Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for P48148

Entry ID Method Resolution Chain Position Source
AF-P48148-F1 Predicted AlphaFoldDB

No variants for P48148

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P48148

No associated diseases with P48148

1 regional properties for P48148

Type Name Position InterPro Accession
domain Small GTP-binding protein domain 5 - 159 IPR005225

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Lipid-anchor ; Cytoplasmic side
  • Cytoplasm, cytoskeleton
  • Apical cell membrane ; Lipid-anchor ; Cytoplasmic side
  • Lateral cell membrane ; Lipid-anchor ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

12 GO annotations of cellular component

Name Definition
apical cortex The region that lies just beneath the plasma membrane on the apical edge of a cell.
apical plasma membrane The region of the plasma membrane located at the apical end of the cell.
cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
cell hair A long, thin cell projection that contains F-actin and tubulin, with microtubules centrally located and F-actin peripherally located.
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
cell-cell contact zone Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
lateral plasma membrane The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
actin binding Binding to monomeric or multimeric forms of actin, including actin filaments.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
kinase binding Binding to a kinase, any enzyme that catalyzes the transfer of a phosphate group.
protein kinase binding Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.

70 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
actin cytoskeleton reorganization A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
actin filament bundle assembly The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
actin filament organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
actin-mediated cell contraction The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.
adherens junction maintenance The maintenance of an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
border follicle cell migration The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
cell elongation involved in imaginal disc-derived wing morphogenesis The process in which a cell elongates and contributes to imaginal disc-derived wing morphogenesis.
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
cellularization The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.
compound eye morphogenesis The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
cortical actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
cortical cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
dendrite morphogenesis The process in which the anatomical structures of a dendrite are generated and organized.
dendrite self-avoidance The process in which dendrites recognize and avoid contact with sister dendrites from the same cell.
determination of left/right symmetry The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.
dorsal closure The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
dorsal closure, leading edge cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a leading edge cell, the dorsal-most cells of the epidermis that migrates during dorsal closure.
dorsal closure, spreading of leading edge cells Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa.
endocytic recycling The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
establishment of planar polarity of embryonic epithelium Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates.
establishment of protein localization The directed movement of a protein to a specific location.
establishment or maintenance of actin cytoskeleton polarity Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures.
establishment or maintenance of cell polarity Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
gastrulation involving germ band extension A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster.
germ-band extension Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further.
glial cell migration The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.
hemocyte migration The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo.
imaginal disc-derived leg morphogenesis The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster.
imaginal disc-derived wing hair organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster.
lumen formation, open tracheal system Creation of the central hole of a tube in an open tracheal system through which gases flow.
maintenance of epithelial cell apical/basal polarity The maintenance of the apicobasal polarity of an epithelial cell.
melanization defense response The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin.
mitotic actomyosin contractile ring assembly Any actomyosin contractile ring assembly that is involved in mitotic cytokinesis.
mitotic cytokinesis A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
motor neuron axon guidance The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.
negative regulation of canonical Wnt signaling pathway Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
neuroblast proliferation The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
open tracheal system development The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
peripheral nervous system development The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
positive regulation of protein serine/threonine kinase activity Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
positive regulation of wound healing Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
posterior midgut invagination Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior.
protein localization Any process in which a protein is transported to, or maintained in, a specific location.
protein localization involved in establishment of planar polarity Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity.
protein localization to adherens junction Any process in which a protein is transported to, and/or maintained at the adherens junction.
pseudocleavage involved in syncytial blastoderm formation Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of actomyosin structure organization Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin.
regulation of axonogenesis Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration.
regulation of cell shape Any process that modulates the surface configuration of a cell.
regulation of cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
regulation of embryonic cell shape Any process that modulates the surface configuration of an embryonic cell.
regulation of filopodium assembly Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.
regulation of locomotor rhythm Any process that modulates the frequency, rate or extent of locomotor rhythm.
regulation of Malpighian tubule size Ensuring that a Malpighian tubule is the correct length and diameter.
regulation of myoblast fusion Any process that modulates the frequency, rate or extent of myoblast fusion.
regulation of tube length, open tracheal system Ensuring that a tube in an open tracheal system is of the correct length.
response to wounding Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
salivary gland morphogenesis The process in which the anatomical structures of the salivary gland are generated and organized.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.
spiracle morphogenesis, open tracheal system The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk.
tracheal pit formation in open tracheal system Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster.
ventral furrow formation Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation.
visual perception The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
wound healing The series of events that restore integrity to a damaged tissue, following an injury.

