Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

6 structures for P49802

Entry ID Method Resolution Chain Position Source
2A72 X-ray 200 A A/B 320-463 PDB
2D9J NMR - A 323-448 PDB
7EWP EM 430 A C 1-495 PDB
7EWR EM 470 A C/E 1-495 PDB
7SHF EM 340 A C 1-463 PDB
AF-P49802-F1 Predicted AlphaFoldDB

252 variants for P49802

Variant ID(s) Position Change Description Diseaes Association Provenance
rs548863531
CA1478403
7 Y>F No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA345662975
rs1467650988
7 Y>H No ClinGen
TOPMed
rs1298829020
CA345662948
11 S>G No ClinGen
gnomAD
CA1478402
CA345662933
rs764551447
13 G>R No ClinGen
ExAC
TOPMed
gnomAD
rs760771554
CA1478401
14 V>A No ClinGen
ExAC
gnomAD
rs892506261
CA40880031
15 A>T No ClinGen
TOPMed
CA345662902
rs1162411700
18 S>T No ClinGen
gnomAD
CA40880028
rs1056550223
19 P>A No ClinGen
TOPMed
gnomAD
CA345662895
rs1056550223
19 P>S No ClinGen
TOPMed
gnomAD
rs939442638
CA40880024
20 N>S No ClinGen
TOPMed
gnomAD
CA40880019
rs1021181842
23 V>A No ClinGen
TOPMed
gnomAD
CA345662871
rs904136462
23 V>L No ClinGen
Ensembl
rs904136462
CA40880021
23 V>M No ClinGen
Ensembl
CA1478369
COSM242617
rs746558865
29 D>G prostate [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
rs758148829
CA1478367
30 V>I No ClinGen
ExAC
TOPMed
gnomAD
CA1478365
rs778008778
33 R>Q No ClinGen
ExAC
gnomAD
COSM78413
rs749609576
CA1478366
33 R>W ovary [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
rs1208853828
CA345662747
COSM679723
COSM1146266
35 Q>R lung [Cosmic] No ClinGen
cosmic curated
gnomAD
rs1316442705
COSM1690047
CA345662733
COSM1690046
37 E>K skin [Cosmic] No ClinGen
cosmic curated
gnomAD
rs141493148
CA1478363
38 K>R No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1307575733
CA345662717
39 N>T No ClinGen
gnomAD
CA345662694
rs1307633146
42 P>L No ClinGen
TOPMed
CA1478361
COSM1668612
COSM1668611
rs755007339
44 R>C skin haematopoietic_and_lymphoid_tissue [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
CA1478362
rs755007339
44 R>G No ClinGen
ExAC
TOPMed
gnomAD
CA1478360
rs751658199
44 R>H No ClinGen
ExAC
TOPMed
gnomAD
CA345662684
rs751658199
44 R>L No ClinGen
ExAC
TOPMed
gnomAD
CA1478359
COSM1502003
COSM1502002
rs766529566
45 T>M lung [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
CA40724717
rs200443168
46 V>I No ClinGen
Ensembl
CA345662672
rs1558716091
47 K>E No ClinGen
Ensembl
rs141019066
CA40724713
49 F>L No ClinGen
ESP
rs1027207051
CA40724709
52 K>R No ClinGen
TOPMed
gnomAD
rs764927353
CA1478356
53 I>M No ClinGen
ExAC
gnomAD
rs765729186
CA40724700
56 V>I No ClinGen
Ensembl
rs1176674546
CA345662597
58 S>P No ClinGen
gnomAD
rs1228779252
CA345662560
61 D>N No ClinGen
TOPMed
CA1478341
rs780101969
62 I>F No ClinGen
ExAC
gnomAD
CA1478340
rs758531037
63 V>I No ClinGen
ExAC
gnomAD
rs545703283
CA1478338
67 I>T No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs761475957
CA1478337
69 N>D No ClinGen
ExAC
gnomAD
CA1478336
rs753691747
69 N>K No ClinGen
ExAC
gnomAD
rs573507054
CA345662490
71 T>A No ClinGen
1000Genomes
TOPMed
gnomAD
CA40657222
rs573507054
71 T>P No ClinGen
1000Genomes
TOPMed
gnomAD
rs764068135
CA1478335
72 I>V No ClinGen
