P47811

SS
Gene name
Mapk14 (Crk1, Csbp1, Csbp2)
Protein name
Mitogen-activated protein kinase 14
Names
MAP kinase 14 , MAPK 14 , EC 2.7.11.24 , CRK1 , Mitogen-activated protein kinase p38 alpha , MAP kinase p38 alpha
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:26416
EC number
2.7.11.24: Protein-serine/threonine kinases
Protein Class

Descriptions

MAPK1 encodes Mitogen-activated protein kinase 1, and is involved in diverse cellular responses by phosphorylating cytoplasmic and nuclear proteins. Unlike other MAP kinases, MAPK1 activates via dual phosphorylation of Thr-186 and Tyr-193 within the activation lip, and mutations at Q105 alone were sufficient for autoactivation. Additionally, in the inactive form, L76, Q10 and I87 form a structural unit that restrains intramolecular autophosphorylation by preventing interactions between activation lip residues and the catalytic base (D149) needed for phosphoryl transfer. Mutations at L76, I87 and additionally S153 increased basal specific activity via autophosphorylation of Thr-186 and Tyr-193.

Autoinhibitory domains (AIDs)

73-152 (Autoinhibitory region) SS

Target domain

24-308 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

167-187 (Activation loop from InterPro)

Target domain

24-308 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

122 structures for P47811

Entry ID Method Resolution Chain Position Source
1LEW X-ray 230 A A 1-360 PDB
1LEZ X-ray 230 A A 1-360 PDB
1YW2 X-ray 201 A A 1-360 PDB
1YWR X-ray 195 A A 1-360 PDB
2EWA X-ray 210 A A 1-360 PDB
2GHL X-ray 210 A A 5-352 PDB
2GHM X-ray 235 A A 5-352 PDB
2GTM X-ray 190 A A 5-352 PDB
2GTN X-ray 180 A A 5-352 PDB
2OZA X-ray 270 A B 2-360 PDB
2PUU X-ray 250 A A 5-352 PDB
3P4K X-ray 230 A A 1-360 PDB
3P5K X-ray 209 A A 2-360 PDB
3P78 X-ray 230 A A 2-360 PDB
3P79 X-ray 210 A A 2-360 PDB
3P7A X-ray 231 A A 2-360 PDB
3P7B X-ray 190 A A 2-360 PDB
3P7C X-ray 230 A A 2-360 PDB
3PY3 X-ray 210 A A 1-360 PDB
3TG1 X-ray 271 A A 1-360 PDB
4KA3 X-ray 271 A A 1-360 PDB
4LOO X-ray 195 A A 1-360 PDB
4LOP X-ray 205 A A/B/C/D 1-360 PDB
4LOQ X-ray 232 A A/B/C/D 1-360 PDB
4TYH X-ray 300 A B 6-353 PDB
5LAR X-ray 150 A A 1-360 PDB
5NZZ X-ray 260 A E/F/G/H 1-360 PDB
5O90 X-ray 249 A A 1-360 PDB
5R8U X-ray 148 A A 1-360 PDB
5R8V X-ray 148 A A 1-360 PDB
5R8W X-ray 150 A A 1-360 PDB
5R8X X-ray 173 A A 1-360 PDB
5R8Y X-ray 168 A A 1-360 PDB
5R8Z X-ray 165 A A 1-360 PDB
5R90 X-ray 162 A A 1-360 PDB
5R91 X-ray 173 A A 1-360 PDB
5R92 X-ray 166 A A 1-360 PDB
5R93 X-ray 149 A A 1-360 PDB
5R94 X-ray 145 A A 1-360 PDB
5R95 X-ray 159 A A 1-360 PDB
5R96 X-ray 177 A A 1-360 PDB
5R97 X-ray 144 A A 1-360 PDB
5R98 X-ray 168 A A 1-360 PDB
5R99 X-ray 189 A A 1-360 PDB
5R9A X-ray 153 A A 1-360 PDB
5R9B X-ray 166 A A 1-360 PDB
