P48435
SS
Gene name |
SOX11 |
Protein name |
Transcription factor SOX-11 |
Names |
cSox11 |
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:396104 |
EC number |
|
Protein Class |
|
Descriptions
Sox11 acts as a transcriptional activator of TEAD2 by binding to its gene promoter. This protein possesses intrinsically disordered regions (IDRs) with large negative charge, some of which involve a consecutive sequence of aspartate (D) or glutamate (E) residues, known as D/E repeats. These D/E repeats can cause autoinhibition through intramolecular electrostatic interaction with HMG boxes and modulate binding to DNA. This autoinhibited state can transition into the uninhibited complex with DNA through an electrostatically driven induced-fit process, which accelerates the target DNA search kinetics in the presence of non-functional high-affinity ligands ('decoys').
Autoinhibitory domains (AIDs)
Target domain |
38-129 (HMG box domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
Autoinhibited structure
Activated structure
1 structures for P48435
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P48435-F1 | Predicted | AlphaFoldDB |
No variants for P48435
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P48435 | |||||
No associated diseases with P48435
1 regional properties for P48435
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | High mobility group box domain | 48 - 118 | IPR009071 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-binding transcription activator activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
| RNA polymerase II cis-regulatory region sequence-specific DNA binding | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| brain development | The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). |
| camera-type eye morphogenesis | The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| neuron differentiation | The process in which a relatively unspecialized cell acquires specialized features of a neuron. |
| positive regulation of canonical Wnt signaling pathway | Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P48436 | SOX9 | Transcription factor SOX-9 | Homo sapiens (Human) | PR |
| O94993 | SOX30 | Transcription factor SOX-30 | Homo sapiens (Human) | PR |
| O15370 | SOX12 | Transcription factor SOX-12 | Homo sapiens (Human) | SS |
| P35716 | SOX11 | Transcription factor SOX-11 | Homo sapiens (Human) | EV |
| Q04887 | Sox9 | Transcription factor SOX-9 | Mus musculus (Mouse) | PR |
| Q04886 | Sox8 | Transcription factor SOX-8 | Mus musculus (Mouse) | SS |
| Q04888 | Sox10 | Transcription factor SOX-10 | Mus musculus (Mouse) | PR |
| Q05738 | Sry | Sex-determining region Y protein | Mus musculus (Mouse) | SS |
| Q04890 | Sox12 | Transcription factor SOX-12 | Mus musculus (Mouse) | SS |
| Q7M6Y2 | Sox11 | Transcription factor SOX-11 | Mus musculus (Mouse) | SS |
| P0C1G9 | Sox11 | Transcription factor SOX-11 | Rattus norvegicus (Rat) | SS |
| Q8T3B9 | sem-2 | Transcription factor sem-2 | Caenorhabditis elegans | SS |
| Q6GLH8 | sox17b.2 | Transcription factor Sox-17-beta.2 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| Q66JF1 | sox11 | Transcription factor Sox-11 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVQQAESAES | ESNLPREAMD | TEEGEFMACS | PVALDESDPD | WCKTASGHIK | RPMNAFMVWS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KIERRKIMEQ | SPDMHNAEIS | KRLGKRWKML | KDSEKIPFIR | EAERLRLKHM | ADYPDYKYRP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RKKPKMDPSA | KPNAGQSPEK | NAPGGGSKSA | KSSGKKCSKL | KAAAASPPKP | GAKAAPHGDY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AGDEYVFGAL | KVSSKAVKCV | FVDEEEEDEE | DEDELQLRIK | QEADDEEEDE | EPGPQQLRRY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NVAKVPASPT | LSSSAESTEG | ASLYEEVRGA | AGGGRLYYSF | KNITKQGPPP | PQPPAGLSPA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SVPLHLHLVG | RQRGGGRPPV | RPQPQLLAAW | PRRRRAGGGA | AAGNLSLSLV | DKDLDSFSEG |
| 370 | 380 | 390 | |||
| SLGSHFEFPD | YCTPELSEMI | AGDWLEANFS | DLVFTY |