ExAC
gnomAD
CA345662464
rs775622578
74 D>E No ClinGen
ExAC
TOPMed
gnomAD
CA345662462
COSM1146261
COSM679729
rs1338519941
75 P>A lung [Cosmic] No ClinGen
cosmic curated
gnomAD
CA345662420
rs1408037935
78 A>V No ClinGen
gnomAD
COSM1139098
rs1464800121
CA345662419
COSM533685
79 L>I lung [Cosmic] No ClinGen
cosmic curated
gnomAD
COSM1139097
rs1352441637
COSM533686
CA345662400
81 L>F prostate [Cosmic] No ClinGen
cosmic curated
TOPMed
gnomAD
CA1478313
rs752664517
87 A>G No ClinGen
ExAC
gnomAD
rs116225378
CA40632136
87 A>T No ClinGen
1000Genomes
CA1478310
rs773920063
89 G>S No ClinGen
ExAC
gnomAD
rs1018514437
CA40632109
93 P>S No ClinGen
Ensembl
CA1478309
rs765891866
94 I>V No ClinGen
ExAC
gnomAD
rs959673437
CA40632100
96 D>G No ClinGen
TOPMed
CA1478308
rs762654930
102 K>R No ClinGen
ExAC
gnomAD
CA40632090
rs202033477
103 D>N No ClinGen
gnomAD
CA40632082
rs202033477
103 D>Y No ClinGen
gnomAD
rs888619562
CA40632075
106 T>A No ClinGen
Ensembl
rs1048514765
CA40632069
107 F>S No ClinGen
gnomAD
CA40632055
rs747767217
109 R>Q No ClinGen
Ensembl
rs370775204
CA1478307
109 R>W No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA345662217
rs1243702189
110 F>I No ClinGen
gnomAD
rs138071681
CA1478305
111 Q>* No ClinGen
ESP
ExAC
rs772399469
CA1478286
112 T>N No ClinGen
ExAC
TOPMed
gnomAD
CA345662119
rs772399469
112 T>S No ClinGen
ExAC
TOPMed
gnomAD
CA1478283
rs771008552
118 S>A No ClinGen
ExAC
gnomAD
COSM1340596
rs770058894
CA1478261
COSM1340595
130 V>I large_intestine [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
rs12759971
CA40578215
136 T>I No ClinGen
Ensembl
CA345662145
rs1456990105
136 T>S No ClinGen
gnomAD
CA40578209
VAR_057153
rs12746550
137 M>L No ClinGen
UniProt
TOPMed
dbSNP
CA345662139
rs12746550
137 M>V No ClinGen
TOPMed
rs1327665185
CA345662116
138 Q>P No ClinGen
gnomAD
rs1204654489
CA345662103
139 N>D No ClinGen
TOPMed
CA345662084
rs1252532005
140 K>Q No ClinGen
TOPMed
CA345662079
rs1479954489
140 K>R No ClinGen
TOPMed
CA345662060
rs1184915764
142 R>* No ClinGen
TOPMed
gnomAD
rs748379736
CA1478260
142 R>Q No ClinGen
ExAC
TOPMed
gnomAD
CA345662051
rs1395888367
143 L>V No ClinGen
gnomAD
rs149172715
CA1478257
146 A>P No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs149172715
CA345662008
146 A>S No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs149172715
CA1478258
146 A>T No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs780001267
CA1478256
147 D>H No ClinGen
ExAC
gnomAD
rs780001267
CA345661998
147 D>N No ClinGen
ExAC
gnomAD
rs1558386363
CA345661972
148 Y>C No ClinGen
Ensembl
rs374541154
CA40577633
154 A>D No ClinGen
ESP
TOPMed
CA1478232
rs755739521
154 A>T No ClinGen
ExAC
gnomAD
CA40577614
rs777326836
157 Q>* No ClinGen
Ensembl
rs758875880
CA1478229
159 A>T No ClinGen
ExAC
gnomAD
CA1478227
rs765867861
162 R>P No ClinGen
ExAC
gnomAD
rs765867861
CA345661708
162 R>Q No ClinGen
ExAC
gnomAD
CA1478228
rs750946518
162 R>W No ClinGen
ExAC
gnomAD
CA345661675
rs1247347526
166 F>L No ClinGen
gnomAD
CA345661660
rs1350419532
168 F>L No ClinGen
gnomAD
rs1224169989
CA345661658
169 M>L No ClinGen
TOPMed
gnomAD
CA345661617
rs1444669862
174 Q>R No ClinGen
gnomAD
