ClinGen gnomAD
CA354187563 rs1368635760	230	R>Q		No	ClinGen gnomAD
rs376884067 CA2570913 COSM581017	232	A>T	lung [Cosmic]	No	ClinGen cosmic curated ESP ExAC gnomAD
CA82803539 rs965581622	232	A>V		No	ClinGen Ensembl
rs758932130 CA2570909	250	A>E		No	ClinGen ExAC gnomAD
rs751263599 CA2570884	253	S>C		No	ClinGen ExAC TOPMed gnomAD
rs753844419 CA354186218	254	P>A		No	ClinGen ExAC gnomAD
CA2570883 rs753844419	254	P>S		No	ClinGen ExAC gnomAD
CA354186181 rs1298459730	255	C>F		No	ClinGen TOPMed gnomAD
CA354186188 rs1298459730	255	C>Y		No	ClinGen TOPMed gnomAD
CA82802024 rs996436531	258	V>L		No	ClinGen Ensembl
CA354185764 rs1257791130	268	T>S		No	ClinGen gnomAD
rs750649549 CA2570880	269	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1336550136 CA354185746	270	V>I		No	ClinGen TOPMed
CA354185660 rs1576297088	273	D>G		No	ClinGen Ensembl
rs1004886057 CA82802014	274	A>S		No	ClinGen Ensembl
rs112486731 CA82802013	274	A>V		No	ClinGen Ensembl
rs1448754153 CA354185345	286	N>D		No	ClinGen gnomAD
COSM1327935 rs1336879899 CA354185338	286	N>S	ovary urinary_tract [Cosmic]	No	ClinGen cosmic curated TOPMed
CA2570874 rs142297776	291	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs759538799 CA2570873	291	A>V		No	ClinGen ExAC TOPMed gnomAD
CA2570869 rs370054725	293	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA354185133 rs1165745415	294	D>A		No	ClinGen TOPMed
rs754140846 CA2570867	294	D>N		No	ClinGen ExAC gnomAD
CA354185096 rs764619803	295	A>E		No	ClinGen TOPMed
COSM202960 rs764619803 CA82801938	295	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated TOPMed
rs1460475197 CA354185076	296	G>E		No	ClinGen TOPMed
CA82801898 rs946675946	301	L>R		No	ClinGen Ensembl
rs916719788 CA82801879	302	V>A		No	ClinGen TOPMed
rs1374849017 CA354183233	306	M>I		No	ClinGen TOPMed gnomAD
CA354182787 rs1358942940	307	H>R		No	ClinGen gnomAD
rs769071901 CA2570845 COSM3800952	314	S>C	urinary_tract [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1245099582 CA354182591	323	I>V		No	ClinGen gnomAD
CA82796146 rs902688762	329	I>T		No	ClinGen Ensembl
rs1233219727 CA354182443	332	Q>E		No	ClinGen gnomAD
rs1317026712 CA354181322	334	I>V		No	ClinGen gnomAD
CA354181218 rs1299894273	338	S>L		No	ClinGen TOPMed
rs1226031500 CA354181235	338	S>P		No	ClinGen gnomAD
rs770263765 CA2570822	341	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA82792261 rs746404486	345	H>N		No	ClinGen ExAC TOPMed gnomAD
rs746404486 CA2570821	345	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA2570818 rs747114336	349	S>G		No	ClinGen ExAC gnomAD
CA82792228 rs778048711	349	S>N		No	ClinGen ExAC TOPMed gnomAD
CA2570817 rs778048711	349	S>T		No	ClinGen ExAC TOPMed gnomAD
CA354180963 rs758586479	350	P>A		No	ClinGen ExAC TOPMed gnomAD
rs758586479 CA2570816	350	P>S		No	ClinGen ExAC TOPMed gnomAD
rs758586479 CA354180962	350	P>T		No	ClinGen ExAC TOPMed gnomAD
CA354180862 rs1417317248	355	K>R		No	ClinGen gnomAD
COSM1037135 rs192240632 CA2570815	361	T>M	endometrium [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA354180662 rs1560018899	365	I>T		No	ClinGen Ensembl
CA2570800 rs775792338	375	T>S		No	ClinGen ExAC gnomAD
rs765590104 CA2570799	376	V>A		No	ClinGen ExAC TOPMed gnomAD
rs1385536626 CA354179334	378	D>V		No	ClinGen gnomAD
CA354179308 rs1256239369	380	N>D		No	ClinGen TOPMed
CA2570797 rs777181799	380	N>S		No	ClinGen ExAC gnomAD
CA2570798 rs777181799	380	N>T		No	ClinGen ExAC gnomAD
CA2570796 rs777283799	381	I>L		No	ClinGen ExAC gnomAD
