P47116

PR
Gene name
PTK2 (STK2, YJR059W, J1725)
Protein name
Serine/threonine-protein kinase PTK2/STK2
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YJR059W
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

7-250 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

405-435 (Activation loop from InterPro)

Target domain

255-562 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P47116

Entry ID Method Resolution Chain Position Source
AF-P47116-F1 Predicted AlphaFoldDB

20 variants for P47116

Variant ID(s) Position Change Description Diseaes Association Provenance
s10-545810 11 D>H No SGRP
s10-545817 13 S>N No SGRP
s10-545969 64 G>S No SGRP
s10-546071 98 S>P No SGRP
s10-546096 106 V>A No SGRP
s10-546596 273 K>Q No SGRP
s10-546739 320 N>K No SGRP
s10-547215 479 I>T No SGRP
s10-547268 497 V>L No SGRP
s10-547311 511 R>K No SGRP
s10-547371 531 K>M No SGRP
s10-547451 558 N>D No SGRP
s10-547590 604 V>A No SGRP
s10-547806 676 K>M No SGRP
s10-547886 703 S>A No SGRP
s10-547896 706 V>A No SGRP
s10-547908 710 L>S No SGRP
s10-547980 734 N>T No SGRP
s10-548016 746 Q>P No SGRP
s10-548126 783 G>R No SGRP

No associated diseases with P47116

3 regional properties for P47116

Type Name Position InterPro Accession
domain Protein kinase domain 255 - 562 IPR000719
active_site Serine/threonine-protein kinase, active site 384 - 396 IPR008271
binding_site Protein kinase, ATP binding site 261 - 285 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

8 GO annotations of biological process

Name Definition
cellular ion homeostasis Any process involved in the maintenance of an internal steady state of ions at the level of a cell.
G1/S transition of mitotic cell cycle The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
protein phosphorylation The process of introducing a phosphate group on to a protein.
putrescine transport The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.
regulation of cell size Any process that modulates the size of a cell.
spermidine transport The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
spermine transport The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

8 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P36004 KKQ8 Probable serine/threonine-protein kinase KKQ8 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P28708 PRR1 Serine/threonine-protein kinase PRR1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P06782 SNF1 Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) EV
Q8AYC9 CHEK1 Serine/threonine-protein kinase Chk1 Gallus gallus (Chicken) PR
O61661 grp Serine/threonine-protein kinase grp Drosophila melanogaster (Fruit fly) SS
O14757 CHEK1 Serine/threonine-protein kinase Chk1 Homo sapiens (Human) EV
O35280 Chek1 Serine/threonine-protein kinase Chk1 Mus musculus (Mouse) PR
Q91ZN7 Chek1 Serine/threonine-protein kinase Chk1 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MAGNGKDKEV DKSPSVSTLK LLGKRLFNSS SHTDNSSLLL SAEQLGNGRS LRKRPTSPSI
70 80 90 100 110 120
SGSGSGGNSP SSSAGARQRS ASLHRRKNNA SVGFSNGSVS SHKSSVALQD LIKHNNNPYL
130 140 150 160 170 180
NSPSDILGTG TGIASTRDRD RAVLDREKEK ERARNKERNT HHAGLPQRSN SMASHHFPNE
190 200 210 220 230 240
NIVYNPYGIS PNHARPDTAF ADTLNTNKEN DLSFYMHDGN SKIRMLPLPI ANPNDFLPED
250 260 270 280 290 300
MKQYSVHLTD NFVFDTDNKP IGSGGSSEVR KVKSSYRQKD VYALKKLNMI YHESPEKFYK
310 320 330 340 350 360
RCSKEFIIAK HLSHNVHITN TFYLLKVPTT TYTTRGWGFI MELGVKDLFQ LMERTGWKNV
370 380 390 400 410 420
PFNEKYCLFK QVAQGIKFCH DNGIAHRDLK PENVLISKEG ICKLTDFGIS DWYHVIPHDY
430 440 450 460 470 480
TSPVKTCQGM IGSPPYTPPE VMYFDAKKHY PEKFQKPYNP LAMDSYALGI MLITMINNII
490 500 510 520 530 540
PFIDSCNTDA RFREFEVSYD NFINHQNPHF RDKGCHKPGP GSEYSLARNF KNTDATRIAW
550 560 570 580 590 600
RLADPNPATR YTMDDLFNDP FFQQIETCVE PNDDDLVRVP ELRKSTSTND FSENSLDAPH
610 620 630 640 650 660
DQEVIHTSNP FLKKETLTSK PRSMLEIAES PSLKQKSKVK DSAKTKTHDV GDEGGNESTK
670 680 690 700 710 720
PKQQDKKENL KKDEVKNGDK DKVIEEATTT NVDSILEKPT PTSTKVEDNL SEDDSTMKEL
730 740 750 760 770 780
KSMLNSTPTT PTHNGPTPLP AKAGTQLDKR MSDLSLKSET PASTKNFSAP NVSSSSNSLR
790 800 810
SLGSPSVSSS KKKKVIHHHL DITNSVTNMS SVSAFISR