P51840

PR
Gene name
Gucy2e (Guc2e, Gucy2d)
Protein name
Retinal guanylyl cyclase 1
Names
RETGC-1, Guanylate cyclase 2E, Guanylyl cyclase GC-E
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:79222
EC number
4.6.1.2: Phosphorus-oxygen lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

475-570 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P51840

Entry ID Method Resolution Chain Position Source
AF-P51840-F1 Predicted AlphaFoldDB

1 variants for P51840

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3321806089 100 E>K No EVA

No associated diseases with P51840

6 regional properties for P51840

Type Name Position InterPro Accession
domain Protein kinase domain 520 - 811 IPR000719
domain Adenylyl cyclase class-3/4/guanylyl cyclase 847 - 1060 IPR001054
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 582 - 802 IPR001245
domain Receptor, ligand binding region 76 - 395 IPR001828
domain Haem NO binding associated 823 - 868 IPR011645
conserved_site Adenylyl cyclase class-4/guanylyl cyclase, conserved site 990 - 1013 IPR018297

Functions

Description
EC Number 4.6.1.2 Phosphorus-oxygen lyases
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
  • Photoreceptor outer segment membrane ; Single-pass type I membrane protein
  • Endoplasmic reticulum membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
photoreceptor outer segment The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
photoreceptor outer segment membrane The membrane surrounding the outer segment of a vertebrate photoreceptor.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

8 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTP binding Binding to GTP, guanosine triphosphate.
guanylate cyclase activity Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
identical protein binding Binding to an identical protein or proteins.
peptide receptor activity Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
protein homodimerization activity Binding to an identical protein to form a homodimer.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein-containing complex binding Binding to a macromolecular complex.

6 GO annotations of biological process

Name Definition
cGMP biosynthetic process The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
cGMP-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.
receptor guanylyl cyclase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.

17 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P46197 NPR2 Atrial natriuretic peptide receptor 2 Bos taurus (Bovine) PR
O02740 GUCY2F Retinal guanylyl cyclase 2 Bos taurus (Bovine) PR
P51841 GUCY2F Retinal guanylyl cyclase 2 Homo sapiens (Human) PR
P20594 NPR2 Atrial natriuretic peptide receptor 2 Homo sapiens (Human) PR
Q02846 GUCY2D Retinal guanylyl cyclase 1 Homo sapiens (Human) PR
Q6VVW5 Npr2 Atrial natriuretic peptide receptor 2 Mus musculus (Mouse) PR
Q5SDA5 Gucy2f Retinal guanylyl cyclase 2 Mus musculus (Mouse) PR
P52785 Gucy2e Retinal guanylyl cyclase 1 Mus musculus (Mouse) PR
P18910 Npr1 Atrial natriuretic peptide receptor 1 Rattus norvegicus (Rat) PR
P16067 Npr2 Atrial natriuretic peptide receptor 2 Rattus norvegicus (Rat) PR
P51842 Gucy2f Retinal guanylyl cyclase 2 Rattus norvegicus (Rat) PR
Q09435 gcy-1 Receptor-type guanylate cyclase gcy-1 Caenorhabditis elegans PR
O16544 gcy-19 Receptor-type guanylate cyclase gcy-19 Caenorhabditis elegans PR
Q18331 gcy-11 Receptor-type guanylate cyclase gcy-11 Caenorhabditis elegans PR
Q10029 gcy-2 Receptor-type guanylate cyclase gcy-2 Caenorhabditis elegans PR
X5M8U1 gcy-17 Receptor-type guanylate cyclase gcy-17 Caenorhabditis elegans PR
Q23682 gcy-5 Receptor-type guanylate cyclase gcy-5 Caenorhabditis elegans PR
10 20 30 40 50 60
MSAWLLPAGG FPGAGFCIPA WQSRSSLSRV LRWPGPGLPG LLLLLLLPSP SAFSAVFKVG
70 80 90 100 110 120
VLGPWACDPI FARARPDLAA RLATDRLNRD LALDGGPWFE VTLLPEPCLT PGSLGAVSSA
130 140 150 160 170 180
LTRVSGLVGP VNPAACRPAE LLAQEAGVAL VPWGCPGTRA AGTTAPAVTP AADALYVLLK
190 200 210 220 230 240
AFRWARVALI TAPQDLWVEA GRALSTALRA RGLPVALVTS MVPSDLSGAR EALRRIRDGP
250 260 270 280 290 300
RVRVVIMVMH SVLLGGEEQR YLLEAAEELG LTDGSLVFLP FDTLHYALSP GPEALAAFVN
310 320 330 340 350 360
SSKLRRAHDA VLTLTRRCPP GGSVQDSLRR AQEHQELPLD LDLKQVSPLF GTIYDAVFLL
370 380 390 400 410 420
AGGVTRARAA VGGGWVSGAS VARQMREAQV FGFCGILGRT EEPSFVLLDT DAAGERLFTT
430 440 450 460 470 480
HLLDPVLGSL RSAGTPVHFP RGAPAPGPDP SCWFDPDVIC NGGVEPGLVF VGFLLVIVVG
490 500 510 520 530 540
LTGAFLAHYL RHRLLHMQMV SGPNKIILTL EDVTFLHPQG GSSRKVAQGS RSSLATRSTS
550 560 570 580 590 600
DIRSVPSQPQ ESTNIGLYEG DWVWLKKFPG EHHMAIRPAT KMAFSKLREL RHENVALYLG
610 620 630 640 650 660
LFLAGTADSP ATPGEGILAV VSEHCARGSL HDLLAQRDIK LDWMFKSSLL LDLIKGMRYL
670 680 690 700 710 720
HHRGVAHGRL KSRNCVVDGR FVLKVTDHGH GRLLEAQRVL PEPPSAEDQL WTAPELLRDP
730 740 750 760 770 780
ALERRGTLAG DVFSLGIIMQ EVVCRSTPYA MLELTPEEVI QRVRSPPPLC RPLVSMDQAP
790 800 810 820 830 840
MECIQLMAQC WAEHPELRPS MDLTFDLFKG INKGRKTNII DSMLRMLEQY SSNLEDLIRE
850 860 870 880 890 900
RTEELEQEKQ KTDRLLTQML PPSVAEALKM GTSVEPEYFE EVTLYFSDIV GFTTISAMSE
910 920 930 940 950 960
PIEVVDLLND LYTLFDAIIG SHDVYKVETI GDAYMVASGL PQRNGQRHAA EIANMSLDIL
970 980 990 1000 1010 1020
SAVGSFRMRH MPEVPVRIRI GLHSGPCVAG VVGLTMPRYC LFGDTVNTAS RMESTGLPYR
1030 1040 1050 1060 1070 1080
IHVNMSTVRI LRALDQGFQM ECRGRTELKG KGVEDTYWLV GRVGFNKPIP KPPDLQPGAS
1090 1100
NHGISLQEIP PERRKKLEKA RPGQFTGK