P47821
Gene name |
SSN8 (GIG3, NUT9, SRB11, UME3) |
Protein name |
RNA polymerase II holoenzyme cyclin-like subunit |
Names |
ACE, Dipeptidyl carboxypeptidase I, Kininase II, Suppressor of RNA polymerase B 11 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YNL025C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P47821
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7KPV | EM | 380 A | B | 1-323 | PDB |
| 7KPX | EM | 440 A | B | 1-323 | PDB |
| AF-P47821-F1 | Predicted | AlphaFoldDB |
3 variants for P47821
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s14-584862 | 144 | E>A | No | SGRP | |
| s14-584390 | 301 | D>E | No | SGRP | |
| s14-584334 | 320 | A>V | No | SGRP |
No associated diseases with P47821
3 regional properties for P47821
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cyclin, N-terminal | 64 - 175 | IPR006671 |
| domain | Cyclin-like domain | 80 - 169 | IPR013763-1 |
| domain | Cyclin-like domain | 185 - 292 | IPR013763-2 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| CKM complex | Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8. |
| mediator complex | A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyclin-dependent protein serine/threonine kinase regulator activity | Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. |
| RNA polymerase II core promoter sequence-specific DNA binding | Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
| positive regulation of transcription by galactose | Any process involving galactose that activates or increases the rate of transcription. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle | Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of transcription by RNA polymerase II | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. |
7 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3ZCK5 | CCNC | Cyclin-C | Bos taurus (Bovine) | PR |
| P55168 | CCNC | Cyclin-C | Gallus gallus (Chicken) | PR |
| P25008 | CycC | Cyclin-C | Drosophila melanogaster (Fruit fly) | PR |
| P24863 | CCNC | Cyclin-C | Homo sapiens (Human) | PR |
| Q62447 | Ccnc | Cyclin-C | Mus musculus (Mouse) | PR |
| P39947 | Ccnc | Cyclin-C | Rattus norvegicus (Rat) | PR |
| Q28F72 | ccnc | Cyclin-C | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGSFWTSTQ | RHHWQYTKAS | LAKERQKLWL | LECQLFPQGL | NIVMDSKQNG | IEQSITKNIP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ITHRDLHYDK | DYNLRIYCYF | LIMKLGRRLN | IRQYALATAH | IYLSRFLIKA | SVREINLYML |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VTTCVYLACK | VEECPQYIRT | LVSEARTLWP | EFIPPDPTKV | TEFEFYLLEE | LESYLIVHHP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YQSLKQIVQV | LKQPPFQITL | SSDDLQNCWS | LINDSYINDV | HLLYPPHIIA | VACLFITISI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HGKPTKGSSL | ASAASEAIRD | PKNSSSPVQI | AFNRFMAESL | VDLEEVMDTI | QEQITLYDHW |
| 310 | 320 | ||||
| DKYHEQWIKF | LLHTLYLRPA | SAI |