5R9C X-ray 174 A A 1-360 PDB
5R9D X-ray 169 A A 1-360 PDB
5R9E X-ray 177 A A 1-360 PDB
5R9F X-ray 199 A A 1-360 PDB
5R9G X-ray 173 A A 1-360 PDB
5R9H X-ray 149 A A 1-360 PDB
5R9I X-ray 181 A A 1-360 PDB
5R9J X-ray 152 A A 1-360 PDB
5R9K X-ray 150 A A 1-360 PDB
5R9L X-ray 147 A A 1-360 PDB
5R9M X-ray 181 A A 1-360 PDB
5R9N X-ray 169 A A 1-360 PDB
5R9O X-ray 160 A A 1-360 PDB
5R9P X-ray 172 A A 1-360 PDB
5R9Q X-ray 165 A A 1-360 PDB
5R9R X-ray 176 A A 1-360 PDB
5R9S X-ray 170 A A 1-360 PDB
5R9T X-ray 180 A A 1-360 PDB
5R9U X-ray 167 A A 1-360 PDB
5R9V X-ray 145 A A 1-360 PDB
5R9W X-ray 189 A A 1-360 PDB
5R9X X-ray 172 A A 1-360 PDB
5R9Y X-ray 157 A A 1-360 PDB
5R9Z X-ray 166 A A 1-360 PDB
5RA0 X-ray 191 A A 1-360 PDB
5RA1 X-ray 161 A A 1-360 PDB
5RA2 X-ray 157 A A 1-360 PDB
5RA3 X-ray 157 A A 1-360 PDB
5RA4 X-ray 159 A A 1-360 PDB
5RA5 X-ray 154 A A 1-360 PDB
5RA6 X-ray 186 A A 1-360 PDB
5RA7 X-ray 192 A A 1-360 PDB
5RA8 X-ray 178 A A 1-360 PDB
5RA9 X-ray 168 A A 1-360 PDB
5UOJ X-ray 210 A A 1-360 PDB
6SO1 X-ray 166 A A 1-360 PDB
6SO2 X-ray 160 A A 1-360 PDB
6SO4 X-ray 151 A A 1-360 PDB
6SOD X-ray 187 A A 1-360 PDB
6SOI X-ray 155 A A 1-359 PDB
6SOT X-ray 154 A A 1-360 PDB
6SOU X-ray 150 A A 1-360 PDB
6SOV X-ray 131 A A 1-360 PDB
6SP9 X-ray 122 A A 1-360 PDB
6SPL X-ray 138 A A 1-360 PDB
6Y4T X-ray 198 A A 1-360 PDB
6Y4U X-ray 186 A A 1-360 PDB
6Y4V X-ray 175 A A 1-360 PDB
6Y4W X-ray 186 A A 1-360 PDB
6Y4X X-ray 160 A A 1-360 PDB
6Y6V X-ray 210 A A 1-360 PDB
6Y7W X-ray 139 A A 1-360 PDB
6Y7X X-ray 145 A A 1-360 PDB
6Y7Y X-ray 151 A A 1-360 PDB
6Y7Z X-ray 135 A A 1-360 PDB
6Y80 X-ray 124 A A 1-360 PDB
6Y81 X-ray 154 A A 1-360 PDB
6Y82 X-ray 144 A A 1-360 PDB
6Y85 X-ray 158 A A 1-360 PDB
6Y8H X-ray 137 A A 1-360 PDB
6YCU X-ray 135 A A 1-360 PDB
6YCW X-ray 134 A A 1-360 PDB
6YJC X-ray 174 A A 1-360 PDB
6YK7 X-ray 190 A A 1-360 PDB
6ZWR X-ray 190 A A 1-360 PDB
7BDO X-ray 270 A A 1-360 PDB
7BDQ X-ray 275 A A 1-360 PDB
7BE4 X-ray 210 A A 1-360 PDB
7BE5 X-ray 180 A A 1-360 PDB
7PVU X-ray 215 A A/B 1-359 PDB
7Z6I X-ray 225 A AAA 1-359 PDB
7Z9T X-ray 260 A AAA/BBB 1-359 PDB
8ACM X-ray 214 A AAA 1-359 PDB
8ACO X-ray 265 A AAA 1-359 PDB
8EFJ X-ray 231 A A 2-360 PDB
AF-P47811-F1 Predicted AlphaFoldDB

17 variants for P47811

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389454041 41 A>V No EVA
rs3389460044 51 A>T No EVA
rs3389449917 59 F>I No EVA
rs3389464922 123 T>P No EVA
rs3389416644 125 D>N No EVA
rs3389442365 130 L>I No EVA
rs3389416620 169 F>L No EVA
rs3389440849 179 M>L No EVA
rs3413123001 205 D>N No EVA
rs3389447291 214 A>T No EVA
rs3389447354 220 R>G No EVA
rs3389416625 243 G>R No EVA
rs3389460030 292 D>N No EVA
rs3553340160 306 A>G No EVA
rs3389464978 309 A>V No EVA
rs3389361257 311 Y>C No EVA
rs3389449893 348 F>L No EVA