CA1478226
rs761913385
175 A>E No ClinGen
ExAC
gnomAD
CA345661611
rs1336538191
175 A>S No ClinGen
gnomAD
rs762798296
CA1478200
177 V>M No ClinGen
ExAC
gnomAD
CA1478199
rs773245027
181 R>G No ClinGen
ExAC
gnomAD
CA40577496
rs868834863
182 D>N No ClinGen
Ensembl
CA345661511
rs1362311123
187 K>M No ClinGen
TOPMed
rs539010919
CA1478198
188 I>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA345661500
rs1316436060
189 L>F No ClinGen
TOPMed
CA345661479
rs1362184452
192 Q>E No ClinGen
TOPMed
CA1478193
rs757704447
200 H>Q No ClinGen
ExAC
TOPMed
gnomAD
CA345661335
rs1218138016
202 P>S No ClinGen
TOPMed
rs528606729
CA40577448
203 V>L No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs528606729
CA1478190
203 V>M No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1446889608
CA345661373
210 T>A No ClinGen
gnomAD
rs1026793444
CA40548801
212 V>A No ClinGen
TOPMed
rs1278741110
CA345661274
219 R>I No ClinGen
TOPMed
rs1572283391
CA345661252
222 N>T No ClinGen
Ensembl
rs765027812
CA1478161
224 H>D No ClinGen
ExAC
gnomAD
rs1345354325
CA345661235
224 H>Q No ClinGen
TOPMed
CA345661225
rs1205364312
226 T>A No ClinGen
TOPMed
gnomAD
CA345661223
rs1358792207
226 T>K No ClinGen
gnomAD
CA345661224
rs1205364312
226 T>S No ClinGen
TOPMed
gnomAD
rs761828408
CA1478160
227 R>Q No ClinGen
ExAC
TOPMed
gnomAD
rs763664917
CA1478158
228 K>T No ClinGen
ExAC
gnomAD
CA1478145
rs758661574
231 Y>C No ClinGen
ExAC
TOPMed
gnomAD
CA1478144
rs750668634
232 G>D No ClinGen
ExAC
gnomAD
CA345661175
rs1228547642
232 G>S No ClinGen
gnomAD
CA345661165
rs757155616
CA1478142
233 L>F No ClinGen
ExAC
gnomAD
CA345661135
rs1392136424
237 I>T No ClinGen
gnomAD
CA345661140
rs1572224082
237 I>V No ClinGen
Ensembl
CA1478140
rs199976031
238 R>G No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs760219259
CA1478139
240 H>Q No ClinGen
ExAC
gnomAD
rs1160188284
CA345661091
244 H>D No ClinGen
TOPMed
gnomAD
rs1480200259
CA345661085
244 H>Q No ClinGen
gnomAD
rs1160188284
CA345661092
244 H>Y No ClinGen
TOPMed
gnomAD
CA345661082
rs1237935531
245 T>A No ClinGen
TOPMed
CA345661074
rs1427324166
246 P>R No ClinGen
gnomAD
rs972020439
CA40543367
246 P>T No ClinGen
TOPMed
gnomAD
CA40543355
rs1056552843
249 E>* No ClinGen
Ensembl
CA1478138
rs775067217
251 K>Q No ClinGen
ExAC
gnomAD
CA1478136
rs759225887
252 P>R No ClinGen
ExAC
gnomAD
CA1478137
rs773208905
252 P>S No ClinGen
ExAC
gnomAD
CA40543341
rs773208905
252 P>T No ClinGen
ExAC
gnomAD
rs773917817
CA1478135
253 P>L No ClinGen
ExAC
gnomAD
rs773917817
CA345661034
253 P>R No ClinGen
ExAC
gnomAD
rs770126499
CA1478134
256 D>N No ClinGen
ExAC
gnomAD
CA345660954
rs1225911094
262 I>M No ClinGen
gnomAD
CA1478114
rs115003204
264 Y>H No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA1478112
rs761238784
267 I>M No ClinGen
ExAC
gnomAD
rs1410561000
CA345660915
268 Q>K No ClinGen
Ensembl
CA345660892
rs1442901420
271 R>G No ClinGen
TOPMed
rs745956675
CA1478109
273 R>Q No ClinGen
ExAC
gnomAD
rs772169550
CA1478110
COSM1584285
COSM171159
273 R>W large_intestine endometrium skin [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
rs779232880
CA1478108
274 L>I No ClinGen
ExAC
gnomAD
CA1478106
