AiPD: Autoinhibited Protein Database

P50148

Gene name	GNAQ (GAQ)
Protein name	Guanine nucleotide-binding protein G
Names	q subunit alpha , Guanine nucleotide-binding protein alpha-q
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2776
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

68-182 (α-H domain) SS

Target domain	189-353 (Ras-like domain)
Relief mechanism	Ligand binding, Partner binding
Assay

AID

68-182 (α-H domain)

Target domain

189-353 (Ras-like domain)

Relief mechanism

Ligand binding (GTP binding), Partner binding(Binding of activated GPCR)

Assay

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100

Goricanec D et al. (2016) "Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding", Proceedings of the National Academy of Sciences of the United States of America, 113, E3629-38

Coleman DE et al. (1999) "Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex", The Journal of biological chemistry, 274, 16669-72

Lutz S et al. (2007) "Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs", Science (New York, N.Y.), 318, 1923-7

Autoinhibited structure

Activated structure

20 structures for P50148

Entry ID	Method	Resolution	Chain	Position	Source
6VU5	EM	350 A	B	1-359	PDB
7EZM	EM	290 A	A	37-359	PDB
7F6G	EM	290 A	B	2-359	PDB
7F6H	EM	290 A	B	2-359	PDB
7F6I	EM	280 A	B	2-359	PDB
7F8W	EM	310 A	A	29-359	PDB
7W3Z	EM	300 A	B	36-359	PDB
7W40	EM	300 A	B	36-359	PDB
7XOW	EM	310 A	A	36-359	PDB
8G59	EM	264 A	A	335-359	PDB
8IA7	EM	310 A	A	36-359	PDB
8IYS	EM	295 A	A	36-359	PDB
8J9N	EM	350 A	C	345-359	PDB
8JPB	EM	307 A	Q	37-359	PDB
8JPC	EM	307 A	Q	37-359	PDB
8JPE	EM	291 A	Q	37-359	PDB
8SZG	EM	360 A	C	29-359	PDB
8UQN	EM	340 A	A	7-359	PDB
8UQO	EM	337 A	A	7-359	PDB
AF-P50148-F1	Predicted				AlphaFoldDB

