Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P51152
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P51152-F1 | Predicted | AlphaFoldDB |
No variants for P51152
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P51152 | |||||
No associated diseases with P51152
8 regional properties for P51152
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclic nucleotide-binding domain | 137 - 253 | IPR000595-1 |
| domain | Cyclic nucleotide-binding domain | 255 - 376 | IPR000595-2 |
| domain | cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain | 25 - 62 | IPR003117 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 164 - 180 | IPR018488-1 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 200 - 217 | IPR018488-2 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 282 - 298 | IPR018488-3 |
| conserved_site | Cyclic nucleotide-binding, conserved site | 324 - 341 | IPR018488-4 |
| domain | RIbeta, dimerization/docking domain | 10 - 64 | IPR042818 |
Functions
12 GO annotations of cellular component
| Name | Definition |
|---|---|
| autophagosome | A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| Golgi apparatus | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| insulin-responsive compartment | A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2. |
| intracellular membrane-bounded organelle | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| recycling endosome | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. |
| recycling endosome membrane | The lipid bilayer surrounding a recycling endosome. |
| synaptic vesicle | A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| GDP binding | Binding to GDP, guanosine 5'-diphosphate. |
| GTP binding | Binding to GTP, guanosine triphosphate. |
| GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| autophagy | The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. |
| cellular response to insulin stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. |
| endosome to lysosome transport | The directed movement of substances from endosomes to lysosomes. |
| protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| protein secretion | The controlled release of proteins from a cell. |
| Rab protein signal transduction | The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state. |
| regulation of exocytosis | Any process that modulates the frequency, rate or extent of exocytosis. |
| vesicle docking involved in exocytosis | The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis. |
8 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P07560 | SEC4 | Ras-related protein SEC4 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| P61007 | RAB8A | Ras-related protein Rab-8A | Canis lupus familiaris (Dog) (Canis familiaris) | PR |
| Q6IQ22 | RAB12 | Ras-related protein Rab-12 | Homo sapiens (Human) | PR |
| P35283 | Rab12 | Ras-related protein Rab-12 | Mus musculus (Mouse) | PR |
| P35284 | Rab12 | Ras-related protein Rab-12 | Rattus norvegicus (Rat) | PR |
| O24466 | RABE1A | Ras-related protein RABE1a | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9SF91 | RABE1E | Ras-related protein RABE1e | Arabidopsis thaliana (Mouse-ear cress) | PR |
| Q9LZD4 | RABE1D | Ras-related protein RABE1d | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| RPADFKLQVI | IIGSRGVGKT | SLMERFTDDT | FCEACKSTVG | VDFKIKTVEL | RGKKIRLQIW |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DTAGQERFNS | ITSAYYRSAK | GIILVYDITK | KETFDDLPKW | MKMIDKYASE | DAELLLVGNK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LDCETDREIT | RQQGEKFAHE | ITGMRFCEAS | AKDNFNVDEI | FLKLVDDILK | KMPLDILRNE |
| 190 | 200 | ||||
| LSNSILSLQP | EPEIPPELPP | PRPHVRCC |