Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P50574

Entry ID Method Resolution Chain Position Source
AF-P50574-F1 Predicted AlphaFoldDB

No variants for P50574

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P50574

No associated diseases with P50574

2 regional properties for P50574

Type Name Position InterPro Accession
domain Rho GTPase-activating protein domain 276 - 469 IPR000198
domain BAR domain 1 - 262 IPR004148

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

12 GO annotations of biological process

Name Definition
cartilage development The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
cell differentiation The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
embryonic viscerocranium morphogenesis The process in which the anatomical structures of the viscerocranium are generated and organized during the embryonic phase. The viscerocranium is the part of the skull comprising the facial bones.
negative regulation of photoreceptor cell differentiation Any process that stops, prevents, or reduces the frequency, rate or extent of photoreceptor cell differentiation. An example of this process is found in Drosophila melanogaster.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
neural crest cell development The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
peripheral nervous system development The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
pharyngeal system development The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.
positive regulation of amacrine cell differentiation Any process that activates or increases the frequency, rate or extent of amacrine cell differentiation.
positive regulation of cell differentiation Any process that activates or increases the frequency, rate or extent of cell differentiation.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P50577 DLX5 Homeobox protein DLX-5 Gallus gallus (Chicken) PR
O60479 DLX3 Homeobox protein DLX-3 Homo sapiens (Human) PR
P56179 DLX6 Homeobox protein DLX-6 Homo sapiens (Human) PR
P70396 Dlx5 Homeobox protein DLX-5 Mus musculus (Mouse) PR
Q64205 Dlx3 Homeobox protein DLX-3 Mus musculus (Mouse) PR
P70397 Dlx6 Homeobox protein DLX-6 Mus musculus (Mouse) PR
P50575 Dlx5 Homeobox protein DLX-5 Rattus norvegicus (Rat) PR
Q9FN29 ATHB-52 Homeobox-leucine zipper protein ATHB-52 Arabidopsis thaliana (Mouse-ear cress) PR
Q01702 dlx3b Homeobox protein Dlx3b Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q98875 dlx1a Homeobox protein Dlx1a Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q98878 dlx4b Homeobox protein Dlx4b Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MTGVFDSLST DMHSNQITSS SYHSLHKSQE SPTLPVSTAT DSSINNNNQQ CAGSPYGQSS
70 80 90 100 110 120
SYQYQNNSMN SVQYNTKSYE LGFGNAFGPY GTYGSCSSPT PADAEKEERE PEIRMVNGKP
130 140 150 160 170 180
KKVRKPRTIY STFQLAALQR RFQKTQYLAL PERAELAASL GLTQTQVKIW FQNRRSKFKK
190 200 210 220 230 240
LWKSGEIPPE QHVASGESPP HPSPPLAAAW DFAHSQRMNT VNSGLSQSSP PNSTTPSFLT
250 260
NYPWYSSTNS AAHLQPPLHH NTTVSAGTIF