No associated diseases with P47811

3 regional properties for P47811

Type Name Position InterPro Accession
domain Protein kinase domain 24 - 308 IPR000719
conserved_site Mitogen-activated protein (MAP) kinase, conserved site 59 - 162 IPR003527
binding_site Protein kinase, ATP binding site 30 - 54 IPR017441

Functions

Description
EC Number 2.7.11.24 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nuclear speck A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle pole Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

9 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
MAP kinase activity Catalysis of the reaction
mitogen-activated protein kinase p38 binding Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation.
NFAT protein binding Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction
protein phosphatase binding Binding to a protein phosphatase.
protein serine kinase activity Catalysis of the reactions
protein serine/threonine kinase activity Catalysis of the reactions

58 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
bone development The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
cartilage condensation The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.
cell morphogenesis The developmental process in which the size or shape of a cell is generated and organized.
cellular response to ionizing radiation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays.
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
cellular response to lipoteichoic acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.
cellular response to tumor necrosis factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
cellular response to UV-B Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm.
cellular response to vascular endothelial growth factor stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
cellular response to virus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
chondrocyte differentiation The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
DNA damage checkpoint signaling A signal transduction process that contributes to a DNA damage checkpoint.
DNA damage response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
fatty acid oxidation The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
glucose import The directed movement of the hexose monosaccharide glucose into a cell or organelle.
glucose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
lipopolysaccharide-mediated signaling pathway The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers
negative regulation of canonical Wnt signaling pathway Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
negative regulation of hippo signaling Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.
osteoblast differentiation The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
osteoclast differentiation The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
p38MAPK cascade An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
placenta development The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
positive regulation of brown fat cell differentiation Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
positive regulation of cardiac muscle cell proliferation Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
positive regulation of erythrocyte differentiation Any process that activates or increases the frequency, rate or extent of erythrocyte differentiation.
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
positive regulation of glucose import Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
positive regulation of interleukin-12 production Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.
positive regulation of myoblast differentiation Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
positive regulation of myoblast fusion Any process that activates or increases the frequency, rate or extent of myoblast fusion.
positive regulation of myotube differentiation Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
positive regulation of protein import into nucleus Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
positive regulation of reactive oxygen species metabolic process Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
regulation of cytokine production involved in inflammatory response Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response.
regulation of DNA-templated transcription Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
regulation of ossification Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
regulation of synaptic membrane adhesion Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
response to dietary excess The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.
response to insulin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
response to lipopolysaccharide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
response to muramyl dipeptide Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.
response to muscle stretch Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.
skeletal muscle tissue development The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are
stem cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
stress-activated MAPK cascade The series of molecular signals in which a stress-activated MAP kinase cascade relays a signal; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.
stress-induced premature senescence A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.
striated muscle cell differentiation The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.
transcription by RNA polymerase II The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
transmembrane receptor protein serine/threonine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.
vascular endothelial growth factor receptor signaling pathway The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