143 variants for P50148

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV002254275 RCV001526543 RCV000043592 VAR_067270 RCV003221795 COSM52975 CA143805 RCV000533476 rs397514698 RCV001526638 RCV000043593 RCV002294003 RCV001705695	183	R>Q	eye Angioosteohypertrophic syndrome Capillary malformation Familial multiple nevi flammei large_intestine Melanoma Variant assessed as Somatic; impact. Sturge-Weber syndrome meninges SWS; found as somatic mosaic mutation in CMC; also found in melanocytomas sample; somatic mutation; shows significant activation of EPHB2 compared to control [Cosmic, ClinVar, NCI-TCGA, UniProt]	Yes	ClinGen cosmic curated ClinVar UniProt Ensembl NCI-TCGA dbSNP
RCV000441114 rs1057519853 CA16602757 COSM28757	209	Q>L	eye skin Uveal melanoma meninges [Cosmic, ClinVar]	Yes	ClinGen cosmic curated ClinVar Ensembl dbSNP
RCV000436244 VAR_067271 RCV000426416 COSM28757 CA16602434 rs121913492	209	Q>L	eye Melanoma Variant assessed as Somatic; impact. skin Uveal melanoma meninges found in blue naevi and uveal melanoma samples; somatic mutation; constitutive activation [Cosmic, ClinVar, NCI-TCGA, UniProt]	Yes	ClinGen cosmic curated ClinVar UniProt Ensembl NCI-TCGA dbSNP
COSM28758 CA16602436 rs121913492 RCV000436033 RCV000425312	209	Q>P	eye NS Melanoma Variant assessed as Somatic; impact. central_nervous_system skin Uveal melanoma meninges [Cosmic, ClinVar, NCI-TCGA]	Yes	ClinGen cosmic curated ClinVar Ensembl NCI-TCGA dbSNP
RCV001327979 CA16602435 COSM28760 rs121913492 RCV000442822	209	Q>R	eye Melanoma [Cosmic, ClinVar]	Yes	ClinGen cosmic curated ClinVar Ensembl dbSNP
rs780163661 CA5094751	2	T>S		No	ClinGen ExAC gnomAD
CA194745058 rs1059518	4	E>D		No	ClinGen Ensembl
rs746420387 CA373999009	6	I>F		No	ClinGen ExAC gnomAD
CA5094749 rs746420387	6	I>L		No	ClinGen ExAC gnomAD
CA373999005 rs779515663	6	I>M		No	ClinGen ExAC TOPMed gnomAD
rs1264916735 CA373999008	6	I>T		No	ClinGen TOPMed
rs746420387 CA5094750	6	I>V		No	ClinGen ExAC gnomAD
CA5094747 rs757711264	7	M>L		No	ClinGen ExAC TOPMed gnomAD
rs1203392784 CA373998996	8	A>T		No	ClinGen gnomAD
TCGA novel	10	C>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	35	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5094738 rs762737987	42	L>V		No	ClinGen ExAC gnomAD
rs1466271329 CA373998754	43	L>P		No	ClinGen gnomAD
TCGA novel	48	G>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	50	S>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs773781296 CA5094692	59	M>L		No	ClinGen ExAC gnomAD
CA373997074 rs1256109740	69	D>E		No	ClinGen gnomAD
CA5094688 rs768341234	76	T>A		No	ClinGen ExAC gnomAD
CA5094687 rs746699009	77	K>R		No	ClinGen ExAC gnomAD
CA373997010 rs1369065497	79	V>L		No	ClinGen gnomAD
rs1251821572 CA373997000	80	Y>F		No	ClinGen TOPMed
CA373996971 rs1192458704	84	F>Y		No	ClinGen TOPMed
CA5094686 COSM1463120 rs761634659	85	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA5094683 rs778978521	87	M>V		No	ClinGen ExAC TOPMed gnomAD
CA373996946 rs1191803927	88	Q>E		No	ClinGen Ensembl
rs1136722 CA194732163	92	R>T		No	ClinGen Ensembl
rs1444819549 CA373996911	93	A>T		No	ClinGen gnomAD
CA5094682 rs757129673	95	D>E		No	ClinGen ExAC gnomAD
COSM404628 CA5094681 rs753716491	96	T>S	lung Variant assessed as Somatic; 0.004093 impact. prostate [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA373996847 rs1416428102	99	I>M		No	ClinGen gnomAD
CA5094677 rs766649624	100	P>L		No	ClinGen ExAC gnomAD
CA5094678 rs766649624	100	P>R		No	ClinGen ExAC gnomAD
CA5094675 rs200106152	101	Y>*		No	ClinGen 1000Genomes ExAC gnomAD
CA373996777 COSM3664424 rs1468666506 COSM3664425	102	K>N	liver [Cosmic]	No	ClinGen cosmic curated gnomAD
CA5094674 rs765827868	103	Y>H		No	ClinGen ExAC TOPMed gnomAD
CA194732161 rs77227613	103	Y>S		No	ClinGen Ensembl
CA194732160 rs200658460	104	E>G		No	ClinGen 1000Genomes
rs1438658973 CA373996734	105	H>D		No	ClinGen TOPMed
CA5094673 rs762200216	107	K>Q		No	ClinGen ExAC gnomAD
CA5094652 rs377726080	108	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1288502233 CA373998605	109	H>N		No	ClinGen gnomAD
CA5094651 rs761095319	109	H>R		No	ClinGen ExAC TOPMed gnomAD
rs775821091 CA5094650	110	A>T		No	ClinGen ExAC gnomAD
CA373998579 rs1430429958	113	V>I		No	ClinGen TOPMed
CA5094648 rs759080789	114	R>G		No	ClinGen ExAC gnomAD
CA194719766 rs1010141343	114	R>Q		No	ClinGen TOPMed gnomAD
rs1425322060 CA373998570	115	E>K		No	ClinGen gnomAD
TCGA novel	116	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373998561 rs1383379438	116	V>L		No	ClinGen TOPMed
CA5094647 rs371301832	117	D>G		No	ClinGen ESP ExAC gnomAD
rs1351194942 CA373998517	122	S>C		No	ClinGen TOPMed
rs1163999044 CA373998520	122	S>P		No	ClinGen TOPMed
CA5094643 RCV000912112 rs192927818	130	D>N		No	ClinGen ClinVar 1000Genomes ExAC TOPMed dbSNP gnomAD
rs1362009464 CA373998455	131	A>G		No	ClinGen TOPMed
CA5094642 rs748011987	134	S>N		No	ClinGen ExAC gnomAD
