P48801

SS
Gene name
FGF3 (FGF-3)
Protein name
Fibroblast growth factor 3
Names
FGF-3 , Heparin-binding growth factor 3 , HBGF-3
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:396267
EC number
Protein Class

Descriptions

The mammalian fibroblast growth factor (FGF)1 family contains at least 22 distinct polypeptides (FGF1–FGF22) that are expressed in a specific spatial and temporal pattern. FGF9 was originally described as a glia-activating factor and is expressed in the nervous system as a potent mitogen for glia cells. FGF9 adopts a beta-trefoil fold similar to other FGFs, but the N- and C-terminal regions outside the beta-trefoil core are ordered (typical FGFs have disordered tails) and involved in reversible dimerization. Due to the dimerization, a significant surface area is buried in the dimer interface that occludes a major receptor binding site of FGF9 within the beta-trefoil core.

Autoinhibitory domains (AIDs)

36-43 (N-terminal helix) SS

Target domain

46-183 (beta-trefoil core)

Relief mechanism

Assay

201-204 (C-terminal helix) SS

Target domain

46-183 (beta-trefoil core)

Relief mechanism

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P48801

Entry ID Method Resolution Chain Position Source
AF-P48801-F1 Predicted AlphaFoldDB

7 variants for P48801

Variant ID(s) Position Change Description Diseaes Association Provenance
rs737689475 10 A>P No EVA
rs739396479 133 S>P No EVA
rs1058527144 147 R>H No EVA
rs735274469 189 D>E No EVA
rs740012413 192 M>R No EVA
rs737941056 197 H>P No EVA
rs736133746 206 L>P No EVA

No associated diseases with P48801

No regional properties for P48801

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P48801

Functions

Description
EC Number
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

2 GO annotations of molecular function

Name Definition
fibroblast growth factor receptor binding Binding to a fibroblast growth factor receptor (FGFR).
growth factor activity The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

9 GO annotations of biological process

Name Definition
animal organ morphogenesis Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
cell differentiation The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
fibroblast growth factor receptor signaling pathway The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
negative regulation of cardiac muscle tissue development Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle tissue development.
positive regulation of cell division Any process that activates or increases the frequency, rate or extent of cell division.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.

28 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P08620 FGF4 Fibroblast growth factor 4 Homo sapiens (Human) PR
Q9NP95 FGF20 Fibroblast growth factor 20 Homo sapiens (Human) SS
Q9HCT0 FGF22 Fibroblast growth factor 22 Homo sapiens (Human) SS
P10767 FGF6 Fibroblast growth factor 6 Homo sapiens (Human) SS
O15520 FGF10 Fibroblast growth factor 10 Homo sapiens (Human) SS
Q92914 FGF11 Fibroblast growth factor 11 Homo sapiens (Human) SS
P31371 FGF9 Fibroblast growth factor 9 Homo sapiens (Human) EV
O43320 FGF16 Fibroblast growth factor 16 Homo sapiens (Human) EV SS
Q9NSA1 FGF21 Fibroblast growth factor 21 Homo sapiens (Human) PR
P11487 FGF3 Fibroblast growth factor 3 Homo sapiens (Human) SS
P21658 Fgf6 Fibroblast growth factor 6 Mus musculus (Mouse) SS
Q9ESS2 Fgf22 Fibroblast growth factor 22 Mus musculus (Mouse) SS
O35565 Fgf10 Fibroblast growth factor 10 Mus musculus (Mouse) SS
P54130 Fgf9 Fibroblast growth factor 9 Mus musculus (Mouse) SS
Q9JJN1 Fgf21 Fibroblast growth factor 21 Mus musculus (Mouse) PR
Q9ESL8 Fgf16 Fibroblast growth factor 16 Mus musculus (Mouse) SS
Q9ESL9 Fgf20 Fibroblast growth factor 20 Mus musculus (Mouse) SS
P11403 Fgf4 Fibroblast growth factor 4 Mus musculus (Mouse) PR
P61329 Fgf12 Fibroblast growth factor 12 Mus musculus (Mouse) PR
P05524 Fgf3 Fibroblast growth factor 3 Mus musculus (Mouse) SS
Q95L12 FGF9 Fibroblast growth factor 9 Sus scrofa (Pig) SS
Q9EST9 Fgf20 Fibroblast growth factor 20 Rattus norvegicus (Rat) SS
O54769 Fgf16 Fibroblast growth factor 16 Rattus norvegicus (Rat) SS
P36364 Fgf9 Fibroblast growth factor 9 Rattus norvegicus (Rat) SS
P70492 Fgf10 Fibroblast growth factor 10 Rattus norvegicus (Rat) SS
Q6PBT8 fgf1 Putative fibroblast growth factor 1 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q2HXK8 fgf16 Fibroblast growth factor 16 Danio rerio (Zebrafish) (Brachydanio rerio) SS
P48802 fgf3 Fibroblast growth factor 3 Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MLVIWLLLLA LLPEPRVPAA TASPRAPRDA GGRGGVYEHL GGAPRRRKLY CATKYHLQIH
70 80 90 100 110 120
PGGKINGTLE KNSVFSILEI TAVDVGIVAI KGLFSGRYLA MNKRGRLYAS ENYNTECEFV
130 140 150 160 170 180
ERIHELGYNT YASRLYRTVP SGASTKRKAS AERLWYVSVN GKGRPRRGFK TRRTQKSSLF
190 200 210
LPRVLDSKDH EMVRLFHTNV RYRESLLKPP SKNQRRRRGR