90 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P32485 HOG1 Mitogen-activated protein kinase HOG1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
A5PKJ4 MAPK7 Mitogen-activated protein kinase 7 Bos taurus (Bovine) SS
Q3T0N5 MAPK13 Mitogen-activated protein kinase 13 Bos taurus (Bovine) SS
P46196 MAPK1 Mitogen-activated protein kinase 1 Bos taurus (Bovine) SS
Q5F3W3 MAPK6 Mitogen-activated protein kinase 6 Gallus gallus (Chicken) SS
Q9N272 MAPK13 Mitogen-activated protein kinase 13 Pan troglodytes (Chimpanzee) SS
Q95NE7 MAPK14 Mitogen-activated protein kinase 14 Pan troglodytes (Chimpanzee) SS
Q9W354 Erk7 Extracellular signal-regulated kinase 7 Drosophila melanogaster (Fruit fly) SS
P40417 rl Mitogen-activated protein kinase ERK-A Drosophila melanogaster (Fruit fly) SS
P83100 p38c Putative mitogen-activated protein kinase 14C Drosophila melanogaster (Fruit fly) SS
O62618 p38a Mitogen-activated protein kinase p38a Drosophila melanogaster (Fruit fly) SS
O61443 p38b Mitogen-activated protein kinase p38b Drosophila melanogaster (Fruit fly) SS
O15264 MAPK13 Mitogen-activated protein kinase 13 Homo sapiens (Human) SS
P53778 MAPK12 Mitogen-activated protein kinase 12 Homo sapiens (Human) SS
P28482 MAPK1 Mitogen-activated protein kinase 1 Homo sapiens (Human) EV
Q16659 MAPK6 Mitogen-activated protein kinase 6 Homo sapiens (Human) SS
P27361 MAPK3 Mitogen-activated protein kinase 3 Homo sapiens (Human) SS
Q13164 MAPK7 Mitogen-activated protein kinase 7 Homo sapiens (Human) SS
Q15759 MAPK11 Mitogen-activated protein kinase 11 Homo sapiens (Human) SS
Q8TD08 MAPK15 Mitogen-activated protein kinase 15 Homo sapiens (Human) SS
P31152 MAPK4 Mitogen-activated protein kinase 4 Homo sapiens (Human) SS
Q16539 MAPK14 Mitogen-activated protein kinase 14 Homo sapiens (Human) SS
Q9JKV2 Cilk1 Serine/threonine-protein kinase ICK Mus musculus (Mouse) PR
Q04859 Mak Serine/threonine-protein kinase MAK Mus musculus (Mouse) PR
Q9WVS4 Mok MAPK/MAK/MRK overlapping kinase Mus musculus (Mouse) PR
Q80Y86 Mapk15 Mitogen-activated protein kinase 15 Mus musculus (Mouse) SS
Q9WTU6 Mapk9 Mitogen-activated protein kinase 9 Mus musculus (Mouse) PR
Q91Y86 Mapk8 Mitogen-activated protein kinase 8 Mus musculus (Mouse) PR
Q63844 Mapk3 Mitogen-activated protein kinase 3 Mus musculus (Mouse) SS
P63085 Mapk1 Mitogen-activated protein kinase 1 Mus musculus (Mouse) SS
Q6P5G0 Mapk4 Mitogen-activated protein kinase 4 Mus musculus (Mouse) SS
Q61532 Mapk6 Mitogen-activated protein kinase 6 Mus musculus (Mouse) SS
Q9WVS8 Mapk7 Mitogen-activated protein kinase 7 Mus musculus (Mouse) SS
O08911 Mapk12 Mitogen-activated protein kinase 12 Mus musculus (Mouse) SS
Q9Z1B7 Mapk13 Mitogen-activated protein kinase 13 Mus musculus (Mouse) SS
Q9WUI1 Mapk11 Mitogen-activated protein kinase 11 Mus musculus (Mouse) SS
Q9WTY9 Mapk13 Mitogen-activated protein kinase 13 Rattus norvegicus (Rat) SS
P63086 Mapk1 Mitogen-activated protein kinase 1 Rattus norvegicus (Rat) SS
Q9Z2A6 Mapk15 Mitogen-activated protein kinase 15 Rattus norvegicus (Rat) SS
P27704 Mapk6 Mitogen-activated protein kinase 6 Rattus norvegicus (Rat) SS
P21708 Mapk3 Mitogen-activated protein kinase 3 Rattus norvegicus (Rat) SS
Q63538 Mapk12 Mitogen-activated protein kinase 12 Rattus norvegicus (Rat) SS
Q63454 Mapk4 Mitogen-activated protein kinase 4 Rattus norvegicus (Rat) SS
P0C865 Mapk7 Mitogen-activated protein kinase 7 Rattus norvegicus (Rat) SS
P70618 Mapk14 Mitogen-activated protein kinase 14 Rattus norvegicus (Rat) SS
Q5ZCI1 MPK10 Mitogen-activated protein kinase 10 Oryza sativa subsp. japonica (Rice) SS
Q5VP69 MPK16 Mitogen-activated protein kinase 16 Oryza sativa subsp. japonica (Rice) SS
Q5SN53 MPK8 Mitogen-activated protein kinase 8 Oryza sativa subsp. japonica (Rice) SS
Q0E459 MPK13 Mitogen-activated protein kinase 13 Oryza sativa subsp. japonica (Rice) SS
Q6Z437 MPK3 Mitogen-activated protein kinase 3 Oryza sativa subsp. japonica (Rice) SS