CA373998429 rs1305477251 COSM281412	135	L>V	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	137	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1295375779 CA373998363	144	C>R		No	ClinGen gnomAD
TCGA novel	150	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA5094638 rs779143139	151	Y>C		No	ClinGen ExAC gnomAD
rs200924131 CA5094636	152	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA194719764 rs923027293	157	T>A		No	ClinGen Ensembl
TCGA novel	159	Y>=	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1215304254 CA373998258	159	Y>H		No	ClinGen TOPMed
TCGA novel	161	L>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373998189 rs1587920943	165	D>A		No	ClinGen Ensembl
rs1402276757 COSM1253350 CA373998179	167	V>I	Variant assessed as Somatic; 0.0 impact. oesophagus [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs777801390 CA5094618	168	A>V		No	ClinGen ExAC gnomAD
CA373998165 rs1587920931	169	D>A		No	ClinGen Ensembl
rs756147804 CA5094617	170	P>A		No	ClinGen ExAC TOPMed gnomAD
CA194717624 rs980935611	170	P>R		No	ClinGen TOPMed gnomAD
TCGA novel	171	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373998146 rs1393447827	172	Y>C		No	ClinGen TOPMed
rs1587920918 CA373998130	175	T>A		No	ClinGen Ensembl
CA373998128 rs1461816732	175	T>K		No	ClinGen TOPMed
CA194717622 rs28764015	191	E>K		No	ClinGen Ensembl
TCGA novel	192	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	197	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373997925 rs1223047296	203	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA373997905 rs1476186591	206	V>I		No	ClinGen TOPMed
CA373997787 rs1423930996	222	N>S		No	ClinGen TOPMed
rs769002669 CA194717256	226	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
TCGA novel	235	Y>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373997689 rs1299114921	236	D>E		No	ClinGen TOPMed
rs1587919416 CA373997675	238	V>A		No	ClinGen Ensembl
rs968608243 CA373997666	240	V>L		No	ClinGen TOPMed
rs968608243 CA194717254	240	V>M		No	ClinGen TOPMed
rs1361664931 CA373997649	242	S>L		No	ClinGen gnomAD
CA5094584 rs759267731	244	N>S		No	ClinGen ExAC TOPMed
rs1449750349	246	N>=	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	248	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1587886275 CA373997588	249	E>G		No	ClinGen Ensembl
TCGA novel	250	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA194710022 rs2013373	256	R>K		No	ClinGen gnomAD
CA373997537 rs2013373	256	R>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs149046601 CA5094557	259	I>V		No	ClinGen ESP ExAC TOPMed
CA373997495 rs1285850636	262	P>L		No	ClinGen TOPMed
rs200517432 CA194710020	264	F>L		No	ClinGen 1000Genomes
rs372073168 CA5094556	265	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs765491785 CA5094555	267	S>F		No	ClinGen ExAC gnomAD
CA194710019 rs1059522	272	F>L		No	ClinGen Ensembl
rs898844416 CA194710018	277	D>Y		No	ClinGen TOPMed
CA194710017 rs1059523	279	L>P		No	ClinGen Ensembl
TCGA novel	279	L>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373997378 rs1182621194	280	E>Q		No	ClinGen TOPMed
CA5094553 rs776673486	284	M>T		No	ClinGen ExAC gnomAD
CA373997348 rs1273681754	284	M>V		No	ClinGen gnomAD
rs886255565 CA194710016	288	L>I		No	ClinGen TOPMed gnomAD
CA194710015 rs201195349	292	F>S		No	ClinGen 1000Genomes
CA5094533 rs374303316	299	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA373996515 rs1311795673	300	R>G		No	ClinGen TOPMed
rs760869735 CA5094532	300	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1236524878 CA373996508	301	D>N		No	ClinGen gnomAD
rs772749242 CA5094530	302	A>S		No	ClinGen ExAC gnomAD
rs774951302 CA5094528	303	Q>K		No	ClinGen ExAC gnomAD
rs777546823 CA5094526	304	A>E		No	ClinGen ExAC gnomAD
CA5094527 rs376987002	304	A>P		No	ClinGen ESP ExAC gnomAD
rs777546823 CA5094525	304	A>V		No	ClinGen ExAC gnomAD
CA5094524 rs769315863	306	R>Q		No	ClinGen ExAC gnomAD
TCGA novel	307	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	307	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1246606508 CA373996442 CA373996441	311	K>N		No	ClinGen TOPMed
rs372746608 CA5094522	312	M>V		No	ClinGen ESP ExAC gnomAD
CA5094520 rs751516475	317	N>K		No	ClinGen ExAC gnomAD
rs183713546 CA5094519	319	D>E		No	ClinGen 1000Genomes ExAC gnomAD
rs1352440197 CA373996392	319	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1216739414 CA373996370	321	D>E		No	ClinGen TOPMed
rs397825484 CA194709238	322	K>Q		No	ClinGen Ensembl
rs1297612239 CA373996349	324	I>M		No	ClinGen gnomAD
TCGA novel	326	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA373996304 rs1238540285	331	A>T		No	ClinGen gnomAD
TCGA novel	333	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1412853649 CA373996278	335	E>K		No	ClinGen gnomAD
CA194709237 rs1059527	337	I>V		No	ClinGen Ensembl
rs1180028656 CA373996254	338	R>C		No	ClinGen TOPMed
CA373996215 rs1257829666	344	V>I		No	ClinGen TOPMed gnomAD
TCGA novel	347	T>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA194709234 rs1059531 VAR_059319	355	E>D		No	ClinGen UniProt Ensembl dbSNP