rs138506883
279 V>I No ClinGen
1000Genomes
ESP
ExAC
gnomAD
rs777694599
CA1478105
280 A>T No ClinGen
ExAC
TOPMed
gnomAD
CA1478103
rs752661406
281 D>E No ClinGen
ExAC
gnomAD
rs755905595
CA1478104
281 D>H No ClinGen
ExAC
TOPMed
gnomAD
CA345660827
rs755905595
281 D>N No ClinGen
ExAC
TOPMed
gnomAD
CA345660817
rs1193619517
282 S>N No ClinGen
gnomAD
CA1478080
rs754885973
285 S>I No ClinGen
ExAC
gnomAD
COSM679748
rs751557145
CA1478079
COSM1146246
287 T>M lung [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
rs1179948133
CA345660760
289 Q>R No ClinGen
gnomAD
CA345660751
rs1473340373
290 Y>C No ClinGen
gnomAD
rs537711209
CA1478076
291 L>V No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
CA1478075
rs764819020
294 D>N No ClinGen
ExAC
gnomAD
rs1249029275
CA345660715
295 P>L No ClinGen
gnomAD
rs1029579821
CA40542273
296 F>C No ClinGen
Ensembl
CA1478073
rs570364518
296 F>L No ClinGen
1000Genomes
ExAC
TOPMed
gnomAD
rs1248444719
CA345660697
298 L>S No ClinGen
TOPMed
CA1478072
rs768006795
300 P>S No ClinGen
ExAC
gnomAD
rs996793877
CA40542261
301 D>H No ClinGen
Ensembl
rs759944109
CA1478071
305 P>S No ClinGen
ExAC
gnomAD
CA345660631
rs1262717759
308 S>F No ClinGen
gnomAD
CA345660629
rs1369810017
309 D>N No ClinGen
gnomAD
rs1276547618
CA345660618
310 D>G No ClinGen
TOPMed
gnomAD
CA345660607
rs1358837517
312 T>A No ClinGen
TOPMed
CA1478067
rs376230048
318 A>V No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs1572201846
CA345660524
321 E>D No ClinGen
Ensembl
CA1478049
rs763064541
322 P>L No ClinGen
ExAC
TOPMed
gnomAD
CA345660512
rs1350493538
323 S>I No ClinGen
TOPMed
CA1478047
rs765416370
326 R>K No ClinGen
ExAC
gnomAD
rs1388918247
CA345660475
328 K>N No ClinGen
TOPMed
gnomAD
rs1171026927
CA345660472
329 R>* No ClinGen
gnomAD
CA1478046
rs761938100
329 R>Q No ClinGen
ExAC
gnomAD
rs868612423
CA40541553
334 M>I No ClinGen
Ensembl
rs1285975331
CA345660435
334 M>T No ClinGen
TOPMed
CA345660426
rs776954930
335 D>E No ClinGen
ExAC
TOPMed
gnomAD
CA345660422
rs1181998043
336 E>* No ClinGen
TOPMed
gnomAD
COSM3934589
rs1181998043
COSM3934590
CA345660423
336 E>K oesophagus [Cosmic] No ClinGen
cosmic curated
TOPMed
gnomAD
CA1478041
rs772001113
342 V>A No ClinGen
ExAC
TOPMed
gnomAD
CA1478043
rs373266607
342 V>F No ClinGen
ESP
ExAC
TOPMed
gnomAD
CA1478042
rs772001113
342 V>G No ClinGen
ExAC
TOPMed
gnomAD
rs1230438214
CA345660356
346 Q>E No ClinGen
gnomAD
CA1478039
rs369492024
346 Q>H No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs114051974
CA1478038
347 F>L No ClinGen
1000Genomes
ExAC
gnomAD
rs1207358094
CA345660341
348 L>F No ClinGen
TOPMed
rs777506102
CA1478037
352 E>K No ClinGen
ExAC
gnomAD
CA1478036
rs777506102
352 E>Q No ClinGen
ExAC
gnomAD
rs1440917101
CA345660287
356 S>G No ClinGen
gnomAD
rs1368085320
CA345660275
357 S>L No ClinGen
gnomAD
rs967507111
CA40541514
361 R>T No ClinGen
Ensembl
rs1480140446
CA345660225
362 F>Y No ClinGen
gnomAD
CA1478014
rs750873367
363 W>C No ClinGen
ExAC
gnomAD
rs1404588640
CA345660198
366 V>A No ClinGen
TOPMed
rs1189398140
CA345660200
366 V>L No ClinGen
gnomAD
rs758189548
CA1478013
368 D>E No ClinGen
ExAC
TOPMed
gnomAD
rs1308415288
CA345660158