rs899364282 CA82789317	382	F>S		No	ClinGen Ensembl
rs760775587 CA354179174	384	A>P		No	ClinGen ExAC gnomAD
CA2570795 rs760775587	384	A>S		No	ClinGen ExAC gnomAD
CA2570794 rs773210024	385	L>F		No	ClinGen ExAC gnomAD
rs1036850990 CA354179136	386	I>S		No	ClinGen TOPMed
rs1036850990 CA82789314	386	I>T		No	ClinGen TOPMed
rs1451340967 CA354179121	387	S>N		No	ClinGen TOPMed gnomAD
CA2570793 rs772368222	392	A>S		No	ClinGen ExAC gnomAD
rs748416546 CA2570792	393	E>Q		No	ClinGen ExAC gnomAD
rs1576277340 CA354178834	397	R>I		No	ClinGen Ensembl
CA354178775 rs1560016713	399	E>A		No	ClinGen Ensembl
CA82789273 rs15633	399	E>Q		No	ClinGen Ensembl
CA2570788 rs781186250	400	A>T		No	ClinGen ExAC gnomAD
rs937366386 CA82789242	403	A>V		No	ClinGen Ensembl
rs751058951 CA354178673	404	I>F		No	ClinGen ExAC TOPMed gnomAD
CA2570786 rs751058951	404	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1374980791 CA354178617	407	A>P		No	ClinGen TOPMed
CA354178561 rs1403589287	409	S>F		No	ClinGen gnomAD
rs752359638 CA2570782	413	A>P		No	ClinGen ExAC gnomAD
CA354178479 rs1167881811	414	E>Q		No	ClinGen gnomAD
CA2570759 rs778503343	418	Y>S		No	ClinGen ExAC gnomAD
CA354176805 rs898848496	422	L>M		No	ClinGen TOPMed gnomAD
CA2570758 rs754671094	423	G>S		No	ClinGen ExAC gnomAD
rs754178190 CA2570757	424	C>S		No	ClinGen ExAC gnomAD
rs1248209726 CA354176779	424	C>Y		No	ClinGen gnomAD
CA2570756 rs766681413	427	P>L		No	ClinGen ExAC gnomAD
CA2570755 rs369415466	433	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs768198808 CA2570753	435	M>T		No	ClinGen ExAC gnomAD
rs1445122514 CA354176610	437	S>C		No	ClinGen Ensembl
CA354176446 rs1274681317	449	N>H		No	ClinGen TOPMed gnomAD
rs774614394 CA2570751	455	E>K		No	ClinGen ExAC gnomAD
rs1233464588 CA354176221	462	G>S		No	ClinGen gnomAD
CA354176138 rs1163178056	466	N>S		No	ClinGen gnomAD
CA354175947 rs148226308	476	Y>*		No	ClinGen ESP TOPMed gnomAD
rs1560012389 CA354175777	482	E>Q		No	ClinGen Ensembl
CA2570726 rs765559962	491	E>A		No	ClinGen ExAC gnomAD
CA2570725 rs760354794	493	Y>C		No	ClinGen ExAC gnomAD
rs1323959968 CA354175408	496	A>G		No	ClinGen gnomAD
rs1343782213 CA354175348	498	D>E		No	ClinGen gnomAD
rs771945739 CA2570723	498	D>Y		No	ClinGen ExAC gnomAD
rs1424038513 CA354175328	500	I>V		No	ClinGen TOPMed
rs1432243136 CA354175228	505	G>R		No	ClinGen TOPMed gnomAD
rs1432243136 CA354175229	505	G>R		No	ClinGen TOPMed gnomAD
rs1560012324 CA354175067	510	D>E		No	ClinGen Ensembl
CA354175082 rs1435064781	510	D>Y		No	ClinGen gnomAD
rs969349638 CA82784200	511	S>G		No	ClinGen TOPMed
rs1407294175 CA354175054	511	S>I		No	ClinGen TOPMed gnomAD
CA354175028 rs1576267347	512	S>N		No	ClinGen Ensembl
CA2570720 rs768068658	513	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1424642640 CA354174982	514	A>V		No	ClinGen TOPMed gnomAD
CA2570718 rs573159535	516	Q>H		No	ClinGen 1000Genomes ExAC gnomAD
CA354174950 rs1246313419	517	V>A		No	ClinGen gnomAD
rs746213432 CA2570716	523	Q>*		No	ClinGen ExAC gnomAD
rs553380334 CA2570714	525	I>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1347770819 CA354174819	528	Q>*		No	ClinGen TOPMed
CA354174815 rs1311427524	528	Q>R		No	ClinGen gnomAD
rs752118749 CA2570713	531	A>T		No	ClinGen ExAC gnomAD
CA354174745 rs15660	532	P>S		No	ClinGen TOPMed
rs15660 CA82784171	532	P>T		No	ClinGen TOPMed
CA2570712 rs200609980	533	M>V		No	ClinGen 1000Genomes ExAC gnomAD
CA354174711 rs1560012233	534	E>K		No	ClinGen Ensembl
CA354174636 rs1339410269	538	L>I		No	ClinGen gnomAD