2 associated diseases with P50148

[MIM: 163000]: Capillary malformations, congenital (CMC)

A form of vascular malformations that are present from birth, tend to grow with the individual, do not regress spontaneously, and show normal rates of endothelial cell turnover. Capillary malformations are distinct from capillary hemangiomas, which are highly proliferative lesions that appear shortly after birth and show rapid growth, slow involution, and endothelial hypercellularity. . Note=The disease is caused by variants affecting the gene represented in this entry.

[MIM: 185300]: Sturge-Weber syndrome (SWS)

A syndrome characterized by an intracranial vascular anomaly, leptomeningeal angiomatosis, most often involving the occipital and posterior parietal lobes. The most common features are facial cutaneous vascular malformations (port-wine stains), seizures, and glaucoma. Stasis results in ischemia underlying the leptomeningeal angiomatosis, leading to calcification and laminar cortical necrosis. The clinical course is highly variable and some children experience intractable seizures, intellectual disability, and recurrent stroke-like episodes. . Note=The disease is caused by variants affecting the gene represented in this entry.

Without disease ID

A form of vascular malformations that are present from birth, tend to grow with the individual, do not regress spontaneously, and show normal rates of endothelial cell turnover. Capillary malformations are distinct from capillary hemangiomas, which are highly proliferative lesions that appear shortly after birth and show rapid growth, slow involution, and endothelial hypercellularity. . Note=The disease is caused by variants affecting the gene represented in this entry.
A syndrome characterized by an intracranial vascular anomaly, leptomeningeal angiomatosis, most often involving the occipital and posterior parietal lobes. The most common features are facial cutaneous vascular malformations (port-wine stains), seizures, and glaucoma. Stasis results in ischemia underlying the leptomeningeal angiomatosis, leading to calcification and laminar cortical necrosis. The clinical course is highly variable and some children experience intractable seizures, intellectual disability, and recurrent stroke-like episodes. . Note=The disease is caused by variants affecting the gene represented in this entry.

No regional properties for P50148

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for P50148

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Lipid-anchor Golgi apparatus Nucleus Nucleus membrane	Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

9 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular exosome	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
Golgi apparatus	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
heterotrimeric G-protein complex	Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
lysosomal membrane	The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
nuclear membrane	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
photoreceptor outer segment	The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
synapse	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

6 GO annotations of molecular function

Name	Definition
G protein-coupled receptor binding	Binding to a G protein-coupled receptor.
G-protein beta/gamma-subunit complex binding	Binding to a complex of G-protein beta/gamma subunits.
GTP binding	Binding to GTP, guanosine triphosphate.
GTPase activator activity	Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
GTPase activity	Catalysis of the reaction
metal ion binding	Binding to a metal ion.

13 GO annotations of biological process

Name	Definition
action potential	A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.
activation of phospholipase C activity	The initiation of the activity of the inactive enzyme phospolipase C as the result of The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand.
adenylate cyclase-activating G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
blood coagulation	The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages
entrainment of circadian clock	The synchronization of a circadian rhythm to environmental time cues such as light.
G protein-coupled acetylcholine receptor signaling pathway	A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription.
glutamate receptor signaling pathway	The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
negative regulation of protein kinase activity	Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
phospholipase C-activating dopamine receptor signaling pathway	A phospholipase C-activating receptor G protein-coupled receptor signaling pathway initiated by dopamine binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
phototransduction, visible light	The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.
protein stabilization	Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
regulation of canonical Wnt signaling pathway	Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
regulation of platelet activation	Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.

30 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P38408	GNA14	Guanine nucleotide-binding protein subunit alpha-14	Bos taurus (Bovine)	PR
Q28294	GNAQ	Guanine nucleotide-binding protein G(q) subunit alpha	Canis lupus familiaris (Dog) (Canis familiaris)	PR
P23625	Galphaq	G protein alpha q subunit	Drosophila melanogaster (Fruit fly)	PR
O95837	GNA14	Guanine nucleotide-binding protein subunit alpha-14	Homo sapiens (Human)	SS
P29992	GNA11	Guanine nucleotide-binding protein subunit alpha-11	Homo sapiens (Human)	SS
P30679	GNA15	Guanine nucleotide-binding protein subunit alpha-15	Homo sapiens (Human)	SS
P11488	GNAT1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P19087	GNAT2	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P08754	GNAI3	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
A8MTJ3	GNAT3	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P19086	GNAZ	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
Q14344	GNA13	Guanine nucleotide-binding protein subunit alpha-13	Homo sapiens (Human)	SS
Q03113	GNA12	Guanine nucleotide-binding protein subunit alpha-12	Homo sapiens (Human)	SS
P38405	GNAL	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P04899	GNAI2	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P63096	GNAI1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	EV
P09471	GNAO1	Guanine nucleotide-binding protein G	Homo sapiens (Human)	SS
P30678	Gna15	Guanine nucleotide-binding protein subunit alpha-15	Mus musculus (Mouse)	PR
P21279	Gnaq	Guanine nucleotide-binding protein G(q) subunit alpha	Mus musculus (Mouse)	PR
Q2PKF4	GNAQ	Guanine nucleotide-binding protein G(q) subunit alpha	Sus scrofa (Pig)	PR
P93564	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Solanum tuberosum (Potato)	SS
O88302	Gna15	Guanine nucleotide-binding protein subunit alpha-15	Rattus norvegicus (Rat)	SS
Q9JID2	Gna11	Guanine nucleotide-binding protein subunit alpha-11	Rattus norvegicus (Rat)	SS
P82471	Gnaq	Guanine nucleotide-binding protein G	Rattus norvegicus (Rat)	SS
Q0DJ33	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Oryza sativa subsp. japonica (Rice)	SS
P49084	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Glycine max (Soybean) (Glycine hispida)	SS
P93163	GPA2	Guanine nucleotide-binding protein alpha-2 subunit	Glycine max (Soybean) (Glycine hispida)	SS
O80462	XLG1	Extra-large guanine nucleotide-binding protein 1	Arabidopsis thaliana (Mouse-ear cress)	PR
P18064	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Arabidopsis thaliana (Mouse-ear cress)	SS
P26981	GPA1	Guanine nucleotide-binding protein alpha-1 subunit	Solanum lycopersicum (Tomato) (Lycopersicon esculentum)	SS

10	20	30	40	50	60
MTLESIMACC	LSEEAKEARR	INDEIERQLR	RDKRDARREL	KLLLLGTGES	GKSTFIKQMR
70	80	90	100	110	120
IIHGSGYSDE	DKRGFTKLVY	QNIFTAMQAM	IRAMDTLKIP	YKYEHNKAHA	QLVREVDVEK
130	140	150	160	170	180
VSAFENPYVD	AIKSLWNDPG	IQECYDRRRE	YQLSDSTKYY	LNDLDRVADP	AYLPTQQDVL
190	200	210	220	230	240
RVRVPTTGII	EYPFDLQSVI	FRMVDVGGQR	SERRKWIHCF	ENVTSIMFLV	ALSEYDQVLV
250	260	270	280	290	300
ESDNENRMEE	SKALFRTIIT	YPWFQNSSVI	LFLNKKDLLE	EKIMYSHLVD	YFPEYDGPQR
310	320	330	340	350
DAQAAREFIL	KMFVDLNPDS	DKIIYSHFTC	ATDTENIRFV	FAAVKDTILQ	LNLKEYNLV