372 R>K No ClinGen
TOPMed
gnomAD
CA40539368
rs1018476186
374 I>V No ClinGen
gnomAD
rs1228532914
CA345660125
377 V>I No ClinGen
gnomAD
COSM1690034
CA345660092
rs1344316159
COSM1690035
382 Q>* skin [Cosmic] No ClinGen
cosmic curated
gnomAD
COSM1685855
CA40539367
rs866505496
COSM1685854
383 E>K skin [Cosmic] No ClinGen
cosmic curated
Ensembl
rs372936482
CA1478009
384 I>M No ClinGen
ESP
ExAC
gnomAD
rs1377093756
CA345660072
385 W>R No ClinGen
gnomAD
CA1478007
rs767265640
388 F>L No ClinGen
ExAC
gnomAD
CA40539347
rs759422202
390 A>D No ClinGen
ExAC
gnomAD
CA40539348
rs1006721270
390 A>S No ClinGen
Ensembl
CA1478006
rs759422202
390 A>V No ClinGen
ExAC
gnomAD
rs1391178312
CA345660033
391 P>S No ClinGen
TOPMed
gnomAD
CA1478003
rs762316382
392 G>A No ClinGen
ExAC
gnomAD
rs772839211
CA1478002
395 S>N No ClinGen
ExAC
TOPMed
gnomAD
rs1261131363
CA345659946
403 S>R No ClinGen
TOPMed
rs17851953
VAR_060604
CA40539330
409 Q>H No ClinGen
UniProt
Ensembl
dbSNP
CA1477999
rs372505807
COSM1473677
COSM1473678
411 V>M breast [Cosmic] No ClinGen
cosmic curated
ESP
ExAC
TOPMed
gnomAD
rs1453698247
CA345659872
414 P>A No ClinGen
gnomAD
CA345659868
rs1388235355
414 P>R No ClinGen
TOPMed
gnomAD
rs1463366057
CA345659862
415 G>E No ClinGen
TOPMed
gnomAD
rs1463366057
CA345659861
415 G>V No ClinGen
TOPMed
gnomAD
CA345659860
rs1249578912
416 R>* No ClinGen
gnomAD
CA1477997
rs746273282
416 R>Q No ClinGen
ExAC
TOPMed
gnomAD
rs929757263
CA40539317
418 T>A No ClinGen
TOPMed
rs1246443542
CA345659236
424 E>K No ClinGen
TOPMed
rs1203749290
CA345659058
436 P>S No ClinGen
TOPMed
gnomAD
CA40538131
rs780215301
437 R>H No ClinGen
Ensembl
COSM1157975
rs776970852
COSM1157974
CA1477974
439 I>V pancreas [Cosmic] No ClinGen
cosmic curated
ExAC
TOPMed
gnomAD
COSM1502021
COSM1502022
CA345658912
rs1307354409
448 L>I lung [Cosmic] No ClinGen
cosmic curated
gnomAD
rs1351182475
CA345658533
457 S>L No ClinGen
gnomAD
rs1391969260
CA345658552
457 S>T No ClinGen
TOPMed
rs141557672
CA345658506
459 D>H No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs141557672
CA1477944
459 D>N No ClinGen
ESP
ExAC
TOPMed
gnomAD
COSM1690029
COSM1690028
CA1477943
rs757243485
460 R>C skin [Cosmic] No ClinGen
cosmic curated
ExAC
gnomAD
CA1477942
rs578115155
COSM3705692
COSM3705693
460 R>H liver [Cosmic] No ClinGen
cosmic curated
1000Genomes
ExAC
TOPMed
gnomAD
CA345658486
rs757243485
460 R>S No ClinGen
ExAC
gnomAD
CA1477939
rs752344716
466 K>I No ClinGen
ExAC
gnomAD
rs145387487
CA1477938
468 A>T No ClinGen
ESP
ExAC
TOPMed
gnomAD
rs763247206
CA1477937
471 V>M No ClinGen
ExAC
gnomAD
CA345658036
rs997687821
475 I>M No ClinGen
TOPMed
rs1030502060
CA40536956
475 I>V No ClinGen
gnomAD
CA345658028
rs1260265849
476 P>H No ClinGen
TOPMed
CA40536945
rs541657079
478 F>S No ClinGen
1000Genomes
rs1449250395
CA345657860
486 P>L No ClinGen
gnomAD
rs574315533
CA40536941
486 P>S No ClinGen
1000Genomes
CA345657847
rs1388648765
487 T>I No ClinGen
TOPMed
gnomAD
rs1005830183
CA40536937
488 L>Q No ClinGen
gnomAD
rs980366085
CA40536916
490 A>V No ClinGen
TOPMed
gnomAD
rs1166689483
CA345657802
492 T>I No ClinGen
Ensembl
CA345657780
rs1294663627
496 L>R No ClinGen
TOPMed
gnomAD