39 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q00246 RHO4 GTP-binding protein RHO4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q17QI8 Rhov Rho-related GTP-binding protein RhoV Bos taurus (Bovine) PR
Q2HJ68 RND1 Rho-related GTP-binding protein Rho6 Bos taurus (Bovine) PR
P61585 RHOA Transforming protein RhoA Bos taurus (Bovine) PR
Q1RMJ6 RHOC Rho-related GTP-binding protein RhoC Bos taurus (Bovine) PR
Q3ZBW5 RHOB Rho-related GTP-binding protein RhoB Bos taurus (Bovine) PR
Q9PSX7 RHOC Rho-related GTP-binding protein RhoC Gallus gallus (Chicken) PR
P24406 RHOA Transforming protein RhoA Canis lupus familiaris (Dog) (Canis familiaris) PR
Q8IMX7 Miro Mitochondrial Rho GTPase Drosophila melanogaster (Fruit fly) PR
Q96L33 RHOV Rho-related GTP-binding protein RhoV Homo sapiens (Human) PR
Q92730 RND1 Rho-related GTP-binding protein Rho6 Homo sapiens (Human) PR
O94844 RHOBTB1 Rho-related BTB domain-containing protein 1 Homo sapiens (Human) PR
P61587 RND3 Rho-related GTP-binding protein RhoE Homo sapiens (Human) PR
O94955 RHOBTB3 Rho-related BTB domain-containing protein 3 Homo sapiens (Human) EV
P08134 RHOC Rho-related GTP-binding protein RhoC Homo sapiens (Human) PR
P61586 RHOA Transforming protein RhoA Homo sapiens (Human) PR
P62745 RHOB Rho-related GTP-binding protein RhoB Homo sapiens (Human) PR
Q8BLR7 Rnd1 Rho-related GTP-binding protein Rho6 Mus musculus (Mouse) PR
P61588 Rnd3 Rho-related GTP-binding protein RhoE Mus musculus (Mouse) PR
Q9DAK3 Rhobtb1 Rho-related BTB domain-containing protein 1 Mus musculus (Mouse) PR
Q9CTN4 Rhobtb3 Rho-related BTB domain-containing protein 3 Mus musculus (Mouse) SS
Q8VDU1 Rhov Rho-related GTP-binding protein RhoV Mus musculus (Mouse) PR
P62746 Rhob Rho-related GTP-binding protein RhoB Mus musculus (Mouse) PR
Q62159 Rhoc Rho-related GTP-binding protein RhoC Mus musculus (Mouse) PR
Q9QUI0 Rhoa Transforming protein RhoA Mus musculus (Mouse) PR
O77683 RND3 Rho-related GTP-binding protein RhoE Sus scrofa (Pig) PR
Q6SA80 Rnd3 Rho-related GTP-binding protein RhoE Rattus norvegicus (Rat) PR
Q9Z1Y0 Rhov Rho-related GTP-binding protein RhoV Rattus norvegicus (Rat) PR
P61589 Rhoa Transforming protein RhoA Rattus norvegicus (Rat) PR
P62747 Rhob Rho-related GTP-binding protein RhoB Rattus norvegicus (Rat) PR
Q9SSX0 RAC1 Rac-like GTP-binding protein 1 Oryza sativa subsp japonica (Rice) PR
Q6Z808 RAC3 Rac-like GTP-binding protein 3 Oryza sativa subsp japonica (Rice) PR
Q68Y52 RAC2 Rac-like GTP-binding protein 2 Oryza sativa subsp japonica (Rice) PR
Q67VP4 RAC4 Rac-like GTP-binding protein 4 Oryza sativa subsp japonica (Rice) PR
Q22038 rho-1 Ras-like GTP-binding protein rhoA Caenorhabditis elegans PR
Q9SU67 ARAC8 Rac-like GTP-binding protein ARAC8 Arabidopsis thaliana (Mouse-ear cress) PR
O82480 ARAC7 Rac-like GTP-binding protein ARAC7 Arabidopsis thaliana (Mouse-ear cress) PR
Q38903 ARAC2 Rac-like GTP-binding protein ARAC2 Arabidopsis thaliana (Mouse-ear cress) PR
O82481 ARAC10 Rac-like GTP-binding protein ARAC10 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MTTIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG KQVELALWDT
70 80 90 100 110 120
AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD
130 140 150 160 170 180
LRNDPNTIRD LAKMKQEPVK PQEGRAMAEK INAFAYLECS AKSKEGVRDV FETATRAALQ
190
VKKRKKTRCL LL