P51842
PR
Gene name |
Gucy2f (Guc2f) |
Protein name |
Retinal guanylyl cyclase 2 |
Names |
RETGC-2, Guanylate cyclase 2F, retinal, Guanylate cyclase F, GC-F, Rod outer segment membrane guanylate cyclase 2, ROS-GC2 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:116556 |
EC number |
4.6.1.2: Phosphorus-oxygen lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P51842
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P51842-F1 | Predicted | AlphaFoldDB |
4 variants for P51842
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3323716849 | 27 | L>I | No | EVA | |
| rs3323654520 | 227 | R>H | No | EVA | |
| rs8160439 | 680 | G>R | No | EVA | |
| rs3323709967 | 1106 | N>K | No | EVA |
No associated diseases with P51842
6 regional properties for P51842
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 532 - 812 | IPR000719 |
| domain | Adenylyl cyclase class-3/4/guanylyl cyclase | 848 - 1061 | IPR001054 |
| domain | Serine-threonine/tyrosine-protein kinase, catalytic domain | 595 - 808 | IPR001245 |
| domain | Receptor, ligand binding region | 73 - 413 | IPR001828 |
| domain | Haem NO binding associated | 824 - 869 | IPR011645 |
| conserved_site | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | 991 - 1014 | IPR018297 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.6.1.2 | Phosphorus-oxygen lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| rod photoreceptor outer segment | The outer segment of a vertebrate rod photoreceptor that contains sealed membrane discs that are not connected to the ciliary membrane and containing rhodopsin photoreceptor proteins. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| guanylate cyclase activity | Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. |
| identical protein binding | Binding to an identical protein or proteins. |
| peptide receptor activity | Combining with an extracellular or intracellular peptide to initiate a change in cell activity. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| protein-containing complex binding | Binding to a macromolecular complex. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cGMP biosynthetic process | The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. |
| cGMP-mediated signaling | Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell. |
| detection of light stimulus involved in visual perception | The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| receptor guanylyl cyclase signaling pathway | The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
23 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P46197 | NPR2 | Atrial natriuretic peptide receptor 2 | Bos taurus (Bovine) | PR |
| O02740 | GUCY2F | Retinal guanylyl cyclase 2 | Bos taurus (Bovine) | PR |
| Q02846 | GUCY2D | Retinal guanylyl cyclase 1 | Homo sapiens (Human) | PR |
| P20594 | NPR2 | Atrial natriuretic peptide receptor 2 | Homo sapiens (Human) | PR |
| P51841 | GUCY2F | Retinal guanylyl cyclase 2 | Homo sapiens (Human) | PR |
| P52785 | Gucy2e | Retinal guanylyl cyclase 1 | Mus musculus (Mouse) | PR |
| Q6VVW5 | Npr2 | Atrial natriuretic peptide receptor 2 | Mus musculus (Mouse) | PR |
| Q5SDA5 | Gucy2f | Retinal guanylyl cyclase 2 | Mus musculus (Mouse) | PR |
| P16067 | Npr2 | Atrial natriuretic peptide receptor 2 | Rattus norvegicus (Rat) | PR |
| P18910 | Npr1 | Atrial natriuretic peptide receptor 1 | Rattus norvegicus (Rat) | PR |
| P51840 | Gucy2e | Retinal guanylyl cyclase 1 | Rattus norvegicus (Rat) | PR |
| Q09435 | gcy-1 | Receptor-type guanylate cyclase gcy-1 | Caenorhabditis elegans | PR |
| O16544 | gcy-19 | Receptor-type guanylate cyclase gcy-19 | Caenorhabditis elegans | PR |
| Q18331 | gcy-11 | Receptor-type guanylate cyclase gcy-11 | Caenorhabditis elegans | PR |
| Q10029 | gcy-2 | Receptor-type guanylate cyclase gcy-2 | Caenorhabditis elegans | PR |
| X5M8U1 | gcy-17 | Receptor-type guanylate cyclase gcy-17 | Caenorhabditis elegans | PR |
| Q23682 | gcy-5 | Receptor-type guanylate cyclase gcy-5 | Caenorhabditis elegans | PR |
| Q9FNE1 | CRK42 | Cysteine-rich receptor-like protein kinase 42 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9FG33 | LECRKS5 | Probable L-type lectin-domain containing receptor kinase S.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9M2S4 | LECRKS4 | L-type lectin-domain containing receptor kinase S.4 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O81292 | LECRK43 | L-type lectin-domain containing receptor kinase IV.3 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| O80939 | LECRK41 | L-type lectin-domain containing receptor kinase IV.1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q96285 | LECRK55 | L-type lectin-domain containing receptor kinase V.5 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFLGPWPFSR | LLSWFAISSR | LSGQHGLTSS | KFLRYLCLLA | LLPLIWWGQA | LPYKIGVIGP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WTCDPFFSKA | LPEVAAALAI | ERISRDMSFD | RSYSFEYVIL | NEDCQTSKAL | TSFISHQQMA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SGFVGPANPG | YCEAASLLGN | SWDKGIFSWA | CVNHELDNKH | SYPTFSRTLP | SPIRVLVTVM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KYFQWAHAGV | ISSDEDIWVH | TANQVSSALR | SHGLPVGVVL | TSGQDSRSIQ | KALQQIRQAD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RIRIIIMCMH | SALIGGETQT | HFLELAHDLK | MTDGTYVFVP | YDVLLYSLPY | KHSPYQVLRN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NQKLREAYDA | VLTITVESHE | KTFYEAFTEA | AAGGEIPEKL | DSHQVSPLFG | TIYNSIYFIA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QAMSNALKEN | GQASAASLTR | HSRNMQFYGF | NQLIRTDSNG | NGISEYVILD | TNGKEWELRG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TYTVDMETEL | LRFRGTPIHF | PGGRPTSADA | KCWFAQGKIC | QGGIDPALAM | MVCFALLLAL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LSINGFAYFI | RRRINKIQLI | KGPNRILLTL | EDVTFINPHF | GSKRGSRASV | SFQIISEVQS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GRSPRLSFSS | GSLTPATYEN | SNIAIYQGDW | VWLKKFPPGD | FGDIKSIKSS | ASDVFEMMKD |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LRHENVNPLL | GFFYDSGMFA | IVSEFCSRRS | LEDILTQDDV | KLDWMFKSSL | LLDLIKGMKY |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LHHREFIHGR | LKSRNCVVDG | RFVLKVTDYG | FNNILEMLRL | SEEEPSEEEL | LWTAPELLRA |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PGGIRLGSFA | GDVYSFAIIM | QEVMVRGAPF | CMMDLSAKEV | IDRLKMPPPV | YRPVVSPEFA |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PPECLQLMKQ | CWAEAAEQRP | TFDEIFNQFK | TFNKGKKTNI | IDSMLRMLEQ | YSSNLEDLIR |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ERTEELEIEK | QKTEKLLTQM | LPPSVAESLK | KGCTVEPEGF | DLVTLYFSDI | VGFTTISAMS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EPIEVVDLLN | DLYTLFDAII | GSHDVYKVET | IGDAYMVASG | LPKRNGSRHA | AEIANMSLDI |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| LSSVGTFKMR | HMPEVPVRIR | IGLHTGPVVA | GVVGLTMPRY | CLFGDTVNTA | SRMESTGLPY |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| RIHVSLSTVT | ILRTLSEGYE | VELRGRTELK | GKGTEETFWL | VGKKGFTKPL | PVPPPVGKDG |
| 1090 | 1100 | ||||
| QVGHGLQPAE | IAAFQRRKAE | RQLVRNKP |