Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P51509
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P51509-F1 | Predicted | AlphaFoldDB |
No variants for P51509
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P51509 | |||||
No associated diseases with P51509
7 regional properties for P51509
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | IPT domain | 315 - 411 | IPR002909 |
| domain | Rel homology domain, DNA-binding domain | 135 - 312 | IPR011539 |
| conserved_site | Rel homology domain, conserved site | 153 - 159 | IPR030492 |
| domain | Transcription factor RelB, RHD domain, N-terminal | 140 - 309 | IPR030496 |
| domain | Rel homology dimerisation domain | 317 - 413 | IPR032397 |
| domain | RelB transactivation domain | 416 - 542 | IPR032400 |
| domain | NFkappaB IPT domain | 316 - 412 | IPR033926 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| I-kappaB kinase/NF-kappaB signaling | The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. |
| inflammatory response | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. |
| innate immune response | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. |
| NIK/NF-kappaB signaling | The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52). |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| response to cytokine | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus. |
| rhythmic process | Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFAPSLAAFR | AMALPIPRLA | PVMKSVQPAS | FPVLGSMAAR | LSTARGGRGL | RAGRRPPGGP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KGAAAAEEMA | VPIGAALQDP | NVGMAPVNDD | LEIIEEVMKE | DGFQPDPPPP | GSPHDPPKLI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PRGLGVPVGR | RDPPRDPPRL | IITEQPKKTG | MRFRYECEGR | SAGSILGESS | TEASKTLPAI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ELLNCQAIPE | VQVTACLVWK | DWPHRVHPHG | LVGKDCSNGL | CQVRLQPHAN | PRHSFSNLGI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QCVKKKEIEA | AIEKKLQLGI | DPFKAGSLKN | HQEVDMNVVR | ICFQASYRDG | SGRTRQLSPV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSEPIFDKKS | TNTSELRICR | MNKESGPCTG | GEELYLLCDK | VQKEDIAVVF | RKEPWEARAD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FSQADVHRQG | AIVLRTPPYR | CVQLSEPVQV | EVFLQRLTDR | ARSRGCPYTY | LPRERDAYGV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KVKRKRGMPD | LLEELSGADP | YGIEAKRRKP | PPGFMDHFAP | LPAADEAFAL | LADPLDPLSH |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LPPPSTPQIL | WGRSYFRTPP | PTETPTPPTA | SWGPICSQGT | SEGGGGRTSP | RYRPPPPLKW |
| GSQWAPPHQ |