Q75KK8 MPK14 Mitogen-activated protein kinase 14 Oryza sativa subsp. japonica (Rice) SS
Q67C40 MPK7 Mitogen-activated protein kinase 7 Oryza sativa subsp. japonica (Rice) SS
Q6L5F7 MPK17 Mitogen-activated protein kinase 17 Oryza sativa subsp. japonica (Rice) SS
Q5VN19 MPK11 Mitogen-activated protein kinase 11 Oryza sativa subsp. japonica (Rice) SS
Q5Z859 MPK4 Mitogen-activated protein kinase 4 Oryza sativa subsp. japonica (Rice) SS
Q5Z9J0 MPK12 Mitogen-activated protein kinase 12 Oryza sativa subsp. japonica (Rice) SS
Q53N72 MPK15 Mitogen-activated protein kinase 15 Oryza sativa subsp. japonica (Rice) SS
Q336X9 MPK6 Mitogen-activated protein kinase 6 Oryza sativa subsp. japonica (Rice) SS
Q5J4W4 MPK2 Mitogen-activated protein kinase 2 Oryza sativa subsp. japonica (Rice) SS
Q84UI5 MPK1 Mitogen-activated protein kinase 1 Oryza sativa subsp. japonica (Rice) SS
Q10N20 MPK5 Mitogen-activated protein kinase 5 Oryza sativa subsp. japonica (Rice) SS
Q11179 mapk-15 Mitogen-activated protein kinase 15 Caenorhabditis elegans SS
O44514 pmk-3 Mitogen-activated protein kinase pmk-3 Caenorhabditis elegans PR
P39745 mpk-1 Mitogen-activated protein kinase mpk-1 Caenorhabditis elegans SS
G5EBT1 sma-5 Mitogen-activated protein kinase sma-5 Caenorhabditis elegans SS
Q8MXI4 pmk-2 Mitogen-activated protein kinase pmk-2 Caenorhabditis elegans SS
Q17446 pmk-1 Mitogen-activated protein kinase pmk-1 Caenorhabditis elegans SS
Q39021 MPK1 Mitogen-activated protein kinase 1 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LM33 MPK8 Mitogen-activated protein kinase 8 Arabidopsis thaliana (Mouse-ear cress) SS
Q9C5C0 MPK18 Mitogen-activated protein kinase 18 Arabidopsis thaliana (Mouse-ear cress) SS
Q39022 MPK2 Mitogen-activated protein kinase 2 Arabidopsis thaliana (Mouse-ear cress) SS
Q9C9U4 MPK15 Mitogen-activated protein kinase 15 Arabidopsis thaliana (Mouse-ear cress) SS
Q84M93 MPK17 Mitogen-activated protein kinase 17 Arabidopsis thaliana (Mouse-ear cress) SS
Q39027 MPK7 Mitogen-activated protein kinase 7 Arabidopsis thaliana (Mouse-ear cress) SS
Q9SJG9 MPK20 Mitogen-activated protein kinase 20 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LUC3 MPK19 Mitogen-activated protein kinase 19 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LV37 MPK9 Mitogen-activated protein kinase 9 Arabidopsis thaliana (Mouse-ear cress) SS
O23236 MPK14 Mitogen-activated protein kinase 14 Arabidopsis thaliana (Mouse-ear cress) SS
Q8W4J2 MPK16 Mitogen-activated protein kinase 16 Arabidopsis thaliana (Mouse-ear cress) SS
Q39023 MPK3 Mitogen-activated protein kinase 3 Arabidopsis thaliana (Mouse-ear cress) SS
Q39026 MPK6 Mitogen-activated protein kinase 6 Arabidopsis thaliana (Mouse-ear cress) SS
Q39025 MPK5 Mitogen-activated protein kinase 5 Arabidopsis thaliana (Mouse-ear cress) SS
Q39024 MPK4 Mitogen-activated protein kinase 4 Arabidopsis thaliana (Mouse-ear cress) SS
Q9M1Z5 MPK10 Mitogen-activated protein kinase 10 Arabidopsis thaliana (Mouse-ear cress) SS
Q8GYQ5 MPK12 Mitogen-activated protein kinase 12 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LMM5 MPK11 Mitogen-activated protein kinase 11 Arabidopsis thaliana (Mouse-ear cress) SS
Q9LQQ9 MPK13 Mitogen-activated protein kinase 13 Arabidopsis thaliana (Mouse-ear cress) SS
O42376 mapk12 Mitogen-activated protein kinase 12 Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9DGE2 mapk14a Mitogen-activated protein kinase 14A Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q9DGE1 mapk14b Mitogen-activated protein kinase 14B Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGHRV AVKKLSRPFQ
70 80 90 100 110 120
SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ
130 140 150 160 170 180
KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT
190 200 210 220 230 240
GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG
250 260 270 280 290 300
TPGAELLKKI SSESARNYIQ SLAQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA
310 320 330 340 350
QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES