P50101
PR
Gene name |
UBP15 (YMR304W, YM9952.06) |
Protein name |
Ubiquitin carboxyl-terminal hydrolase 15 |
Names |
Deubiquitinating enzyme 15, Ubiquitin thioesterase 15, Ubiquitin-specific-processing protease 15 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YMR304W |
EC number |
3.4.19.12: Omega peptidases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P50101
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P50101-F1 | Predicted | AlphaFoldDB |
20 variants for P50101
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s13-875433 | 150 | L>M | No | SGRP | |
| s13-876108 | 375 | Y>H | No | SGRP | |
| s13-876505 | 507 | E>G | No | SGRP | |
| s13-876529 | 515 | G>D | No | SGRP | |
| s13-876537 | 518 | Q>E | No | SGRP | |
| s13-876746 | 587 | I>M | No | SGRP | |
| s13-876944 | 653 | M>I | No | SGRP | |
| s13-877042 | 686 | R>M | No | SGRP | |
| s13-877101 | 706 | A>T | No | SGRP | |
| s13-877202 | 739 | K>N | No | SGRP | |
| s13-877395 | 804 | I>L | No | SGRP | |
| s13-877434 | 817 | K>E | No | SGRP | |
| s13-877527 | 848 | I>V | No | SGRP | |
| s13-877656 | 891 | E>K | No | SGRP | |
| s13-877743 | 920 | V>M | No | SGRP | |
| s13-877785 | 934 | I>F | No | SGRP | |
| s13-878151 | 1056 | H>N | No | SGRP | |
| s13-878183 | 1066 | E>D | No | SGRP | |
| s13-878218 | 1078 | E>G | No | SGRP | |
| s13-878482 | 1166 | S>L | No | SGRP |
No associated diseases with P50101
7 regional properties for P50101
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | 205 - 533 | IPR001394 |
| domain | MATH/TRAF domain | 39 - 179 | IPR002083 |
| conserved_site | Ubiquitin specific protease, conserved site | 206 - 221 | IPR018200-1 |
| conserved_site | Ubiquitin specific protease, conserved site | 449 - 466 | IPR018200-2 |
| domain | Ubiquitin carboxyl-terminal hydrolase 7, ICP0-binding domain | 649 - 936 | IPR024729 |
| domain | Ubiquitin specific protease domain | 205 - 536 | IPR028889 |
| domain | Ubiquitin carboxyl-terminal hydrolase, C-terminal | 966 - 1217 | IPR029346 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.4.19.12 | Omega peptidases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| peroxisome | A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cysteine-type deubiquitinase activity | An thiol-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. |
| cysteine-type endopeptidase activity | Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| free ubiquitin chain depolymerization | The process in which free ubiquitin chains, compounds composed of a large number of ubiquitin monomers, are broken down. |
| protein deubiquitination | The removal of one or more ubiquitin groups from a protein. |
| regulation of protein stability | Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSEDELGSI | GTVFPGSPID | KSIGSILPQF | DEEVETLLED | SFTWNIPDWN | ELTNPKYNSP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RFRIGDFEWD | ILLFPQGNHN | KGVAVYLEPH | PEEKLDETTG | EMVPVDPDWY | CCAQFAIGIS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RPGNGDTINL | INKSHHRFNA | LDTDWGFANL | IDLNNLKHPS | KGRPLSFLNE | GTLNITAYVR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ILKDPTGVLW | HNFLNYDSKK | VTGYVGFRNQ | GATCYLNSLL | QSYFFTKYFR | KLVYEIPTEH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ESPNNSVPLA | LQRAFYQLQV | SDIPLDTLEL | TRSFGWDTAE | SFTQHDVQEL | NRILMDRLEN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NMKGTPVEGK | LNEIFVGKMK | SYIKCINVDY | ESARVEDFWD | LQLNVKNFKN | LQESFDNYIE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MELMNGENQY | AAQDYGLQDA | QKGVIFESFP | PVLHLQLKRF | EYDFNYDQMV | KVNDKYEFPE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TIDLSPFVDK | DVLKKTLDSE | NKDKNPYVYN | LHGVLVHSGD | ISTGHYYTLI | KPGVEDQWYR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FDDERVWRVT | KKQVFQENFG | CDRLPDEKVR | TMTRGEYQNY | IIQRHTSAYM | LVYIRQEQEE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DLLRPVLESD | VPKHVITRVR | EEIKERETKE | KEIREAHLYV | TLRLHSIKEF | IHYEGFDYFA |
| 610 | 620 | 630 | 640 | 650 | 660 |
| HDGFRLFAEE | LNDSGLQQIN | LKVLRTTKLS | DIFASIKETM | NIPQERDVKY | WKMDYRRNST |
| 670 | 680 | 690 | 700 | 710 | 720 |
| LRLTQPINFE | SVNITLQEAL | KKEKKRTMQT | QYGEEGVAST | EEDDKALLET | VSFLDLFIEE |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PYLELQFLNK | LKEASLISKA | QLDDELISTI | RTNLPELTKG | GIEPVFATDN | KSNLLFVKSY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| DPHTQKLLGF | GHFAVNQLQQ | LSDISAIIED | SISSNEKLTF | YEEVQPGTIN | EIYMKETIYD |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ADIDTGDIVS | FEVPGAVLPD | TFPVYATIKD | FYSYLRYRVK | LKFSKFDGSS | EEYGVSNEIP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ESFEFWISAY | APYDDLARMV | SKYAHVKPEY | LKIIALYSNG | RFVLKSTSLL | NDYLLKDFNC |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| DQIPPFAFEV | LSVPLKELER | LRPIKLYWLK | NSYIHYQCFE | FEVANDYTES | QFLEKVQHKI |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| GFTDEEKENI | LLWTNTNFQF | QGLLSDQNTF | KDVSKHSLLF | GRILPEESKL | FKELNRLENV |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| QTSSLEDFMD | DENATDRPMD | DEQDLGMAIE | HSEDMKGRIV | VVQQYFKDLE | NRHGISFLFN |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| LIPDETFPKT | KDRLHAKFGL | GQKEFSKIKL | SIGYSTEEGT | VFRSLQGFSD | EELDKVILYD |
| 1210 | 1220 | ||||
| IMSNLDYIYM | DHPDRLRSHS | SYDRPMIIKN |