No associated diseases with P49802

4 regional properties for P49802

Type Name Position InterPro Accession
domain DEP domain 37 - 112 IPR000591
domain G-protein gamma-like domain 254 - 316 IPR015898
domain RGS domain 330 - 448 IPR016137
domain Regulator of G-protein signalling, DHEX domain 113 - 214 IPR040759

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
  • Cytoplasm
  • Cell membrane
  • Membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594)
  • Interaction with RGS7BP promotes location at the cell membrane (PubMed:15897264)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

4 GO annotations of molecular function

Name Definition
G-protein alpha-subunit binding Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
G-protein beta-subunit binding Binding to a G-protein beta subunit.
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

10 GO annotations of biological process

Name Definition
brain development The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
G protein-coupled receptor signaling pathway The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
negative regulation of signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
positive regulation of potassium ion transmembrane transport Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport.
regulation of G protein-coupled receptor signaling pathway Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
response to amphetamine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.
response to cold Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
response to ethanol Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.

7 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O46471 RGS16 Regulator of G-protein signaling 16 Bos taurus (Bovine) PR
Q3T0T8 RGS5 Regulator of G-protein signaling 5 Bos taurus (Bovine) PR
O15539 RGS5 Regulator of G-protein signaling 5 Homo sapiens (Human) PR
Q9Z2H1 Rgs11 Regulator of G-protein signaling 11 Mus musculus (Mouse) PR
Q0QWG9 Grid2ip Delphilin Mus musculus (Mouse) PR
O54829 Rgs7 Regulator of G-protein signaling 7 Mus musculus (Mouse) PR
Q18312 rgs-3 Regulator of G-protein signaling rgs-3 Caenorhabditis elegans PR
10 20 30 40 50 60
MAQGNNYGQT SNGVADESPN MLVYRKMEDV IARMQDEKNG IPIRTVKSFL SKIPSVFSGS
70 80 90 100 110 120
DIVQWLIKNL TIEDPVEALH LGTLMAAHGY FFPISDHVLT LKDDGTFYRF QTPYFWPSNC
130 140 150 160 170 180
WEPENTDYAV YLCKRTMQNK ARLELADYEA ESLARLQRAF ARKWEFIFMQ AEAQAKVDKK
190 200 210 220 230 240
RDKIERKILD SQERAFWDVH RPVPGCVNTT EVDIKKSSRM RNPHKTRKSV YGLQNDIRSH
250 260 270 280 290 300
SPTHTPTPET KPPTEDELQQ QIKYWQIQLD RHRLKMSKVA DSLLSYTEQY LEYDPFLLPP
310 320 330 340 350 360
DPSNPWLSDD TTFWELEASK EPSQQRVKRW GFGMDEALKD PVGREQFLKF LESEFSSENL
370 380 390 400 410 420
RFWLAVEDLK KRPIKEVPSR VQEIWQEFLA PGAPSAINLD SKSYDKTTQN VKEPGRYTFE
430 440 450 460 470 480
DAQEHIYKLM KSDSYPRFIR SSAYQELLQA KKKSGNSMDR RTSFEKFAQN VGRNIPIFPC
490
HKNCTPTLRA STNLL