P51942
Gene name |
Matn1 (Cmp, Crtm) |
Protein name |
Cartilage matrix protein |
Names |
Matrilin-1 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:17180 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P51942
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P51942-F1 | Predicted | AlphaFoldDB |
18 variants for P51942
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388718751 | 104 | S>A | No | EVA | |
| rs3388718449 | 137 | S>N | No | EVA | |
| rs3388716892 | 227 | V>A | No | EVA | |
| rs3388711208 | 234 | G>R | No | EVA | |
| rs3388716300 | 262 | D>V | No | EVA | |
| rs3388694336 | 323 | Y>F | No | EVA | |
| rs3388713820 | 328 | R>S | No | EVA | |
| rs3388716905 | 380 | A>V | No | EVA | |
| rs3388694422 | 381 | Q>L | No | EVA | |
| rs3388694347 | 393 | Q>H | No | EVA | |
| rs3388705225 | 431 | V>M | No | EVA | |
| rs3388718793 | 432 | A>T | No | EVA | |
| rs3388711212 | 447 | I>S | No | EVA | |
| rs3388716987 | 463 | A>V | No | EVA | |
| rs3388703169 | 479 | Q>H | No | EVA | |
| rs3394868225 | 483 | R>G | No | EVA | |
| rs3394706370 | 489 | S>R | No | EVA | |
| rs3388716267 | 492 | L>Q | No | EVA |
No associated diseases with P51942
5 regional properties for P51942
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EGF-like domain | 230 - 267 | IPR000742 |
| domain | EGF-like calcium-binding domain | 235 - 267 | IPR001881 |
| domain | von Willebrand factor, type A | 43 - 225 | IPR002035-1 |
| domain | von Willebrand factor, type A | 277 - 456 | IPR002035-2 |
| domain | Matrilin, coiled-coil trimerisation domain | 454 - 500 | IPR019466 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| collagen-containing extracellular matrix | An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. |
| extracellular matrix | A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. |
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| extracellular matrix structural constituent | The action of a molecule that contributes to the structural integrity of the extracellular matrix. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| chondrocyte differentiation | The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage. |
| extracellular matrix organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. |
| growth plate cartilage chondrocyte morphogenesis | The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized. |
| regulation of bone mineralization | Any process that modulates the frequency, rate or extent of bone mineralization. |
13 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q868Z9 | Ppn | Papilin | Drosophila melanogaster (Fruit fly) | SS |
| Q04721 | NOTCH2 | Neurogenic locus notch homolog protein 2 | Homo sapiens (Human) | EV |
| P46531 | NOTCH1 | Neurogenic locus notch homolog protein 1 | Homo sapiens (Human) | EV |
| P21941 | MATN1 | Cartilage matrix protein | Homo sapiens (Human) | PR |
| Q6GUQ1 | Egfl8 | Epidermal growth factor-like protein 8 | Mus musculus (Mouse) | PR |
| Q01705 | Notch1 | Neurogenic locus notch homolog protein 1 | Mus musculus (Mouse) | SS |
| Q91V88 | Npnt | Nephronectin | Mus musculus (Mouse) | PR |
| O35516 | Notch2 | Neurogenic locus notch homolog protein 2 | Mus musculus (Mouse) | SS |
| Q9QW30 | Notch2 | Neurogenic locus notch homolog protein 2 | Rattus norvegicus (Rat) | SS |
| Q07008 | Notch1 | Neurogenic locus notch homolog protein 1 | Rattus norvegicus (Rat) | SS |
| P13508 | glp-1 | Protein glp-1 | Caenorhabditis elegans | EV |
| A2RUV0 | notch1 | Neurogenic locus notch homolog protein 1 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| P46530 | notch1a | Neurogenic locus notch homolog protein 1 | Danio rerio (Zebrafish) (Brachydanio rerio) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKVTSGPAFA | LCSLLLLLLL | LLQVPDSLSL | VPQPRGHLCR | TRPTDLVFVV | DSSRSVRPVE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FEKVKVFLSQ | VIESLDVGPN | ATRVGLVNYA | STVKPEFPLR | AHGSKASLLQ | AVRRIQPLST |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GTMTGLALQF | AITKALSDAE | GGRARSPDIS | KVVIVVTDGR | PQDSVRDVSE | RARASGIELF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AIGVGRVDKA | TLRQIASEPQ | DEHVDYVESY | NVIEKLAKKF | QEAFCVVSDL | CATGDHDCEQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LCVSSPGSYT | CACHEGFTLN | SDGKTCNVCR | GGGSGSATDL | VFLIDGSKSV | RPENFELVKK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FINQIVDTLD | VSDRLAQVGL | VQYSSSIRQE | FPLGRFHTKK | DIKAAVRNMS | YMEKGTMTGA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ALKYLIDNSF | TVSSGARPGA | QKVGIVFTDG | RSQDYINDAA | RKAKDLGFKM | FAVGVGNAVE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EELREIASEP | VADHYFYTAD | FKTINQIGKK | LQKQICVEED | PCACESILKF | EAKVEGLLQA |
| 490 | |||||
| LTRKLEAVSG | RLAVLENRII |