No associated diseases with P52294

9 regional properties for P52294

Type	Name	Position	InterPro Accession
repeat	Armadillo	114 - 198	IPR000225-1
repeat	Armadillo	200 - 241	IPR000225-2
repeat	Armadillo	244 - 283	IPR000225-3
repeat	Armadillo	285 - 325	IPR000225-4
repeat	Armadillo	327 - 369	IPR000225-5
repeat	Armadillo	369 - 409	IPR000225-6
repeat	Armadillo	412 - 452	IPR000225-7
domain	Importin-alpha, importin-beta-binding domain	1 - 104	IPR002652
repeat	Atypical Arm repeat	466 - 515	IPR032413

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
dendrite	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
glutamatergic synapse	A synapse that uses glutamate as a neurotransmitter.
NLS-dependent protein nuclear import complex	A dimer consisting of an alpha and a beta-subunit that imports proteins with an NLS into the nucleus through a nuclear pore.
nuclear pore	A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
postsynaptic density	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.

2 GO annotations of molecular function

Name	Definition
nuclear import signal receptor activity	Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein.
nuclear localization sequence binding	Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.

7 GO annotations of biological process

Name	Definition
NLS-bearing protein import into nucleus	The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope.
postsynapse to nucleus signaling pathway	The series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications).
regulation of apoptotic process	Any process that modulates the occurrence or rate of cell death by apoptotic process.
regulation of canonical Wnt signaling pathway	Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
regulation of DNA recombination	Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.
satellite cell activation involved in skeletal muscle regeneration	The process that initiates skeletal muscle satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.
skeletal muscle satellite cell proliferation	The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.

30 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q02821	SRP1	Importin subunit alpha	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	SS
Q0V7M0	KPNA6	Importin subunit alpha-7	Bos taurus (Bovine)	SS
C1JZ66	KPNA7	Importin subunit alpha-8	Bos taurus (Bovine)	PR
A2VE08	KPNA1	Importin subunit alpha-5	Bos taurus (Bovine)	SS
Q5ZML1	KPNA1	Importin subunit alpha-5	Gallus gallus (Chicken)	SS
P52295	Pen	Importin subunit alpha	Drosophila melanogaster (Fruit fly)	SS
A9QM74	KPNA7	Importin subunit alpha-8	Homo sapiens (Human)	EV
O00505	KPNA3	Importin subunit alpha-4	Homo sapiens (Human)	SS
O00629	KPNA4	Importin subunit alpha-3	Homo sapiens (Human)	SS
O15131	KPNA5	Importin subunit alpha-6	Homo sapiens (Human)	SS
O60684	KPNA6	Importin subunit alpha-7	Homo sapiens (Human)	SS
P52292	KPNA2	Importin subunit alpha-1	Homo sapiens (Human)	EV
P52293	Kpna2	Importin subunit alpha-1	Mus musculus (Mouse)	EV
O35344	Kpna3	Importin subunit alpha-4	Mus musculus (Mouse)	SS
O35343	Kpna4	Importin subunit alpha-3	Mus musculus (Mouse)	SS
C0LLJ0	Kpna7	Importin subunit alpha-8	Mus musculus (Mouse)	SS
O35345	Kpna6	Importin subunit alpha-7	Mus musculus (Mouse)	PR
Q60960	Kpna1	Importin subunit alpha-5	Mus musculus (Mouse)	SS
C6K7I2	KPNA7	Importin subunit alpha-8	Sus scrofa (Pig)	SS
Q56R16	Kpna5	Importin subunit alpha-6	Rattus norvegicus (Rat)	SS
P83953	Kpna1	Importin subunit alpha-5	Rattus norvegicus (Rat)	SS
Q71VM4	Os01g0253300	Importin subunit alpha-1a	Oryza sativa subsp. japonica (Rice)	SS
P91276	ima-2	Importin subunit alpha-2	Caenorhabditis elegans	SS
Q19969	ima-3	Importin subunit alpha-3	Caenorhabditis elegans	SS
O04294	IMPA3	Importin subunit alpha-3	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FJ09	IMPA5	Importin subunit alpha-5	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9M9X7	IMPA7	Importin subunit alpha-7	Arabidopsis thaliana (Mouse-ear cress)	SS
Q9FWY7	IMPA6	Importin subunit alpha-6	Arabidopsis thaliana (Mouse-ear cress)	SS
O22478		Importin subunit alpha	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	SS
Q503E9	kpna5	Importin subunit alpha-6	Danio rerio (Zebrafish) (Brachydanio rerio)	SS

10	20	30	40	50	60
MTTPGKENFR	LKSYKNKSLN	PDEMRRRREE	EGLQLRKQKR	EEQLFKRRNV	ATAEEETEEE
70	80	90	100	110	120
VMSDGGFHEA	QISNMEMAPG	GVITSDMIEM	IFSKSPEQQL	SATQKFRKLL	SKEPNPPIDE
130	140	150	160	170	180
VISTPGVVAR	FVEFLKRKEN	CTLQFESAWV	LTNIASGNSL	QTRIVIQAGA	VPIFIELLSS
190	200	210	220	230	240
EFEDVQEQAV	WALGNIAGDS	TMCRDYVLDC	NILPPLLQLF	SKQNRLTMTR	NAVWALSNLC
250	260	270	280	290	300
RGKSPPPEFA	KVSPCLNVLS	WLLFVSDTDV	LADACWALSY	LSDGPNDKIQ	AVIDAGVCRR
310	320	330	340	350	360
LVELLMHNDY	KVVSPALRAV	GNIVTGDDIQ	TQVILNCSAL	QSLLHLLSSP	KESIKKEACW
370	380	390	400	410	420
TISNITAGNR	AQIQTVIDAN	IFPALISILQ	TAEFRTRKEA	AWAITNATSG	GSAEQIKYLV
430	440	450	460	470	480
ELGCIKPLCD	LLTVMDSKIV	QVALNGLENI	LRLGEQEAKR	NGTGINPYCA	LIEEAYGLDK
490	500	510	520	530
IEFLQSHENQ	EIYQKAFDLI	EHYFGTEDED	SSIAPQVDLN	QQQYIFQQCE	APMEGFQL