P48848

PR
Gene name
zwf
Protein name
Glucose-6-phosphate 1-dehydrogenase
Names
G6PD
Species
Nostoc punctiforme (strain ATCC 29133 / PCC 73102)
KEGG Pathway
npu:Npun_F4025
EC number
1.1.1.49: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P48848

Entry ID Method Resolution Chain Position Source
AF-P48848-F1 Predicted AlphaFoldDB

No variants for P48848

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P48848

No associated diseases with P48848

3 regional properties for P48848

Type Name Position InterPro Accession
active_site Glucose-6-phosphate dehydrogenase, active site 196 - 202 IPR019796
domain Glucose-6-phosphate dehydrogenase, NAD-binding 25 - 206 IPR022674
domain Glucose-6-phosphate dehydrogenase, C-terminal 208 - 507 IPR022675

Functions

Description
EC Number 1.1.1.49 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
glucose-6-phosphate dehydrogenase activity Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.

2 GO annotations of biological process

Name Definition
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
pentose-phosphate shunt The metabolic process in which glucose-6-phosphate is oxidized to form carbon dioxide (CO2) and ribulose 5-phosphate, coupled to reduction of NADP+ to NADPH; ribulose 5-P then enters a series of reactions that can yield biosynthetic precursors (ribose-5-phosphate and erythrose-4-phosphate) and glycolytic intermediates (fructose-6-phosphate and glyceraldehyde-3-phosphate).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVSLLENPLR VGLQQQGMPE PQIIVIFGAS GDLTWRKLVP ALYKLRRERR IPPETTIVGV
70 80 90 100 110 120
ARREWSHEYF REQMQKGMEE AHPDVDLGEL WQDFSQGLFY SPGDIDNPES YQKLKTLLSE
130 140 150 160 170 180
LDEKRGTRGN RMFYLSVAPS FFPEAIKQLG SGGMLEDPYK HRLVIEKPFG RDLASAQSLN
190 200 210 220 230 240
QVVQKYCKEH QVYRIDHYLG KETVQNLLVF RFANAIFEPL WNRQFVDHVQ ITVAETVGVE
250 260 270 280 290 300
DRAGYYESAG ALRDMLQNHL MQLYCLTAME APNAMDADSI RTEKVKVLQA TRLADVHNLS
310 320 330 340 350 360
RSAVRGQYSA GWMKGQAVPG YRTEPGVDPN STTPTYVAMK FLVDNWRWKG VPFYLRTGKR
370 380 390 400 410 420
MPKKVSEIAI HFREVPSRMF QSAAQQTNAN ILTMRIQPNE GISLRFDVKM PGAEFRTRSV
430 440 450 460 470 480
DMDFSYGSFG IQATSDAYDR LFLDCMMGDQ TLFTRADEVE AAWQVVTPAL SVWDAPADPT
490 500
TIPQYEAGTW EPEQAELLIN QDGRRWRRL